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Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers from Northwestern University developed a novel approach to integrate metal-sulfur active sites into metal-organic frameworks, which significantly outperformed their non-sulfur counterparts in hydrogenation catalysis. The study provides a powerful new strategy to design and study metal-sulfur catalysts for various applications.
Researchers at Tohoku University developed a surface reconstruction pathway to produce durable non-noble metal-based cathodes for efficient hydrogen evolution reaction (HER) performance, paving the way for affordable commercial production.
A new study emphasizes the importance of pushing metal site design limits to optimize hydrogen evolution reaction in single atom catalysts. Researchers found that hydrogen binding energy calculation can serve as a good predictor of activity, and neighboring nitrogen atoms can host catalytic activity to negate poisoning effects.
Researchers investigated MOR zeolite's unique pore structure, finding acid sites within 8-membered ring side pockets as active sites for syngas-to-ethylene conversion. A critical threshold of 60 nm was identified for 12MR channel length, optimizing ZnAlOx-MOR bifunctional catalysts with high CO conversion and ethylene selectivity.
Researchers developed two silver-based bimetallic clusters that increase Faradaic efficiency and yield of urea through charge polarization modulation. Ag14Pd outperforms Ag13Au5 in NO3RR, while Ag13Au5 excels in CO2RR with higher urea formation rates.
Researchers unveil Ba-Si orthosilicate oxynitride-hydride as a transition metal-free catalyst, offering a more sustainable approach to ammonia production. The novel catalyst demonstrates exceptional stability and higher activity than conventional ruthenium-loaded MgO catalysts.
Researchers introduce a trimetallic catalyst supported on defective ceria, achieving extraordinary efficiency in CO2 reduction. The unique metal-support interaction fine-tunes the electronic structure, enabling optimal performance and setting new benchmarks in catalysis.
Researchers developed an automated analytical method to analyze single atom catalysts, which could lead to more efficient fuel production and sustainable energy. The new tool, called MS-QuantEXAFS, automates the analysis process, reducing time from days to months.
Chemists at Brookhaven Lab develop new theoretical framework to accurately predict catalyst behavior, revealing how conditions like temperature and pressure can change a catalyst's structure, efficiency, and products. The study highlights the significant impact of reaction environment on catalytic performance.
A new MOF has been developed using a 'Merged-Net Strategy' inspired by skyscraper architecture, resulting in enhanced porosity and structural stability. The material exhibits superior water adsorption capacity and reusability compared to conventional MOFs.
Researchers have discovered a novel transition-metal-free aluminosilicate ferrierite zeolite catalyst that enables direct conversion of methane to methanol. The new process achieves 305 π mol gˑ minǘ methanol production rate with high selectivity, presenting an environmentally friendly solution for converting greenhouse gases into valu...
A novel multifunctional catalyst has been developed to convert methane into valuable hydrocarbons, reducing greenhouse gas emissions and energy consumption. The catalyst's spatial distribution of Cu and acid sites determines the final products, with uniform distribution leading to stable and efficient methanol production.
Researchers developed a stable air-stable plasmonic reduction catalyst that enhances ethene production from acetylene using visible light. The catalyst achieves an efficiency of 320 mmol g<sup>−1</sup> h<sup>−1</sup> with 90% selectivity, surpassing known plasmonic and thermal catalysts.
Researchers evaluate the latest applications of single-atom catalysts in five challenging 'holy grail' reactions, achieving selective production of valuable chemical products. Advanced spectroscopic techniques and DFT calculations help understand reaction mechanisms and structure-activity relationships.
Researchers created artificial allosteric sites in protein complexes using computational design to regulate concerted functions. This breakthrough holds promise for industry, biology, medicine, and agriculture.
A novel Cu-based catalyst with improved catalytic performance for CO2 reduction has been developed by leveraging strong metal-support interactions and defect sites cooperativity. The DFNS/TiO2-Cu catalyst showed excellent activity and stability, outperforming other copper-based thermal catalysts.
Researchers at Brookhaven National Laboratory have produced the first atomic-level structure of an enzyme that selectively breaks carbon-hydrogen bonds, suggesting ways to engineer it for producing desired products. The detailed structure reveals how the enzyme operates under ordinary conditions and produces few unwanted byproducts.
Scientists studied F1-ATPase function in bacteria to clarify the angle of rotation during ATP hydrolysis. The study revealed three sets of short and long dwells associated with different intervals per revolution, resolving a long-term debate over the ATP-cleavage shaft angle.
A research team at Dalian Institute of Chemical Physics reveals the synergistic interplay mechanism of dual active sites on bimetallic oxide for efficient syngas conversion. They identified key intermediates and proposed a catalytic mechanism using advanced solid-state NMR technologies.
