Research on health and aging in later life. Covers attention and cognition, longevity, organ aging, and age-related disease.
Researchers found that combining BCL-2 inhibitors can selectively eliminate senescent cells, improving efficacy and reducing toxicity by targeting high-MCL-1 expressing subpopulation of cells. This synergistic approach enables lower doses of drugs to be used, overcoming resistance to monotherapy.
A new study published in the Journal of the American Heart Association found that low physical function after age 65 is associated with a greater risk of developing heart attack, heart failure, and stroke. The study used the Short Physical Performance Battery (SPPB) test to assess physical function in 5,570 adults over 75 years old.
A combination of anemia and weak muscles in older people increases the risk of death by 64% for men and 117% for women. The two conditions together pose a significant risk, especially for elderly women, according to a study published in Archives of Gerontology and Geriatrics.
A recent study by Florida Atlantic University found that only seven out of 50 largest US cities have strong evacuation plans in place, highlighting a need for improvement in preparing for natural disasters. The study suggests that cities with experience in major hurricanes tend to develop stronger plans.
A recent study published in the Journal of Aging and Physical Activity found that higher levels of light physical activity and moderate-to-vigorous physical activity were associated with lower risk of death. In contrast, higher sedentary time was linked to increased mortality risk, regardless of genetic predisposition for longevity.
A study by DTU and SSI found that COVID-19 caused a significant loss of healthy life in Denmark, with an estimated 30,000 years lost. The majority of deaths occurred among elderly men, while younger populations were largely unaffected.
The USPSTF recommends prescribing statins for adults aged 40-75 with one or more CVD risk factors and estimated 10-year CVD risk of 10% or greater. For those aged 76 or older, the evidence is insufficient to make a recommendation. Statin use can significantly reduce CVD events and mortality in this population.
A study of 350 older adults found that those with multiple chronic health conditions, especially women, are more prone to large blood pressure drops and lower brain oxygenation after standing up. This increases their risk of dizziness, faints, and falls, highlighting the importance of detecting and managing multi-morbidity.
Researchers developed a method combining musical tests with EEG measurement to detect cognitive decline in old age. The study tested 50 elderly people who scored low on the mini-mental test, showing promising results in detecting mental deterioration.
A randomized clinical trial found that GlyNAC supplementation improves age-associated defects in older humans, including oxidative stress and mitochondrial dysfunction. This led to improvements in muscle strength, gait speed, exercise capacity, and other health outcomes, showing promise for promoting healthy aging.
The study found a 31% decline in sleep medication use between 2013 and 2018, with the strongest decrease in FDA-approved medications. Behavioral treatments for insomnia are increasingly encouraged due to their effectiveness and reduced risk of adverse outcomes.
Researchers analyzed data from over 3,000 participants and found no association between electrocardiogram measures and telomere length. The study suggests that ECG prolongation is age-dependent but not a marker of biological aging.
Research reveals that nursing homes in disadvantaged neighborhoods have lower clinical staff hours compared to those in more well-off areas. This disparity is particularly pronounced for registered nurses and physical therapists.
Researchers found a link between atrial cardiopathy and dementia in older adults, with those having the condition at a higher risk of developing dementia over time. The study suggests that subtle changes in the left atrium may be an independent risk factor for dementia, even after controlling for other vascular risk factors.
A new scale called the Geriatric Oncology-Potentially Inappropriate Medications (GO-PIMs) Scale was found to be more effective at predicting frailty than conventional methods. The scale identifies high-risk medications linked to falls and fatigue, allowing oncology teams to deprescribe them and improve patients' overall health.
Researchers at UNH will develop and test social assistive robots to aid in the care of individuals with Alzheimer’s disease and related dementia in their own homes. The robots will be equipped with smart home devices, artificial intelligence, and wearables to track patients' activity levels and health management.
A new poll shows that 61% of people over 50 who have already gotten at least one dose of COVID-19 vaccine are very likely to roll up their sleeves for an updated booster shot. Health providers' recommendations will play a crucial role in increasing vaccination rates among older adults.
A recent clinical trial led by Massachusetts General Hospital validated a strategy for increasing shared decision-making about colorectal cancer screening in older patients. Brief physician training plus reminders resulted in patients reporting higher quality conversations, with more discussing their preferences and having more options...
Staff turnover affects both residents and their families, compromising the quality of care. Continuity of nursing home staff and leadership is essential for delivering personalized care, as frontline workers deliver 90% of care. Researchers emphasize the need to attract and retain well-trained staff who enjoy working with older adults.
