Articles tagged with Bipolar Disorder
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A large-scale animal study reveals that brain pH and lactate levels are a common feature across various neuropsychiatric conditions, including schizophrenia, bipolar disorder, autism, depression, epilepsy, and Alzheimer's disease. Changes in brain energy metabolism are linked to cognitive impairment, particularly working memory.
A new review paper from Brigham and Women's Hospital concludes that menopause does not uniformly elevate the risk of depression and other mental health conditions. Certain groups, such as those with a history of depression or severe sleep disturbances, are more likely to experience depressive symptoms during menopause.
A University of Cincinnati study found liraglutide to be efficacious and safe for weight loss in individuals with stable bipolar disorder, without destabilizing the illness. The drug reduced binge eating behavior and significantly lowered hemoglobin A1C levels.
Recent research suggests that problems with sleep and internal body clock can trigger or worsen psychiatric disorders. The study highlights the importance of understanding the relationship between sleep, circadian rhythms, and mental health, which could lead to new preventative measures and therapies.
A large study published in Psychiatry Research reveals that individuals with bipolar disorder are 4-6 times more likely to die prematurely than the general population. In contrast, smokers are only twice as likely to die, highlighting the need for targeted preventive efforts to address mental health risks.
The latest APA journal issues provide new insights into psychotic disorders, including altered neurodevelopment and early symptoms associated with schizophrenia risk. The issues also highlight racial disparities in diagnosis and predictors of first psychotic episodes. Psychiatric Services features research on barriers to addiction trea...
A large-scale study found that metformin can reduce weight gain and increase adherence to treatment in youth with bipolar disorder. The medication, typically used for Type 2 diabetes, was effective in preventing weight gain and showed promise as a potential solution to this common side effect of SGAs.
Researchers developed a new way to diagnose bipolar disorder using a simple blood test that can identify up to 30% of patients. The test, combined with digital mental health assessments, can differentiate between major depressive disorder and bipolar disorder.
Researchers developed a wearable device to track bipolar disorder patients' skin electrical activity, detecting manic and depressed phases. The study aims to improve diagnosis and treatment with personalized, rapid interventions.
The NY Genome Center will use patient-derived stem cells models combined with functional genomics and genome engineering to shed light on the biological processes underlying bipolar disorder. The study aims to address gaps in knowledge of genetic risk for bipolar disorder and advance treatment strategies.
A study by the University of Gothenburg reveals that obesity significantly worsens life expectancy and mortality risks in individuals with bipolar disorders. The findings show a rapid increase in BMI among those with bipolar disorders, leading to a higher risk of premature death and comorbidity.
Research from Aarhus University suggests that smoking may increase the risk of depression, bipolar disorder, and schizophrenia by 250 percent. The study analyzed genetic data from over half a million people and found that certain genetic variants linked to smoking also contribute to mental illness.
A clinical trial suggests that extending antidepressant treatment beyond eight weeks can help prevent depressive relapses in patients with bipolar disorder. The study found that continued treatment was associated with a 40% lower risk of relapse compared to tapering off and switching to a placebo.
A recent study published in Nature Mental Health reveals that amotivation and anhedonia are key factors in determining social functioning among individuals with psychiatric disorders. The research found that these negative symptoms have a stronger impact on social functioning than expressive dysfunction, especially in patients with sch...
Research found that people with bipolar disorder are 6 times more likely to die from external causes and twice as likely to die from physical illness. Alcohol is a major contributing factor to the increased risk of death from somatic causes.
Researchers identified three neurobehavioral profiles that distinguish individuals with elevated mania vulnerability based on reward sensitivity and sleep-circadian characteristics. These profiles can help detect mania risk and provide targets for early interventions.
A recent study published in JAMA Psychiatry found that fewer boys aged 15-19 commit suicide in Swedish regions with higher bipolar diagnoses. The study, which analyzed registry data from 2008 to 2021, showed an inverse association between population-adjusted bipolar diagnoses and confirmed suicides among males.
A study of 6.6 million individuals found a significant association between cannabis use disorder and an increased risk of developing bipolar disorder and unipolar depression. The findings may inform policies regarding cannabis use control.
New research shows that people with bipolar disorder or depression are more likely to be hospitalized if their verbal memory is poor. The study found an approximately 84% increased risk of admission to a psychiatric ward due to impaired verbal memory.
A new study found that emotion-focused therapy increased activation and connectivity of the amygdala in patients with bipolar disorder, leading to improved emotion processing. In contrast, cognitive-behavioral therapy showed increased activation of brain regions related to social function but not altered amygdala activity.