Scientists at Helmholtz-Zentrum Berlin examined the chemistry of Cobalt-Iron Oxyhydroxides using X-ray absorption spectroscopy. They discovered that iron is present in higher oxidation states than previously thought, which could lead to improved electrocatalysts for water splitting and carbon dioxide reduction.
Researchers discovered the most efficient way to produce ammonia through electrochemical synthesis, increasing its sustainability. The D5 step site on ruthenium nanoparticles was found to be the most active site for the nitrogen reduction reaction.
Researchers at UCF have developed single-atom platinum catalysts that reduce the amount of precious metals needed in catalytic converters. These improvements can enhance catalytic performance while minimizing environmental harm.
A germline mutation of topoisomerase II B affects the movement of proteins in the nuclei of cells with this mutation. The study reveals that the mutation impacts nuclear dynamics and provides a platform to understand the biological relevance of such mutations.
Scientists developed a method to control the synthesis of single-atom catalysts, enabling the creation of bimetallic Fe-Co electrocatalysts with desired properties. These catalysts showed superior ammonia yield rates and faradaic efficiency under electrocatalytic nitrogen reduction reaction conditions.
The THERACAT project aims to deliver drugs only to tumor sites using bio-orthogonal catalysis, a promising approach for targeted cancer treatment. Researchers developed nanoparticles bearing metal catalysts to efficiently convert inactive pro-drugs into active drugs at the tumor site.
Researchers in China designed a strategy to improve zinc-air battery performance by combining two transition metals, atomic iron and nickel, which deliver high electrocatalytic activity. The resulting rechargeable batteries achieve high peak power density, working rates, and long lifespan.
Researchers used x-ray crystallography to study the main protease of SARS-CoV-2 at various temperatures, revealing subtle conformational changes and potential targets for drug design. These findings may inspire the development of new antiviral drugs to counteract COVID-19 and prevent future pandemics.
Researchers at Johns Hopkins Medicine have probed the atomic structure of proteins, finding that wiggling and movement play a critical role in their ability to function. The study's findings may help scientists design new drugs that can modify or disrupt protein movements to alter their functions.
A new artificial enzyme has successfully degraded lignin, a stubborn polymer in woody plants, offering hope for developing a new renewable energy source. The enzyme, developed by mimicking natural enzymes that break down lignin in nature, shows promise for producing valuable products from lignin.
Researchers at Northwestern University discovered key structures controlling methane conversion in methane-eating bacteria, enabling potential human-made biological catalysts. The findings may lead to biotechnological applications such as harnessing methane from fracking sites or cleaning up oil spills.
Researchers at the University of Delaware have developed a novel catalytic technology that converts non-edible plants into renewable fuels, chemicals and plastics. By pulsing hydrogen gas on and off, they increase the population of active sites on catalysts, allowing reactions to occur up to 10 times faster.
Researchers at Rice University have developed a theory showing how manipulating quasiparticles could help improve chemical reactions. By applying electric fields, holes can be made to migrate across the surface of catalyst particles, activating neighboring sites and increasing the efficiency of the reaction.
A research team led by Prof. ZHANG Kaiming uncovered a previously unrecognized mechanism for processive substrate degradation by the Lon protease. The study reveals that the protein degradation occurs at each individual proteolytic active site, following a C-to-N processive cleavage mechanism.
A team at Brookhaven National Laboratory has identified a common industrial catalyst that can efficiently convert methane to methanol with or without water. The findings suggest strategies for improving the water-free conversion, achieving 30% selectivity in the absence of water, and 80% selectivity with water.
Researchers synthesized a uniform Cu-N-C single-atom catalyst that exhibits comparable alkaline ORR activity to Pt/C. The active site structure undergoes dynamic changes during the reaction, transforming into HO-Cu-N2 under reaction conditions.
Researchers have discovered a way to induce magnetic waves in antiferromagnets using ultrafast laser pulses, potentially leading to faster and more efficient data storage. This technology could endow materials with new functionalities for energy-efficient and ultrafast data storage applications.
A new technique called HT-MEK enables the simultaneous performance of thousands of enzyme experiments, allowing scientists to deeply probe into enzyme functions and structure. This could reveal clues about how enzymes work together to achieve their remarkable reactivity, enabling researchers to 'do enzymatic tricks' themselves.
Researchers have identified highly conserved sequences in viral proteins that could make them effective drug targets. The study found two promising sites: one overlapping the RNA binding site of nsp13 and another containing the catalytic site of nsp12, both involved in viral RNA replication and transcription.
Researchers at University of Freiburg discover how vanadium-dependent nitrogenase binds two CO molecules simultaneously, enabling reductive process for industrial applications. This breakthrough sheds new light on the mechanistic principles behind nitrogenase's ability to reduce toxic gas carbon monoxide.
