The partnership is dedicated to tackling health issues arising from climate change, reflecting both institutions' commitment to innovative research. The five selected projects will bring together top researchers from Duke and Duke-NUS, leveraging unique strengths to advance basic, translational, and clinical research.
A new nanomedicine, ZnDHT NM, selectively targets cancer stem-like cells (CSCs) and tumor cells, promoting CSC differentiation while inhibiting EMT. This approach also leads to the release of toxic compounds in tumor cells, inducing apoptosis/ferroptosis pathways.
Researchers developed a new stainless-steel alloy that preserves material strength without relying on nickel. By using additive manufacturing and combining austenitic and ferritic stainless steels, the team created bimetallic structures with improved hardness and strength.
Researchers found that intracranial hemorrhages double the risk of dementia in people. The study analyzed Medicare claims and observed a two-fold increase in dementia diagnoses within 5.6 years after a hemorrhage.
INSEAD experts Tim Gordon and Theos Evgeniou explore the dual races of AI-driven economic growth and global leadership in a free webinar. They examine risks of market bubbles and discuss strategic implications for businesses and policymakers.
A new study tracks US health care spending by health condition and county, revealing broad variation in spending patterns. The research highlights the need to identify outliers and assess healthcare gaps, particularly in regions with high inequalities in healthcare access.
Researchers successfully developed CoQ10-producing rice through targeted gene editing, offering a cost-effective approach to nutritional fortification. The discovery provides great potential benefit for human health, particularly heart protection, and expands the food sources of CoQ10.
A new study finds that methane emissions are being underreported by at least 170 million to 3.3 billion tons of carbon over a decade, depending on the metric used. Companies may have underestimated their carbon footprint by as much as the annual carbon emissions of the UK in 2022.
The INSEAD webinar focuses on Access Afya's journey to scale its affordable healthcare model while maintaining its mission. The company will share insights into its innovative approach and sustainable impact through a discussion with CEO Daphne Ngunjiri and Commercial Growth & Finance Director Danny McCabe.
Researchers at the University of Illinois have developed a methodology for multiple CubeSats to act as service agents for assembling or repairing space telescopes. The method minimizes fuel consumption and guarantees safe operations without collisions.
Researchers developed a portable, reversible fluorescent hydrogel sensor to detect methylglyoxal in multiple scenarios. The sensor's detection limits reached 59 nM, offering an innovative solution for flavor standardization in wine production and health monitoring in diabetes patients.
Researchers developed a novel green pesticide formulation using modified carbon dots and calcium carbonate particles. The new formula enhances adhesion to leaves, resists degradation from sunlight, and releases the active ingredient gradually for sustained effectiveness.
A new catalyst, Ru3Zn0.85W0.15Ox (RZW), has been developed to improve the efficiency and stability of oxygen evolution reaction (OER) in acidic media, enabling more efficient green hydrogen production. The catalyst harnesses the unique electron-withdrawing properties of tungsten and sacrificial behavior of zinc to enhance OER performance.
Researchers used Quantum Approximate Optimization Algorithm (QAOA) to cluster jets in high-energy particle collisions, achieving performance comparable to classical algorithms. The study demonstrates the potential of quantum computing in improving jet clustering for practical applications.
Researchers at Penn State suggest that human-like life is the natural evolutionary outcome for planets like Earth, with conditions becoming hospitable to complex life over time. This new model shifts the focus from improbable events to the interplay between life and environment, opening up exciting new avenues of research.
Researchers have developed a new gene switch that uses nitroglycerine to trigger the production of insulin and regulate blood sugar levels in people with diabetes. This switch is made exclusively of human constituents, eliminating the risk of false triggering or immune reactions.
A new clinical trial will evaluate whether adding ketamine to standard treatment can improve outcomes for patients suffering from status epilepticus. The trial, called KESETT, hopes to determine whether ketamine can terminate the seizures in more patients than current treatments.
Researchers at Salk Institute discover SSRIs like Prozac regulate immune response, preventing sepsis in mice. The findings suggest a potential new use for the popular drug, which could lead to life-saving treatments and enhanced global preparedness for pandemics.
A new study by the University of Southampton has found that brake pad emissions can be more toxic than diesel exhaust, particularly due to high copper content. The research highlights the need for policy changes to mitigate the health effects of vehicle particulate matter, as electric vehicles are not emission-free.
Researchers found evidence of sodium carbonate, halite, and sodium sulfates on Ryugu, indicating liquid saline water once existed within its parent body. This discovery provides insights into the chemical history of Ryugu and sheds light on the loss of liquid water in the outer Solar System.
A new global guideline has been published to manage fungal infections caused by Candida, affecting millions worldwide annually. The guideline establishes standards for prevention, diagnosis, and innovative treatment approaches.