Researchers have developed a new technique to study the molecular causes of pediatric bipolar disorder by growing brain cells in the laboratory. The approach identified significant changes linked to the psychiatric condition, including a gene mutation that may be responsible for the disorder.
A new study finds that electroconvulsive therapy (ECT), lithium, and clozapine may reduce suicide rates in adolescent men with severe mental illness. The study suggests that early intervention with medico-psychiatric treatment can lower suicide rates among late-teenage boys.
Mutant mice lacking FADS1/2 genes exhibit bipolar swings in behavior, featuring phases of abnormally low activity and hyperactivity. Omega-3 fatty acid supplements and a mood stabilizer reverse behavioral changes, suggesting these mice as a valuable model for studying BD.
Researchers found adult smokers with bipolar disorder and schizophrenia drink the most caffeine, while those with mental illness are at highest risk of negative health consequences. The study suggests mood, metabolism, and self-medication may explain use patterns among this population.
Research identifies significant barriers in ER care for patients with mental health and substance use disorders, including emotional, diagnostic, and logistical challenges. Broad changes are needed to improve emergency care for this patient population.
A study from Japan found that variations in psychiatric diagnoses across different cultures can affect the efficacy of antipsychotics in clinical trials. Researchers analyzed data from 28 double-blind randomized trials and found that psychotic features were associated with varying therapeutic responses to antipsychotic medications.
A recent analysis of Psychiatric Genomics Consortium datasets found genetic correlations between psychiatric disorders differ between European and East Asian populations. Japanese psychiatrists tend to diagnose bipolar disorder less frequently in patients with psychotic features.
A Geisinger study of over 90,000 patients confirmed a strong link between genetics and neuropsychiatric disorders. The research revealed that approximately one in 100 participants carried a rare gene variant increasing the risk for conditions like schizophrenia and autism spectrum disorder.
Researchers are investigating the antidepressant and anxiolytic properties of psilocybin and cannabis to improve treatment options for mental illnesses. The findings suggest that these compounds may offer new avenues for symptom relief in a range of mental health conditions.
A recent study identifies a specific gene, GNL3, that regulates neural proliferation in response to lithium, which is used to treat bipolar disorder. This gene plays an important role in brain function and has been implicated in risk for bipolar disorder, schizophrenia, and inter-individual variations in intelligence.
A new study from Dartmouth College found that specific intensities of exercise over a long period are associated with different aspects of memory and mental health. Participants who exercised at moderate intensities performed better on episodic memory tasks, while those who exercised at high intensities did better on spatial memory tasks.
Researchers say stereotypes and stigma surrounding mental illness can lead to poor workplace behavior. Employees with mental illnesses may face fear of discrimination, which drives inauthenticity and counterproductive work behaviors.
Research teams at Mass General Brigham will conduct large-scale studies to treat acute suicidal depressed state and bipolar depression. The studies aim to compare the effectiveness of various treatments and provide valuable data on treatment outcomes.
A large study has found six predictors that can help determine the optimal lithium dose for patients with bipolar disorder. The predictors include age, sex, kidney function, and medication use. The researchers hope to develop a digital app to aid psychiatrists in finding the right dose.
A study of over 8 million adults in England found significant increases in neuropsychiatric illnesses after hospitalization for COVID-19 or other severe acute respiratory infections. Risks were similar for both conditions.
A new study identifies 152 genetic variants shared across multiple psychiatric disorders, including schizophrenia and bipolar disorder. This finding could lead to the development of therapies addressing multiple disorders with one treatment.
The COVID-19 pandemic has led to an increase in mental health visits in pediatric primary care, with significant rises in eating disorders and mood disorders. The study highlights the importance of screening and managing youth mental health conditions in primary care during periods of social isolation.
A systematic review and meta-analysis of 108 studies found that people with severe mental illness, including schizophrenia, have twice the cardiovascular-related mortality rate as the general population. The association has grown stronger over recent decades, with a possible link to changes in antipsychotic use and smoking prevalence.
Researchers at The University of Toledo found that low-dose lithium acts as a powerful anti-aging agent in the kidneys by blocking GSK3-beta, an enzyme associated with cellular aging. Studies showed improved kidney function and reduced albuminuria in mice and psychiatric patients treated with lithium.
A recent brain imaging study has found evidence of weakening connections between key brain areas in adolescents at high genetic risk of developing bipolar disorder. This study suggests that early intervention strategies may be effective in preventing the progression towards major changes in the brain.
