Articles tagged with Bipolar Disorder
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The study reveals that the paraventricular thalamic nucleus (PVT) is the central pathological substrate of bipolar disorder, with notable alterations in cell number and gene expression. This discovery highlights the PVT as a potential diagnostic and therapeutic target for improving patient outcomes.
The study found that mania accounts for more than 80% of the genetic variation in bipolar disorder. The researchers identified 71 genetic variants linked specifically to mania, including 18 regions of genes that had never previously been associated with bipolar disorder.
A Swedish study of prematurely born adults found increased morbidity in physical and mental health, yet they reported a high quality of life. The study, which followed participants from birth to age 26-29, suggests that premature birth does not necessarily limit daily life.
A recent study published in PLOS Medicine found that individuals who received emergency or hospital care for hallucinogen use are at a higher risk of developing mania and bipolar disorder. The study revealed a six-fold increased risk of mania diagnosis within three years for those who received such care.
A major meta-analysis found that nitrous oxide can offer fast-acting depressive symptom relief for adults with major depressive disorder and treatment-resistant depression. The study showed significant improvements in mood within 24 hours, but repeated dosing over several weeks was needed to sustain clinical benefit.
A study published in The Lancet Psychiatry found that metformin can help manage weight gain in overweight or obese youth taking medication for bipolar disorder, making it a potential standard of care treatment. The MOBILITY trial showed modest but significant benefits of metformin over no treatment, with well-tolerated side effects.
The study identified dozens of genetic regions that influence the size and thickness of the corpus callosum and its subregions. The research team created an AI-powered tool that finds and measures the corpus callosum in brain MRI scans automatically, allowing for unprecedented analysis of brain structure at scale and precision.
A University of Minnesota Medical School research team, led by Ziad Nahas, has been awarded a $4.4 million grant to explore how large-scale brain networks regulate mood in bipolar disorder. The team will test a novel type of brain stimulation called Personalized and Adaptive Cortico Electrostimulation (PACE) to relieve symptoms and ide...
The Mount Sinai team will investigate neural mechanisms underlying bipolar disorder and pioneer novel neuromodulation-based treatment strategies.
International Consortium of Women's Mental Health Experts recommend classifying postpartum psychosis as a distinct category within standardized medical coding systems. This classification is crucial for improving patient outcomes and saving lives, particularly due to the risks associated with the condition to both patients and infants.
A new study from Karolinska Institutet and UCL found that living in a safe neighborhood with high personal trust reduces psychosis risk among Swedish or European origin residents, but increases it for North African or Middle Eastern origin individuals. The researchers emphasize the need for inclusive environments to promote mental heal...
Researchers from the University of South Australia explore the connection between the gut and brain to decipher their role in mental health and wellbeing. The study found that changes in the gut microbiome can directly affect brain chemistry, suggesting a potential link between gut health and mental illness.
A renowned geneticist, Dr. Martin Alda, has made a groundbreaking discovery that bipolar disorder is composed of multiple genetically distinct disorders, transforming treatment approaches worldwide. His research also highlights the importance of combining basic research with clinical observations to advance psychiatric care.
Research in African populations aims to understand the link between depression and hypertension, two conditions affecting millions worldwide. The study will focus on identifying shared genetic mechanisms, which could lead to more effective treatment strategies for complex diseases.
Johns Hopkins researchers used machine learning to analyze electric activity of mini-brains grown in a lab, revealing unique firing patterns associated with schizophrenia and bipolar disorder. The study improves accuracy in distinguishing between healthy and unhealthy brain organoids, paving the way for potential diagnostic tests and p...
Breakthrough Discoveries for Thriving with Bipolar Disorder (BD²) has announced a fourth round of Discovery Research funding for bipolar disorder. The program aims to support groundbreaking research into the genetic, molecular, cellular, circuit, and behavioral mechanisms of the disorder.
The study found sex differences in age at diagnosis, treatment onset, illness duration, illicit drug use, and smoking among individuals with bipolar disorder and schizophrenia. Females showed better functioning and neurocognitive performance than males, while males had higher rates of substance use.
Research finds that bipolar disorder is associated with neurodegenerative protein accumulation and tau pathology in the paraventricular thalamus, potentially contributing to its symptoms. The study also identifies a new marker, CHMP2B-positive granulovacuolar degeneration, in about half of BD cases.
Professor Gregor Hasler's pioneering research reveals how psychedelics like LSD, psilocybin, and MDMA enhance neuroplasticity, allowing the brain to rewire itself and break free from depression, PTSD, and addiction. His discoveries have the potential to fundamentally alter international approaches to mental health treatment.