In a groundbreaking study, researchers observed flies displaying play-like behaviors, such as swinging and sliding, in response to a rotating carousel. The findings provide valuable insights into the genetic and neuronal factors underlying playful behavior in insects.
The research reveals that interfacial magnon-plasmon coupling is responsible for the disappearance of nonreciprocal SHG in MnPSe₃/graphene heterojunctions. The strength of this coupling can be tuned by adjusting the band gap of underlayer materials.
The team led by Xiaolong Su prepares hybrid polarization-cat entangled state with OAM degree of freedom, demonstrating non-zero logarithmic negativities for various OAM states. This breakthrough enables increased information capacity in quantum communication and takes a crucial step towards hybrid quantum information processing.
A significant increase in FAP-related publications has been observed since 2019, with China, the USA, and Germany leading productivity. FAPI-based radiotracers have shown promising results in diagnosing various cancers, particularly gastrointestinal malignancies.
The 2024 Chinese Society of Clinical Oncology Breast Cancer (CSCO BC) guidelines offer a comprehensive approach to managing breast cancer, informed by high-quality clinical studies and real-world data from China. The updated guidelines prioritize precision medicine, recommending tailored treatment approaches for various subtypes of bre...
A team of scientists found that Earth's current ice-covered state is not typical for the planet's history and was only achieved through a lucky coincidence. The researchers concluded that no single process could drive these cold climates, and that multiple processes working together were necessary.
This article examines the molecular mechanisms underlying icaritin's anti-cancer properties and discusses recent progress in its application. Icaritin, a prenylflavonoid natural product, shows diverse pharmacological effects, including anti-inflammatory, immune-regulatory, and anti-oxidation properties.
Researchers at Case Western Reserve University found that manufactured separation materials don't function as intended due to blocked pores, leading to inefficient and expensive separations. Single-molecule microscopy technique revealed the behavior of individual molecules, allowing for predictive performance and design improvements.
A Finnish cohort study found that higher physical activity and lower screen time in childhood are associated with reduced perceived stress and depressive symptoms in adolescence. The findings emphasize the importance of promoting physical activity and reducing screen time to support mental health in youth.
The report documents 80% of Palmyra's city destroyed or on verge of collapse, with 10,000 people returning to a population of 100,000. Damage to archaeological heritage is severe, with iconic sites like the Tetrapylon and Roman theatre severely damaged.
A new optical technology developed at UC Riverside enables gravitational-wave detectors to reach extreme laser powers, overcoming limitations that hinder the detection of cosmic phenomena. This breakthrough is expected to significantly expand our view of the universe, particularly in the earliest stages of its history.
Researchers found that seamounts support vast numbers of predators, including sharks and tuna, with shark biomass being 41 times higher at shallow seamounts. The study suggests that seamounts serve as 'hubs' for predators to gather, socialize, mate, or rest, and concentrate food in predictable spots.
Researchers explore the contribution of exceptional points to electro-optic tunability, modulation, and nonreciprocal responses in silicon microring. A novel EP system enables precise phase-sensitive control of coupling between clockwise and counterclockwise modes, leading to enhanced amplitude modulation.
Researchers find that intense laser pulses cause tunnel ionization, generating photocarriers and altering the lattice energy surface, leading to ultrafast melting of wide-gap ceramic materials like MgO. The study demonstrates a universal microscopic mechanism for laser-induced phase transitions.
A research team developed a multi-medium approach to identify reproducible volatile organic compounds (VOCs) in lung cancer cells. The study found two VOCs with lower levels in cancerous cells, which showed reproducibility and were validated through targeted detection of animal models.
A new gene therapy has shown promise in treating a rare form of epilepsy, specifically Dravet syndrome, by replacing the SCN1B gene variant. The therapy increased survival rates, reduced seizure severity, and restored brain neuron excitability in mice with the condition.
Researchers at Institute of Science Tokyo developed porous organic crystals with ultrahigh-density amines, achieving fast CO2 adsorption and high thermal stability. The unique 2.5-dimensional skeleton reduces the cost for CO2 separation from flue gases.
A study reveals that 65.8% of adults have low trust in their healthcare system's use of artificial intelligence, and 57.7% fear AI-related harm. Hospitals should increase or improve their communications with patients about AI tools to build trust.
A recent study reveals that intermittent fasting can impair beta-cell function and maturation in young mice, potentially leading to diabetes. Researchers found that adolescent mice showed a decline in insulin production after prolonged fasting, with defective beta cells resembling those of type 1 diabetes patients.
A new dataset of nearly 4,000 nearby supernovae has revealed a surprising diversity in the explosive transients of white dwarf stars, with multiple exotic ways they can blow up. These discoveries have implications for measuring distances in the Universe and understanding dark energy.