A new study published in the European Journal of Ageing found that having a partner had a greater impact on reducing loneliness among older adults during the pandemic's first wave. Not having a partner was the most significant factor, with those without a partner experiencing a higher risk of moving into loneliness.
Researchers found a rapid decline in sense of smell predicts cognitive impairment, including dementia and smaller brain areas, in individuals with Alzheimer’s disease. The study suggests using smell tests as an early screening tool to identify high-risk patients.
A study of 1,813 older women found that accelerated biological aging is associated with lower odds of living to be 90 years old and maintaining physical and cognitive function. Slower age acceleration was linked to a reduced risk of mortality.
A new study within the Veterans Health Administration system identified effective strategies to reduce benzodiazepine prescriptions for older adults. The researchers found that initiatives focusing on passive strategies like education and patient identification have limited success in lowering prescription rates.
A Dartmouth-led research team will assess the effectiveness of visit information provided to older adult patients and caregivers in improving quality of life. The CHRONICLE Trial aims to determine whether audio recordings or written summaries are more effective in sharing healthcare visit information.
According to a new poll, nearly 40% of older adults (50-80) use at least one integrative medicine strategy to alleviate symptoms or relax. However, only 18% discuss these strategies with their healthcare providers. The poll highlights the importance of primary care clinicians discussing integrative approaches with patients.
A new study has developed cut-off points to measure handgrip strength in the general population, considering gender, body height, and aging. Low handgrip strength is linked to increased mortality risk and may indicate underlying health conditions such as heart and lung problems.
A study found an association between prior head injury and a reduced sense of smell in older adults, particularly those with multiple injuries and more severe trauma. The researchers suggest that repeated blows to the head may damage olfactory receptors, leading to anosmia.
A new study from Regenstrief Institute found that pharmacist-led deprescribing care coordinators can significantly reduce prescription of anticholinergics in older adults. The study used two pharmacist-focused models, including face-to-face and telephone outreach, which collectively decreased anticholinergic use by 73%.
A recent study found higher antibody titers after the third and fourth Pfizer-BioNTech vaccine doses in individuals aged 60 or older. This population is at high risk of severe SARS-CoV-2 disease, making timely vaccination crucial.
Researchers found that federal rental assistance programs are associated with lower HbA1c levels among middle-age and older adults. The study assessed nearly 40,000 participants across the US, revealing a significant correlation between program participation and improved blood sugar control.
A study published in Journal of the American Geriatrics Society found that older adults with high psychological resilience can walk faster and longer after hip surgery than those with low resilience. Researchers measured resilience through a questionnaire and assessed walking capacity at baseline and 16 weeks later.
A Rutgers study found that women are more likely to die or require repeat surgery five years after abdominal aortic aneurysm repair. The researchers highlighted the need for increased inclusion of women in aortic device creation and trial enrollment, given differences in aortic anatomy between men and women.
A meta-analysis of 54 studies confirms that caregiver engagement across healthcare transitions is crucial in preventing rehospitalizations and enhancing patient outcomes. Caregivers play a critical role in facilitating care transitions when the healthcare team actively partners with them.
Researchers analyzed data from wearable activity monitors on nearly 600 participants to identify changes in movement patterns that may predict cognitive decline. The study found significant differences in activity during waking hours and afternoons, with fragmented activity being a key indicator of mild cognitive impairment or Alzheime...
A study found a link between depression, an inflammatory diet, and the development of frailty. Consuming a pro-inflammatory diet may exacerbate the development of frailty in individuals with depressive symptoms.
Researchers found associations between perceived discrimination and epigenetic aging in US middle-aged and older adults. Depressive symptoms were identified as a potential mediator in these relationships, particularly among women and White adults.
Researchers at UNO and UNL are using machine learning to investigate the metabolic cost of different phases of the gait cycle across different age groups. The goal is to create practical applications for gait rehabilitation, such as designing improved assistive devices.
According to a recent study published in JAMA Network Open, adolescents were found to have a significantly higher incidence rate and relative risk of COVID-19 infection from wild-type SARS-CoV-2 compared to older adults. The study analyzed data from the start of the pandemic through fall 2020 across 16 of the 19 states examined.
Young people face higher health risks from alcohol consumption, while older adults without underlying conditions may benefit from small amounts. The study recommends age and region-based guidelines to minimize risks and maximize potential benefits.
A recent hearing test was associated with a lower risk of underreporting hearing loss and a greater likelihood of using hearing aids among older adults. The study found that individuals who had recently undergone a hearing test were more likely to be aware of their hearing loss and take steps to address it.
