Articles tagged with Bipolar Disorder
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Researchers found that astrocytes from patients with bipolar disorder secrete more IL-6, which worsens symptoms and negatively impacts neuronal activity. The study highlights the potential role of astrocyte-mediated inflammatory signaling in psychiatric diseases.
Researchers developed a test to distinguish between forms of BDNF proteins, which can predict depression and bipolar disorder. The test uses serum mBDNF levels as a biomarker for diagnosis.
Researchers found that decreased activation of gene LEF1 disrupts neuronal function and promotes hyperexcitability in brain cells, a hallmark of bipolar disorder. Increasing LEF1 expression may lead to new drug targets and biomarkers for lithium nonresponsiveness.
A study published in eLife found that individuals with bipolar disorder who exhibit pessimistic beliefs are more likely to experience relapse. The study suggests that the way patients update their beliefs can be used as a risk prediction tool, allowing for timely intervention and improved outcomes.
A review of 39 randomized clinical trials found that combining therapy with medication is more effective in preventing illness recurrence in people with bipolar disorder. Psychoeducation and group therapy were particularly helpful in reducing symptoms and improving outcomes.
A machine learning system has been developed that can predict the development of Bipolar Disorder up to 4 years before onset in young people. The system identified risk factors such as suicidal tendencies and financial problems, allowing doctors to take preventative measures.
A study from the Danish psychiatry project iPSYCH identified genetic risk factors for developing bipolar disorder and psychoses among people with depression. The results may contribute to ensuring correct diagnosis is made earlier, leading to better treatment outcomes.
A team of scientists created a map highlighting the brain circuits affected in mania, which could lead to more effective treatments for bipolar disorder. The study identified specific regions, including the orbitofrontal cortex and inferior temporal cortex, as key players in mood regulation and emotional processing.
Researchers at Kumamoto University found that DNA methylation in the serotonin transporter gene is inversely correlated with amygdala volume in male patients with schizophrenia and bipolar disorder. The study suggests a potential biomarker for onset prediction, diagnosis, and therapeutic effects.
A study found that individuals with bipolar disorder who switched to high-deductible health plans experienced a moderate decrease in nonpsychiatrist mental health outpatient visits. However, rates of psychiatrist visits, medication use, emergency department visits, and hospitalizations remained unchanged.
Patients with multiple family members suffering from severe mental disorders require more intensive treatment, but respond equally well as those without a family history. The study found that family mental health affects patients' lives beyond the disorder itself.
Researchers at Hokkaido University developed a paper-based device to measure lithium ion concentration in blood, which can help treat bipolar disorder patients. The device is user-friendly, low-cost, and comparable in detection ability to conventional instruments.
A new study by Salk researchers finds that altered potassium levels in neurons may contribute to mood swings in bipolar disorder. The study reveals two distinct types of neurons in people with bipolar disorder who respond to lithium and those who don't, highlighting the need for personalized treatment approaches.
Researchers discovered that lower circHomer1a levels in the brain's frontal cortex are correlated with schizophrenia symptoms and impaired cognitive flexibility in mice. The study suggests that circular RNAs play a crucial regulatory role in gene expression, potentially serving as biomarkers for diagnosis and treatment targets.
A University of Miami study has found that the profiles of genes influencing cognition are similar across people with schizophrenia, bipolar disorder, and the general population. This discovery could lead to more effective therapies for improving cognitive function in patients with severe mental illness.
A UCLA-led study found that family-focused therapy can delay new and recurring bipolar symptoms in children and teens. The treatment, which involves teaching patients and families better communication skills, resulted in 77% of adolescents recovering from initial symptoms within four years.
A new study uses an interactive voice application with AI to monitor patients' mental health, offering personalized analysis and finding accuracy comparable to physician assessments. The application, MyCoachConnect, analyzed patients' speech patterns and found unique changes over time, helping track mental states.
A new wearable lithium monitor developed by the University of Surrey has the potential to revolutionize the treatment of bipolar disorder. The device can detect lithium levels and potentially provide warning signals for high levels, reducing the risk of toxicity.
A study of over 200 patients with bipolar disorder found that high levels of inflammation, as measured by C-reactive protein, were significantly linked to poor cognitive performance. This suggests a potentially modifiable risk factor for cognitive deficits, and highlights the importance of addressing inflammation in treatment.
A systematic review and meta-analysis of seven studies with 4.3 million participants found a potential association between bipolar disorder and an increased likelihood of a subsequent Parkinson disease diagnosis. However, subgroup analyses suggest possible overestimation of the magnitude of the associations.
