Cell Proliferation
Articles tagged with Cell Proliferation
Embryos can tolerate disruption of cell division at certain stages of development
Embryos can tolerate disruption of cell division at certain stages of development, particularly during the gastrula phase where a mechanism called the spindle assembly checkpoint helps them withstand misaligned chromosomes. Disruptions during other stages, such as the pre-gastrula period, are more deadly and lead to defects.
Proteins cluster in cells for faster performance
Researchers at the University of Groningen discovered that protein clustering in cells leads to reduced movement and improved efficiency in amino acid production. This finding has practical implications for designing efficient cell factories and increasing substance production inside cells.
Scientists uncover molecular ‘switch’ that could make pancreatic cancer more treatable
Researchers identified a key gene GATA6 that helps control the 'switch' between aggressive and manageable states in pancreatic cancer cells. By targeting this pathway, combination therapies with standard chemotherapy may improve treatment outcomes.
New center for cell research
The new center combines large-scale equipment and methods to study individual cells in detail, detecting molecular differences and analyzing reactions to biochemical or genetic changes. This enables new perspectives for medical diagnostics and research, including personalized medicine.
Understanding how cancer cells use water pressure to move through the body
Researchers at Kyushu University discovered that cancer cells use a previously unrecognized physical mechanism called CODE to create water pressure that aids in their migration. This finding opens new avenues for therapies targeting amoeboid movement, a key strategy used by most advanced cancer cells.
A broken DNA repair tool accelerates aging
A Goethe University-led study reveals how mutations in the SPRTN enzyme cause chronic inflammation and premature ageing. The research team found that damaged DNA in the cell nucleus leaks into the cytoplasm, activating defense mechanisms and leading to chronic inflammation.
Cancer loses its sense of time to avoid stress responses
Researchers at OIST have discovered that certain cancers can 'lose their sense of time' to avoid cellular stress responses. The study highlights the role of USP28 in stabilizing p53, a known tumor suppressor, and how mutations in this protein can disrupt its function.
Discovery of plant reproductive success provides insights into human fertility
Scientists have discovered a protein called SCEP3 that ensures even chromosome segregation in plants, preventing infertility and genetic diseases. This finding has implications for plant breeding and understanding human fertility, with the equivalent gene SIX6OS1 potentially playing a role in promoting correct chromosome segregation.
How are metabolism and cell growth connected? — A mystery over 180 years old
Researchers have identified a novel principle in biology that mathematically explains why the growth of organisms slows as nutrients become more abundant. The global constraint principle unifies two classic biological laws and provides a fresh perspective for looking at growth across all forms of life.
acCELLerate facilitates custom cell banking solutions for pharmaceutical and biotechnology research with ATCC authenticated cell lines
AcCELLerate has partnered with ATCC to provide customized Master, Working, and assay-ready instaCELL banks for research clients. Researchers will gain access to high-quality, authenticated cell lines with increased assay reproducibility.
Working together, cells extend their senses
Researchers discovered that a collective of epithelial cells can work together to sense beyond their direct environment, up to 100 microns away. This new ability allows cancer cells to migrate and evade detection with enhanced precision, making it a potential target for therapy.
Menin: A new therapeutic target for bladder cancer
A recent study found that menin promotes bladder cancer malignancy by enhancing TFAP2C/β-catenin signaling, suggesting its potential as a therapeutic target and prognostic marker. Menin upregulates TFAP2C expression, which regulates β-catenin gene transcription via binding to its proximal promoter.
AI learns biological variability to develop a high-performance serum-free culture medium
Researchers developed a machine learning model that accounts for biological variability to identify optimal formulations for serum-free culture media. The model achieved approximately 1.6-fold higher cell density compared to commercially available products.
Finding microproteins to treat obesity and metabolic disorders
Researchers at the Salk Institute have identified dozens of microproteins that play a crucial role in regulating fat cell proliferation and lipid accumulation. This breakthrough discovery offers new potential drug targets for treating obesity and metabolic disorders, building on recent advances in CRISPR gene editing technologies.
New mRNA-based therapy that shows promise in heart regeneration after heart attack
Researchers identified a new strategy to repair damaged heart tissue by reactivating the PSAT1 gene through synthetic modified messenger RNA. The study found that mice treated with PSAT1-modRNA showed robust increases in cardiomyocyte proliferation, reduced tissue scarring, and improved heart function.