Preliminary findings suggest that neuroimaging and mobile sensing can identify neural and behavioral markers of bipolar disorder and mood recurrence. Dr. Danella Hafeman's research uses fMRI and mobile sensing to detect early indicators of depressive and manic symptoms.
Researchers have found subtle abnormalities in heart muscle function and blood pumping in young adults with bipolar disorder before the onset of heart failure. The study suggests a link between underlying coronary vascular dysfunction and cardiac impairment.
A large international real-world data study found that antidepressant use does not significantly increase the risk of manic episodes in patients with bipolar depression. The study analyzed data from 122,843 outpatients and employed propensity score matching to control for confounding factors.
A wearable sensor could revolutionize lithium monitoring for people with bipolar disorder by tracking medication levels through sweat. The USC-made device, which is the first of its kind, eliminates the need for blood draws and offers a personalized and easily accessible monitoring system.
Dr. Mirko Manchia's groundbreaking research identifies genetic markers predicting treatment response in bipolar patients, enabling precision medicine approaches to transform psychiatric care. He envisions a future where genetic testing becomes routine in psychiatric care.
The BD² Integrated Network, a collaborative research model, aims to improve care and outcomes for people with bipolar disorder. The Ottawa Hospital Research Institute will receive $2.3 million to join the network, accelerating recruitment and advancing discovery.
A new systematic review reveals a significant connection between the gut microbiome and brain function in bipolar patients, affecting treatment responses. Patients who responded to treatment had distinct gut microbiome profiles similar to healthy individuals.
Researchers at Harvard University's Wyss Institute have successfully created human microglia cells in a dish, using induced pluripotent stem cells, within four days. This breakthrough enables new avenues for brain disease-focused research and potential therapeutic perspectives.
Professor Benedetti's research explores the intersection of genetics, environmental factors, and treatment response in mood disorders. His work has led to breakthroughs in chronotherapeutics and immuno-psychiatry, revealing crucial insights into immune-inflammatory mechanisms and gene variants influencing brain function.
A comprehensive review reveals that early ECT sessions show substantial improvement, but subsequent sessions may lead to diminishing returns and cognitive side effects. The researchers propose a response-guided sequential treatment strategy, categorizing patients into three groups based on their response patterns.
Research found that women whose sister experienced postpartum psychosis are over 10 times more likely to experience it themselves. The study highlights genetic and shared environmental influences and suggests early recognition and prevention are crucial.
Researchers found that specific combinations of personality traits can predict bipolar disorder outcomes, with certain styles raising and others lowering the risk of depression. The study used data from over 2,500 people with bipolar disorder and suggests a personalized approach to treatment planning.
Scientists at deCODE genetics identified associations between rare loss-of-function variants in HECTD2 and AKAP11 genes and the risk of bipolar disorder. The study suggests that these gene products may be promising targets for new treatments, as they interact with key cellular pathways involved in the disorder.
The BD² Integrated Network, a collaborative model connecting bipolar disorder research and care, has expanded to 10 sites with four new institutions joining the network. The model combines traditional longitudinal cohort study and learning health network to improve outcomes for people with bipolar disorder.
Researchers from Aarhus University found a machine-learning algorithm that can predict patients with high risk of developing schizophrenia or bipolar disorder within the next five years. The study analyzed electronic health record data and identified key factors, including words describing symptoms in clinical notes.
Heavy screen use, particularly social media and video games, is associated with an increased risk of developing manic symptoms in U.S. preteens. The study found that prolonged screen time can lead to behaviors characteristic of bipolar-spectrum disorders, including inflated self-esteem, decreased sleep needs, and impulsivity.
Researchers used machine learning to predict diagnostic transition to schizophrenia and bipolar disorder, with schizophrenia being notably easier to forecast. By analyzing routine clinical data, the study suggests a possible approach for early intervention and personalized treatment plans.
A new study published in Brain Medicine reveals that over 26.7% of schizophrenia patients experience distinct manic symptoms, which can be predicted by the severity of positive symptoms such as hallucinations and delusions.
A pilot study will explore whether a ketogenic diet helps stabilize mood symptoms in teens and young adults with bipolar disorder. Preliminary research suggests improvements in mood and executive function among older adults.
Research by Professor Stephen M. Stahl suggests that Jackson Pollock incorporated images into his pre-drip paintings, possibly due to spatial skills linked to bipolar disorder. The same images appear in multiple drip paintings, implying a deliberate encoding of images.
Researchers at McGill University discovered a novel brain mechanism that explains why bipolar patients alternate between mania and depression. A dopamine-based 'second brain clock' controls mood shifts, operating in tandem with the body's natural sleep-wake cycle.
