Researchers at Stanford University School of Medicine have developed a new approach to programming CAR-T cells that can prolong their activity and increase their effectiveness against human cancer cells. The technique uses ATAC-Seq to understand what happens when T cells become exhausted, and modifying CAR-T cells to restore balance in...
Researchers have characterized three genes associated with insecticide resistance in malaria mosquitoes, found to cause resistance to all four classes of public health insecticides. This breakthrough work provides much-needed tools for monitoring the growing problem through molecular testing.
Researchers developed a modified Mg metal anode via surface ion-exchange reaction, enabling stable electrochemical performance and reversible plating/stripping at high current densities. The artificial layer improves ion transport kinetics, reducing overpotential and increasing battery lifespan.
Researchers have developed a non-invasive method to visualize kidney disease in live animals using genetically modified mice. They found that a promising chemical found in citrus fruit, G-Hes, reduces inflammation in the kidneys when fed to mice with kidney disease.
Researchers genetically engineered CAR T cells with molecular tags, allowing them to be monitored in animal models using PET imaging. This technology enables clinicians to track the number and location of CAR T cells over time, providing a more accurate measure of therapy durability and potential efficacy.
A Cornell University study found that non-GMO labeled produce experiences a significant boost in demand when accompanied by a GMO label on other products. The 'halo effect' suggests consumers perceive non-GMO labels as more trustworthy and desirable.
A Clemson University researcher is developing genetically improved perennial grasses that can thrive with less water and serve as a sustainable fuel source. The goal is to create more stress-resistant plants through molecular strategies, including site-specific DNA recombination systems.
A novel transfection method called nano-electro-injection delivers DNA into immune cells two to three times more efficiently than conventional methods. This technique improves the process of generating high-quality genetically modified immune cells for cancer immunotherapy, reducing cell stress and improving cell health.
A team of US and Chinese scientists, led by UCI Professors Xiangmin Xu and Rozanne Sandri-Goldin, will develop a new brain mapping tool using genetically engineered herpesviruses. The tool aims to enhance signal outputs and generate variants carrying different functional payloads.
Researchers have designed a new class of modified pantothenamides that stop malaria parasites from replicating in humans and preventing transmission to mosquitoes. These compounds are effective against malaria parasites resistant to currently available drugs.
Scientists genetically modified mycoparasites to express Green Fluorescent Protein, revealing they can live up to 21-days on host plant surfaces without harming the environment. The study showed that these mycoparasites cannot spread in sterile soil or decomposing leaves, addressing concerns about their impact.
Research using stable isotopes shows that some mammals thrive on agricultural products in modified landscapes, while others rely on forest resources. Habitat loss from agriculture may pose conservation challenges, highlighting the need for sustainable land-use practices.
Consuming more gluten during early childhood is associated with higher risk of celiac disease and autoimmunity among genetically predisposed children. The study found a significant increase in risk for every 1-gram per day increase in gluten consumption.
Researchers at the University of Pittsburgh School of Medicine have successfully grown genetically modified miniature human livers in a laboratory setting. These mini livers mimic non-alcoholic fatty liver disease progression and can be used to test therapeutics, providing a valuable tool for understanding and treating diseases.
Researchers at the University of Illinois identified genetic signatures that distinguish male from female waterhemp and Palmer amaranth plants, a crucial step in developing genetic control. The discovery aims to introduce genetically modified male plants that would contain a gene drive to control the damaging weeds.
A team at Technical University of Munich has developed modified T cells using CRISPR-Cas9, which can recognize specific antigens without mixed receptors. These near-natural cells have the same structure but are capable of being genetically modified, making them suitable for cancer therapy and potential solutions to immunotherapy problems.
Researchers have developed a genetically modified virus that kills cancer cells and makes them sensitive to chemotherapy drugs, halting tumor progression in mice. The combination of p53 gene therapy and cabazitaxel resulted in full control of tumor growth, with an additive or synergistic effect.
A new roadmap by the Engineering Biology Research Consortium outlines potential breakthroughs in synthetic biology, including genetically modified crops, disease-fighting microbes, and novel biofuels. The report aims to secure federal support for this field to address societal challenges and fuel economic growth.
A recent study published in the Journal of Environmental Psychology found that people's existing knowledge about genetically modified food is a significant determining factor of their attitudes towards it. Learning the underlying science leads to more positive attitudes, a greater willingness to eat them, and a lowered perception of GM...
Researchers propose lab-grown insect meat as a solution to environmental concerns, combining benefits of insect farming, GM livestock and plant-based meat substitutes. The technology requires fewer resources and less energy-intensive control, with potential for mass food production and scalable cost-effectiveness.