A new Baycrest study found that individuals with no dementia risk factors have similar brain health as people who are 10 to 20 years younger. Lifestyle factors such as managing diabetes, addressing hearing loss, and quitting smoking can reduce cognitive decline by up to three years of aging.
Researchers found that CXCL9 levels were higher in pre-fracture blood samples of Chinese men with subsequent hip fractures, improving the prediction of osteoporotic hip fracture risk in men. In contrast, no association was found between CXCL10 and hip fracture risk in either gender.
A new study found that the fourth COVID-19 vaccine reduces the risk of death among elderly individuals in long-term care facilities by 72%. The study, which included approximately 40,000 residents, also showed a significant reduction in hospitalizations and infections.
A study of 56,000 older adults found that health-related social needs were associated with significantly higher rates of acute care utilization. Unreliable transportation was particularly linked to hospital stays and emergency department visits.
Researchers challenge the notion that natural selection declines after reproduction is complete. Instead, they propose that older adults play a crucial role in maintaining their fitness through intergenerational transfers of resources and knowledge.
Research from Washington University in St. Louis finds that positive social interactions are associated with a greater sense of purpose in older adults, particularly those who are retired. The study suggests that the quality of relationships and social connections play a significant role in shaping one's sense of purpose.
A recent study by Elizabeth Kessler, MD, found that older patients with advanced bladder cancer prioritize open communication with their care providers about treatment expectations and quality of life changes. The research also highlights the importance of involving families in care planning and aligning care with patients' core priori...
A Baycrest study found that expert knowledge helps memorize new information by providing a mental organizational structure. Experts grouped birds based on specific features, while non-experts relied on superficial characteristics like color. This structure supports memory and may mitigate age-related decline.
A study found that patients and their caregivers agreed on the severity of physical symptoms like pain and functionality, but disagreed on psychological symptoms like depression and anxiety. The researchers also noted that caregivers who were under stress overreported their patient's symptoms.
A study found that younger U.S. adults are less likely to be screened for colorectal cancer despite being eligible under new guidelines, with greater disparities observed across race, ethnicity, income, education, and insurance coverage. Screening participation increased over time but was smallest among individuals age 50-54.
A study found that older adults with superior memories, known as 'SuperAgers,' have a greater thickness in the anterior mid-cingulate cortex, potentially making it a biomarker for predicting delirium after surgery. This region of the brain regulates effort and behaviors, and its structure can be improved with training.
A study found that men exhibiting mild behavioural impairment symptoms are at risk of faster cognitive decline compared to women. Researchers identified key behavioral changes, such as apathy and false beliefs, which may help identify people at higher risk of developing dementia.
A new study published in The American Journal of Clinical Nutrition found that consuming a Mediterranean-style diet may prevent frailty in older adults. Higher intake of carotenoids was associated with reduced likelihood of frailty development.
The Canadian Consortium on Neurodegeneration in Aging launches Brain Health PRO, a digital educational program offering interactive modules to improve physical and mental health. The program aims to reduce dementia risk by focusing on modifiable domains such as exercise, nutrition, and sleep.
A systematic review and meta-analysis of 16 studies involving 76,373 participants found a significant association between visual impairment and cognitive decline in older adults. The study highlights the need for further research on the effectiveness of treating sight problems to prevent cognitive impairment and dementia.
A comprehensive survey of scientific literature suggests that nearly all known biological pathways are linked to Alzheimer's disease. The study found that immune, metabolic and depression-related pathways were consistently cited as major mechanisms contributing to the disease.
A new study from UTHealth Houston found that flu vaccination was associated with a 40% lower risk of developing Alzheimer’s disease in US adults over a four-year period. The study analyzed a large sample of patients and found that consistent flu vaccination every year had the strongest protective effect.
A study of 552 older adults found that those exposed to light during sleep were significantly more likely to develop obesity, high blood pressure and diabetes. The study suggests that minimizing light exposure at night can help prevent these conditions.
Researchers found that patients who felt younger at hospital admission showed better functional independence at discharge. This effect was seen in both those rehabilitated from osteoporotic fractures and strokes. A younger subjective age is associated with improved rehabilitation outcomes, stronger than chronological age or physical mu...
Researchers identified DNA damage-inducible transcript 4 (DDIT4) as a critical factor regulated by histone deacetylase 4 (HDAC4) in skin aging. Overexpression of HDAC4 rescued cells from senescence, while DDIT4 overexpression reversed changes associated with aging.