Articles tagged with Immune Response
Genetic variations in metallothionein and zinc transporter genes impact zinc homeostasis and immune function. SNPs may influence the response to zinc supplementation in individuals with certain non-communicable diseases.
TGF-β1 is a potent modulator of immune and glial cell functions, regulating processes like fibrosis, atrophy, and muscle regeneration. Researchers discuss therapeutic strategies to inhibit the deleterious actions of TGF-β1 in skeletal muscle.
Researchers have developed techniques to personalize anticancer vaccines based on individual patient genomic information, targeting unique tumor mutations. Early results show promise in inducing potent immune responses.
Researchers found that certain E. coli strains trigger protective immune responses while others evade them, leading to recurrent infections. The study suggests developing broad-spectrum vaccines should consider the diverse pathogens encountered in the community.
Researchers at Scripps Research have identified a crucial immune system-regulating protein called ABHD12, which is linked to a rare genetic disease featuring brain and nerve problems. The study suggests that targeting ABHD12 may offer new avenues for treating cancers and chronic viral infections.
Researchers develop method to identify tumor-specific factors in blood that can elicit a protective immune response, potentially leading to an effective vaccine against cancer. The technique relies on peptide arrays and frameshift mutations, which have been shown to be more effective stimulators of immune response than point mutations.
Researchers designed a quadrivalent fusion glycoprotein vaccine against human parainfluenza viruses, inducing up to 500-fold higher neutralizing immune responses. The shape-stabilized glycoproteins may offer a general class of vaccines against widespread parainfluenzas and related pathogens.
A study published in PNAS found that the Mincle receptor initiates an antibacterial response to Group A Streptococcus upon recognition of MGDG, an anchor of lipoteichoic acid. The receptor plays a critical role in the immune response to GAS and may provide a therapeutic option by increasing antibacterial immunity.
Researchers have identified a cellular target that may improve vaccine efficacy in immunocompromised individuals, who are highly susceptible to fungal infections. The study found that targeting CBLB, a protein important in regulating immune response, can elicit immunity through a unique T cell pathway.
Research discovered that actin cytoskeleton remodeling in breast cancer cells protects them from immune cell attack by limiting the transfer of cytotoxic proteins. The 'actin response' is associated with increased levels of immune-inhibitory ligands, rendering cancer cells resistant to NK cell-mediated cytotoxicity.
A new study by CNIC researchers reveals that immune cells like neutrophils help maintain normal function of healthy tissues, performing roles unrelated to immunity. The findings suggest that the immune system is essential for day-to-day health, with potential benefits in some tissues and risks in others.
Targeting immune checkpoints in microglia may reduce neuroinflammation in neurodegenerative diseases. Dysregulation of these checkpoints is linked to diseases such as Alzheimer's, Parkinson's, and ALS.
Researchers found that mice recovering from heart attacks are more likely to die if treated with antibiotics, which can eliminate both bad and good microbes. Restoring the gut microbiome through fecal transplants or probiotics boosted survival rates.
Salmonella bacteria produce proteins that mimic DNA and target specific immune response genes, leaving others untouched. This precise mechanism allows the bacteria to fine-tune the host's immune system.
A Phase 1 clinical trial is testing the safety and immune-stimulating ability of an experimental nasal influenza vaccine in healthy children and teens. The investigational vaccine, developed by FluGen, Inc., has been designed to replicate only once in the body and prompt a robust immune response.
The article discusses clinical early warning scores as new clinical tools to predict future clinical deterioration, particularly related to sepsis. It provides a critical review of the state-of-the-art in early warning algorithms and suggests further research initiatives.
A new protein called emicizumab, administered via subcutaneous injection, has shown significant reductions in bleeding episodes in patients with haemophilia A. Weekly and fortnightly dosing regimens have been found to reduce bleed rates by 96% and 97%, respectively.
Researchers discover immune cells in eye contribute to progressive vision loss from glaucoma. Elevated eye pressure triggers autoimmune response attacking neurons, leading to optic nerve degeneration and permanent vision loss. The findings offer a promising new target for future therapies.
Researchers at Ohio State University have developed a unique vaccine that employs an uncommon two-pronged approach to fighting the Zika virus. The single-dose vaccine proved effective in triggering an immune response that prevented later infection by Zika virus.
A recent study led by Georgia State University identifies a gene from Ebola virus in myotis bats, which has been adapted to regulate their own immune response. The researchers found that the gene is attenuated in its ability to inhibit the immune response, but shares a similar structure with the Ebola VP35 protein.
