Articles tagged with Gene Expression
Researchers have made a breakthrough in understanding the binding between KLF1 protein and DNA in human cells, which controls gene expression and has significant implications for diseases such as cancer. The study uses new experimental methods to measure binding to many DNA sequences simultaneously in both test tubes and human cells.
Researchers at the University of Texas M. D. Anderson Cancer Center discovered that inflexible DNA within nucleosomes regulates the positioning of INO80, a chromatin remodeling complex. This unique mechanism allows INO80 to position itself on the surface of nucleosomes at the right location.
A study by University of California, Riverside scientists found that alternative RNA processing, or
The coralME tool creates detailed genome-scale models of metabolism, gene and protein expression from large amounts of data. The models uncover how microbes respond to certain nutrients and predict what nutrients favor the formation of undesired products.
A mouse study by University of California, Riverside scientists suggests microplastic exposure may accelerate the development of atherosclerosis in males. The study found microplastics dramatically worsened plaque buildup in male mice, but not females.
Rockefeller researchers found a molecular switch in breast cancer cells that reprograms gene expression towards tumor growth and stress resistance. This switch is mediated by the MED1 subunit of RNA polymerase II and can be activated under stressful conditions, leading to faster-growing and more stress-resistant tumors.
A study by The Hospital for Sick Children reveals a previously overlooked layer of genetic variation in short tandem repeats (STRs) that can influence gene regulation and shape disease risk. This discovery may inform future research and precision therapeutic development in support of Precision Child Health.
A study led by SickKids scientists discovered a previously overlooked layer of genetic variation that could help explain individual differences in disease risk and treatment response. The researchers found that subtle changes in short tandem repeats can impact gene function, revealing new insights into neurodevelopmental conditions.
Researchers developed a novel mouse model to visualize RNA Polymerase II during elongation, shedding light on gene expression dynamics. The study revealed dynamic patterns of gene transcription activity in various tissues and developmental states, with implications for understanding development, differentiation, and disease mechanisms.
A study published in Chinese Medical Journal identified tumor-promoting keratinocytes linked to HPV infection and poor prognosis. These cells were found to interact with immune cells, promoting tumor proliferation and differentiation.
Researchers at Weill Cornell Medicine have developed a powerful new gene-switch tool called Cyclone, which allows scientists to turn on or off target genes with precision. The tool uses a non-toxic molecule acyclovir to suppress gene activity, and has the potential to be adopted throughout biomedical research and gene therapies.
The Aedes aegypti Mosquito Cell Atlas provides comprehensive cellular-level resolution of gene expression in every tissue, from antennae to legs. This atlas has yielded new insights into the genetic secrets of Aedes aegypti, including novel cell types and subtle differences between male and female mosquitoes.
Researchers at Chinese Academy of Sciences identify a key gene and protein involved in controlling DNA looping, leading to increased grain yield and nitrogen efficiency. The discovery paves the way for future crop breeding strategies to improve sustainability.
Boston University researcher Brian Cleary has been awarded a five-year, $2.25 million NIH grant to investigate how gene expression changes over time in single cells. His project aims to develop new computational-experimental approaches to track RNA velocity vector fields and deepen understanding of cell physiology.
Researchers used CRISPR technology to identify HMGN1, a nuclear binding protein that contributes to trisomy 21-related CHDs. The study found that an overabundance of HMGN1 leads to abnormal heart development and gene expression.
A new human lung alveolus chip model enables investigation of viral replication, inflammatory responses, and genetic off-target effects of a novel pan-influenza CRISPR therapy. The study achieved significant reductions in virus load and host inflammatory response after a single administration.
Long-term exposure to fine air pollutants like PM2.5 can impair metabolic health by disrupting the normal function of brown fat through complex epigenetic changes. The study identified two enzymes, HDAC9 and KDM2B, as key drivers of this process.
Researchers at Stanford University tracked the evolution of fruit fly populations in response to pesticide exposure, finding that resistance alleles persist through a mechanism known as 'dominance reversal.' This process allows alleles to function as either dominant or recessive depending on environmental conditions, maintaining geneti...
UCSF researchers develop a new strategy to prime CAR T cell therapy by combining it with diabetes drugs, increasing the efficacy of NECTIN4-CAR T cells in treating urothelial carcinoma. The study shows that using thiazolidinediones enhances NECTIN4 expression, making tumor cells more susceptible to the treatment.
Researchers identified genes associated with breastfeeding disorders and postpartum breast cancer in the mammary gland, revealing potential new targets for investigation. The study provides a detailed atlas of genetic expression for the adult developmental cycle of the mammary gland.
