Articles tagged with Bipolar Disorder
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Researchers at the University of Cincinnati developed a genetic fuzzy logic AI that predicted treatment outcomes for bipolar patients with 100% accuracy, surpassing conventional models. The AI, called LITHIA, can analyze vast amounts of data to identify the best treatment options, offering new hope for those affected by bipolar disorder.
Researchers at Lancaster University found that online self-management support for parents with Bipolar Disorder improves parenting skills, child behavior, and reduces parenting stress. The intervention combines self-management strategies with mood management to promote consistent parenting.
A recent study has identified the molecular mechanism behind lithium's effectiveness in treating bipolar disorder, providing a clear path to developing new diagnostic tests and therapies. The research, led by Sanford Burnham Prebys Medical Discovery Institute, utilized human induced pluripotent stem cells to map lithium's response path...
A global consortium has created the first map of bipolar disorder's impact on the brain, revealing clear differences in brain regions controlling inhibition and emotion. The study found significant thinning of gray matter in patients with bipolar disorder, particularly in areas responsible for emotional regulation.
The Heinz C. Prechter Bipolar Research Program has received a $5 million gift commitment from the World Heritage Foundation - Prechter Family Fund, which will double donations to bipolar disorder research. The program aims to identify effective solutions for people with bipolar disorder through long-term studies and DNA analysis.
Researchers developed ERPonline to help people with bipolar disorder recognize and respond to early warning signs of relapse. Accessing the online tool was associated with improved beliefs about mood and increased monitoring of early warning signs compared to non-users.
Scientists at the Salk Institute have developed a new method to predict which individuals with bipolar disorder will respond to lithium therapy. Using a system trained on electrical firing patterns of neurons from six patients, the method achieved 92% accuracy in classifying responders and nonresponders.
Research validates PLCgamma1 as a promising candidate gene for bipolar disorder, linking it to manic-like behavior and synaptic imbalance. The study reveals that loss of PLCgamma1 from forebrain leads to behavioral abnormalities and manic episodes.
Researchers have discovered two novel genetic risk factors for bipolar disorder, FADS1 and FADS2, which play a crucial role in lipid metabolism. These findings support the notion that lipid abnormalities may contribute to the development of BD.
A new NIH-funded study aims to test ways family members can maintain their health while caring for relatives with bipolar disorder. Researchers will match caregivers with tailored self-management techniques, including breathing exercises and training in self-help skills, to reduce stress and improve overall health.
A recent study published in JAACAP found that obesity among adolescents with bipolar disorder is associated with increased illness severity, including more suicide attempts and psychiatric hospitalizations. However, the study also found that overweight adolescents with bipolar disorder are not more common than their peers.
Researchers identified 13 gene groups common to all three mental disorders, including those involved in protein production, immune response and brain cell communication. The study suggests that targeting these shared pathways could lead to new treatment strategies.
A study of 522 children found that those born to parents with schizophrenia or bipolar disorder scored higher on a behavior checklist and were at increased risk for anxiety, ADHD, and neurocognitive problems. The children also came from families with lower social status and more adverse life events.
A University of Manchester study found that people with bipolar disorder are 2.63 times more likely to have experienced emotional, physical, or sexual abuse as children compared to the general population. This strong link has implications for treatment and personalized therapy plans.
A follow-up study finds that bipolar adolescents are at higher risk for substance use disorder and smoking five years later. The presence of conduct disorder, particularly when combined with bipolar symptoms, significantly increases this risk.
Researchers have made patients' stem cells available for worldwide study to better understand bipolar disorder, a serious mental illness with extreme mood swings. The shared stem cells can be turned into brain cells in the lab, enabling scientists to study how the disease affects brain cells and potentially lead to new treatments.
A study by University of New South Wales and Italian researchers found a significant delay in diagnosing bipolar disorder, with an average delay of almost six years. This delay can lead to missed opportunities for early intervention and reduced severity of episodes.
Researchers found that mindfulness-based cognitive therapy increases activity in brain regions controlling emotional processing, leading to reduced anxiety in youth at risk of bipolar disorder. The study's pilot trial showed significant improvements in clinician-rated and youth-rated anxiety following 12 weeks of treatment.
Research found that patients hospitalized for mania were more likely to be on antibiotics to treat active infections than healthy controls. This link between infection, antibiotics, and manic episodes adds evidence to the gut-brain axis theory, suggesting that a person's microbiome plays a role in psychiatric symptoms.
