Articles tagged with Lung Cancer
The new guidelines provide uniform standards for treating brain tumour complications such as epileptic attacks, brain edema, haemorrhage, or thrombosis worldwide. The initiative aims to increase patient safety and improve treatment outcomes.
Researchers at Memorial Sloan Kettering Cancer Center have identified a new target for aggressive lung adenocarcinomas driven by the KEAP1 and STK11 mutations. By inhibiting ferroptosis, these tumors rely on this blockade to grow and survive.
Research suggests stress hormones and immune cells may contribute to tumor recurrence by reactivating dormant cancer cells. Targeting stress hormones with approved drugs like beta-blockers could potentially prevent tumors from returning.
A new study has shed light on the role of p53 target gene Zmat3 in lymphoma and lung cancer development. Researchers found that disabling Zmat3 had little impact on tumor development, suggesting that other proteins may be involved in preventing cancer formation.
Researchers found an overall 17% risk reduction for metastatic or fatal cancer and a 38% reduction among those with normal BMI. The study suggests that vitamin D may reduce the risk of developing advanced cancers, particularly in individuals with normal weight.
A study led by Massachusetts General Hospital found that early treatment with lorlatinib improved survival rates and reduced the risk of brain metastasis in ALK-positive lung cancer patients. Lorlatinib was shown to be effective as a first-line therapy, reducing the risk of cancer progression or death by 72%.
A study by University of Utah researchers found that experienced radiologists can miss clear abnormalities when looking for one specific issue, highlighting the limits of human cognition. The experiment demonstrates that years of experience don't guarantee detection of critical findings.
Researchers found patients with a particular type of human leukocyte antigen (HLA) B44 were more likely to benefit from immunotherapy in melanoma but not non-small cell lung cancer. The study identified mutations driving the different responses, paving the way for better patient stratification and potential therapy design.
A new model predicts the risk of severe side effects in cancer patients during chemotherapy by analyzing genetic signatures. The study identified a network of genes linked to bone marrow toxicity and developed a classification system to predict patient risk.
Researchers from MD Anderson Cancer Center present promising clinical data on combination therapies for patients with metastatic melanoma and advanced refractory solid tumors. The treatments showed activity in activating immune pathways, leading to antitumor responses.
A study published in Cancer Discovery found that patients with advanced-stage lung cancer had greater enrichment of oral commensals in the lung than those with early-stage disease, leading to decreased survival. The presence of specific bacteria was associated with tumor progression and activation of inflammatory pathways.
A meta-analysis of eight randomized clinical trials found that low-dose CT screening reduces lung cancer-caused death by 0.4%, translating to one preventable death per 250 at-risk adults. The study suggests the benefits may outweigh potential harms from overdiagnosis, aligning with US Preventive Services Task Force recommendations.
Researchers found a significant increase in cancer survival rates among Medicaid expansion states compared to non-expansion states. The study analyzed data from breast, colorectal, and lung cancer patients and discovered improved survival outcomes following the expansion of healthcare coverage.
A new report from UCSF links climate change to a significant increase in global cancer rates, particularly lung, skin, and gastrointestinal cancers. The study highlights the need for urgent action to mitigate climate change and reduce air pollution to prevent cancer cases and deaths.
A large-scale study found that LDCT scans can identify a significant number of adults with low bone mineral density, equating to 49 million and 22.8 million Chinese citizens, respectively. The study revealed an unexpectedly high prevalence of osteoporosis in men, which may impact management strategies.
Dr. Donna D. Zhang's research focuses on harnessing nuclear factor erythroid-2-related factor 2 to prevent or treat arsenic-induced diseases. She aims to identify new pharmaceuticals to address adverse health effects resulting from arsenic exposure.
A new study examined recent data on African American patients with early-stage non-small cell lung cancer and found that while Black patients are now more likely to receive effective treatments, disparities persist. The use of surgery remained a significant disparity across racial groups, despite increasing utilization over time.
A new study from Penn Medicine found that proton therapy reduces the risk of radiation-induced heart diseases in lung cancer patients. Mini-strokes and heart attacks were significantly less common among patients who underwent proton therapy compared to those treated with conventional photon-based radiation therapy.
Researchers developed a vaccine targeting KRAS gene mutations in lung, bowel and pancreatic cancers. In mice studies, vaccinated animals showed improved survival rates compared to unvaccinated ones.
A new deep learning model using PET/CT imaging can classify EGFR mutation status in non-small cell lung cancer, predicting the most effective treatment option. The model shows promise as a clinical decision support tool for personalized treatment choices.