Researchers found that guanylate cyclase enzyme plays a crucial role in the allergic immune response, and its inhibition can lead to reduced symptoms. The study used knock-out mice lacking this enzyme to show that Th1 responses can suppress Th2 responses, resulting in weaker allergy symptoms.
A new study found that levels of α-Gal antibodies vary with age and are higher in low transmission zones. IgM response was associated with protection against clinical malaria, especially in infants, while total IgG were linked to malaria risk. The results suggest α-Gal could be a promising molecule for future malaria vaccines
A gene signature in the bloodstream could reveal whether someone is going to develop active tuberculosis disease months before symptoms begin. Researchers developed a new 20-gene signature that distinguishes between TB and viral infections, showing promise for early detection and treatment.
Researchers at The Wistar Institute found that older melanoma patients have a better response to immune checkpoint blockade therapy due to decreased regulatory T cells and increased killer CD8 T cells. Combining anti-PD1 and anti-CD25 treatment may improve response rates in younger patients.
Research reveals that E. coli infection can induce delirium in aging rats by reducing levels of brain-derived neurotrophic factor (BDNF), a protein essential for long-term memory formation. The study suggests that immune system activation, such as after surgery or infection, may contribute to cognitive decline in the elderly.
Researchers at UTA found a strong immune response in diseased corals leads to lower expression of genes associated with growth and reproduction. This trade-off may impact coral resilience and ecosystem recovery under climate change pressure.
Researchers developed a single-administration vaccine strategy using an injectable microsphere bearing inactivated polio vaccine, which releases stable antigen over time. The study found that injecting the microspheres into rats elicited a strong immune response against all three IPV antigens.
Research in mice shows that chronic intestinal worm infection reduces the number of white blood cells in lymph nodes near the BCG vaccine injection site, hindering the immune response to tuberculosis. De-worming treatments can restore immune function after infection.
A new study from Caltech sheds light on how a specific species of beneficial bacteria harnesses the body's immune response to settle in the gut. The researchers found that the bacteria are encased in a thick capsule made of carbohydrates, which is necessary for colonization and helps anchor them to epithelial cells.
A new study reveals that a polydnavirus suppresses the defense mechanisms of both caterpillar hosts and plant hosts, allowing parasitic wasps to thrive. The virus reduces glucose oxidase in caterpillars' saliva, triggering lower enzyme activity and defense-gene expression in plants.
A new implantable device could help insulin-producing cells live longer after transplant and improve treatment of type 1 diabetes. The device, developed by MIT researchers, supplies oxygen to transplanted islet cells, allowing them to remain viable for several months and maintain normal blood glucose levels.
A University of Oregon-led project found that high immune function during childhood is associated with significant growth reduction. Chronic exposure to parasitic worms was linked to reduced stature and lower-leg growth, highlighting the metabolic cost of a robust immune system.
A new study published in PNAS demonstrates that a novel hormone replacement therapy can improve cognitive function and working memory capacity in patients with adrenal insufficiency. The therapy involves replicating the natural secretion patterns of cortisol, resulting in better outcomes compared to traditional constant infusion methods.
A study by Hokkaido University researchers has identified prostaglandin E2 (PGE2) as a key player in impairing the immune response of cattle affected by Johne's disease. The discovery offers hope for developing a method to control this chronic enteritis caused by Mycobacterium avium subsp. paratuberculosis.
A new study by Brigham and Women's Hospital investigators explores the influence of biological sex on transplant outcomes. Researchers found that female donor sex is associated with increased transplant organ rejection rates in male recipients, while hormone receptors may play a role in these differences.
A study published in Biological Psychiatry reveals distinct molecular changes in gene expression between men and women with major depressive disorder, suggesting different pathology and treatment needs.
A new study has identified a specific structure within memory cells that enables them to respond rapidly to infections and vaccinations. This discovery sheds light on how the body remembers disease-causing pathogens and can react more quickly upon renewed exposure.
A new study led by researchers at the Nara Institute of Science and Technology found that plants use SOG1 to repair DNA damage, but unlike p53 in animals, SOG1 targets genes involved in immune response only to fungal infections.
A large-scale study of French volunteers found significant immune variation among individuals due to differences in sex and age, as well as genetic variations. These findings shed new light on potential causes of diseases such as pollen allergy and lupus erythematosus.
A new study by Gladstone Institutes researchers shows that infection sites impact the immune system's response to a virus and its spread through the body. The study found that different routes of sexual transmission trigger distinct immune responses, influencing the virus's dissemination.
