Articles tagged with Skin
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Researchers at the University of British Columbia have developed a topical CRISPR-based therapy that can correct faulty genes in human skin, potentially treating genetic skin conditions like ARCI and eczema. The treatment, using lipid nanoparticle technology, restores up to 30% of normal skin function.
A landmark study found that consuming vitamin C-rich foods like kiwifruit boosts plasma and skin vitamin C levels, improving skin thickness and stimulating renewal. Increasing daily vitamin C intake is recommended to support optimal skin function.
A Nigerian survey found that 80% of children exposed to skin bleaching products were under 2 years old, with mothers citing aesthetic preferences and social benefits as primary reasons for use. The study highlights the need for policy interventions to safeguard children's health from the risks associated with skin lightening products.
Nanoemulsions in cosmetics provide efficient carriers for active ingredients, maintaining product efficacy and bioavailability. Their stability ensures sustained release of actives, reducing the need for frequent application.
A major study has found that people with eczema can bathe either daily or weekly without affecting their symptoms. The study, published in the British Journal of Dermatology, involved 438 participants and showed no significant difference in eczema symptoms between the two groups.
The congress will focus on key mechanisms of skin ageing, including cellular senescence, mitochondrial dysfunction, and microbiome-skin interactions. Top experts in dermatology and longevity science will present new strategies for enhancing skin vitality and combating age-related decline.
A new Cochrane review found that immediate skin-to-skin contact between newborns and their mothers significantly improves exclusive breastfeeding rates, optimal body temperature, breathing, and heart rate. The review suggests that skin-to-skin contact should be the global standard of care for all babies after birth.
Researchers at University of California San Diego School of Medicine discovered that quorum sensing in S. aureus delays wound healing and found targeting the agr system could disarm bacteria without antibiotics, preserving healthy skin bacteria to enhance recovery.
A recent study published in Integrative and Comparative Biology found that bonnethead sharks' skin undergoes significant changes as they mature, with younger sharks having fewer ridges on their denticles. These changes likely improve swimming performance and protect the skin from predators or injuries.
A topical formulation has been shown to reduce the incidence of hand-foot neuropathy in cancer patients undergoing chemotherapy, improving quality of life. The cream, developed at UMH, acts directly on neurosensory pain receptors, reducing hypersensitivity and tolerance to chemotherapy.
A cohort study suggests nicotinamide reduces skin cancer risk, with greatest effect seen after initial skin cancer diagnosis, indicating potential chemopreventive properties of the vitamin B3 derivative
Scientists found that stretching the skin stimulates immune cells and increases its ability to absorb large molecules, including vaccines. This approach resulted in higher antibody levels against the H1N1 flu antigen compared to traditional needle-free delivery methods.
Researchers suggest that phototherapy for newborn jaundice may require adjustments based on a baby's skin tone. The study found that darker-skinned infants may receive up to 5.7 times less effective light dose under identical settings, leading to predicted bilirubin reductions of about 40.8 percent compared to lighter-skinned infants.
Researchers at Penn State developed a wearable sensor that accurately measures chloride ion levels in sweat, enabling early diagnosis of cystic fibrosis. The sensor uses multiple types of hydrogel to track small fluctuations in chloride ion levels, providing real-time information on an individual's health.
The conference will explore the latest breakthroughs in skin ageing research, targeting molecular mechanisms and real-world applications. Key findings include the importance of understanding skin ageing's intrinsic and extrinsic factors to develop comprehensive solutions.
A parasitic worm has evolved to suppress neurons in the skin to evade detection, reducing its own survival. Researchers discovered that the worm produces molecules blocking TRPV1+ activity, essential for pain sensation and immune responses, allowing it to infect the skin undetected.
Researchers discovered that components in young human blood serum can restore youthful properties to skin when combined with bone marrow cells. This study highlights the role of bone marrow in supporting skin health and may lead to novel approaches to address age-related changes.
This review synthesizes mechanisms, clinical manifestations, and management strategies for biologics targeting TNF-α, IL-17, IL-12/23, IL-4/13, and PD-1/PD-L1. Immune drift leads to Th2 dominance, Th2/Th22 imbalance, compensatory Th2 activation, unchecked Th1/Th17 expansion, and epidermal dyshomeostasis.
Researchers at the University of Michigan have identified a complete sensory pathway for sensing cool temperatures, which is separate from the pathway for hot temperatures. This discovery provides insight into how the skin detects its surroundings and responds to environmental changes.
Researchers found that ChatGPT-4 performed better across demographic groups, while LLaVA showed significant sex-related biases in diagnosing skin diseases from medical images. The study emphasizes the need to address these biases to ensure AI models are safe and effective for all patients.