A study of 12 million children found a moderate association between strabismus and anxiety disorder, schizophrenia, bipolar disorder, and depressive disorder. The findings suggest that children with crossed eyes may be at higher risk for developing these mental health conditions.
A randomized study of over 1,000 people with PTSD and/or bipolar disorder shows that telehealth and integrated care models can improve treatment engagement and outcomes. Patients who received guidance from local clinic team members and in-person follow-up with nurses or social workers had better results.
Scientists have discovered recently evolved regions in the 'dark genome' that code for proteins associated with schizophrenia and bipolar disorder. These protein biomarkers could help distinguish between the two conditions and identify patients at risk of psychosis or suicide.
Researchers developed a method to image lithium in living cells, finding that neurons from bipolar disorder patients accumulate higher levels of lithium than healthy controls. This new tool could help optimize lithium dosage and improve treatment outcomes for patients with bipolar disorder.
Longitudinal study reveals cortical thinning in people with bipolar disorder, especially those with more manic episodes. The findings suggest that bipolar disorder may be a neuroprogressive disorder, worsened by the progression of symptoms.
A new register study at Umea University found that people with psychotic or bipolar disorders are significantly more likely to die from influenza, pneumonia, or sepsis. The proportion of deaths due to these conditions was sixfold in certain age groups, highlighting the need for preventive measures.
A computational framework will be developed to characterize how genetic variants work at the cellular level in psychiatric diseases like schizophrenia and bipolar disorder. The framework aims to integrate data from live and postmortem samples, humans and mice, to accurately pinpoint which mutations result in disorders.
Researchers investigated whether allergic diseases cause mental health conditions, finding little evidence of a causal relationship. The study used Mendelian Randomisation to identify genetic variants linked to allergies and mental health, but found no associations between the two.
A new study by Penn State researchers found that a specific diet designed to alter fatty acid intake can improve mood variability in patients with bipolar disorders. The diet reduced omega-6 consumption and increased omega-3 consumption, resulting in improved symptoms like pain and anxiety.
Patients with bipolar disorder experiencing manic episodes show abnormal brain changes, including faster cortical thinning, compared to those without episodes. The study also found associations between brain ventricle enlargement and accelerated cognitive decline in bipolar patients.
Researchers from University Hospitals Cleveland Medical Center and Case Western Reserve University School of Medicine found that combining long-term injectable medications with psychosocial intervention improves adherence and symptoms in patients with bipolar disorder. The study enrolled 30 people with bipolar disorder who had adherenc...
A recent study found that manualized Equine Assisted Therapy (EAT-PTSD) is safe, feasible, and clinically viable for treating veterans with PTSD. The therapy resulted in marked reductions in both clinician-rated and self-reported symptoms of PTSD and depression.
Researchers conducted a new trial to adapt Dialectical Behaviour Therapy (DPT) for people with frequent Bipolar mood swings. The study aimed to evaluate the feasibility and acceptability of this adapted therapy, finding that it has demand from individuals with Bipolar disorder.
A new study found that diagnosis of post-traumatic stress disorder (PTSD) or genetic predisposition to PTSD is associated with increased risk of suicide death among individuals with bipolar disorder. The research suggests that understanding the genetic contribution to PTSD can help identify different strategies for suicide prevention.
Researchers from iPSYCH have identified 33 new genetic variants associated with bipolar disorder, more than doubling the number of known genetic risk factors. These variants play a role in brain functions and signalling between nerve cells, providing potential ideas for new treatments.
A study found six key factors that hinder people with bipolar disorder from taking their medication as prescribed. Patient beliefs and knowledge about the condition, as well as fear of addiction and lack of support from healthcare professionals, were among the factors identified.
A study published in Nature Genetics found 64 genome regions associated with an increased risk of bipolar disorder, providing new insights into the condition's underlying biology. The research also highlights potential therapeutic targets for future treatments.
A new study from Aarhus University finds that almost half of parents with children to a parent with schizophrenia or bipolar disorder also meet the criteria for a mental disorder. This can impact family life and child development. The study suggests increased attention is needed for these families, with specialized efforts recommended.
The Baszucki Brain Research Fund has launched a multimillion-dollar program to advance therapeutic discovery for bipolar disorder, aiming to improve treatment options for affected individuals. The grant program will provide up to $200,000 per year to support pilot research and translational efforts.
Researchers at University of Wisconsin-Madison discovered a disrupted Akt protein pathway in men with bipolar disorder, leading to memory problems and weakened brain connections. The findings offer a new target for treating bipolar disorder's often-overlooked cognitive impairments.