The study reveals that efavirenz alters the gene expression of important factors essential for genomic stability, particularly down-regulating S-phase and DNA replication genes. This suggests that efavirenz may be used in synergy with chemo/radiotherapy to treat lung cancer.
The HAMRC will investigate novel approaches to characterize lung cancer epidemiology, somatic mutation burden, and the relationship between HIV-1 infection and accelerated aging. The team aims to develop diagnostic computational imaging algorithms to discern lung cancer from respiratory infections.
Researchers at Princess Margaret Cancer Centre found that over 80% of advanced NSCLC patients had genomic alterations detected in cfDNA. Liquid biopsies were shown to be a timely and effective method for diagnosing and monitoring the disease, with actionable alterations detected in over 56% of treatment-naïve patients.
A pilot study comparing liquid biopsy with tissue-based test found that liquid biopsy results were approximately 10 days faster than tissue biopsy. Liquid biopsy identified actionable genes in 14 cases, while tissue biopsy only detected them in 11 cases.
A clinical trial of selpercatinib has shown promising results for patients with non-small cell lung cancer, achieving high response rates and prolonged survival. The drug specifically targets cancers driven by mutations in the gene RET, with minimal side effects.
A study suggests that a national biennial lung cancer screening program could be cost-effective for Māori in New Zealand. The program aims to reduce population inequities relating to lung cancer among Māori. Early-stage lung cancer can be curable, and screening may help save lives by identifying the disease at an early stage.
A large randomized trial found that post-operative radiotherapy (PORT) does not significantly improve disease-free survival in completely resected non-small-cell lung cancer (NSCLC) patients. The study included 501 patients and showed no significant difference in overall survival between the PORT group and the control group.
A phase 1 clinical trial of sotorasib (AMG 510) demonstrated anti-cancer activity in patients with heavily pretreated advanced solid tumors. Patients with non-small cell lung cancer had a 32% response rate and median progression-free survival of 6.3 months.
In a Phase I clinical trial, sotorasib achieved a confirmed response rate of 32.2% and disease control rate of 88.1% in patients with KRAS G12C-mutant non-small cell lung cancer, with durable clinical benefits and manageable toxicities
A recent study found that combining aspirin, metformin, and statins may decrease lung cancer incidence and mortality. The research analyzed data from over 732,000 Koreans and discovered that concurrent use of these medications was associated with lower risk and mortality rates.
A recent Finnish twin study reveals that smoking is the primary cause of subarachnoid hemorrhages, which account for up to half of all deaths within months of the haemorrhage. The research indicates a strong causal link between smoking and fatal brain haemorrhages, highlighting the importance of quitting or never starting smoking.
Researchers have developed an accelerated platform to identify and test potential treatments for early-stage lung cancer using 'organoids' created from lung cells. The studies revealed reduced expression of genes that are markers of mature lung alveolar cells, and increased expression of genes involved in early lung development.
A new study has found that social smokers are more than twice as likely to die of lung disease and eight times as likely to die of lung cancer compared to non-smokers. Researchers say cutting down on smoking is not a substitute for quitting, highlighting the risks of social smoking regardless of the number of cigarettes smoked.
A large cohort study found no association between maternal H1N1 vaccination during pregnancy and risk for autism spectrum disorder (ASD) in children. Researchers also found that vaccine exposure in the first trimester did not increase ASD or autistic disorder (AD) risks.
Researchers identified a non-coding RNA molecule, ALAL-1, that aids lung cancer cell proliferation and immune evasion. Lowering ALAL-1 levels reduces tumor growth in mice, suggesting it as a possible therapeutic target.
A team of researchers at the Medical University of South Carolina has identified a critical player in resistance to targeted therapy in lung cancer. The protein NRP2b was found to drive resistance in non-small cell lung cancer cells that had become resistant to therapy, and inhibiting it caused the death of these cells.
Lung cancer incidence rates have decreased in both Black and white men and women since the 1990s, with steeper declines in Black populations. Historically higher smoking rates in Black adults have disappeared, leading to a reversal of the racial gap in lung cancer incidence among young adults.
A study found that current USPSTF and CMS guidelines for lung cancer screening undercount African Americans due to their age, smoking history, and quitting time. The PLCOm2012 model improved sensitivity in both Whites and African American ever-smokers, eliminating the eligibility disparity.
Researchers used nationwide cancer mapping statistics to develop a mathematical model that reveals patterns of cancer incidence by remoteness. The study found cancers having higher incidence in remote areas include head and neck, liver, lung, oesophageal, cervical, and uterine cancers.
