A phase 2b clinical trial led by Mass General Brigham researchers shows that MAR001 can significantly reduce triglyceride levels within 12 weeks for patients with high triglyceride levels. The therapy targets ANGPTL4, a protein that naturally inhibits lipoprotein lipase, an enzyme that breaks down triglycerides.
A researcher at Freie Universität Berlin develops a theoretical framework to search for possible relativistic traces in lunar tides using high-precision measurements. The study extends Newton's classical model by an additional term based on gravitational wave polarization, offering a quantitative basis for future searches.
Researchers from the KM3NeT collaboration analysed 5,828 atmospheric neutrino events to test for violations of Lorentz invariance, finding no evidence but setting new limits on possible effects. The results are promising for future studies of neutrino oscillations and potential discrete spacetime.
A research team has identified the conditions that allow rapidly feeding supermassive black holes to launch powerful relativistic jets. The team observed 3C 120, an active galaxy with a supermassive black hole rapidly accreting matter while launching a powerful jet.
Researchers at GSI/FAIR successfully measured the chemical bond strength of seaborgium hexacarbonyl complex, finding a weaker bond than expected. The results contradict the trend of increasing bond strength in lighter homolog elements, attributed to relativistic effects.
Researchers reconstruct the thermodynamic derivation of general relativity, connecting quantum information to spacetime geometry. The study suggests that gravity emerges from the quantum world, with the shape of spacetime governed by how quantum states can be distinguished from one another.
Researchers at OIST successfully moved a levitating, centimeter-wide diamond using the force generated by electron spin alone, directly observing a quantum effect on an object subject to gravity. This achievement sets a new baseline for studying the boundary between classical and quantum physics.
A new study by Mass General Brigham researchers shows that a longer duration Food Is Medicine program associated with improved adult cardiometabolic health. Participants who received weekly plant-based grocery packages for 2.7 years showed dose-dependent reductions in diastolic blood pressure, body weight, and BMI.
Underweight patients face a significantly higher risk of death after emergency general surgery, with a 92% increased odds compared to normal-weight patients. Those who are both underweight and frail have the worst clinical outcomes, including longer hospital stays and higher readmission rates.
The 2026 World Medical Innovation Forum brought together 250+ leaders to discuss emerging treatments, AI, and scientific breakthroughs. Mass General Brigham's Chief Innovation Officer highlighted the forum's goal of accelerating innovation to improve patient care.
Researchers at Nagoya University have developed a method to detect hidden matter around black holes by analyzing changes in ringdown waves. The study found that hidden matter affects ringdown differently depending on its pressure arrangement around the black hole.
Researchers have reconstructed a collision that launched a runaway black hole, shedding light on galaxy mergers and gravitational wave observatories. The simulation revealed that the two black holes had to be spinning fast and misaligned, producing a recoil of nearly 1,000 km/s.
Researchers have discovered a wave-interference effect that makes sound energy appear to outrun fundamental limits without breaking physics. This finding could improve whale tracking by pinpointing the location of whales based on the phase of their calls.
A study by Mass General Brigham researchers found that preeclampsia, preterm birth, gestational diabetes, and other adverse outcomes were associated with greater social needs, such as inadequate food, employment, and education among Black and Latina women. Integrating social needs assessment into postpartum care could improve long-term...
Patients with long-term relationships to their family physicians may experience fewer urgent hospital admissions and lower hospital costs. This is due to consistently seeing the same general practitioner, which is associated with reduced hospital costs but not fewer urgent admissions.
A retrospective study found patients registered for longer periods had 9-21% lower odds of urgent hospital admission and 17-28% lower costs. Consistently seeing the same general practitioner was associated with 6-7% lower hospital costs but not fewer urgent admissions.
Researchers at Mass General Brigham have been awarded $25.8 million in ARPA-H funding to develop a scalable gene editing platform for treating rare genetic vascular diseases. The VESSEL program aims to create durable, potentially one-time treatments for severe genetic vasculopathies.
Researchers analyze the 'ringdown' phase of black hole collisions to test Einstein's theory of General Relativity and uncover secrets about these mysterious objects. Future observatories may reveal fresh evidence for new physics and challenge current models.
Researchers have discovered that relativistic effects play a crucial role in the bonding of heavy elements like bismuth. The traditional picture of triple-bonded molecules does not hold true for these elements. Instead, the bonds are more complex and involve hybrid sigma-pi bonds.
A cohort study of nearly 20,000 NFL players revealed that players are dying of dementia and Parkinson’s disease at much higher rates than the general population. The study found a fourfold increase in neurodegenerative mortality among NFL players compared to the general population.
