Articles tagged with Protein Expression
A new study found that a disrupted biological clock increases the risk of heart disease in mice treated with radiation therapy, highlighting the potential role of protein Bmal1 in protecting the heart. The research could lead to personalized medicine approaches and optimized timing for radiation therapy to minimize side effects.
Researchers at Karolinska Institutet found that CaV3.1 channels lead to excessive calcium influx, impairing beta cell function and glucose homeostasis. This hyperactivation is a critical pathogenic mechanism in diabetes development.
Researchers found that a problem in gene-regulatory process can cause normal cells to turn malignant and produce Wilms' tumor. The implicated reader protein causes problems by acquiring a new property and being too active, leading to abnormal gene expression and tumor formation.
The study reveals that EGFR overexpression is associated with lower expression of multiple proliferation genes, leading to replication stress and decreased survival. Interestingly, certain proteins like CLPTM1L and PBXIP1 are upregulated in EGFR-activated cases, but this does not promote increased proliferation.
Researchers uncover the first steps in chromatin-opening process, revealing pioneer transcription factor Rap1's role in regulating gene expression. The study provides a biological model for other pioneer transcription factors and tools for investigating them at the single-molecule level.
Researchers identify protein CaVbeta1E that promotes muscle mass maintenance via GDF5 signaling, counteracting sarcopenia. The study opens a new field of activity in developing therapeutic strategies against muscular decline associated with aging.
Researchers developed a bacterial genetic oscillator that records changes in microbiome growth patterns, providing an objective measurement of time. The system uses an oscillating gene circuit to track cell divisions and analyze bacterial growth rates, offering insights into the dynamics of the gut microbiome.
The study found that HIV-1 Tat protein expression leads to perturbations in the human cellular proteome, affecting gene expression and cellular processes. This has significant implications for understanding HIV-1 latency reversal and potential therapeutic strategies.
A new study by the University of Turku and Tampere University found that chronic enteroviral infection can modify broadly pancreatic cellular functions, including alterations in protein expression and secretion. The study suggests that such infections may have adverse health effects, particularly on the development of type 1 diabetes.
A new study reveals that psychopathic violent offenders exhibit abnormal expression of genes and immune-response-related molecular pathways, which have also been linked to autism. The findings suggest that targeting the opioid system could be a feasible treatment approach for psychopathy.
A study reveals the three-dimensional genomic structure of male germ cells, showing a fine-tuned balance between chromatin remodelling and architectural proteins. This structure determines gene expression in these cells, which are essential for reproduction.
Scientists identified two subtypes of pNETs, type A (ARX-expressing) and type B (PDX1-expressing), with dramatically different risks of recurrence following surgical treatment. Type B tumors have an excellent prognosis, while type A tumors require vigilant monitoring for potential recurrence.
Researchers funded by Neuroendocrine Tumor Research Foundation (NETRF) discover molecular information that can help predict the recurrence of non-functional pancreatic neuroendocrine tumors. The study identifies two new subtypes of pNETs, one with a high risk of recurrence and another with an excellent prognosis.
A team at IRB Barcelona has identified Mitofusin 2 as a protein that protects against non-alcoholic fatty liver disease. Early diagnosis and treatment options for this condition are limited, but researchers hope to enhance levels of Mitofusin 2 without side effects.
Scientists at Vanderbilt University Medical Center have identified a potential treatment target for malignant rhabdoid tumor (MRT), a rare and aggressive childhood cancer. Blocking the MYC protein could be effectively treated in cancers driven by SNF5 loss, offering new hope for children with this lethal disease.
Researchers found that CBX4 gene therapy helps to regenerate hMSCs and prevent osteoarthritis in mice. The study showed that CBX4 promotes nucleolar homeostasis, which is essential for maintaining healthy stem cells.
Aging retinal pigment epithelial cells undergo senescence due to increased oxidative stress, leading to age-related macular degeneration. Researchers found that inhibiting post-translational modifications, specifically SUMOylation, can alleviate this process, reducing SASP genes expression and proinflammatory factors.
A recent study published in Nature Communications identifies Satb1 as a protein regulator that induces the pathogenic properties of Th17 cells, leading to multiple sclerosis and other inflammatory autoimmune disorders. By targeting Satb1 gene expression in Th17 cells, novel treatments may be developed to alleviate or eliminate disease ...
Researchers from the University of Konstanz develop an RNA-based inducible system for switching on genes in C. elegans, closing a significant gap in the research on genetic switches. The new approach establishes a novel inducible disease model for Huntington's disease, opening up new opportunities for research and application.
