Articles tagged with Cardiomyopathy
A new study by Cleveland Clinic and Dyania Health demonstrates the potential of large language models in accurately identifying patients who could benefit from clinical research. The AI system reviewed 1,476 patients and identified 46 as potential matches, resulting in a more diverse patient population.
A new study from Uppsala University reveals a substantial increase in cardiomyopathy diagnoses in Sweden between 2004 and 2023, associated with high excess mortality rates. The study highlights the need for improved detection and targeted treatments to address this growing public health concern.
Researchers at University of California San Diego discover gene therapy restoring connexin-43 improves heart function and extends survival in several forms of arrhythmogenic cardiomyopathy. The approach may have broader therapeutic potential across multiple genetic forms of the disease, addressing a critical unmet need.
Researchers have shown that human hearts can regrow muscle cells after a heart attack, paving the way for new treatments to reverse heart failure. The discovery was made possible by pioneering techniques that use living tissue samples taken from patients during bypass surgery.
Researchers at The Lundquist Institute have identified PTRH2 as a critical gene that protects the maternal heart during pregnancy, shedding light on the causes of peripartum cardiomyopathy. Loss of this gene leads to severe postpartum heart failure, highlighting the urgent need for better treatments.
A simple echocardiography method analyzes myocardial deformation to predict cardiac complications in chronic Chagas disease. The study found that patients with a greater GLS value had a higher risk of death and complications.
The American Heart Association brought hypertrophic cardiomyopathy and Hands-Only CPR awareness to a historic college football game, aiming to empower young athletes and their families with critical knowledge. The organization aims to double cardiac arrest survival rates by 2030 through its Nation of Lifesavers movement.
Researchers have found that atrial electromechanical dissociation (AEMD) can predict stroke risk in people with transthyretin amyloid cardiomyopathy, even when the heart rhythm appears normal. A non-invasive assessment tool may help identify those at increased risk and guide earlier conversations about preventive strategies.
A new study from the University of Copenhagen enables researchers to investigate the cause of heart diseases by analyzing thousands of proteins in heart tissue. This groundbreaking method reveals molecular patterns characteristic of heart diseases.
A recent study revealed ROS-induced oxidative stress accelerates hypertrophic cardiomyopathy (HCM) in MYBPC3-deleted hiPSC-CMs. The researchers found that melatonin alleviates HCM by inhibiting the PI3K/AKT/FOXO3a signaling pathways.
Late-breaking clinical trials and science at TCT 2025 will present pivotal data on novel therapies, devices, and techniques aimed at preventing and treating cardiovascular conditions. The symposium delivers high-impact findings that shape clinical practice and enhance outcomes for patients with heart and vascular disease.
A cardiac device trial published in eClinicalMedicine found that improving enrollment of females in such trials can better guide care for all patients. One-year interim study results revealed that participants assigned male at birth were twice as likely to die or experience life-threatening heart rhythm abnormalities, while females sho...
The American College of Cardiology has established a digital registry for hypertrophic cardiomyopathy (HCM) to broaden understanding and provide equitable access to treatment. The registry will capture data on HCM symptoms, diagnostic images, treatment plans, and outcomes to improve diagnosis and management.
Researchers found that individuals with a mutation in the TTN gene are 21 times more likely to develop dilated cardiomyopathy than those without. Lifestyle factors such as being overweight or having high alcohol consumption contribute to an earlier diagnosis, and men with the mutation are more likely to develop DCM at a younger age.
A groundbreaking study published in Science Signaling has identified protein tyrosine phosphatase PTP1B as a key driver of maladaptive cardiac metabolism and dysfunction under dietary stress. Mice lacking PTP1B in cardiomyocytes were resistant to harmful changes, highlighting the enzyme's role in heart disease progression.
Scientists are working on a genetic cure for the world's most common inherited heart disease, hypertrophic cardiomyopathy (HCM), with a new gene editing tool. The team aims to correct mutations that cause the disease, which affects 14 million people worldwide.
Researchers found common variants in TTN and BAG3 associated with reduced late-onset cardiomyopathy in childhood cancer survivors, similar to the general population. However, rare variants linked to early-onset cardiomyopathy in adults showed no association with late-onset risk in children.
Researchers found that MRI scans can detect heart inflammation, scarring, and impaired function in carriers of a mutated LMNA gene. This information can help clinicians predict which patients are at higher risk and inform decisions about treatments such as defibrillators or transplants.
A new AI algorithm, Viz HCM, can quickly and specifically identify high-risk heart patients with hypertrophic cardiomyopathy (HCM) and provide individualized risk assessments. The algorithm's findings can help doctors prioritize the highest-risk patients for earlier appointments and treatment.
A new AI algorithm has been calibrated to quickly identify patients with hypertrophic cardiomyopathy (HCM) and provide individualized risk assessments. The tool can help prioritize high-risk patients for earlier appointments and treatment, leading to better patient outcomes.