A Swedish study found that trigger events like exposure to violence were linked to increased risk of violent crime among patients with schizophrenia and bipolar disorder. The study also revealed a higher risk for individuals without psychiatric diagnoses who experienced similar triggers.
Researchers from Scripps Florida have discovered a link between bipolar disorder and the striatum, a brain region involved in motor planning and reward perception. The study identified 14 genes differentially expressed in bipolar patients compared to non-bipolar controls, suggesting a causal role in the disorder.
Research at Umeå University found a link between low cortisol levels and increased risk of obesity, dyslipidaemia and metabolic syndrome in patients with recurrent depressions or bipolar disorder. Cortisol regulation is linked to worsened physical health in these patients.
Researchers have identified 84 potential inherited gene mutations that may contribute to severe forms of bipolar disorder. The study used advanced genome sequencing techniques to analyze DNA from 36 family members with the disease, finding rare genetic variations that were overrepresented in those with bipolar disorder.
Researchers at McLean Hospital discovered that individuals with bipolar disorder have altered somatostatin expression in the brain's amygdala, which regulates anxiety and stress response. This altered circadian function is linked to severity of depression and anxiety symptoms, providing potential neural correlates for circadian rhythm ...
Researchers are exploring whether deep brain stimulation (DBS) can provide relief for patients with bipolar disorder who do not respond to medications. The study aims to identify structural targets in the brain that may be involved in the disorder and potentially treat it through DBS.
A study of 6,671 individuals found lower rates of self-harm and unintentional injuries among those taking lithium compared to other mood stabilizers. Lithium may reduce impulsive aggression in addition to stabilizing mood.
A new study suggests a genetic overlap between bipolar disorder and autism, adding to the growing understanding that many psychiatric diseases share common roots. The research identified 84 rare genetic variations linked to bipolar disorder that were also associated with schizophrenia and autism.
A Johns Hopkins study found that men with schizophrenia and bipolar disorder have a higher rate of yeast infections than those without these disorders. Women with schizophrenia also performed worse on memory tests after testing positive for yeast infections.
A new study found that electronic health records (EHRs) frequently fail to capture comprehensive mental health data, resulting in potential medication errors and patient harm. The research highlights the importance of supplementing EHR-derived data with external sources to improve patient care.
A study found that mice with a genetic mutation exhibiting periodic changes in locomotor activity and mood-like behaviors, similar to humans with bipolar disorder. Gene expression patterns in the brain identified circadian genes as key players in regulating infradian oscillations.
A new Scripps Research Institute study has identified specific genetic variations associated with increased susceptibility to bipolar disorder and other conditions. The research focuses on a gene called PDE10A, which produces proteins that regulate intracellular levels of cAMP, influencing biological processes like learning and memory.
Researchers are testing SPI-1005, an oral drug containing ebselen, as a potential treatment for bipolar disorder. The treatment has shown promise in addressing the lack of effective options for patients with this condition.
Studies have shown that medications used to treat bipolar disorder, particularly mood stabilizers, can increase grey matter volume and normalize white matter disorganization. These findings suggest a predominantly ameliorative effect of psychopharmacological treatment on brain anatomy.
A study found that around 10% of UK primary care patients prescribed antidepressants for depression or anxiety have undiagnosed bipolar disorder. The condition often presents with depression and can be difficult to diagnose, leading to inappropriate treatment.
A new study suggests that childhood trauma is associated with worse impulse control in adulthood, particularly among those without bipolar disorder. The research found that adults who experienced physical, emotional, or sexual abuse as children performed poorly on a quick task measuring inhibitory control.
Naturally occurring brain wiring changes can help patients at high genetic risk of developing bipolar disorder avoid the illness. Researchers found that resilient siblings showed additional changes in brain wiring within networks involved in emotional processing, which may help them avoid the disease.
Researchers identified 13 inherited sleep and activity measures linked to bipolar disorder, including later waking times and shorter periods of activity. The study provides clues to the genetic nature of the disorder and potential new approaches for prevention and treatment.
Researchers at Karolinska Institutet identified a gene variant linked to psychotic symptoms and cognitive impairment in people with bipolar disorder. The study found that the gene variant affects levels of specific proteins in the brain, which may lead to new targeted drug development.
Research found a heightened risk of subsequent mania and bipolar disorder in adults treated with certain antidepressants, including SSRIs and venlafaxine. The peak age for diagnosis was among patients aged 26 to 35, with an annual risk of 1.2%.