Researchers at Penn State simplify black hole mergers by applying thermodynamic principles, achieving accurate predictions of the final remnant's mass and spin. The maximum entropy conjecture shows that the merging black holes' energy and angular momentum map onto those of a sequence of hypothetical remnants, reaching a maximum entropy...
A new theoretical framework, Relativity of Spacetime Superpositions, shows that some scenarios describing quantum gravity are equivalent to classical physics with no quantum gravity signatures. The framework helps identify which experimental signatures require a quantum description of gravity.
Researchers at Penn State have developed a new measure for entropy that is more closely tied to the black hole's physical properties of spin and energy. This allows them to extend the first and second laws of thermodynamics to dynamic black holes, enabling better understanding of their processes.
Astronomers have successfully observed the previously elusive 'event horizon' of a black hole at the moment of collision, allowing for new insights into quantum physics and general relativity. This breakthrough enables astrophysicists to study extreme gravity and phenomena like frame dragging near the event horizon.
Gravastars may form when a star collapses under its own mass, triggering the creation of a mini universe with dark energy. This equilibrium stabilizes the object, preventing it from becoming a black hole.
Researchers propose alternative to dark energy as cause of the accelerating expansion of the universe, based on instability in Einstein-Euler equations. The study suggests a more natural explanation for cosmic acceleration within the framework of Einstein's original theory.
Researchers in China used AI-enhanced point-of-care ultrasound to train general practitioners in detecting carotid artery plaque. They found that the GPs accurately identified plaque 87% of the time and cleared patients correctly when no plaque existed.
The GWTC-5.0 catalog includes 161 new gravitational wave events detected between April 10, 2024 and January 28, 2025, bringing the total number of confirmed events to 390.
Researchers from Vienna and Frankfurt have developed a mathematical formula describing critical collapse, where spacetime organizes into a regular structure that may form a black hole. This phenomenon is similar to the formation of ice crystals in liquid water.
A new study published in JAMA Network Open found that patients with low-risk pancreatic cystic lesions have a high risk of developing pancreatic cancer. The study highlights the need for long-term personalized surveillance strategies for these patients, which could enable earlier detection and treatment of the disease.
Scientists have developed a theoretical model showing that atomic clocks can observe the quantum superposition of time. The researchers used modern techniques to detect the signature of entanglement between the clock's motion and its internal energy, improving sensitivity by 100-1000 times.
Researchers developed a method to identify and catalogue quasinormal modes in black hole mergers, providing a systematic way to resolve ongoing debate. The technique detects fundamental 'notes', overtones, and nonlinear modes, enabling precise tests of general relativity.
Researchers from the LIGO–Virgo–KAGRA Collaboration demonstrate how Astro Calibration technique improves signal processing by leveraging astrophysical models and comparison to predicted signals. This enhances detection of cosmic phenomena like black hole mergers, refining estimates of masses, spins, distance, and location.
A study by researchers at the University of Pittsburgh found that older scientists produce fewer disruptive new ideas than younger ones, creating a 'nostalgia effect' that influences scientific advancement. As scientists age, their papers tend to cite older research in new combinations rather than introducing wholly new concepts.
Researchers developed a new polygenic risk score (PRS) that estimates a person's inherited risk for eight common cardiovascular conditions. The test combines information from many genetic variants and evaluates a person's risk for coronary artery disease, atrial fibrillation, type 2 diabetes, and more.
Researchers at MIT have discovered a mathematical connection between quantum mechanics and classical physics, enabling the description of quantum behavior using everyday classical ideas. The team's findings shed light on phenomena such as the double-slit experiment, which has long been challenging to explain using classical tools.
A team of physicists has discovered a way to boost the intensity of high-power laser light, opening up new possibilities for experiments in quantum electrodynamics. The breakthrough uses an unusual process to create extremely bright ultraviolet light, which can be focused into a tiny point creating immense energy concentration.
Hang Yu, a MSU assistant professor, has been awarded the National Science Foundation's CAREER award to study binary neutron stars and create more accurate theoretical models for gravitational wave signals. His work aims to reveal new signatures of these signals and test neutron star physics to accuracy.
A team of physicists has discovered that atomic clocks can probe time in a way that reveals its quantum nature. By manipulating the vacuum itself, they created squeezed states that exhibit subtle quantum behavior, allowing a single clock to measure how it ticks both faster and slower simultaneously.
Researchers use high-resolution simulations to model the disruption of stars near supermassive black holes, uncovering details about their mass, spin, and orientation. The study sheds light on the formation of tidal disruption events (TDEs), which offer a unique way to observe these invisible objects.
Quantum physicists have observed pairs of helium atoms entangled in motion, representing a major advancement on previous experiments using photons. This breakthrough enables new ways to examine the interaction between quantum mechanics and gravity at the universal scale.
