Researchers from Bonn University Hospital identify structurally and temporally coherent substructures in networks, known as 'tipping subnetworks', which can lead to extreme events. The method provides new possibilities for early detection of critical transitions with potential applications in medicine, climate research, and beyond.
The Society for Vascular Medicine identifies top research priorities for peripheral artery disease (PAD) to reduce incidence and improve health outcomes. The report aims to accelerate discovery and inform funding agencies about high-priority topics in epidemiology, basic science, clinical research, and implementation studies.
A team of researchers at Nagoya University has discovered a fast-moving, high-temperature gas flow in the center of the Centaurus cluster of galaxies. This finding may solve the 'cooling flow problem', which explains why galaxy clusters appear to be warm despite emitting X-rays.
Researchers at the University of Utah have developed RiskPath, an Explainable AI toolkit that predicts disease progression years before symptoms manifest. The technology analyzes health data to identify high-risk individuals with unprecedented accuracy, offering new insights into risk factor interactions and disease development.
Physicists at the University of Miami have discovered a unique molecule that can conduct electricity without losing energy, paving the way for smaller and more powerful computing devices. The molecule, composed of chemical elements found in nature, offers unparalleled electrical conductance and stability under everyday conditions.
A team of researchers has revealed the molecular mechanisms underlying the binding of small extracellular vesicles to host cells, which could lead to the development of more effective cancer treatments. The study found that EVs primarily bind to laminin via CD151-associated integrin heterodimers and GM1, eliciting responses in recipien...
Researchers at the University of Tsukuba investigated the developmental fate of shell-forming cells in limpets using single-cell transcriptome and gene expression analyses. They found that the developmental fate of these cells was specified independently of interactions with neighboring cell lineages, contradicting conventional hypothe...
Researchers at Scripps Research used computer modeling to illustrate how antibodies recognize lipids in the HIV virus, highlighting a potential new approach for vaccine design. The study identified two key structural features on the antibodies that enable them to target well-defined membrane features.
Monoclonal antibody nirsevimab provides strong real-world protection against severe respiratory syncytial virus (RSV) infections in infants. The analysis found that nirsevimab reduces hospitalization rates by 83% and intensive care admissions by 81% in children aged 12 months and younger.
A new MRI technique measures a person's 'functional age' of their heart, revealing how unhealthy lifestyles add years to their heart's aging process. This method has the potential to transform heart disease diagnosis and offer a lifeline to millions by catching problems early.
A new analysis predicts that reducing Medicaid access could lead to thousands of additional deaths among working-age Americans and disastrous financial burdens. The study found that eliminating the ACA provision expanding Medicaid access could drive millions to delay needed care.
Researchers have shown that good gut bacteria can manipulate the immune system's response, leading to rheumatoid arthritis. The study found that T cells in the gut can transform into super-powerful and potent cells that attack the body's tissues.
Scientists have engineered a new drug candidate to target the deadly Mycobacterium abscessus infection, which is growing threat among immunocompromised patients and those with certain lung diseases. The new findings offer a promising solution for cystic fibrosis patients who are most endangered by M. abscessus infections.
Scott Solomon, a biologist and teaching professor at Rice University, has been awarded the prestigious Piper Professor honor for his exceptional teaching and service to students. He is known for igniting students' curiosity and helping them connect scientific knowledge to real-world applications through immersive field-based courses.
Researchers found that Eato protein protects neurons from destruction and helps phagocytes clean up damaged neurons. The study suggests new treatment strategies for neurodegenerative diseases like Alzheimer's and Parkinson's.
University of Oklahoma researchers discovered ZIP4 protein drives glioblastoma progression through extracellular vesicles and reprogrammed microglial plasticity. The study identifies ZIP4 and TREM1 as promising therapeutic targets for treating aggressive brain cancer.
Researchers at MIT developed a technique to improve the reliability of conformal classification, which can produce impractably large prediction sets. By combining test-time augmentation with conformal prediction, they reduced prediction set sizes by up to 30 percent while maintaining probability guarantees.
The conference brings together leading experts to examine cardiovascular disease trends and share insights on prevention and management. ACC Asia 2025 will also recognize over 30 individuals who have earned the Fellow of the ACC designation.
Scientists discovered that certain bacteria can trigger their own cell death as a defense mechanism against viruses, utilizing components of the bacterial immune system. This phenomenon could be exploited to develop novel antimicrobial treatments and fight drug-resistant infections.
A new $2.7 million NIH grant aims to develop a one-step confirmatory laboratory test for active syphilis infection, which can be diagnosed within 10 minutes. The proposed platform uses electrochemical sensors to detect both treponemal and non-treponemal antibodies, providing a more definitive diagnosis and treatment plan.
