Articles tagged with Immunization
A Phase II trial will investigate a prime-boost regimen using two different COVID-19 vaccines, with the goal of expanding access to vaccines in Africa. The study aims to demonstrate the safety and efficacy of a mixed schedule of COVID-19 vaccines.
A modelling study suggests COVID-19 certification increases vaccine uptake in countries with below-average vaccination coverage. In six countries, certification was linked to a significant uptick in anticipation of restrictions and continued increases after introduction.
A new mRNA vaccine, CV2CoV, has demonstrated a ten-fold higher antibody response and significantly improved protective efficacy against COVID-19 compared to the original CVnCoV. The second-generation vaccine induced antigen-specific memory B cell responses and T cell responses in non-human primates.
States allowing minors to consent to HPV vaccination without parental involvement showed higher vaccine series initiation rates from 2015 to 2018, according to a JAMA Pediatrics analysis of nearly 82,000 adolescents. The study found increased vaccine uptake in these states compared to those with parental consent requirements.
An updated vaccination strategy is credited with averting an outbreak of urban yellow fever in São Paulo State, according to research published in Scientific Reports. The study found that the virus spread rapidly, reaching cities never affected before, and that a high number of cases were reported in areas with low vaccination coverage.
A new study published in The Lancet confirms that HPV vaccination has led to a significant reduction in cervical cancer rates in England. Women who were vaccinated between the ages of 12-13 had an 87% lower incidence of cervical cancer compared to previous generations.
Researchers at Johns Hopkins Medicine found that antibody levels against SARS-CoV-2 stay higher in people who were infected by the virus and then received protection from mRNA vaccine compared to those who only got vaccinated. A longer interval between virus exposure and first vaccine dose may enhance antibody response.
A Brazilian study demonstrates that a hyperimmune serum consisting of purified antibody fragments produced in horses can be an efficient approach to combat covid-19. The neutralizing activity of the sera has been proved to be high against the P.1 (Gamma) and P.2 variants, improving animal clinical conditions in hamsters.
An international research team has demonstrated that adaptations to infections are passed on to offspring in mice, with improved immune responses and resistance to subsequent infections observed. This study provides new insights into the role of epigenetics in shaping the immune system across generations.
Researchers compared immune responses elicited by three COVID-19 vaccines over an eight-month follow-up period. The mRNA vaccines showed high peak antibody responses that declined sharply, while the single-shot Ad26 vaccine induced lower initial antibody responses but stable levels over time.
A study by Northwestern University scientists has shown that coronavirus vaccines and prior infections can provide broad immunity against other, similar coronaviruses. The findings build a rationale for universal coronavirus vaccines.
A Michigan-based study found a dramatic drop in vaccinations across the lifespan during the early pandemic, but a recent rebound has been noted. The researchers emphasize the importance of continued vaccinations to prevent outbreaks of infectious diseases like measles.
A new study suggests that a plant-based diet can improve vaccine efficacy and reduce COVID-related health issues. Studies have shown that healthcare workers with lower waist circumferences had better immune responses to the Pfizer vaccine.
An Australian study found that trust in government approval of safe COVID-19 vaccines is the primary driver of vaccine uptake. Perceived effectiveness in protecting others was also a significant factor. The study revealed lower rates of vaccine uptake among younger, unemployed individuals and those with lower altruistic beliefs.
A predictive model estimated that cervical cancer may be eliminated in the US by 2030 in low-poverty areas, but not until 2044 in high-poverty areas. Health care disparities are a major contributor to these disparities, including lower vaccination rates and higher prevalence of cancer-causing HPV types.
A comprehensive study of 6.2 million patients found no serious health effects linked to mRNA COVID-19 vaccines, with some early findings previously reported at CDC meetings. The Vaccine Safety Datalink's COVID-19 rapid cycle analysis will continue tracking vaccinated patients for at least 2 years.
A study assessing Pfizer-BioNTech vaccine safety in highly allergic individuals found a lower incidence of severe adverse reactions compared to previously reported rates. The results suggest the vaccine may be a viable option for these high-risk groups.
Researchers identified and contacted patients with cancer who could benefit from targeted nonelectronic communication regarding COVID-19 immunization. The study used an analytics-based approach to reach marginalized populations, highlighting the importance of targeted outreach in increasing vaccine uptake.
Immunocompromised individuals are at risk for prolonged viral shedding and the emergence of novel variants of concern. Healthcare providers must develop precise guidelines for monitoring and treating these patients.
Researchers identified two proteins, HMW1 and HMW2, that stimulate protective immunity against diverse NTHi strains. Immunization with these proteins provides protection against bacterial colonization by other strains, highlighting the vaccine potential for a nontypeable Haemophilus influenzae vaccine.