Researchers have developed a method to discover how DNA controls genes, revealing the genetic 'switches' that regulate important genes. The TESLA-seq technique identifies regulatory regions more quickly and accurately than existing methods, linking them to over 70 genes in a specific region.
A new method called spVelo calculates RNA velocity to understand how cells become specialized. By incorporating spatial information and processing multiple batches at once, the method overcomes previous challenges.
Bentz will investigate how maternal hormones shape behavior across generations in House sparrows, with implications for understanding animal adaptation. The research aims to identify gene networks that respond to early testosterone exposure and track changes from development through adulthood.
Researchers mapped the surface envelope glycoprotein of human endogenous retroviruses, opening doors to new diagnostic and therapeutic opportunities. The study revealed specific antibodies that target the viral proteins, potentially leading to new cancer immunotherapies and treatments for autoimmune diseases.
Researchers developed Vesalius to interpret complex data on cancer cell interactions, leading to potential discoveries in treating hard-to-treat cancers. The tool analyzes whole tissue architecture to identify predictive biomarkers and inform treatment options based on individual disease types.
Researchers used gene expression data to identify genes related to stress responses in wild varieties, which could be beneficial for developing hardier crops. Domesticated species showed genes related to hormone regulation and chemical detoxification.
A Yale research team has created a computer tool called chronODE that can pinpoint when genes turn on and off during brain development. The tool may offer applications in disease modeling and basic genomic research, and could lead to future therapeutic uses.
Researchers investigated pipetting speed's effect on yeast growth and gene expression, finding it had little to no impact within a tested range. The study provides guidelines for increasing efficiency and reproducibility in robot-based experiments.
A new method called DynaTag has been developed for mapping protein binding to DNA, providing high-resolution results. This innovation enables the analysis of single cells across various tissues and enhances understanding of developmental biological processes and disease mechanisms.
Researchers have identified hundreds of RNA regulatory switches in living cells that can be used to develop new treatments for diseases. The discovery, published in Nature Biotechnology, uses a novel method to map the complex structures of RNA molecules and uncover functional switches with high accuracy.
Conventional dendritic cells have been found to originate from both myeloid and lymphoid progenitors, revealing their unique functions and developmental pathways. These lymphoid-derived cDCs exhibit potent functions in immune suppression and allergy induction, and follow diverse developmental pathways.
Researchers have identified CDX1 and CDX2 as key molecules that counteract β-catenin and suppress stemness in colon cancer. Deletion or overexpression of these proteins increased tumor aggressiveness and expression of cancer stemness-related genes, suggesting a potential therapeutic target.
A combination of two approved cancer medications may slow or reverse Alzheimer's symptoms by reversing gene expression changes in neurons and brain cells. Researchers analyzed public data from deceased donors and found a link between these drugs and reduced risk of developing the disease.
Studies have shown that emotional or psychological stress enhances pain responses, but the effects of social pain transmission remain elusive. Researchers found that ultrasonic vocalizations emitted by mice in response to pain stimuli can induce emotional transmission and hyperalgesia in other mice.
The new GseaVis package offers highly customizable visualizations, including enrichment plots, ranked gene heatmaps, and circular layouts, addressing the limitations of existing tools. It integrates seamlessly with established R libraries and workflows, making it accessible to researchers at various skill levels.
Researchers discovered a key molecular sensor detecting changes in intracellular pH that regulates immune defense against bacterial infections and influences inflammatory diseases and cancer. The findings may lead to innovative strategies for disease prevention and treatment by altering how the internal environment shapes immune function.
A novel 3D culture method enables self-organization of precursor cell types into functional liver organoids capable of producing essential clotting factors. The breakthrough advances organoid-based therapies, drug testing, and disease modeling for liver diseases, including hemophilia A.
Researchers created an 'encyclopedia of sugar utilization pathways' in 263 Bifidobacterium genomes. This resource helps predict which strains thrive in different conditions, enabling personalized probiotics to match children's lifestyles and dietary needs. The study suggests a potential solution to improving outcomes for preterm infants.
A new approach for understanding chromatin's 3D structure and its influence on gene regulation has been developed by scientists at Sanford Burnham Prebys. The method measures a genomic region's proximity to the isolated center of a chromatin clump, revealing that surface regions are more active than core regions.
A recent study published in Nature reveals that weight loss triggers the breakdown and recycling of fats called lipids, potentially leading to improved health outcomes. Weight loss also clears out senescent cells, which are ageing and damaged cells that accumulate in tissues, reducing inflammation and scarring.