Researchers developed an AI system to classify tiny powdery pollen grains produced by fir, spruce, and pine trees, enhancing speed and accuracy. The tool can aid allergy sufferers, urban planners, farmers, and wildlife conservation efforts.
Studies project a 40% increase in tobacco-related coronary heart disease deaths by 2030, with Black women and American Indian/Alaska Native groups disproportionately affected. Cannabis use disorder is also linked to increased risk of cardiogenic shock, acute myocardial infarction, and arrhythmias.
A HSS study using artificial intelligence identifies two distinct pain archetypes and determines key predictive factors for severe pain after knee replacement. The study utilizes machine learning to analyze patient data and provide personalized pain management plans.
The Digital Evolution Index reveals a crucial inflection point in the global digital landscape, with slowing growth and plateauing digital inclusion metrics. Emerging post-pandemic challenges include the 'winner-takes-most' scenario driven by AI, highlighting the need for resilient digital economies.
The FAVOR III China Trial showed that machine learning-based approach identify top 10 prognostic factors for predicting 2-year major adverse cardiovascular events (MACE) after Quantitative Flow Ratio (QFR)-guided Percutaneous Coronary Intervention (PCI). Patients with pre-random PCI strategy changed, Left Circumflex artery (LCX) lesion...
Professor Paul Armsworth, a theoretical ecologist at University of Tennessee, has been recognized as an ESA Fellow for his contributions to ecological research and conservation. He bridges theory and practice to inform management and policy decisions, benefiting Tennessee and the broader society.
A new approach, GlycoCaging, delivers medicine directly to the lower gut at significantly lower doses than current treatments, potentially helping people with inflammatory bowel disease. The technique has been shown to be effective in mice and has potential for treatment in humans, as most people have the ability to activate the drugs.
A recent study by the University of Surrey suggests that hotel managers may need to adapt to AI-driven system management, shifting their focus from controlling to coaching staff. Effective communication, emotional intelligence, and creativity are key strategies for managers to navigate this transformation.
A USC team has developed an advanced platform to analyze chimeric antigen receptor (CAR) T cells, revealing how their manufacturing conditions impact effectiveness. The tool uses laser technology to analyze 36 characteristics of a single cell, providing a clearer view of CAR T cell behavior.
A study by the American Psychological Association reveals that people tend to believe they've earned good things through karmic merit, while bad events in others are due to punishment. The research shows how supernatural beliefs like karma help people make sense of their experiences and feel good about themselves.
A recent study has identified the 'cell of origin' of lung squamous cell carcinoma (LUSC), a second most common type of lung cancer among smokers. The research found that basal cells expressing the gene Krt5 become dominant in the trachea and eventually invade large areas of the lung, forming tumors.
New data reveals women are 8% more likely to experience major complications after TAVI and 50% more likely after LAAO device placement. Black patients with chronic limb-threatening ischemia face a significantly higher combined rate of major amputation and death, yet are 10% less likely to see a vascular specialist.
A global analysis reveals significant differences in disease rates, diagnosis, treatment, and death between males and females for three common conditions. Males are more likely to get sick and die from hypertension, diabetes, and HIV/AIDS, while also being less likely to seek medical care.
A study by UTHealth Houston found that some public transit shelter designs can trap heat and increase temperatures, posing a significant risk to bus riders' health. Providing shade through trees or strategic shelter design can mitigate this issue.
Researchers have re-tested California sea lion Ronan's rhythm skills, finding she can bob her head to a beat with precision comparable to that of humans. The study suggests that biomusicality is not exclusive to humans and challenges existing theories on the subject.
The Center for Open Science has issued a Request for Proposals to develop and improve the Open Science Framework, a free project management platform for researchers. Selected partners will work closely with COS and its community to implement improvements aligned with community priorities.
The latest APA journal issues focus on improving depression care and mental health in disaster-affected communities. Research also explores school-based prevention efforts, with publications like the American Journal of Psychiatry and Psychiatric Services featuring diverse treatment strategies.
A study of 500 early cardiogenic shock patients found that nearly one-quarter experienced poor outcomes, including increased risk of care escalation, deterioration, and in-hospital mortality. The research underscores the need for timely diagnosis and treatment to improve survival rates among this vulnerable population.
Researchers at Mass General Brigham found that patients with relapsed/refractory mature T- and NK-cell lymphomas had improved survival rates when treated with small molecule inhibitors as second-line therapy, followed by epigenetic modifiers as third-line therapy. The study, published in the British Journal of Haematolog, also showed t...
A new study analyzing citizen science data reveals that North American bird populations are shrinking most rapidly where they are still most abundant. This pattern suggests ecological stress, primarily driven by climate change and habitat loss, is the primary driver of decline.