Researchers at Oxford University have successfully conducted human trials on the 'rescued' drug ebselen, which may offer a safer alternative to lithium for treating bipolar disorder. The initial trial found that ebselen had similar effects on the brain as lithium and showed promise in reducing side effects.
Researchers discovered that bipolar patients' brain cells are more sensitive to stimuli, leading to differing responses to lithium. The study suggests a starting point for probing cellular differences and developing new treatments.
A multicenter study confirms lithium's efficacy and safety for children with bipolar disorder in the short term. The study showed significant improvement in symptoms compared to placebo, without significant weight gain or serious side effects.
The Brain & Behavior Research Foundation honored nine scientists for their work in schizophrenia, mood disorders, and cognitive neuroscience. The awards recognize the transformative power of neuroscience to improve mental health.
A University of Chicago team aims to establish a new system of diagnosis for psychotic diseases using biomarkers, which may guide the development of novel therapies. The Bipolar-Schizophrenia Network on Intermediate Phenotypes will recruit additional study participants over five years.
Researchers at University of California, Irvine discovered that valproic acid preserves the M-current during seizures, which contributes to neuronal hyperexcitability. This finding points to new drug discovery approaches with fewer side effects.
Researchers discovered a consistent reduction in gray matter volume in the right anterior insula portion of the brain across all 4 ethnic groups studied. This finding suggests that this region may provide valuable information for diagnostic evaluations in various Axis I disorders.
Teens with major depression or bipolar disorder are more likely to have several cardiovascular disease risk factors, including high blood pressure and obesity. Early monitoring is urged to reduce the risk of cardiovascular disease among young people.
Researchers developed an objective method to differentiate between bipolar disorder and major depressive disorder (MDD) based on urine metabolites. A panel of six biomarkers showed an 89-91% accuracy rate in predicting each condition.
Poor sleep quality predicts increased severity and frequency of depression and mania in women with bipolar disorder. For men, baseline depression score and neuroticism are stronger predictors of mood outcome. Improving sleep quality could help patients avoid mood episodes and improve quality of life.
A new study finds that genetic risk scores for schizophrenia and bipolar disorder are higher in creative individuals, suggesting a shared genetic root with creativity. This association could provide new clues about the underlying biological pathways of psychiatric disorders.
Women with depression and bipolar disorder performed poorly on a test of cognitive control, which requires sustained concentration. Brain scans showed different levels of activity in the right posterior parietal cortex compared to healthy women.
Research by Mark Zimmerman suggests borderline personality disorder's psychosocial morbidity and suicidality comparable to bipolar disorder. The study highlights the need for improved detection and treatment of BPD.
A new study by Tel Aviv University researchers found that an insulin-like hormone, IGF-1, increases lithium sensitivity in blood cells of patients who do not respond to traditional treatment. This breakthrough may pave the way for improving the efficacy of lithium in treating bipolar disorder.
A new study by CAMH reveals that people with severe schizophrenia have distinct differences in their brain networks compared to those with schizophrenia, bipolar disorder, and healthy individuals. The research provides strong evidence that schizophrenia is not one but rather multiple brain disorders.
Researchers discovered a strong correlation between short, distinct episodes of manic symptoms and the development of bipolar disorder in high-risk children. The study suggests that monitoring these symptoms could lead to earlier identification and treatment.
A systematic review found a significant link between cannabis use and the onset of mania symptoms in individuals with pre-existing bipolar disorder. Cannabis use was also shown to worsen mania symptoms in those without pre-existing bipolar disorder, highlighting a major clinical problem.
Researchers at the University of Iowa have discovered previously unrecognized differences in the brains of patients with bipolar disorder using a novel MRI imaging approach. The study found elevated signal in cerebral white matter and cerebellar region of patients, suggesting abnormal cell metabolism may play a role in the disorder.
This special issue of Harvard Review of Psychiatry provides an overview of recent advances in understanding and treating bipolar disorder. Key findings include the role of white matter disease, stress and HPA axis function, effectiveness of lithium, stimulants for depression, functional remediation, and issues in network meta-analysis.
A transgenic mouse with a rare human genetic variation in the dopamine transporter protein may lead to improvements in ADHD, autism and bipolar disorder diagnosis and treatment. The mice exhibit unusual "darting behavior," which could be related to impulsivity and abnormal dopamine release.
Pregnant women with bipolar disorder face a higher risk of premature birth and complications. The study suggests modifying lifestyle and behavioral factors may help reduce this risk.