Racial and ethnic disparities in vaccine uptake have persisted over the last decade, highlighting the urgent need to achieve equity in immunization rates. Concerted efforts are needed to address socio-economic disparities, particularly among adults 65 years or older.
The World Health Organization has fired 500 staff on the polio programme, potentially ending a multibillion-dollar crusade. Despite reducing cases by 99.99%, polio efforts have been stagnant for years, raising questions about the effectiveness of funding and integration with routine immunization services.
A proposed Canadian Immunization Services model could provide a coordinated approach to vaccination across the country, addressing fragmentation in data sharing, vaccine procurement, and supply chain management. The independent not-for-profit corporation would be funded by provinces, territories, and potentially the federal government.
Researchers found that the Mission Indradhanush program increased full immunization rates by 27% and the rate of receiving all vaccines at recommended ages by 8%. The program also improved vaccination rates for children who received treatment in multiple phases.
Researchers developed two groups of molecules that effectively inhibit SARS-CoV-2 variants, bypassing mutations and disabling viral entry. The nanobodies recognize a conserved region of the receptor binding domain, blocking viral entry even when human antibodies cannot.
A real-world study found the first dose of the BNT162b2 (BioNTech/Pfizer) vaccine to be highly effective in preventing SARS-CoV-2 infection 13 to 24 days after immunization. The study revealed a significant reduction in infection rates among vaccinated individuals, highlighting the vaccine's effectiveness in real-world settings.
A new study by Texas A&M researchers found significant decreases in childhood vaccination rates in Texas during the COVID-19 pandemic. Vaccination rates declined by 47% for 5-month-old children and 58% for 16-month-old children, with rural locations experiencing greater declines than urban areas.
High-quality vaccination programs protect people of all ages, from infants to the elderly, but many adults remain under- or unvaccinated. The article highlights the importance of vaccines in preventing life-threatening diseases and discusses challenges in ensuring equitable access to vaccines.
The introduction of immunization passports may help countries reopen and revitalize their economies while reducing the spread of SARS-CoV-2. To implement these passports effectively, governments must establish secure digital immunization records and ensure adherence to international standards.
The Advisory Committee on Immunization Practices (ACIP) has released its 2021 Recommended Adult Immunization Schedule, which includes interim recommendations for COVID-19 vaccination. The updated schedule features revised content and harmonized changes with the Child and Adolescent Immunization Schedule.
Taiwan's rapid response to COVID-19 has led to a decrease in overall death rates compared to 2019, suggesting mask-wearing and physical distancing had a positive impact. Immunization experts also call on clinicians to utilize immunization information systems to facilitate fair and equitable COVID-19 vaccine distribution.
The 4CMenB vaccine has shown 79% effectiveness in preventing meningococcus group B disease among children and young adults. In a real-world study, nearly all vaccinated cases survived, while unvaccinated cases experienced severe outcomes, including death and long-term injuries.
The COVID-19 vaccine's effectiveness and risks require transparent communication to build trust and achieve herd immunity. Healthcare professionals must provide comprehensive information on the pros and cons of vaccination to influence uptake.
The COVID-19 Peer Hub program is connecting over 4000 immunisation professionals globally to share ideas and practices to counteract vaccine avoidance. Preliminary findings show that the program has been useful for their work, with 90% of participants reporting positive outcomes.
Researchers develop efficient immunization strategy using limited network information, significantly reducing disease spread for small groups of individuals. By focusing on the most connected nodes, they achieve a lower fraction of nodes needed to stop the epidemic, highlighting the potential for effective control measures.
New analysis shows HPV vaccines are safe for males, with similar side effects to females. The study evaluated reports of adverse events from the U.S. Vaccine Adverse Event Reporting System between 2006 and 2018.
NACI prioritizes populations at high risk of severe illness and death, essential workers, and Indigenous communities for early COVID-19 immunization. The recommendations aim to minimize serious illness and deaths while ensuring equitable access to vaccines.
The Society for Healthcare Epidemiology of America recommends immunizations against vaccine-preventable diseases for healthcare personnel, educators, and students. Medical contraindications are the only exception to receiving recommended immunizations.
A new study by the International Vaccine Access Center at Johns Hopkins Bloomberg School of Public Health estimates that immunization programs will save $681.9 billion for 2011-20 and $828.5 billion for 2021-30, with a return on investment ratio of up to 51:1.
A study estimates the return on investment (ROI) of immunization programs for ten pathogens in ninety-four low- and middle-income countries over a two-decade period. The authors found a cost-of-illness approach yielded a ROI of 22.2 per dollar invested, while a value-of-a-statistical-life approach calculated an ROI of 51.8.