A team led by Prof. Peng Wu designed a structured, binder-free MWW-type titanosilicate catalyst that achieves high PO selectivity under mild reaction conditions, with a lifetime of 2400 hours and low solvent consumption.
Scientists successfully achieved homogeneous catalyst by dissolving electrocatalytic metals in molten gallium, improving formic acid selectivity and reducing hydrogen evolution. The new method brings a significant breakthrough for synthesizing heterogeneous catalysts with enhanced stability.
Researchers discovered a unique molecular mechanism in CbA5H that shields the catalytic cofactor from oxygen attack, allowing it to repeatedly survive and resume activity. This protective function is provided by a thiol group binding directly to the substrate coordination site of the catalytic cluster.
Researchers have uncovered the mechanism behind severe cases of G6PD deficiency, identifying a chain of amino acids that warps the shape of the condition's namesake protein. This breakthrough could pave the way for new treatments and therapeutics for Class I patients, who currently rely on blood transfusions.
Advanced sequencing technique reveals 19 new RNA mycoviruses in fungus Aspergillus, including 9 undetected by conventional methods. The study also identifies novel RdRp gene structures, challenging existing understanding of RNA virus genetics.
Researchers have developed a novel heterogeneous catalyst combining intermetallic and support materials to improve Suzuki cross-coupling reaction stability and efficiency. The new Pd-ZrC catalyst exhibits high stability, large effective surface area, and enhanced catalytic performance compared to existing compounds.
Researchers from Japan's Institute for Molecular Science have described a bacterial cellulose degradation system in detail, revealing its similarities and differences with the fungal system. The study found that the bacterial system exhibits higher processivity, enabling faster cellulose degradation.
A new crystal model system accurately identifies catalytic active sites in electrocatalysis, revealing pyridine N as a suitable active site for CO2 reduction. The study provides significant insights into the reaction mechanism and catalyst performance.
Researchers identified ebselen's binding activity to SARS-CoV-2 main protease, suggesting its potential as a treatment. The distant binding site may provide an alternative target for repurposed drugs.
Researchers have discovered that graphitic nitrogen (GN) dopants significantly improve the activity of adjacent carbon atoms for electrocatalytic CO2 reduction to CO. The study found a 95% Faradaic efficiency at -0.5 V versus reversible hydrogen electrode, outperforming other N-dopant types.
Researchers from Ruhr-University Bochum and Max Planck Institute discovered that the zinc component of the methanol catalyst is positively charged and has two copper-based active sites. This finding offers ideas for optimizing the catalyst in the future.
The researchers developed new synthesis methods for polyheterocyclic compounds containing triazolo and tetrazolo moieties. These compounds were found to act as inhibitors for the Tankyrase I enzyme, showing potential in cancer treatment
Researchers at Hokkaido University have created a novel, silica-supported catalyst that enables efficient propane dehydrogenation without catalyst deactivation. The catalyst maintains high propylene selectivity and stability even at temperatures above 600°C.
Researchers at TIFR create metal-free catalyst that converts CO2 to methane with excellent productivity and selectivity. The catalyst is recyclable and shows significant increase in production rate after regeneration cycles.
Researchers at UNIST have developed a novel catalyst for electrochemical chlorine generation, overcoming the drawbacks of existing metal oxide-based catalysts. The new catalyst, Pt1/CNT, exhibits high efficiency and selectivity for chlorine ions, enabling more efficient and affordable production.
Scientists have developed a method to synthesize carbon nanotubes (CNTs) with a selectivity of 90%, challenging existing theories. The new approach allows for the production of specific types of CNTs, such as (2n, n) CNTs, which are ideal for electronic applications.
A new enzyme, HypX, has been discovered to produce carbon monoxide essential for the maturation of NiFe-hydrogenase. The enzyme's unique reaction process involves coenzyme A, revealing a novel physiological function of CoA.
Researchers discovered a modified enzyme produced by fungus Trichoderma harzianum that increases glucose release from biomass for fermentation. The modified protein proved 300% more efficient than the wild-type enzyme in terms of glucose release, making it suitable for industrial application.
Researchers developed a new class of single-atom nanozymes with intrinsic enzyme-like active sites, overcoming conventional nanozyme drawbacks. The discovery provides a new perspective on catalytic mechanism and rational design of nanozymes.
Researchers developed nanomicrocell catalysts with integrated active sites, reducing energy barriers and improving catalytic properties. The catalyst system enhances transportation efficiency of electrons and charge carriers, opening a new window for advanced catalyst synthesis.
Researchers from University of East Anglia discovered a protein called NosL that helps assemble the copper-sulfide cluster active site in nitrogenase reductase, an enzyme that destroys N2O. The team's findings may help pave the way for strategies to mitigate the damaging effects of nitrous oxide on the environment.