A new study highlights the risks of climate change on cocoa production, which supports four to six million small-holder farmers. Increasing pollination rates above current levels could boost yields by 20%, according to researchers.
Scientists have released new high-quality genome sequences for two critically endangered pangolin species, revealing genetic vulnerabilities and extinction risks. The research provides essential information for rescue operations and focusing on the best ways to conserve these unique animals.
A study found that even with impeccable cleaning, hospital sink drains can host bacterial populations that change over time. Dominant species include Stenotrophomonas and Pseudomonas aeruginosa, known to cause ventilator-associated pneumonia and sepsis.
Researchers at HSE Centre for Language and Brain create Russian-language adaptation of Rey Auditory Verbal Learning Test (RAVLT), suitable for testing adults of all ages. The adapted test has been incorporated into the RAVLT World tablet application, providing automated administration and scoring.
Researchers have discovered Random Antimicrobial Peptide Mixtures (RPMs) as a promising non-antibiotic antimicrobial agent for cultured meat production. RPMs successfully eliminate bacterial contamination without harming stem cell viability or contributing to antibiotic resistance.
Researchers at Stanford University have illuminated how enzymes speed up life-sustaining biochemical reactions so dramatically. By understanding the chemical and physical interactions responsible for enzyme's enormous reaction rates, scientists may be able to design new enzymes that rival those found in nature.
A new photocatalytic chemical mechanical polishing (PCMP) slurry has been developed for Single Crystal Diamond (SCD) polishing, resulting in exceptionally smooth surfaces with minimal damage. The Material Removal Rate (MRR) peaks at 1168 nm·h−1, emphasizing the efficiency and effectiveness of this advanced polishing technique.
A recent study by Stanford University researchers found that deploying carbon capture technologies would be more expensive and harmful than transitioning to renewable energy sources. The authors compared two extreme scenarios: a complete switch to renewable energy versus maintaining current fossil fuel reliance with some renewables, nu...
A study published in Annals of Neurology found that severe early-life adversity accelerates brain aging and amplifies neurodegenerative processes in women. Researchers analyzed biomarkers, brain scans, and cognitive tests to determine the link between childhood trauma and later dementia risk.
A new study introduces an innovative framework that quantifies the direct impacts of typhoons on vegetation canopy structure and photosynthesis. The research assesses both immediate damage and long-term recovery, providing crucial insights for coastal ecosystem management and disaster risk assessment amid climate change.
Researchers from UCL and the University of Ljubljana conducted a systematic study on the smells of nine ancient Egyptian mummified bodies, identifying materials used in mumification and evolution of practices. The study also provides insights into how museums conserve remains and preserves their olfactory heritage.
Researchers at Texas A&M University have developed a new catalytic graphitization technology to convert petroleum coke into graphite, reducing emissions and cost associated with conventional synthetic graphite production. The process uses lower temperatures and shorter times, making it more sustainable and efficient.
A team of researchers has identified a new chronic blood clotting disorder, VITT-like monoclonal gammopathy of thrombotic significance (MGTS), characterized by antibodies similar to those causing vaccine-induced immune thrombocytopenia and thrombosis (VITT). The disorder can lead to severe symptoms despite treatment with full-dose bloo...
The NUS Institute for Functional Intelligent Materials is hosting the AI4X 2025 conference to explore how AI is driving breakthroughs across various natural sciences. Scientists, industry leaders, and innovators will share their knowledge on applying AI to Natural Science and Finance.
Researchers at PNNL developed a mini flow battery test system that requires less starting material while delivering comparable performance to standard lab-scale systems. This innovation reduces time and resources needed for testing new battery materials, accelerating the discovery of grid energy storage technology.
Researchers have designed a compact, high-efficiency flow battery test system that requires an order of magnitude less starting material while delivering results comparable to standard lab-scale systems. The mini flow cell design is geared towards rapid screening and development of new battery materials, reducing the time and resources...
Researchers discovered that many marine fungi isolated from Hawai'i's nearshore environment have the ability to degrade plastic. The team then conditioned these fungi to consume polyurethane and other types of plastics more efficiently. By studying their adaptability, scientists hope to develop new solutions for cleaning up oceans.
US researchers found that self-sampling using vaginal swabs is as effective as speculum-based testing for detecting high-risk HPV types. The study suggests that self-sampling could reduce the incidence of cervical cancer in women with physical disabilities, who often face barriers to traditional screening methods.
A study by University of Gothenburg researchers found that consuming sulforaphane from broccoli sprouts improved blood sugar levels in people with prediabetes. The compound had a significant effect on fasting blood sugar levels, particularly in those with certain pathophysiological and microbiome characteristics.