In a Phase 3 study, ensartinib demonstrated statistically significant longer progression-free survival compared to crizotinib in ALK+ NSCLC patients. The study found that ensartinib significantly prolonged overall response rate and time-to-treatment-failure rate in brain metastases
The combination of first-line nivolumab and ipilimumab demonstrated an improvement in overall survival compared to platinum-based chemotherapy for patients with unresectable malignant pleural mesothelioma. The study showed a two-year overall survival rate of 40.8% for the treatment arm vs 27.0% for the chemotherapy arm.
A new study reveals that heavier smokers face a 17-fold increase in emphysema and an 8-fold increase in atherosclerosis. The study found associations with 28 separate health conditions, including lung cancer and cardiovascular diseases.
A recent study published in Nature Communications reveals that an enzyme called HDAC3 plays a crucial role in regulating lung macrophage development and homeostasis. The research found that inhibiting this enzyme may provide a new therapeutic approach for treating lung cancer and inflammatory diseases in the airway.
Dr. Tanmay Lele's research focuses on mechanobiology, exploring how cells sense external mechanical forces and generate mechanical forces in cancer. He aims to develop new knowledge of human cancers and their progression, with the goal of improving diagnosis and treatment.
The study found that focusing on subjects less likely to remain in the program, such as smokers and those with negative low-dose CT exams, improves cost-effectiveness and maximizes societal benefits. Adherence increased progressively with higher Lung-RADS categories, and having smoked previously was a significant predictor of adherence.
A comprehensive proteomic analysis of 103 Chinese patients with lung adenocarcinoma revealed molecular characteristics associated with clinical outcomes and potential prognostic biomarkers. The study identified 27 potential plasma biomarkers and several drug targets for LUAD, providing new insights into the disease.
A comprehensive study of lung cancer in non-smokers found that the disease is biologically distinct from smoking-related cases. Genetic changes vary depending on age and sex, with young women showing particular patterns that drive aggressive cancer progression.
This study developed a hemolysis correction equation to improve serum Neuron-specific enolase (NSE) concentration accuracy in small-cell lung cancer diagnostics. The corrected results showed an increased AUC and lower cut-off value for SCLC detection, indicating the importance of hemolysis correction.
A study by researchers at Karolinska Institutet found a significant association between income and survival after surgery for lung cancer. Patients with low household disposable income had significantly worse long-term survival compared to those with high income, even after adjusting for common comorbidities.
A new radiomics model can identify early stage lung cancer patients at high risk for poor survival outcomes and require aggressive follow-up or adjuvant therapy. The model uses two radiomic features to stratify patients into three risk groups, which may have more aggressive cancer despite early detection.
A study suggests that blocking two sugar-transporting proteins could help slow the growth of lung tumors. Researchers genetically engineered mice with lung cancer and found that tumors grew slower when both glucose transporters were lacking.
Researchers at Nagoya University have developed a near-infrared photoimmunotherapy (NIR-PIT) treatment targeting podoplanin-positive cells in malignant pleural mesothelioma (MPM). NIR-PIT has shown promise in reducing fluorescence from cancer-tagged cells and demonstrating anti-cancer effects.
KinaRx aims to create more effective drugs using a novel platform that targets gene mutations driving cancer growth. The company has developed novel RET inhibitors with promising results in preclinical experiments.
The study found that patients treated with chemotherapy had a significantly increased risk of dying from COVID-19, while those on anticoagulants and corticosteroids also faced higher mortality risks. In contrast, immunotherapies showed no increased risk of mortality.
miR-151a regulates endothelial cell motility and angiogenesis, with Slug expression required for these functions, providing new insights into the processes in the lung niche environment. The study highlights the potential of miR-151a as a therapeutic target against lung cancer.
Scientists discover that nicotine, found in tobacco, promotes the spread of non-small-cell lung cancer cells into the brain. Researchers identify parthenolide as a potential treatment option to prevent brain metastasis.
Researchers discovered resistance to tumor inhibitors arises from gradual adaptation to selective pressures, providing opportunity for effective therapies. The study advances in evolution of resistance and offers evolutionary-informed therapies for future treatments.
Researchers found that continued nicotine use promotes brain metastasis in lung cancer patients, who often struggle to quit due to nicotine addiction. Parthenolide, a compound from the herb Feverfew, blocks this effect and may prevent brain tumors, offering new hope for treatment.
Researchers at UT Arlington are using machine-learning algorithms and computational biology to refine lung cancer treatments. The project aims to customize patient treatment based on individualized prediction models that integrate pathological images and molecular profiling data.
Researchers identified a type of cell fusion between cancer cells and white blood cells called tumor-macrophage fusion (TMF), where the size and number of TMFs may predict disease-free survival. Larger TMFs were linked to shorter disease-free survival rates.