A study published in Journal of the Mechanical Behavior of Biomedical Materials found that wrinkled skin is caused by its tendency to buckle under pressure due to age-related changes in its mechanical properties. As people age, their skin becomes more prone to wrinkles as it stretches and contracts in different directions.
Researchers discovered a unique nanostructure in blue shark skin that produces their iconic blue coloration, which also suggests a potential capacity for color change. Tiny changes in guanine crystal spacing can alter the shark's body color to suit its environment.
A compound called NSC51349 has shown promise as an antiviral treatment against cutaneous human papillomaviruses (HPVs), reducing viral load without harming host cells. The discovery offers new potential for treating skin infections and cancers in immunocompromised individuals.
Researchers from Binghamton University confirm the long-held 'urban myth' that saltwater dries out skin, increasing tissue stiffness and stress. A simple solution to alleviate tightness is taking a shower after coming out of the ocean.
A groundbreaking review identifies the skin as a central hub for systemic inflammation regulation, linking it to multiple organs through bidirectional crosstalk. The study reveals IL-17A as a master regulator of multi-organ crosstalk, driving various diseases simultaneously.
Researchers discover certain skin bacteria metabolize cis-urocanic acid using enzyme urocanase, fine-tuning immune response to UV radiation. This finding opens the door to microbiome-aware sun protection, where resident microbes are considered in sun protection strategies.
New research from Binghamton University reveals that the topography patterns of wrinkled fingers remain constant after multiple immersions. The study found that blood vessels beneath the skin contract and move in relation to other vessels, resulting in consistent wrinkles.
Recent high-quality deepfake videos can feature realistic heartbeats and minute changes in face color, making them challenging to detect. Researchers found that even small variations in skin tone and facial motion can replicate the original pulse in deepfakes.
A randomized clinical trial found no association between immediate skin-to-skin contact and improved neurodevelopmental outcomes in very preterm neonates. However, the intervention was shown to enhance breastfeeding practices up to 12 months compared to standard care.
Prolonged sitting impairs forearm cutaneous vascular function, but alternating local skin cooling and heating alleviates this effect. This study found that ambient temperature modulation can mitigate the decline in cutaneous vascular function.
Researchers at the University of Maryland discovered a way to predict treatment success for cutaneous leishmaniasis, a devastating skin infection. By analyzing a patient's immune system, they identified a distinctive pattern that distinguishes responders from non-responders, with 90% accuracy.
The device uses AI technology to detect potential heart problems and provides real-time health insights. It has multiple points touching the skin near the heart, allowing for more accurate tracking even during movement.
Researchers found that ultrafine bubble showers significantly suppressed inflammation in mice with atopic dermatitis caused by external factors. The treatment also improved skin protective barrier proteins. However, no significant effects were seen in mice with atopic dermatitis caused by genetic factors.
Compound K exhibits anti-aging properties by enhancing skin barrier function, preventing photoaging, and regulating autophagy. It also protects against mitochondrial dysfunction and promotes tight junctions between keratinocytes.
Researchers from UMass Amherst have discovered that epithelial cells communicate with slow electrical signals, 1,000 times slower than nerve impulses. This finding could enable new applications in wearable sensors, wound healing and more.
Researchers found that disrupting bacterial metabolism can help the body tolerate infection and heal more effectively. By inhibiting a specific metabolic pathway, they successfully reduced tissue damage in a mouse model of necrotizing skin infection.
Researchers at NIH identified characteristic symptoms of topical steroid withdrawal (TSW), including elevated nicotinamide adenine dinucleotide (NAD+) levels, which can be diagnosed using provisional criteria. TSW treatment may involve mitochondrial complex I-blocking drugs, such as metformin or berberine.
A study co-led by the University of Zurich has shown that gluconolactone significantly increases the number and function of regulatory T cells in both mice and humans, promoting a more balanced immune environment. This effect was observed in lupus patients as well, with visible improvements in clinical studies after just two weeks.
A team of researchers from Aalto University developed a hydrogel with a unique structure that combines high stiffness with flexibility and self-healing capabilities. The material uses exceptionally large and ultra-thin specific clay nanosheets, allowing it to self-heal via entanglement.
Researchers have identified a new starting point for therapy by targeting SSAT enzyme in psoriasis, restoring regulatory T cell function and breaking inflammation cycle. This approach could lead to a promising alternative treatment option with fewer side effects.
Dermatology researchers have identified a novel skin disease in a male patient with erythroderma, a rare and severe inflammation that causes widespread redness and scaling. Targeted treatment with biologic inhibitors reversed symptoms, providing a promising diagnostic tool for precision-medicine.