Researchers at the University of Waterloo have developed a new theory that suggests the universe's rapid early expansion could emerge naturally from a deeper, more complete theory of quantum gravity. This approach offers a unified picture that connects the earliest moments of the universe to modern cosmology.
Astronomers have confirmed the connection between magnetars and superluminous supernovae, finding definitive evidence for a magnetar forming in the core collapse of a recent supernova. The discovery corroborates a theory proposed 16 years ago and establishes a new phenomenon in exploding stars.
A team of international researchers led by a UC Santa Barbara graduate student has confirmed a long-standing theory of stellar death by applying the principles of general relativity to a superluminous supernova. The discovery suggests that a magnetar, a rapidly spinning neutron star with a massive magnetic field, powers the supernova, ...
The updated catalogue, GWTC-4, doubles the number of events, revealing 128 new gravitational signals and a kaleidoscope of cosmic collisions, including massive black hole binaries and neutron star binaries. The data provides unprecedented precision to test Einstein's General Relativity and probe the universe's evolution.
A new study by Mass General Brigham highlights the efficacy of proton therapy in achieving excellent tumor control rates while minimizing side effects compared to traditional radiotherapy. Proton therapy limits radiation exposure to healthy tissue, potentially preserving cognition and hormone function.
The absence of exoplanets orbiting tight binary stars is attributed to the effects of general relativity, which causes gravitational tugs from the stars to make a planet's orbit precess. This process makes it difficult for close-in planets to survive, with 75% being destroyed due to tidal disruptions or ejection from the system.
Researchers at Mass General Brigham report preclinical efficacy and human safety data for high-dose inhaled nitric oxide as a potential antimicrobial therapy. The treatment demonstrated strong antipseudomonal effects and was safe and feasible in early human studies.
Physicists Igor Pikovski and Jack Harris are developing a superfluid-helium resonator to detect individual gravitons from astrophysical gravitational waves, pushing the field of quantum gravity forward. The experiment aims to immerse a gram-scale cylindrical resonator in a superfluid-helium container and use laser-based measurements to...
Researchers found evidence that dark matter and neutrinos interact, offering a rare glimpse into the universe's darkest regions. The study casts doubt on the long-standing cosmological model, suggesting interactions between dark matter and neutrinos could explain a discrepancy in cosmic structure formation.
Dr. Noritaka Ichinohe challenges the long-held assumption that averaging away individual differences is necessary in psychiatric research. Instead, biological heterogeneity is seen as a phenomenon demanding explanation. The author's work on primate brain mapping and molecular subtyping has identified convergence points between species ...
A new study by Mass General Brigham researchers found that patients with depression are at higher risk of cardiovascular disease due to stress-related brain activity, nervous system dysregulation, and chronic inflammation. The study also suggests that addressing chronic stress, anxiety, or depression is crucial for heart health.
Mass General Brigham's new AI company, AIwithCare, has developed a software platform that leverages generative AI to screen patients for clinical trial eligibility. The tool, RECTIFIER, was found to accurately identify eligible patients and enroll them in clinical trials at a lower cost than traditional methods.
Scientists have observed a swirling vortex in spacetime caused by a rapidly rotating black hole, confirming predictions made by Einstein more than a century ago. The team detected rhythmic changes in X-ray and radio signals from the event, showing that the disk and jet were wobbling in unison every 20 days.
Researchers at the University of Amsterdam developed a new model to track dark matter's effect on black holes' gravitational waves. The study focuses on extreme mass-ratio inspirals, where a smaller object orbits a massive black hole, emitting gravitational waves that can reveal dark matter's distribution around black holes.
Researchers developed a comprehensive model of luminous black hole accretion, including radiation flows and interactions with surrounding gas. Their simulations reproduce consistent behaviors across various black hole systems, providing insight into extreme nonlinear processes.
Groundbreaking simulations reveal how black holes create dazzling light shows by material zipping around them. The results could help explain hundreds of faintly luminous objects spotted in the early universe.
Researchers at TU Wien have developed a new approach to unifying quantum physics and general relativity theory, discovering striking deviations from previous results. The approach uses geodesics and quantized metric to make predictions for measurable quantities.
Researchers from Mass General Brigham Cancer Institute present promising new treatment options for acute myeloid leukemia, autoimmune bleeding disorders, and multiple myeloma. The studies show improved event-free survival, higher overall response rates, and better quality of life for patients treated with novel therapies.
A qualitative study of 25 general practitioners found that trust in patients deepens over time as part of a mutually trusting relationship. General practitioners initially assume trust but may lack it for complex patients who manipulate the system for secondary gain.