A team of researchers has developed a gene-therapy strategy to treat arrhythmogenic right ventricular cardiomyopathy type 5 (ARVC5), a rare and deadly hereditary disease. The treatment, using adeno-associated viruses, improved cardiac function and prolonged survival in mice with ARVC5-like disease.
Preoperative anemia is a recognized risk factor for adverse outcomes in CABG, but it does not affect the long-term survival advantage associated with CABG. This study provides evidence that surgical intervention can still be beneficial for ICM patients despite preoperative anemia.
A study published in Nature Cardiovascular Research found that tricaprin improved long-term survival and recovery from heart failure in patients with triglyceride deposit cardiomyovasculopathy. The supplement reversed structural changes and improved heart muscle function, leading to higher survival rates compared to controls.
A new study identified USP5 as an enzyme crucial for breaking down unneeded or damaged proteins in the heart. Low levels of USP5 lead to protein buildup, triggering dilated cardiomyopathy in animal models. Increasing USP5 levels helps clear protein 'junk', improving heart function and reducing disease progression.
University of Birmingham researchers have been awarded a grant to study the mechanisms driving early cardiac dysfunction in CKD. The study aims to identify interventions that can reverse or prevent heart disease in its earliest stages.
A new study suggests that current guidelines for diagnosing a potentially deadly heart condition may be missing women due to natural differences in sex and body size. The researchers developed a personalized approach using AI, which improved diagnosis accuracy by 20 percentage points for female patients.
Trametinib reduces mortality and morbidity in children with severe HCM caused by pathogenic variants in the RAS/MAPK pathway. The study provides strong evidence for personalized treatment targeting the underlying genetic causes of RASopathies.
The American Heart Association strongly supports the legislation, which aims to double survival rates from cardiac arrest nationwide by 2030. The HEARTS Act includes key provisions such as CPR training, AEDs, and cardiac emergency response plans, which can more than double survival rates in schools with these resources.
Researchers have discovered a potential target to address diabetic cardiomyopathy, a serious condition affecting diabetic patients. The PPARβ/δ receptor's activation can help slow down inflammation and fibrosis, providing a new therapeutic strategy.
The American Heart Association has launched a new three-year initiative to standardize HCM systems of care and support better management of the disease. The initiative aims to overcome gaps in care for hypertrophic cardiomyopathy, leading to delayed treatment, increased risk of complications, and preventable death.
A study by St. Jude Children's Research Hospital has identified a serum protein panel test that accurately predicts cardiomyopathy risk in childhood cancer survivors. The test, using a panel of 27 proteins, was tested on 46 survivors and correctly predicted risk in 38 cases.
A new study has found that hundreds of genes, rather than a single 'aberrant' genetic variant, contribute to the development of dilated cardiomyopathy. Researchers developed a polygenic risk score to assess individual risk and found those with the highest genetic risk had a fourfold chance of developing the disease.
The Heart Institute is celebrated for delivering unparalleled treatment and support to children with heart conditions. It has consistently provided high-quality cardiac care and specialized disease management for all forms of cardiomyopathy.
Patients with transthyretin amyloid cardiomyopathy experience frequent decline in kidney function, associated with higher mortality risk. eGFR decline is an independent marker of disease progression guiding treatment optimization.
New study suggests that small group differences may reflect important benefits for individual patients with cardiomyopathy. The authors recommend explicitly describing patient-level data to support clinical interpretation of results.
The Kansas City Cardiomyopathy Questionnaire (KCCQ) demonstrated strong psychometric properties in patients with severe tricuspid regurgitation. The KCCQ can effectively measure symptoms, function, and quality of life, making it a valuable tool for assessing patient outcomes.
Researchers at the University of Arizona Health Sciences are studying the molecular mechanisms of coagulation factor XII as a contributor to heart failure with reduced ejection. The goal is to develop better preventive and treatment options for this irreversible condition, which affects millions of Americans.
A study at the European Society of Cardiology Congress found that an AI-enabled digital stethoscope helped doctors identify twice as many cases of pregnancy-related heart failure compared to a control group. The tool was 12 times more likely to flag heart pump weakness, leading to better diagnosis and potentially life-saving treatment.
A phase 3 study has shown that vutrisiran, an RNA interference therapeutic, reduces all-cause mortality and recurrent cardiovascular events by 28% and 33% respectively in patients with transthyretin amyloidosis with cardiomyopathy. The treatment also improves functional capacity, quality of life, and NYHA class.
This study identified three novel TTN variants associated with dilated cardiomyopathy in Chinese patients. The variants were found through whole-exome sequencing and are expected to contribute to the disease's molecular mechanisms. The discovery broadens the spectrum of TTN variants and may aid in genetic screening for related diseases.