A new study reveals that Alzheimer's risk genes influence tau buildup and spread in distinct pathways, challenging traditional views of the disease. Four gene types were identified: Network-Aligned Vulnerability and Resilience, and Network-Independent Vulnerability and Resilience.
Researchers at the Wyss Institute have identified vorinostat as a promising treatment for Rett Syndrome using an AI-driven drug discovery process and innovative disease modeling. The findings demonstrate disease-modifying abilities across multiple tissues, offering hope for a potentially curative treatment.
Professor Eran Meshorer's groundbreaking research in epigenetics and stem cell biology has uncovered critical insights into chromatin structure and gene expression. His work has broad implications for regenerative medicine, developmental biology, and understanding neurological disorders.
Researchers at St. Jude Children's Research Hospital have identified a novel combination therapy approach to treat pediatric acute myeloid leukemia (AML) fueled by NUP98 fusions. Targeting the complex alone or in combination with another anticancer drug significantly increased survival in AML model systems.
Researchers found that co-exposure to bisphenol A and retinoic acid disrupts neurodevelopmental gene signaling, leading to brain abnormalities. The study suggests a potential link between chemical exposure and neurodevelopmental disorders like autism spectrum disorder and attention deficit hyperactivity disorder.
Researchers developed a new computational tool using generative AI to identify key gene combinations underlying complex illnesses. The method amplifies limited gene expression data, enabling researchers to resolve patterns of gene activity that cause complex traits.
Research suggests that interacting with dogs can modify a child's risk of developing atopic eczema, potentially due to the impact on immune cells. The findings provide new insights into the complex relationship between genetics and environment in the development of eczema.
Researchers have identified two genes, RNF144B and ENPP1, that cause calcium pyrophosphate deposition disease in Americans of European and African descent. This discovery opens up promising new avenues for targeted prevention and treatment of CPPD disease, which is currently lacking effective options.
A new study reveals that DNA methylation mediates the transgenerational inheritance of acquired cold tolerance in rice, supporting Lamarck's theory. Researchers developed a novel breeding strategy to develop stress-resilient crops, offering a promising avenue to tackle agricultural challenges posed by global climate change.
A new study reveals that the weight of fathers during adolescence can harm genes in future children, linked to asthma, obesity, and low lung function. The effect is more pronounced in female children, highlighting a potential vulnerability window for lifestyle influences.
Researchers at the University of Pennsylvania developed novel promoters that drive specific gene expression in rod and cone photoreceptors, outperforming most currently used promoters. These tools address the challenge of treating advanced stages of inherited retinal diseases, potentially restoring vision.
Researchers from Kyushu University find the X-linked mutation behind orange fur in house cats, revealing a new mechanism for promoting orange coloring. The 'ARHGAP36' gene is found to be active in melanocytes of orange patches, reducing activity in genes involved in melanogenesis.
Scientists at Boston Children's Hospital discovered that native nucleosomes contain a physical code governing their role in genome architecture. This insight could lead to new understanding of the maintenance of cellular function and the development of diseases like autoimmunity and cancer.
A study by Baylor College of Medicine researchers identifies 123 genes associated with increased AD risk in humans, including MTCH2, which shows promise as a potential therapeutic target. The team also found that reversing the alterations in these genes has a neuroprotective effect in living organisms.
Researchers discovered that cruciferous plants like cabbage and wasabi repurpose stomatal genes for defense, producing pungent compounds that deter herbivores. FAMA regulates both gas exchange and myrosin cell production, a key trigger for this defense mechanism.
Researchers developed tomoseqr, a user-friendly software to estimate 3D spatial gene expression distribution. The software successfully reproduced known gene expression patterns and mapped the 3D spatial distribution of genes in zebrafish and planarians.
Researchers found that selfish genes use self-assembly properties to harm cells, with aggregate size and distribution being key factors in toxicity. The study also reveals an evolutionary arms race between sabotage and salvation, where rapid evolution of 'selfish' genes can lead to their own destruction.
Researchers found that pancreatic cancer cells gain a survival edge by carrying copies of critical cancer genes on circular pieces of DNA outside chromosomes. The discovery highlights the importance of targeting extrachromosomal DNA in treating the disease.
Researchers have developed a computational tool, Spotiphy, that uses generative AI to enhance the resolution of sequencing-based spatial transcriptomics without sacrificing gene coverage. This breakthrough enables single-cell resolution in tissue imaging while maintaining full transcriptome coverage.
Researchers discovered that sulfur bacteria from the Desulfobacteraceae family work together like a team to break down diverse organic compounds. By analyzing six strains, they found similar molecular strategies and a highly energy-efficient central metabolism pathway, enabling them to thrive in oxygen-free environments.