A Rutgers-led study found that heavy drinking can trigger genetic changes that increase craving for alcohol. The study suggests that these changes may contribute to the powerful addiction of alcoholism and potentially lead to new treatments.
Researchers discovered that people with bipolar disorder have lower levels of the CPG2 protein, which regulates glutamate receptor numbers at excitatory synapses. Genetic variations in the SYNE1 gene, encoding the protein, undermine its expression and function in neurons.
Researchers at Texas Biomed are investigating the role of DNA methylation in Hispanic childhood obesity. The four-year grant aims to understand how changes in genes and proteins contribute to obesity and potentially develop targeted treatments.
Researchers discovered small populations of T cells expressing functional SAP at normal levels in patients with XLP1, potentially modifying disease severity. This finding suggests gene therapy or adoptive cellular therapy could be effective treatments for the disease.
MIT biological engineers have developed a way to regulate RNA expression, giving precise control over the dose of therapeutic protein a patient receives. This technology allows doctors to tailor treatment for individual patients and offers a quick way to turn off protein production if necessary.
Scientists have found that low TIP60 expression leads to uncontrolled jumping gene expression, triggering tissue inflammation that supports tumor growth. The discovery opens new avenues for cancer treatment using anti-HIV drugs.
A study published in the Journal of the American Heart Association reveals that reproducing Scn5a missplicing in mice with myotonic dystrophy type 1 (DM1) recapitulates cardiac function defects present in patients. The findings highlight a non-mutational mechanism contributing to arrhythmias and open possibilities for novel interventions.
ASTN2 helps move proteins away from the membrane, supporting neuronal connections; defects lead to neurodevelopmental disorders like autism and intellectual disabilities. The cerebellum's complex roles in cognition and language may be linked to ASTN2 dysfunction.
Researchers developed a new method to distinguish changes in protein synthesis from degradation in single living cells. They found that protein synthesis and degradation rates change significantly during the cell cycle, with nearly half of proteins stopping to be degraded during mitosis.
Salivary proteins could be part of a feedback loop that influences food taste and dietary choices. Researchers found that drinking bitter foods altered saliva protein composition, which corresponded to changes in sensory ratings.
A study by Columbia University researchers found that rogue RNA-binding proteins, including TDP-43, FUS, and hnRNP A1, accumulate in the brains of patients with ALS and frontotemporal dementia. This discovery suggests a common disease mechanism between inherited and sporadic forms of both diseases.
Researchers discovered CPEB4, a molecule regulating protein synthesis, is impaired in most autism cases. The study found defects in CPEB4 lead to dysregulation of hundreds of genes associated with autism.
A new carrier to transfer genes into plants has enabled crop scientists to study traits and diseases in wheat and maize more quickly and easily. The Foxtail mosaic virus (FoMV) has overcome limitations of existing carriers, allowing for the expression of a wide range of proteins in host plants.
Researchers found that variants of the LOXL1 gene are associated with increased levels of the protein, which clogs the outflow pathway and causes high pressure in the eye. The long non-coding RNA lncLOXL1 regulates the gene's expression and is thought to contribute to the disease progression.
Researchers at University of Bath and Cardiff University have developed a novel switch to control genome editing, enabling reliable protein expression on demand. The switch uses a cheap, non-toxic amino acid as the control mechanism, addressing concerns over antibiotic resistance and 'leakiness'.
Scientists at RIKEN have identified a key mechanism by which plant genes are regulated in response to light. The research found that blue light triggers a shift in the start site of gene expression, allowing plants to carry out photosynthesis and grow.
Researchers at Massachusetts General Hospital identify SMCHD1 as critical regulator of X chromosome inactivation, allowing genes to be suppressed. The study's findings have implications for treating diseases associated with misfolded chromatin and hold promise for reactivating the inactive X chromosome.
Researchers discovered that porcine deltacoronavirus can infect human cells by binding to aminopeptidase N, which is conserved across animal species; this suggests a possible mechanism of transmission from pigs to other animals and potentially humans.
A team of University of Tsukuba-centered researchers discovered a novel biomarker, citrullinated ITIH4 protein, that is highly specific to patients with rheumatoid arthritis. The levels of this protein decreased in correlation with the reduction of disease activity score after effective treatment.
Researchers discovered that visual experience triggers changes in brain protein expression, which enhances learning and processing of sensory information in tadpoles. This finding suggests a possible new role for proteins in sensory processing in people with autism spectrum disorder.