Researchers used WES to identify a novel deletion variant in the DSP gene associated with sudden cardiac death. This finding highlights the importance of post-mortem genetic testing for accurate risk assessment and personalized medicine.
Researchers at UAB have developed a method to assess cardiac dynamics in fruit flies using deep learning and high-speed video microscopy. The study uses this approach to analyze the effects of aging and dilated cardiomyopathy on heart function, with potential applications for human cardiovascular research.
Researchers develop a model of heart disease by tricking stem cells to behave like mature heart cells with a mutation that causes hypertrophic cardiomyopathy. The study reveals the connection between mechanical stress and electrical function in hearts, shedding light on why genetic mutations can cause arrhythmias.
A clinical trial found that aficamten significantly increased maximum oxygen use in patients with obstructive hypertrophic cardiomyopathy. This improvement enables patients to perform everyday tasks more easily, such as walking and household chores. Researchers believe aficamten has promise as a treatment for this condition.
The American College of Cardiology and American Heart Association have released a new clinical guideline for effectively managing individuals diagnosed with hypertrophic cardiomyopathy. The guideline recommends exercise as part of a healthy lifestyle, including low-to-moderate intensity recreational activities, while also introducing a...
A new Spanish study provides the first stratification of the risk of developing dilated cardiomyopathy among symptom-free genetic carriers. Researchers found that nearly 11% of genetic carriers developed the disease within a median follow-up period of 37 months.
A recent study investigates the correlation between Takotsubo cardiomyopathy (TCM) and Guillain–Barré syndrome (GBS), revealing key factors that distinguish TCM patients from those with classical GBS. The researchers identified age at onset, disability scores, muscle weakness, and cranial nerve involvement as significant differences.
A review of mitochondrial energy metabolism in diabetic cardiomyopathy reveals disrupted dynamics and oxidative stress as key triggers. Targeted therapies, such as antioxidants and ketogenic diets, show promise in combating this debilitating condition.
A study presented at the American College of Cardiology's Annual Scientific Session found that young adults prescribed ADHD stimulants were significantly more likely to develop cardiomyopathy. The overall risk remained low, but researchers suggested further studies could identify subgroups at greater risk.
A study found that up to 87% of childhood cancer survivors are not following recommended screening guidelines, leaving them vulnerable to late effects such as heart disease and certain cancers. The lack of awareness and barriers to adherence may contribute to this low rate, highlighting the need for improved support and education.
A new vest can map electric impulses of the heart in fine detail, detecting abnormalities from a potentially fatal heart disease much earlier. The study found that the vest identified electrical changes among 1 in 4 individuals with a gene mutation for whom no signs of disease were detected via standard tests.
A new genetic marker for cardiomyopathy has been identified through whole genome sequencing, suggesting that tandem repeat expansions may cause four percent of cases. This discovery provides a promising lead for early detection and the development of precision therapies.
A new study found that chronic exposure to PM2.5 is associated with increased risk of hospital admission for various cardiovascular conditions, particularly ischemic heart disease and cerebrovascular disease. The study suggests that lowering annual average PM2.5 levels could decrease overall cardiovascular hospitalizations by 15%.
A study published in Nature Cardiovascular Research reveals that a dynamic synergy between cell types facilitates cardiac renewal, challenging existing paradigms. Targeting the microenvironment rather than specific cell types is key to healing injured hearts.
Researchers have found that a gene-based therapy targeting plakophilin-2 can interrupt the progression of arrhythmogenic right ventricular cardiomyopathy, a rare inherited disorder. The treatment reduced episodes of arrhythmia and slowed the deterioration of the heart's walls in mice.
Researchers found that two common biomarkers, global longitudinal strain and N-terminal-pro-B-type natriuretic peptide, can identify asymptomatic childhood cancer survivors at elevated risk of declining heart muscle function. These biomarkers may lead to earlier treatment to prevent further heart damage.
A recent study published by the Mayo Clinic found that an AI-enabled digital stethoscope can detect peripartum cardiomyopathy, a potentially life-threatening condition, more accurately than regular care. The researchers identified twice as many cases using the AI-powered tool.
A new study by UCL researchers suggests that a vest mapping the heart's electrical activity could help identify people at high risk of sudden cardiac death. The electrocardiographic imaging (ECGI) vest combines signals with MRI images to generate 3D models, potentially predicting risk factors for life-threatening heart rhythms.
Researchers uncover the role of IGF2BP2 in responding to cardiac stress, highlighting its potential reversibility and clinical relevance. Elevated IGF2BP2 expression leads to dilated cardiomyopathy, but controlled reduction prompts recovery.
Researchers developed a gene therapy approach to target the root cause of ACM, restoring plakophilin-2 levels and improving heart function. Clinical trials starting in 2024 aim to explore this approach in patients with PKP2 mutations.