Researchers used genetically modified fruit flies to test candidate treatments for a patient with KRAS-mutant metastatic colorectal cancer. The approach identified trametinib plus zoledronate as a promising combination that prolonged survival and reduced targeted tumors.
A new study concludes that EU's restrictive regulation of GMO crops cannot be justified, even considering risks to the environment. The researchers argue that GMO crops can be consistent with organic farming principles and should not be treated differently from conventional products.
A new model predicts substantial reduction of malaria transmitting mosquitoes in West Africa by introducing genetically modified male mosquitoes with a driving-Y chromosome. The approach, which targets the most important species of malaria mosquitoes, has the potential to reduce populations and ultimately eliminate disease transmission.
A global moratorium on heritable genome editing is proposed by a group of international scientists and ethicists due to safety concerns and the need for societal consensus. The proposal aims to establish an international framework and provide time for public discussions before germline editing is permitted.
The proliferation of genetically modified seeds in India has led to 'choice overload,' where farmers struggle to make decisions due to a vast array of options. Farmers prioritize community expectations and social status over yield, driven by the desire to be successful and modern.
A recent study found that about half of US consumers have positive attitudes towards genetically modified food, while nearly 14% have negative perceptions. The survey also revealed that demographics such as age and education level play a role in shaping opinions on GM science.
Researchers have successfully produced high-quality human proteins in eggs from genetically modified hens, offering a promising alternative to expensive mammalian cell culture techniques. The study found that the proteins worked at least as well as those produced using existing methods, with no adverse effects on the chickens.
A genetically modified virus injection into tumor has effectively treated almost 40 percent of patients with metastatic melanoma. The treatment, talimogene laherparepvec (TVEC), stimulates the immune system to attack cancer cells, leading to a complete local response rate of 39 percent in stage IIIB disease.
Researchers at Salk Institute mapped the genomes and epigenomes of genetically modified plant lines with high resolution, revealing molecular-level changes when foreign DNA is inserted. This study provides new methods for minimizing potential off-target effects in transgenic plants.
A new study found that a conversion message by British environmentalist Mark Lynas, who turned from an opponent to an advocate of GM crops, had a greater impact on public attitudes than a direct advocacy message. The study suggests that people's minds may be more easily changeable on this issue.
Researchers found that genetically engineered protein 3K3A-APC protects against Alzheimer's-like symptoms in mice by reducing amyloid-β toxin accumulation and inflammation. The study suggests 3K3A-APC as an alternative therapy for early stage Alzheimer's disease.
A study published in Nature Human Behaviour found that people who strongly oppose genetically modified foods often believe they know more about the topic than they actually do. Despite a scientific consensus on GM food safety and nutritional benefits, many opponents think they are knowledgeable on the subject.
Researchers developed nanosized LiFePO4 modified electrodes for biochemical analysis, detecting rutin and hemoglobin with high sensitivity. The electrodes achieved detection limits of 8.0 nmol L-1 for rutin and 0.068 mmol L-1 for trichloroacetic acid reduction.
Researchers studied genetically modified mice with neurofibromatosis type 1 (NF1), a condition associated with sleep problems. The mice exhibited fragmented and irregular sleep patterns, similar to people with NF1. This study could help identify molecular mechanisms underlying sleep disturbances in humans.
Researchers have created a genetically modified houseplant that can efficiently remove at least two toxins, formaldehyde and benzene, from the air. The plant's detoxifying potential was boosted by introducing a mammalian gene called CYP2E1 into its genome.
Researchers have genetically modified a common houseplant to remove chloroform and benzene from the air, two hazardous compounds linked to cancer. The modified pothos ivy plants express a protein that converts these pollutants into harmless molecules, which can support plant growth.
Researchers discovered that genetically vulnerable mice exposed to marijuana showed increased inflammation in brain cells linked to serious mental illnesses. The study suggests that marijuana's brain-damaging effects may be more pronounced in teens with a specific genetic mutation.
Researchers developed genetically modified pigs resistant to classical swine fever virus using CRISPR/Cas9 and RNA interference. These tansgenic pigs can effectively limit CSFV replication and reduce disease severity, with stable transmission to offspring.
A McGill-led research team has developed a computational process to track the transmission histories of rare genetic diseases, tracing CAID back to two European founding families in 17th century Quebec. The researchers hope to extend their search techniques to more common genetically based diseases and identify new genetic variants.
Researchers reported promising early results from a clinical study of genetically engineered immune cells that recognize and fight cancer cells. The treatment generated excellent responses when used after chemotherapy, with 71% of patients achieving complete response.