A CNIC-coordinated project will investigate the oxidative phosphorylation system (OXPHOS) and its structural heterogeneity, with potential implications for metabolic plasticity. Researchers from various countries and specialties will collaborate to develop new methods and gain a deeper understanding of this fundamental biological process.
Researchers have developed novel proteomics methods to address unanswered questions in cancer research, including protein variation within tumors. This study reveals significant variations in expression of multiple proteins between areas from the center and periphery of a tumor.
New research reveals that all-trans-retinoic acid regulates immune system responses in the mouse intestine by controlling expression of HIC1 protein in innate lymphoid cells. This finding could lead to new strategies to protect against infection and intestinal imbalance.
Researchers found that Rev-erb controls gene expression in mouse liver via interactions between on-and-off regions on the same chromosome. The study demonstrates how Rev-erb represses transcription by loosening chromosome loops, leading to circadian repression of transcription.
A study by Tokyo Medical and Dental University found that protein YAP rescued SCA1 pathology when expressed during development, but not as an adult. The researchers also discovered a link between YAP and the transcriptional co-activator RORα, which plays a crucial role in cerebellum development.
Researchers found that overexpressing FKBP1b restored gene expression in hippocampal neurons, improving water maze performance and reversing age-related memory impairments in rats. The study suggests addressing FKBP1b deficiency may be a new avenue for countering age-related memory loss.
Researchers at UC Davis have created a method to produce all 34 proteins required for mRNA translation in the correct proportions within a single mixed culture. This breakthrough enables rapid and high-purity reconstitution of cellular reactions, making it useful for various applications such as disease diagnosis and drug development.
A recent study by Korean researchers identified a potential mechanism of licorice extract inhibiting dopaminergic neuronal cell death in Parkinson's disease. The study found that liquiritigenin, a compound extracted from licorice, induces the expression of RNF146 protein and removes excessive PAR accumulation, resulting in inhibition o...
M344 altered key gene expression in a cellular model of AD, preventing cognitive decline and improving memory. In mouse models, low-dose administration of M344 prevented cognitive decline and improved learning and memory.
A study associates schizophrenia with defective processing of messenger RNA in cells, suggesting a link between the spliceosome complex and brain dysfunctions. The researchers found altered proteins in two brain regions, including those involved in calcium-mediated signaling and myelination.
Researchers at the University of Basel developed a rapid test to diagnose Sp110 protein deficiency, a severe immune defect. The test uses flow cytometry to detect the presence of Sp110 protein in patient blood cells, enabling quick diagnosis in hours.
Researchers at Kansas State University are developing new treatments for E. coli by inhibiting the activity of NleB, a protein that contributes to bacterial virulence. The study resolves an ongoing debate about the protein's function in different strains of E. coli.
Researchers have developed novel secreted reporter proteins that can be detected for several months after infusion into the liver, demonstrating potential for monitoring therapeutic gene delivery and ongoing expression. The findings show promise for scaling up this method to humans.
Scientists have developed a powerful new technique called LASSO cloning that can clone thousands of long DNA sequences at once, speeding up the creation of proteins and discovery of new medicines. This innovation enables researchers to analyze what genes' proteins do, leading to potential breakthroughs in scores of diseases.
Researchers at Stanford University School of Medicine have identified an unexpected layer of gene regulation in ribosomes, challenging scientists' understanding of how cells control their genes. The discovery reveals that ribosomal proteins tune the translation process to specialize in specific cellular pathways.
Researchers at Tokyo Medical and Dental University identified equivalent monocyte progenitors in humans, expanding our understanding of immune cell development. The study found distinct subgroups of cells with different protein expressions, shedding light on potential therapeutic applications targeting these cells.
Researchers at KAUST have identified the molecular liaison responsible for promoting inflammation in endothelial tissues. They found that CD44 and PSGL-1 are key E-selectin ligands involved in this process.
A novel signaling system in S. pneumoniae strains may control gene expression and virulence in co-colonizing strains, according to a study published in PLOS Pathogens.
Research reveals survivin protein protects fat cells from death in obese individuals, potentially leading to new obesity and cancer treatments. The study found higher levels of survivin in obese subjects, suggesting it could be a target for therapy.
Researchers find that members of the DUX family of proteins, specifically DUX4, trigger gene expression program in human embryos. DUX4 stimulates expression of genes induced during zygotic genome activation by binding to their regulatory regions.
A research team at DGIST has discovered a candidate substance that can prevent and potentially cure Parkinson's disease by inducing the expression of the parkin protein. Cortisol, a stress hormone, promotes the production of this protein, which protects dopaminergic neurons from death.