Researchers used fitness tracker data and machine learning to detect bipolar disorder mood swings with 80.1% accuracy for depression and 89.1% accuracy for mania. The study's findings move the field toward personalized algorithms suitable for all patients, regardless of compliance or device access.
Leila Nabulsi is expanding her research program to pinpoint brain pathways affected by bipolar disorder. She will leverage the ENIGMA consortium and advanced statistical methods to build a database of brain changes, potentially improving diagnosis and treatment.
A study published in JAMA Psychiatry found a significant association between genetic predisposition and sexual trauma with increased risk for schizophrenia, bipolar disorder, and major depression. The research highlights the importance of considering social and environmental factors in human genetics studies.
A recent Canadian study reveals that transgender populations in Canada experience a significantly higher prevalence of serious mental disorders and suicidality compared to cisgender peers. The study, published in JAMA, is based on data from nearly 10,000 Canadians aged 15 or older.
Researchers have uncovered a shared genetic basis for bipolar disorder type I and epilepsy, identifying 1,300 genetic variants influencing both conditions. The study suggests that mood stabilizers may be effective in treating both illnesses, and could lead to personalized medicine approaches.
A new study published in PLOS Mental Health found a relationship between daily sunlight exposure, physical activity, and depressed state. The research used wrist-based activity sensors to collect data from individuals with depression and those without, revealing that more depressed states were associated with lower daytime activity.
Researchers report significant strides in enhancing early diagnosis of bipolar disorder in adolescents by combining multimodal MRI with behavioral assessments. This approach reveals specific changes in brain networks signaling early-stage bipolar disorder, potentially leading to better and more personalized treatments. The study's find...
Research suggests that diagnostic labels for people experiencing mild mental health issues can increase empathy and support, but also undermine perceived agency and expectations of overcoming problems. This study found varying responses depending on the disorder, with some conditions eliciting high empathy and accommodation support.
Researchers have discovered a link between cognitive impairments and brain network organization in individuals at risk of developing psychotic disorders such as schizophrenia. This finding suggests an opportunity for early diagnosis and intervention, potentially through non-invasive neuromodulation.
A new study suggests that even temporary increases in drinking can have lasting effects on bipolar symptoms, but the opposite isn't true. The research found that individuals with bipolar disorder who drink more than typical for them are more likely to experience an increase in depressive and/or manic symptoms over six months.
A new potential therapy for depressed patients with bipolar disorder has emerged, significantly shortening treatment time from four to six weeks. Accelerated intermittent theta burst stimulation (aiTBS) reduced treatment to just five days, yielding substantial decreases in depressive symptoms.
Researchers discovered that brain regions, including anterior insula and striatum, are involved in the biased response to pleasure in people with bipolar disorder. In those with bipolar disorder, these brain regions show reduced communication, leading to a 'vicious cycle' of escalating mood and risk-taking behavior.
A study by the University of Toronto found that 43% of Canadians with a history of bipolar disorder were symptom-free and 23.5% had achieved complete mental health. Factors contributing to psychological flourishing included having a trusted confidant, using spirituality as coping mechanisms, and absence of disabling chronic pain.
Researchers have identified shared genetic links between disturbed sleep, neurodevelopmental and neuropsychiatric conditions. Polygenic scores for certain conditions are associated with chronotype and insomnia, suggesting potential new therapies.
Researchers at King's College London found that thousands of DNA sequences from ancient viral infections contribute to psychiatric disorder susceptibility. Five specific Human Endogenous Retroviruses (HERVs) were associated with increased risk for schizophrenia, bipolar disorder, and depression.
Researchers found a genetic link between higher circulating levels of arachidonic acid and lower risk for bipolar disorder. The study suggests that altering arachidonic acid synthesis pathways may reduce bipolar disorder risk, particularly in those with compromised pathways.
Researchers identified a genetic link between higher levels of arachidonic acid and lower risk of bipolar disorder. Arachidonic acid, found in meat, seafood, and human milk, may hold potential for lifestyle or dietary interventions to prevent or treat the condition.
Research reveals 66-75% of people experiencing homelessness have underlying mental health conditions, with males affected more severely. The study emphasizes the need for integrated interventions and gender-specific approaches to address homelessness and related health disparities.
A trio of studies show increased diagnosis and treatment of anxiety, depression, and PTSD in pregnant and new mothers with private insurance, but disparities persist. The findings suggest that policy changes and increased awareness have contributed to the rise in diagnoses and treatments.
A new study by the University of Southampton found that a commonly used questionnaire for monitoring depression treatment in primary care does not provide immediate benefits. However, patients who tracked their scores reported improved overall wellbeing and quality of life after six months.