Researchers used genetically modified mice with a highly permeable blood-brain barrier to test whether prions in blood can enter the brain. Their results suggest that passage of prions through the blood-brain barrier may not be relevant to disease development. Instead, prions likely reach the brain by traveling along nerves.
Researchers at Hiroshima University have developed a biocontainment strategy to safely control the spread of genetically modified cyanobacteria. By engineering microalgae to depend on a specific nutrient, they prevent its survival outside of a controlled environment.
A survey of 2,537 US adults found that roughly half believe the average person faces a serious health risk from food additives over their lifetime. Similarly, about half think genetically modified foods are worse for one's health. Women and those with low science knowledge tend to express more concern about these issues.
A genetically programable strain of yeast fueled by light-harvesting nanoparticles can efficiently convert carbon into high-value chemicals. This new biohybrid system overcomes existing limitations in bioinorganic systems, offering a promising method for producing high-value chemicals.
Researchers found that people who believe GMOs are beneficial are less likely to support labeling of nano products, while those who distrust scientific authorities more favor labeling. The study aims to better inform shoppers' purchasing decisions and help businesses understand consumer views on emerging technologies.
Scientists have successfully modified arsenene with chloromethylene groups, improving its semiconducting properties. The modified material exhibits strong luminescence and electronic properties, making it attractive for optoelectronic applications.
Researchers at Boston Children's Hospital have developed a new method to create customized mouse models for studying the brain. This technique involves using a natural toxin to kill off developing brain cells, allowing scientists to reconstitute the forebrain from genetically engineered stem cells. The resulting mice have tightly contr...
Scientists and legal scholars warn that DARPA's Insect Allies program could be misused for biological warfare due to the ease of dispersing genetically edited viruses into fields. The technology has the potential to rapidly alter crop properties, raising concerns about its peaceful use.
A US defense agency program aims to genetically modify crops using infectious viruses, sparking concerns about its potential military applications and the risk of creating new biological weapons. The approach, known as HEGAAs, would deliver the viruses through insects, raising questions about transparency and public deliberation.
Scientists at the University of Konstanz have gained detailed structural insights into DNA polymerases interacting with modified substrates. This knowledge can be used to advance genome sequencing and other areas of molecular biology-based diagnostics.
A study found similar trends in streamflow in natural and human-modified watersheds, indicating climate-induced changes. Streamflow decreased in the southern US and increased in northeastern states and Canadian prairies.
A groundbreaking study by Oregon State University demonstrates the potential for genetically modified forest trees to prevent new seedlings from establishing. Researchers successfully engineered containment traits that limit the spread of genetically modified or exotic poplar trees, mitigating societal concerns over gene flow.
Researchers have discovered a second-generation drug that can silence the gene responsible for inherited ALS by injecting it into rodents. The new version of the drug is more effective at reducing SOD1 protein production and delaying disease progression. It may be ready for early-stage clinical trials.
Dr. Raj Ladher of NCBS receives grant to study protein protocadherin-15 and its role in hearing loss. The funds will aid in understanding how modified protocadherin-15 affects hair cell response to sound, which could lead to treatment development for hearing loss.
Research at Osaka University reveals SATB1's vital role in maintaining pluripotency of hematopoietic stem cells, influencing self-renewal ability and lymphoid lineage differentiation. High SATB1 expression enhances lymphoid differentiation ability.
Researchers at University of California San Diego School of Medicine and University of Minnesota have developed a new CAR-T immunotherapy using natural killer cells engineered from human induced pluripotent stem cells. These cells demonstrated heightened activity against ovarian cancer with less toxicity, offering potential advantages ...
A study from the University of Vermont found that mandatory labeling in Vermont improved consumer attitudes toward genetically modified food, with opposition falling by 19%. The simple disclosure reduced fear and increased transparency, allowing consumers to make informed decisions.
A new study from the American Association for the Advancement of Science found that mandatory labeling of genetically engineered (GE) foods in Vermont led to a 19% reduction in opposition to these products. By providing transparency, labels may alleviate public concerns about GE food safety.
A genetically modified poliovirus therapy developed at Duke Cancer Institute has shown significantly improved long-term survival for patients with recurrent glioblastoma, with a three-year survival rate of 21 percent. The therapy preferentially targets tumor cells and ignites a targeted immune response.
A recent study by Professor Jesper Lassen found no correlation between public reservations about genetically modified foods and parliamentary debate. Politicians focus on benefits and risks, ignoring the moral and ethical dimensions that concern citizens most.