Scientists zero in on cellular mechanism fueling drug-resistant cancers
Researchers have discovered a key role of centrosomes in signaling cells to proliferate despite DNA damage, enabling cancer resistance. The study suggests targeting Polo-like kinase 1 could prevent adaptation to therapy-induced DNA damage and drug resistance.
AI tool set to transform characterisation and treatment of cancers
Researchers developed an AI tool called AAnet to characterize cancer cell diversity, identifying five distinct cell groups with different gene expression profiles. This could lead to more targeted therapies and improved patient outcomes.
Uncovering how cells allocate space to make way for new growth
Researchers developed a systems approach to measuring organelle changes in living cells as they grow. The study found that certain organelles grow faster than others and that the vacuole plays a key role in buffering the cell against randomness.
CNIC team reveals how the heart is organized from the earliest stages of embryonic development
Researchers at CNIC uncover how the heart forms during earliest embryonic development, shedding light on congenital heart defects and regenerative medicine. The heart originates from two separate cell populations that coordinate their formation simultaneously.
Studying how bacteria grow to fight infections
Dr. Cara Boutte is studying how certain bacteria grow by building their cell walls, which could lead to more effective antibiotics. Understanding this growth pattern could help scientists develop targeted and effective treatments for infections like tuberculosis.
Technique rapidly measures cells’ density, reflecting health and developmental state
Researchers at MIT developed a method to quickly measure cell density, which can predict whether immunotherapies will work in patients or how tumors will respond to drug treatment. The technique uses a combined microfluidic device and fluorescent microscope to measure up to 30,000 cells in an hour.
Tumor byproduct blocks immune cells from fighting cancer
A team of researchers has identified a novel oncometabolite that accumulates in tumors and impairs immune cells' ability to fight cancer. The study highlights how the metabolic environment of tumors influences T cell function, opening new possibilities for improving cancer immunotherapy by targeting tumor metabolism.
City of Hope-led study demystifies tumor formation’s two-step process — a foundational understanding needed to prevent cancer
Researchers at City of Hope discovered that mutated cells can persist for years without becoming cancer and require an additional inflammatory push for malignancy to occur. Chronic inflammation is a key trigger for tumor formation, making it essential to avoid situations like high-fat diets and obesity.
Study unravels mystery of cancer-fueling enzyme—could lead to new therapies
Researchers uncover a universal mechanism by which CDK7 controls human cell proliferation, shutting down key transcription factors within minutes. This breakthrough could lead to more precise cancer therapies with less collateral damage.
GTF3C2 promotes the proliferation of hepatocellular carcinoma cells through the USP21/MEK2/ERK1/2 pathway
GTF3C2 expression is upregulated in HCC tissues, promoting tumor growth and poor survival outcomes. The GTF3C2/USP21/MEK2/ERK1/2 pathway regulates HCC cell proliferation and tumor growth.
TNIP1 knockdown induces the growth arrest and apoptosis of breast cancer cells by activating the NF-κB pathway
This study investigates TNIP1's role in regulating cell proliferation and apoptosis in breast cancer. TNIP1 knockdown was found to induce growth arrest and activate the NF-κB pathway, leading to increased apoptosis in breast cancer cells. The findings highlight TNIP1 as a crucial marker for breast cancer therapies.
Candidate genes in canine hepatocellular carcinoma for molecular targeted therapy
Researchers at Osaka Metropolitan University assessed target genes in canine hepatocellular carcinoma (HCC) to develop molecular targeted therapies. The study identified potential gene targets, including PDGFB, which may improve treatment options for unresectable HCC.
uOttawa study unveils new insights into how neural stem cells are activated in the adult human brain
A University of Ottawa neuroscientist has led a Canadian research team to discover how neural stem cells integrate signals from different cell types and decode them. The study found that low daughter cell numbers trigger activation, while high numbers keep them in quiescence, offering new insights into cellular relationships and potent...
Microscopic discovery in cancer cells could have a big impact
Researchers at Texas A&M University have uncovered a mechanism behind cancer progression: the stiffening of tumor cell's environment. This spreading causes increased cell proliferation and tumor growth.
Key role of Kif23 in early brain development and insights into microcephaly pathogenesis
A recent study has identified Kif23 as a key regulator of embryonic brain development, highlighting its potential link to microcephaly. The research found that Kif23 is essential for neural progenitor cell proliferation and differentiation, with deficiency leading to decreased cell growth and increased apoptosis.
