UCLA investigators present new research on targeted drug delivery for colorectal cancer, COVID-19's impact on breast cancer outcomes, and AI in cancer diagnosis. These studies offer insights into overcoming drug resistance, enhancing immune responses, and improving outcomes for patients with difficult-to-treat cancers.
The INSPIRE Conference will discuss key project findings, tools, and resources on inclusive gender equality in research and innovation. The event aims to sustain change and address future challenges through dialogue among policymakers, researchers, and stakeholders.
Researchers focus on developing transformer efficiency and heat recovery to enhance hydrogen production energy efficiency. The goal is to significantly reduce electricity consumption by up to 35% and increase net efficiency to 85%.
Scientists develop a new generation of energy-efficient transistors made from thin, lightweight electrically conducting films. The film-based switch can control the flow of electric current with high precision, enabling complex motion sequences or fixed positions.
The study found that ATF5 plays a critical role in coordinating mitochondrial quality control and adaptive stress signaling in skeletal muscle. Absence of ATF5 resulted in increased muscle fatigability and elevated ROS production, highlighting its importance in maintaining muscle function with age.
Researchers have mapped the molecular mechanism behind allergic reactions and developed tailored antibodies to block life-threatening responses. The findings suggest a new approach to targeting the most important allergens and provide a starting point for developing more precise treatments for severe allergy.
A randomized, open-label bridging clinical trial was conducted to evaluate the immunogenicity and safety of a 9-valent HPV vaccine in adolescents aged 9-17 years compared to young women. The study found non-inferior immune responses with seroconversion rates comparable to those in young women receiving three doses.
Mount Sinai ophthalmologist has developed a groundbreaking device enabling precise measurement of aqueous outflow during eye surgery. The technology offers improved accuracy and reduced complications, potentially transforming the field of ophthalmology.
Researchers found that far-right influencer Tommy Robinson used his Telegram channel to comment on events and legitimise violence during anti-immigration protests in 2024, shaping followers' interpretations of events without issuing direct instructions. The study identifies key tactics used by influencers to create emotional conditions...
A new study by IIASA researchers reveals that China's economic growth is being driven by the skills of its workforce, not just its large working-age population. Improvements in skill composition have become a key driver of economic expansion, and a more favorable age structure enhances economic returns to workforce skills.
The clinical guideline emphasizes personalized care, recommending pre-exercise cardiovascular risk assessment and individualized exercise prescriptions. Adults with T2D are advised to engage in at least 150 minutes of moderate-intensity aerobic exercise per week, or a combination of aerobic and resistance training.
A proposed embedded ethics approach facilitates ethically responsible research with human stem-cell-based embryo models by integrating continuous dialogue among scientists, ethicists, and regulators. This framework helps build trust and serves as a public policy tool to ensure that research meets both scientific and societal values.
A team-based program in community health clinics helped low-income patients reduce their blood pressure more than standard care alone. After 18 months, patients in the team-based program saw a significant drop in systolic blood pressure and showed better adherence to hypertension treatment.
Researchers found that watching an online performance in real time boosts several aspects of the viewing experience, including a common factor of heightened sense of presence. The liveness effect weakens when viewers cannot see a performer's face, but going live can benefit streamers by motivating audience engagement.
The research team will analyze mouse models and human brain tissue to identify cell types that show early signs of stress before neurons die. The multiscale model simulates how the progressive loss or disconnection of specific neurons disrupts memory-related brain networks.
Adults aged 75 or older without adenoma on prior colonoscopy have lower risk of subsequent colorectal cancer and CRC death. Despite this, those with prior adenoma may consider deprioritizing surveillance colonoscopy relative to other health concerns.
A study found that children who need dental care the most are less likely to participate in school-based cavity prevention programs, which can lead to significant savings for state Medicaid programs. Improving participation among high-risk children could save up to $2.4 million annually.
A national study found that unmet health-related social needs are associated with lower colorectal cancer screening rates, particularly among adults aged 50-64. Addressing these needs may support age-specific strategies to improve screening rates.
Scientists used CAR-T cell therapy to treat a patient with severe autoimmune hemolytic anemia, immune thrombocytopenia, and antiphospholipid antibody syndrome. The treatment achieved lasting remission without additional treatment for over a year.
Researchers identify previously unknown microbe living in close partnership with another organism inside stromatolites, providing insights into how complex life began. The discovery sheds light on the evolution of eukaryotes and the emergence of mitochondria.
A new machine-learning method detects sudden changes in fluid behavior, improving simulation capabilities for everyday applications like weather prediction and nuclear reactor safety. This enables faster design testing, real-time adjustments, and reduced computational burden.
A new study uses an AI model to predict type 2 diabetes risk based on behavioral and psychosocial information. The digital twin model found that loneliness, insomnia, and poor mental health substantially raise a person's future risk of developing the disease.
A new study found that nearly half of young survivors of the October 7 attacks developed atypical sensory patterns, causing everyday stimuli to be perceived as overwhelming threats. This altered sensory processing is directly tied to emotional distress and anxiety in children.
Researchers compare viral and MASLD cirrhosis pathogenic mechanisms, identifying shared pathways and diagnostic differences. The study aims to establish a framework for prevention, diagnosis, treatment, and monitoring of MASLD cirrhosis.
During the Covid-19 crisis, small community sports clubs in Brazilian favelas adapted to meet urgent needs by distributing food parcels, sharing public health information, and transporting residents to vaccination centres. These efforts strengthened trust and cooperation with local communities.