The city of Santa Cruz has implemented a two-cents-per-ounce tax on soda and other sugary beverages, generating an estimated $1.3 million per year for the city. The tax, supported by the American Heart Association, aims to reduce purchases of these drinks and combat public health issues.
Researchers discovered compromised NAD+ metabolism in WS cells and found that boosting NAD+ levels using nicotinamide riboside decreased senescence in both stem cells and primary fibroblasts. The study suggests targeting NAD+ metabolism for age-related and genetic diseases.
A Dartmouth team's AI model recognized Navajo with near-perfect accuracy, identifying related languages such as Apache and Native Alaskan languages. The study suggests that this technology could be a bridge to including smaller languages in online translation services.
Researchers discovered neuroestrogen's role in regulating food intake and hunger. Neuroestrogen enhances the brain's responsiveness to leptin, a hormone that helps regulate hunger.
The National Multiple Sclerosis Society has committed $18.1 million to support research projects aligned with its Pathways to Cures roadmap, which aims to stop MS, restore function, and end the disease. The funding includes 16 research grants and 28 training fellowships in the US and internationally.
Researchers discovered a symbiotic gut fungus that produces a molecule capable of reversing liver disease progression in mice. The findings may inform future therapeutic approaches to treat metabolic dysfunction-associated steatohepatitis (MASH), a highly prevalent disease affecting one in four adults worldwide.
Researchers at Boyce Thompson Institute developed a new method for transforming maize using leaf whorls, reducing the need for advanced growing facilities. The new technique has been tested on two maize genotypes and shown to be effective in boosting plant resistance.
Researchers used satellite data to verify that global warming is causing earlier spring leaf flush in Japan. The study found that high temperatures in 2023 and 2024 led to a 3-7 day shift in the start of season, with some regions experiencing an 9-day earlier onset.
The University of Jena, Germany won the prestigious Dance your PhD competition in Biology with its engaging video Plant Vaccination, showcasing Priya Reddy's doctoral thesis on plant immune research. The video combines scientific accuracy with creative freedom, highlighting the potential of science to reach a wider audience.
New research from the University of Copenhagen found that reducing skeletal muscle NAD+ levels in mice by 85% did not accelerate aging or impair whole-body metabolism. The study suggests that skeletal muscle can tolerate substantial NAD depletion without loss of function or accelerated aging.
Researchers discovered how certain bacteria breathe by generating electricity, using a natural process that pushes electrons into their surroundings. This finding could enable new developments in clean energy and industrial biotechnology.
A new study at Columbia University Mailman School of Public Health found an increase in use of only psychotherapy, from 11.5% to 15.4%, and a decline in patients taking medication only, from 68% to 62%. The shift may be attributed to various factors beyond the COVID pandemic.
A nationwide study found that ambulatory surgery centers (ASCs) are treating 15% more patients from socially vulnerable areas for cardiac interventions, despite lower adverse event rates. The study also showed that ASC patients had a higher rate of repeat PCI compared to hospital outpatient department patients.
A new report published in the COPD Foundation's journal found virtual pulmonary rehabilitation to be a safe and effective alternative for people with COPD who require supplemental oxygen. The program improved clinical outcomes and quality of life for participants, demonstrating its potential to increase access to care.
This study found a decline in racial and ethnic disparities in receipt of ERBB2-targeted therapies among older Medicare beneficiaries with ERBB2-positive breast cancer. The narrowing of disparities may be attributed to changes in healthcare practices or policies over time.
Researchers from Kyushu University found that lipid peroxidation of lysosomes plays a key role in ferroptosis-mediated cell death, leading to iron leakage and membrane permeabilization. Administration of chloroquine promotes ferroptosis even in cancer cells less susceptible to the process.
The ERGO-CATH study reveals traditional lead aprons cause 43% discomfort among interventional cardiologists due to high-risk positions like cervical axial rotation. Researchers advocate for novel lead-less solutions, such as the Rampart device, to shield staff from radiation exposure and prevent orthopedic pain.
Researchers investigated the clinical outcomes of concurrent TTFields therapy with CRT in patients with newly diagnosed glioblastoma, finding no significant difference in survival outcomes compared to adjuvant therapy. The study also showed comparable safety profiles for both treatment groups.
The 56th Annual Meeting of the American Physical Society's Division of Atomic, Molecular and Optical Physics will present new research on quantum computing, lasers, and Bose-Einstein condensates. Over 1,200 physicists from around the world will convene in Portland, Oregon, June 16-20.
Scientists at Henry Ford Health + Michigan State University Health Sciences have identified a circulating microRNA called miR-126-3p as a mechanistic biomarker of knee osteoarthritis. This discovery may lead to the development of blood tests for early detection and therapeutics for slowing or stopping disease progression.