Researchers analyzed blood samples from 35 healthy adults and found a marked increase in antibody-producing B cells and circulating T follicular helper cells after vaccination. The study's findings suggest that intranasal vaccination might be more effective than injections, with implications for ideal inoculation routes.
A multidisciplinary team of Penn researchers will investigate immune system response to cancers and develop new therapies for gynecologic cancers. The team will examine how patients vary in their responses to different anti-cancer therapies and identify key factors contributing to treatment success.
Researchers developed a new method to track cell-to-cell interactions, dubbed LIPSTIC, which allows for the identification and counting of specific cells involved in immune responses. This breakthrough enables scientists to better understand how the immune system functions in live animals.
Researchers identified the role of Gimap5 in regulating T cell function and found that GSK3 inhibitors can improve immune system function in mice and restore normal T cell function in human cells. This discovery may lead to new treatments for autoimmune diseases such as Type 1 diabetes, systemic lupus erythematosus, or asthma.
Researchers at the University of Kansas have developed a method to screen millions of human antibodies for rapid therapeutic discovery, overcoming limitations of single-cell cloning. The breakthrough technology identifies highly potent antibodies and provides insights into human immune responses to vaccines and infections.
A Brazilian research team discovered a cellular signaling pathway involved in both the immune response to Zika and neurogenesis, a process of new neuron formation. The study found that peptides from the renin-angiotensin system played a key role in this pathway.
Researchers found that SOBER1, a plant protein, removes acetyl groups added by bacterial proteins, preventing the plant's immune response. This discovery could lead to strategies to boost plants' natural immunity or contain infections threatening agricultural crops.
Researchers have identified an antibody that can block entry to the host cell, providing a basis for safe and broad-spectrum anti-dengue therapy. The study also revealed the structural basis of the antibody binding to individual dengue viruses, which could help explain why some vaccines may not work.
Researchers explore the use of nanoparticles, microneedle patches, and polymer particles to enhance vaccine effectiveness and delivery. These innovative biomaterials may improve responses in HIV, cancer, and autoimmune disorders, reducing medical waste and expanding vaccine accessibility.
A Canadian academic investigated the claim of man flu, suggesting adult men have a higher risk of hospital admission and influenza-associated deaths compared to women. Men also exhibit higher rates of complications and mortality from acute respiratory diseases due to their less robust immune system.
A novel compound omaveloxolone has been shown to restore immune response in patients with melanoma, improving antitumour responses when combined with checkpoint inhibitors. The study found a 57% overall response rate in patients who had not received prior checkpoint inhibitor treatment.
Researchers have discovered that macrophages form a barrier around kidneys and that dendritic cells communicate with each other to control the magnitude of the immune response. This complex mechanism challenges previous ideas about how the kidney reacts to injury, and may lead to new strategies for protecting individuals' kidney health.
A new Zika vaccine has demonstrated well-tolerability and induced potentially protective immune responses in three phase 1 clinical trials. The vaccine, called ZPIV, was developed by the Walter Reed Army Institute of Research and is being evaluated in several trials to determine its safety and efficacy.
A research group at Osaka University has identified key molecules involved in severe malaria. The study found that RIFIN proteins expressed on infected erythrocytes suppress the host immune response by binding to an inhibitory receptor, contributing to the pathogenesis of severe malaria.
New research from the University of Queensland shows that chronic stress can lead to a weakened immune response in cancer patients. The study found that lymphoma progression was accelerated in mouse models when stress pathways were induced, resulting in reduced effectiveness of immunotherapies.
A Yale study finds that Zika infection triggers immune cells to attack neurons, causing paralysis and death in mice models lacking antiviral response. Suppressing the immune response might be an approach to treating Guillain-Barré syndrome, a condition affecting some people infected with Zika.
Researchers at the University of Edinburgh identified a previously unknown mechanism by which immune responses are regulated. The discovery found that Th2 cells express EGFR, releasing defense molecules only in response to parasites, preventing tissue damage.
Researchers have developed a novel approach to combat cancer using synthetic designer cells that mimic T-cells. These cells can detect and kill cancer cells while minimizing side effects, offering a promising new treatment option.
A study on guppy fish reveals how their immune genes evolve to resist parasites while maintaining critical function over millions of years. The research sheds light on the evolutionary dynamics of the immune system and its ability to adapt to new threats.
Researchers at Salk Institute identify Lkb1 protein as key regulator of Tregs, which play a crucial role in preventing autoimmunity and suppressing cancer growth. The discovery has significant implications for developing effective treatments for these diseases.