A study published in Biological Psychiatry found that relatives of patients with schizophrenia and bipolar disorder have unique brain abnormalities, despite symptom overlap. The findings suggest that familial risk for these disorders influences brain development already early in life.
A new study suggests a significant link between exposure to environmental pollution and an increase in the prevalence of neuropsychiatric disorders. The study found poor air quality associated with increased rates of bipolar disorder and major depression in both the US and Denmark.
Research highlights patchy care, delayed diagnosis, and lack of guidance for treating first-time manic episodes. Effective treatments are available but often overlooked, exacerbating symptoms and worsening health outcomes.
A systematic review suggests that lithium's effects on breastfeeding are poorly understood due to sparse and poorly designed studies. Expert recommendations vary, and more research is necessary to inform patient decisions.
A national Taiwanese health database study found people with bipolar disorder were nearly seven times as likely to develop Parkinson's disease as those without the condition. The risk was higher for those hospitalized more frequently, developing the disease at a younger age.
A newly discovered epigenetic hotspot in the genome may drive psychosis in schizophrenia and bipolar disorder, potentially leading to new treatment targets and biomarkers. The hotspot affects dopamine production and synaptic development, which are critical regulators of brain function.
Researchers identified 20 new genetic associations with bipolar disorder in a massive study of over 50,000 subjects across 14 countries. The findings highlight the complexity of the disease and its overlap with other psychiatric disorders.
A genome-wide study found that copy number variants (CNVs) are more closely associated with a 'schizophrenia-like' bipolar disorder subtype than the broader form of bipolar disorder. This suggests a distinct mechanism underlying the biology of schizoaffective disorder, which shares symptoms with schizophrenia.
Researchers discovered that people with bipolar disorder have lower levels of the CPG2 protein, which regulates glutamate receptor numbers at excitatory synapses. Genetic variations in the SYNE1 gene, encoding the protein, undermine its expression and function in neurons.
A new study from Johns Hopkins Bloomberg School of Public Health found that increasing physical activity during the day is associated with improved spirits. The research also suggests that tracking sleep, activity, mood, and energy levels concurrently can provide valuable insights for people with bipolar disorder.
A new specialist programme at South London and Maudsley NHS Foundation Trust has been shown to significantly reduce hospital readmissions for people with bipolar disorder. The OPTIMA Mood Disorders Service provides intensive, specialist treatment tailored to individual needs, resulting in lower rates of re-admission.
New reviews on symptom stability over time for bipolar disorder and psychotic disorders highlight the importance of diagnostic accuracy for prognosis and treatment. Diagnostic instability is associated with factors such as extreme age, female sex, and substance abuse, emphasizing the need for enhanced tools to quantify risk.
A new multi-national database will help researchers address questions about bipolar disorder throughout the adult lifespan. The database will aggregate data from over 1,000 patients worldwide, enabling scientists to uncover patterns of and predictors for the condition.
A pilot study found that pregnant women with a history of depression or bipolar disorder process infant facial and vocal signals of emotion differently. Pregnant women with bipolar disorder had difficulty recognizing all facial expressions, while those with previous depression showed a negative bias in adult facial expression recogniti...
A clinical trial suggests that individuals with bipolar disorder who have a high-quality diet, low BMI, or anti-inflammatory properties may respond better to nutraceutical treatment. The study found statistically significant results but emphasizes the need for replication in larger trials before firm conclusions can be drawn.
Researchers found that brain activity in the amygdala responds differently to facial expressions in individuals with bipolar disorder versus those with depression. The study demonstrated 80% accuracy in distinguishing between the two conditions. This finding holds promise for improving diagnosis and treatment of these disorders.
Research using brain scans found that neurons in the amygdala respond differently in people with bipolar disorder versus those with depression. The study showed an 80% accuracy rate in distinguishing between the two conditions. This discovery could lead to more accurate diagnoses and better treatment outcomes for patients.
Researchers from the University of Surrey developed a fiber-based sensor that can detect lithium concentration levels in blood, providing an easy-to-use alternative to invasive blood samples. The sensor is ready to use and doesn't require pre-conditioning, making it ideal for people with bipolar disorder and depression.
Researchers developed a novel psychological intervention to treat anxiety in bipolar disorder, which was effective in improving clinical outcomes and reducing suicidality. The intervention included individualized formulation-driven approach and cognitive behavioral strategies to address anxiety experiences.