A team of researchers from SMART has developed a novel approach to induce strong and broad immunity against the dengue virus. Sequential immunization was found to be more effective in inducing higher levels of neutralizing antibodies to all four DENV serotypes than traditional tetravalent-formulated immunization.
A modelling study published in The Lancet Global Health found that continuing routine childhood vaccination programmes in Africa during the pandemic could save around 702,000 child lives from vaccine-preventable diseases. This number far exceeds the potential risks of COVID-19 transmission to older family members.
The Phase 1 trial demonstrated that repeated immunisation with PD01A is safe and well-tolerated, with a substantial reduction in alpha-synuclein oligomers and stable motor scores. The results suggest that PD01A may offer a promising strategy for long-term management of Parkinson's disease.
A study by ISGlobal reveals that gene expression in peripheral blood cells can predict vaccine-induced protection against malaria. Boosting the immune system before vaccination may improve vaccine efficacy.
The ACIP released its 2020 Recommended Immunization Schedule for adults with changes to vaccine administration and shared clinical decision-making. The schedule includes new instructions for discussing HPV vaccination, pneumococcal conjugate vaccines, and meningitis B vaccines.
Experts cite urgent need for influenza vaccinations to prevent outbreaks in detained migrants and asylum seekers. The logistics of vaccine administration are relatively straightforward, with a low risk of adverse effects.
A study of 6,980 pediatric solid organ transplant recipients found that 15.6% were hospitalized with a vaccine-preventable infection within the first five years after transplant, 87 times higher than in the general population. The researchers call for improved immunization rates to reduce this risk.
A school-based HPV vaccination program in British Columbia has significantly reduced cervical pre-cancer rates among women, with a 57% reduction found in those vaccinated as Grade 6 girls compared to unvaccinated women. Regular cervical screening is crucial in preventing cervical cancer from developing.
An expert in The BMJ argues that the expansion of the digital GP service, GP at Hand, may worsen primary care for vulnerable patients. Despite its popularity, the service primarily caters to a healthy and affluent population, leaving GPs with complex cases to manage.
Researchers warn that current vaccination policies may not be enough to prevent measles resurgence in seven high-income countries. The study suggests that countries like the UK, Ireland, and US would benefit from compulsory vaccination at school entry to achieve stable herd immunity levels.
A NYU researcher has won a $100,000 Gates Foundation grant to improve vaccination rates in Pakistan using artificial intelligence and mobile tools. The project aims to develop algorithms to prioritize resources and target efforts more effectively, predicting and providing feedback on optimal locations and times for vaccinations.
Researchers found diphtheria, tetanus, and whooping cough vaccination levels in Nigeria, DRC, Ethiopia, Mozambique, and Cambodia below the 80% threshold. Targeted campaigns can improve immunization service delivery, especially in areas with poor routine immunization coverage.
The report identified major barriers to influenza immunization among racial minorities, including older adults with low socioeconomic status and chronic health conditions. To address these gaps, Sustainable Healthy Communities launched a population health initiative, DRIVE, aiming to improve immunization rates in underserved communities.
After Japan's HPV vaccination suspension, researchers at Osaka University suggest ways to reduce cervical cancer risk and promote vaccination. They propose targeted immunization for older women, the nine-valent vaccine, and a behavioral economics approach to boost public acceptance.
Researchers describe a DNA immunization platform that stimulates innate and adaptive immunity to produce high levels of antigen-specific antibody responses. The approach activates multiple pathways of innate immunity, leading to the development of high-affinity antibodies in mouse, rabbit, and human models.
A recent observational study of 626 pregnancies found that maternal Tdap immunization in the third trimester is associated with higher concentrations of pertussis antibodies in infants. Immunizing mothers earlier in the third trimester may maximize these antibody levels, but definitive immunity levels for whooping cough are unknown.
Researchers found a broad range of cost per dose delivered across Indian states, with personnel costs accounting for 57% of total costs. The weighted average national cost per dose was $2.29, which is lower than the current allocation of $25 per child.
A new nanoparticle vaccine developed by MIT researchers can deliver multiple doses of the polio vaccine in just one injection, making it easier to immunize children in remote regions. The vaccine uses a biodegradable polymer that releases the vaccine in bursts at defined time points, providing long-lasting immunity.
According to Public Health Ontario and ICES, whooping cough cases in Ontario are more frequent than previously known, with estimated cases being nearly double reported cases. This highlights the need for people to ensure their immunizations are up-to-date to limit potential infection and spread.
Researchers found that mobile phone reminders linked with incentives boosted immunization rates from 33% to 50% in a rural Indian village. The study used special software and GPS technology to track caregiver and child information, and delivered automated reminders to participants' mobile phones with incentives of free talk time minutes.