Researchers discovered that a topical ABT-263 treatment effectively reduces aged skin senescence markers, priming the skin for improved subsequent wound healing. The treatment also triggered inflammation, which surprisingly helped the healing process by 'waking up' the skin's repair systems.
Researchers have identified a targeted therapy that could bring relief to people living with lichen planus, a chronic inflammatory skin condition. The treatment, baricitinib, selectively blocks specific inflammatory pathways, reducing inflammation and suppressing the overactive immune response that contributes to the disease.
A new study explains how scratching aggravates inflammation and swelling in a type of eczema called allergic contact dermatitis. Scratching activates mast cells, which drive itchiness and inflammation, but also triggers the release of substance P, which protects against bacteria.
A recent study found that electric fans provide little cooling relief for older adults indoors during extreme heat due to their limited sweat production. Dr. Fergus O'Connor from Griffith University suggests using air conditioning at a higher temperature in conjunction with a fan to provide effective cooling and reduce operating costs.
Research on preservative mechanisms aims to develop improved preservation methods and identify effective antimicrobial compounds. Factors such as concentration, exposure time, and specific microorganism targeting influence preservative effectiveness, making targeted modifications crucial for enhanced antimicrobial properties.
A Swedish study found that topical steroid withdrawal (TSW) is characterized by symptoms such as redness, pain, and itching, often accompanied by sleep problems. The study aimed to understand the phenomenon of TSW, which many patients consider a cortisone dependence.
Cutaneous electrohydraulic (CUTE) wearable devices can produce a range of tactile sensations, including pressing and vibrations, with unprecedented control. Users perceive most cues as pleasant, highlighting the technology's potential for assistive technologies and augmented reality.
Researchers found that emphasizing high-spatial-frequency components of skin lightness decreases the perception of moisture, closely resembling physiological phenomena associated with skin dryness. The study aimed to investigate visual cues for skin moisture and dryness, shedding new light on this crucial aspect of human health.
A study from the University of Notre Dame found nine out of 22 watch bands contained high levels of perfluorohexanoic acid (PFHxA), a type of PFAS. Elevated PFAS levels were more prevalent in higher-priced watchbands, posing concerns for dermal absorption and potential health risks.
Researchers found that SYM2081 suppressed mast cell degranulation and proliferation in mouse models and human skin samples, paving the way for new topical treatments to prevent itching and inflammation. The study suggests that activating GluK2 could be a promising way to prevent rosacea and other inflammatory skin conditions.
A study published in JAMA Network Open found that hospital-acquired pressure ulcers are associated with poorer neurological outcomes and reduced motor function in patients with acute cervical spinal cord injury. The findings suggest that preventing pressure ulcers can help protect these patients and lead to improved medical care.
A new study found that a remote telemedicine tool called SpotCheck is highly accurate in diagnosing melanoma, with experts able to remotely examine skin lesions using dermoscopy. The tool has the potential to address diagnostic and treatment disparities for lower-income populations with limited access to dermatologists.
Developed by University of Copenhagen researchers, a new nanofiber patch reduces psoriasis treatment frequency to once a day, improving comfort for patients. The patch releases two active ingredients at different rates, addressing the need for multiple products in psoriasis treatment.
Researchers successfully immortalized lip cells, enabling the development of clinically relevant lab-based models to test treatments for lip injuries and infections. The 3D cell model was tested with Candida albicans yeast, showing promising results for wound healing and infection studies.
A team of researchers at the University of Toronto has discovered a unique stem cell type, the neural crest stem cell, which can be reprogrammed into different cell types. This discovery challenges longstanding theories in cellular reprogramming and highlights the potential of these cells for stem cell transplantation to treat disease.
A research team from Hokkaido University has developed a flexible multimodal wearable sensor patch that can detect arrhythmia, coughs, and falls using edge computing on a smartphone. The sensor patch generates large amounts of data that must be processed to be understood.
Researchers will explore the role of exosomes in delivering regenerative compounds, while also investigating olfactory receptors' unexpected functions in skin health. The conference aims to slow or reverse skin aging through novel approaches to mitochondrial function and microbiota balance.
Researchers found that pig skin attached to underlying tissue reduced damage from puncture by about 60% at slower speeds and 73% at higher speeds compared to the same tissue without skin. Synthetic skin offered less protection, reducing the damage by less than 40% at slower speeds and less than 30% at higher speeds.
Researchers created a single cell atlas of prenatal human skin, providing a molecular recipe for building skin. The study also led to the creation of a mini organ model that grows hair, offering insights into scarless skin repair and potential clinical applications in regenerative medicine.