Single gene causes embryo notochord deformity in zebrafish
Researchers at Osaka Metropolitan University found that suppression of Pcdh8 is essential for proper notochord elongation in zebrafish embryos. This study may lead to novel tumor therapies in humans due to the gene's role in controlling cell proliferation.
Revolutionizing biology education: Scientists film ‘giant’ mimivirus in action
Researchers at Tokyo University of Science have successfully captured viral infection process under a light microscope using the giant Mimivirus. The footage showcases the proliferation of the virus and its release from cells, highlighting its biological significance in ecosystems.
University of Cincinnati study sheds light on copper’s role in driving kidney cancer
A new University of Cincinnati Cancer Center study reveals how copper helps clear cell renal cell carcinoma cells grow and advance. Copper accumulation is associated with worse outcomes for patients with ccRCC, and it boosts energy and growth in cancer cells.
Cancer risk linked to p53 in ulcerative colitis
Researchers found a link between non-functional p53 genes and the regenerative cell state in ulcerative colitis, leading to cancer progression. A new diagnostic test could identify aberrant cells earlier using molecular tools.
How aging affects stem cells: A fly's tale
Scientists identified key changes in chromosome structure and gene expression that affect stem cell function during aging. Blocking a specific gene, ced-6, triggered stem cell exhaustion at any age, indicating a general process that maintains balance when proliferation is too high.
Glitch in protein synthesis could affect tumour growth
A glitch in protein synthesis, known as stop codon readthrough, may affect tumour growth and cancer cell proliferation. The study found that preventing this process can lead to increased degradation of target proteins and a delayed cell cycle, resulting in slower tumour growth.
The secret to sleepy cells’ control of inflammatory secretions
A new study reveals a link between senescent cells and the protein HIRA, which helps pack and unpack DNA. The research team discovered that HIRA is necessary for the cells to begin emitting inflammatory molecules, leading to chronic inflammation in the body.
Microscopic packets could deliver diabetes-preventing therapeutics
Texas A&M researchers are investigating the use of extracellular vesicles to deliver immune-suppressing proteins, potentially reducing the immune system's attack on insulin-producing beta-cells. The goal is to develop a novel treatment for type 1 diabetes, which currently has only lifelong insulin therapy as an approved option.
How cell nuclei organize eyes and brain
Researchers found that cell nuclei control tissue stiffness and ordering in eye and brain tissues, revealing a new role for the nucleus in organ formation. This discovery challenges existing views on tissue organization and has implications for understanding diseases associated with impaired architecture.
New study reveals unique histone tag in adult oligodendrocyte progenitor cells, opening doors for advanced myelin repair therapies
Researchers at CUNY ASRC identify distinct histone tag in adult oligodendrocyte progenitor cells that regulates their proliferation and may lead to innovative therapies for neurodegenerative diseases. The discovery holds promise for advancing myelin repair and improving patient outcomes.
Serotonin uptake regulates ependymoma tumor growth
Researchers found that hyperactivated neurons drive cancer proliferation and that serotonin uptake by ependymoma cells promotes tumor growth. Inhibiting this process blocked tumor growth, opening doors for drug discovery.
Chinese Medical Journal Review explores immunotherapy strategies for liver cancer
Researchers explore various immunotherapies, including immune checkpoint inhibitors and adoptive cell therapies, as promising treatments for hepatocellular carcinoma. The review aims to overcome current limitations of targeted therapies by regulating the body's immune systems.
Key driver for epithelial cancer development identified
A distinct TNF-α signaling program has been identified as a key driver of epithelial cancer development, contributing to cell proliferation and invasion. The researchers found that this program is active in both normal tissues and tumors, but its level of activity correlates with tumor aggressiveness.
Hepatitis B: "Sleep timer" for immune cells discovered
A team of researchers has discovered a mechanism by which the liver's immune cells are suppressed in chronic hepatitis B, leading to organ damage. The 'sleep timer' function allows immune cells to weaken their activity over time, preventing them from proliferating excessively and causing further damage.
UNC-Chapel Hill researchers investigate chemical modifications to gain deeper insights into genetic regulation mechanisms
Researchers investigate chemical modifications to genetic regulation mechanisms, finding that Set8 controls gene activity through a mechanism other than histone modification. This study refines our understanding of genetic regulation relevant to human diseases like cancer.