Researchers found a significant association between cured meat consumption and mania, suggesting nitrates may contribute to the abnormal mood state. The study, published in Molecular Psychiatry, analyzed data from over 1,000 individuals with and without psychiatric disorders.
Researchers at RIKEN Center for Brain Science found mitochondrial dysfunction affects serotonergic neurons in mice with ANT1 mutations, linking the two pathways.
A large study of over 91,000 people found a strong association between disrupted body clock rhythms and an increased risk of depression, bipolar disorder, and poor wellbeing. Disruptions to normal daily circadian rhythms were linked to mood instability, loneliness, lower happiness, and worse cognitive function.
Researchers found higher levels of vitamin D binding protein in children with bipolar disorder compared to those without mood disorders. The study suggests a potential blood test to confirm bipolar diagnosis, which could improve care and reduce the current 10-year average lag time.
A study published in JAMA Psychiatry found that lithium treatment significantly reduces the risk of rehospitalization for individuals with bipolar disorder, with a 30% lower risk compared to no treatment. Long-acting injections of antipsychotics also showed promise, reducing the risk by 30%.
A new study published in Biological Psychiatry found that bipolar I and II disorders have different biological causes, with stronger family clustering for each subtype. The research also identified distinct gender differences and genetic correlations between the subtypes.
A University of Michigan team has identified seven distinct phenotypes in people with bipolar disorder, each with unique biological mechanisms and external influences. These findings have the potential to help patients, clinicians, and researchers better understand the condition.
Researchers at UTHealth found that individuals with bipolar disorder exhibit accelerated epigenetic aging, which may explain why they are more prone to age-related diseases and have shorter lifespans. The study suggests that lifestyle factors such as diet, exercise, and substance use can contribute to this premature aging.
Teenage cannabis use at least 2-3 times weekly is directly associated with suffering from symptoms of hypomania in later years. The study found that adolescent cannabis use is an independent risk factor for future hypomania, suggesting a potential causal link.
Researchers found that heart rate variability measured by an electrocardiogram indicated whether subjects had major depression or bipolar disorder. Patients with bipolar disorder had higher blood levels of inflammation biomarkers than those with major depression.
Researchers at McLean Hospital discovered a unique brain training program that improves cognitive skills in individuals with bipolar disorder. The study found significant improvements in cognitive performance, memory, and visual learning, with sustained benefits six months after treatment.
Patients with bipolar disorder who received bright light therapy at midday experienced a higher remission rate of 68% compared to 22.2% on placebo, with significant reductions in depression scores and improvements in daily functioning.
A genetic variant associated with multiple psychiatric disorders is linked to changes in a brain network that may increase an individual's risk of developing bipolar disorder or schizophrenia. The variant affects the expression of the SNAP25 protein, impacting information processing between brain regions involved in regulating emotions.
Researchers created mice lacking ankyrin-G protein, displaying hyperactivity and reduced anxiety. Lithium treatment reversed these behaviors, mirroring human bipolar disorder symptoms.
A first-of-its-kind study reveals that expanding waistlines and body fat distribution are key factors contributing to obesity in individuals with psychotic disorders. The research found that nearly two-thirds of those with schizophrenia and more than half of those with bipolar disorder were obese 20 years after their first hospitalizat...
A study by researchers at Mount Sinai identified a brain mechanism that makes siblings of bipolar patients resilient to the disease. The brain can adapt to its biological risk, opening new avenues for research on enhancing resilience.
A study led by the University of California, Berkeley, found that people with mental illness reoffend less if placed on specialty probation, a program using individualized treatment-oriented approaches. Specialty probationers had a 52% recidivism rate over two years compared to 29% for traditional probationers.
A new study found that individuals with bipolar disorder often face exclusion and stigma at work, leading to negative outcomes. The research highlights the importance of intervening to improve relationships with co-workers and supervisors, and suggests that workplace support is crucial for individuals with severe mental illness.
A study published in Neuropsychopharmacology found decreased brain pH levels in mouse models of schizophrenia, bipolar disorder, and autism spectrum disorder. The research suggests that lower brain pH may be an underlying pathophysiology for these mental disorders.
Research suggests that individuals with a family history of bipolar disorder may experience faster biological aging. The study found that patients treated with lithium had longer telomeres, which could help reverse age-related changes. This association may explain the higher rates of aging-related diseases among bipolar disorder patients.
Researchers found differences in immune system factors between men and women with bipolar disorder, particularly in zinc levels associated with depression severity in women. This study suggests that biological changes in the body could be used to diagnose the disease and tailor treatments differently for men and women.