Pregnant fish can also get “baby brain”, but not the way that mammals do
Research reveals that pregnancy-related brain impairment affects live-bearing fish, particularly in decision-making and sensory reception. Unlike mammals, pregnant fish show decreased cell proliferation in olfactory regions, compromising scent interpretation.
Heart regeneration: The key role of a growth factor has been discovered
A growth factor called BMP7 has been found to promote cardiomyocyte proliferation and regeneration in both zebrafish and adult mice. This discovery offers a promising new approach to treating heart disease by stimulating cardiac muscle cell regrowth even in later stages of life.
Inhibitory effect of miR-377 on prostate cancer cells
Researchers found that miR-377 reduces MYC mRNA levels, leading to increased Bax and PTEN expression and decreased CDK4. This results in induced apoptosis, inhibited proliferation, and arrested cell cycle in prostate cancer cells.
Anticancer potential of CLK kinase inhibitors 1C8 and GPS167 via EMT and antiviral immune response
The study investigates the anticancer potential of CLK kinase inhibitors 1C8 and GPS167, which inhibit CLOCK kinases and affect cancer cell proliferation. The compounds also alter the expression and alternative splicing of transcripts involved in EMT and antiviral immune response.
Derivatives of the thalidomide compound drive resistant cancer cells to their deaths
Researchers at Goethe University Frankfurt have discovered thalidomide derivatives that target and degrade BCL-2, a protein essential for the survival of cancer cells. The derivatives bind to CRBN, reprogramming its binding surface to mark BCL-2 for degradation, ultimately leading to cell death.
A new mechanical transducer was revealed
Researchers have uncovered a novel regulator governing how cells respond to mechanical cues, finding that ETV4 bridges cell density dynamics to stem cell differentiation. This discovery has significant implications for controlling cancer cells through mechanical cues.
Geologists, biologists unearth the atomic fingerprints of cancer
Researchers employ a geology tool to analyze hydrogen atoms in cancer cells, finding a distinct ratio compared to healthy tissue. This discovery may lead to new ways to spot cancer early on and inform strategies for studying its growth and spread.
Cover paper: Senescent characteristics of human corneal endothelial cells upon UV-A exposure
Researchers investigate senescence phenotypes of human corneal endothelial cells upon treatment with ultraviolet (UV)-A. Cells exhibit enlarged morphology, increased β-galactosidase activity and decreased proliferation. UV-A-induced senescent cells show similar gene expression profiles to ionizing radiation (IR)-induced cells.
Novel therapeutic bispecific antibodies for B-cell lymphoma
Researchers developed novel therapeutic bispecific antibodies targeting IgM and B-cell surface antigens, which directly inhibited cell proliferation via cell-cycle arrest and apoptosis in vitro. These findings suggest that anti-IgM/B-cell surface antigen-binding specific antibodies are promising therapeutic agents for B-cell malignancies.
Exploring the role of MIA-602 in overcoming Doxorubicin-resistance in acute myeloid leukemia
Researchers discovered MIA-602's effectiveness against Doxorubicin-resistant acute myeloid leukemia (AML), demonstrating reduced cell viability and tumor volume. The study suggests MIA-602 as a potential alternative treatment approach for AML, potentially circumventing chemotherapy side effects.
European treatment recommendations in the fight against acute lymphoblastic leukemia
The European LeukemiaNet has published two-part guidelines for adult acute lymphoblastic leukemia treatment, covering diagnostics, prognostic factors, response assessments, and comprehensive management. These recommendations are based on a decade of systematic work by European experts, improving the prognosis of adult patients with ALL.
BCAS1 defines a heterogeneous cell population in diffuse glioma patients
Researchers have uncovered the molecular and ultrastructural features of BCAS1+ cells in diffuse gliomas, highlighting their proliferative capacity and distribution. The study provides a comprehensive characterization of the BCAS1+ cell population within diffuse gliomas, shedding light on its role in tumor malignancy.
Artificial intelligence helps unlock advances in wireless communications
Next-generation mobile networks are being optimized for increased data loads and faster speeds using AI-driven techniques. The technology enables instantaneous communications between devices and the environment.
Therapeutically harnessing cancer stem cell-derived exosomes
Cancer stem cell-derived exosomes (CSC-Exos) are essential for communication between CSCs and other cells in the tumor microenvironment, contributing to cancer progression. The editorial highlights their potential as a novel clinical tool for diagnosis, prognosis, prevention of tumor recurrence, and therapeutic strategy