KIT presents groundbreaking technologies for future energy supply, transportation and communication. The institution demonstrates visioner modes of travel, new options in robotics, decisive steps towards the first nuclear fusion reactor.
Researchers from Tohoku University examined the role of materials databases in supporting modern artificial intelligence tools used in materials science. They found that database architecture can directly affect AI model performance and reliability. The study aims to improve database quality, connectivity, and develop new AI systems th...
New research highlights a critical paradox in marine conservation: protected areas can become 'toxic traps' for pollutants. The authors propose an integrated management framework to address this issue. Effective conservation requires considering ecosystem health and pollutant exposure.
Researchers at DGIST have developed a novel catalytic technology that can easily assemble key structural frameworks of bioactive compounds exclusively in the desired mirror-image form. The technology uses an inexpensive nickel catalyst to synthesize β-methylene carbonyl derivatives, which are crucial for pharmaceuticals.
New research reveals that mosquito net chemical coatings impact performance, with PFAS-based coatings altering how well a net works. The study suggests integrating conventional bioassays with surface chemistry and behavioral analysis to strengthen product development and regulatory evaluation.
A large regional species pool, driven by favorable climates, varied habitats, and stable historical climates, supports both high diversity and many rare trees. Forests with larger species pools require prioritized protection to preserve forest diversity and save rare and endemic species from human disturbance.
A new cathode material with a dual-crystal-phase structure improves the performance and stability of aqueous zinc-ion batteries. The material offers high capacity, rapid charging capabilities, and exceptional longevity.
Researchers developed a high-performance catalyst using abundant materials, exhibiting superior oxygen evolution activity and remarkable stability. The novel design paradigm, achieved through heterojunction-doping synergy, positions it as a viable alternative to iridium-based catalysts.
A new study found that influenza was detected in 11% of winter deaths, but only 17% had a confirmed diagnosis before death. The study highlights the gap between detection and official mortality records, suggesting influenza may play a larger role in winter mortality than routine surveillance captures.
A new high-density 10K SNP array for wax gourd has been created using GBTS technology. The array was used to analyze genetic distances among elite inbred lines and commercial cultivars, revealing two major groups with distinct population structures.
A new study introduces NARA, a computational framework that combines firefly algorithm with uncertainty-aware machine learning to make atomic structure prediction more robust. The method achieves higher efficiency than the widely used basin-hopping algorithm and recovers competing structures in a single run.
Researchers at Hiroshima University have developed a new approach to predicting harmful algal blooms by coupling three models and accounting for plankton species interactions. This improved forecasting can help prevent economic losses and protect fish stocks in countries like Chile, which has been hit hard by these blooms.
Researchers have discovered a brood pheromone released by clonal raider ant larvae that temporarily suppresses egg-laying in adult ants. The pheromone, MEHMP, is produced exclusively by larvae and helps synchronize brood care and reproduction in the colony.
A new optical-coupled scanning probe microscope uses a remote liquefaction cryogen-free system to visualize individual atoms and probe electronic and chemical properties without freezing budget. The system achieves stable base temperature and low noise levels, making it ideal for continuous experiments and studies of slow processes.
The Journal of Fast-Track Health will publish original research on global health challenges, including communicable and non-communicable diseases. The journal aims to bridge the gap between urban and national health responses through rigorous science and practice-oriented approaches.
A rapid and visual on-site detection system for Epizootic Hemorrhagic Disease Virus (EHDV) has been developed based on RT-ERA and CRISPR-Cas12a. This system achieves high sensitivity and specificity, making it suitable for point-of-care testing in field settings.
Enzyme-based glycan editing allows dynamic remodeling of N-glycans on living cells without compromising function. Recent breakthroughs include targeted tumor therapy and dual-transferase engineering of immune cells, highlighting the potential for precision glycobiology in immunity, cancer, and development.
Researchers developed a novel 'steric hindrance' strategy to create advanced single-atom catalysts outperforming traditional platinum benchmarks. The bulky metalloporphyrins provide spatial shields around metal centers, preventing agglomeration and ensuring high-performance in oxygen reduction reactions.
New research proposes that rock grains bond together at microscopic contact points, governing friction and stress release during earthquakes. This finding challenges existing models and suggests tectonic plates behave differently than previously assumed.
A study by researchers at the University of Gothenburg found that children born before 24 weeks of gestation incur significant societal costs, peaking in the first year of life. The need for support persists long after initial care, with severe complications often leading to more extensive and long-term support needs.
A new analysis of satellite data shows that global nighttime lighting is increasing by about 2% per year, despite regional fluctuations. In Europe, nighttime light emissions declined by 4% overall, but increased in China and India due to urbanization.
A new AI framework corrects forecast biases, achieving a 20% reduction in root-mean-square error for air temperature forecasts. The model supports bias correction of oceanic variables, enhancing forecast accuracy in meteorological and oceanic scenarios.
A new study from Finland shows that sauna bathing releases white blood cells into the bloodstream, playing a key role in the body's defense against pathogens and diseases. This periodic release of white blood cells is beneficial for immune defense.
Researchers developed a new imaging technique that captures both intensity and phase changes of an object in a single measurement. This allows scientists to observe ultrafast phenomena with unprecedented detail and speed, enabling the study of materials, biological processes, and high-power laser technologies.
A study of over 1500 patients with brain bleeds found that brain swelling in the first 24 hours and within 72 hours increased the risk of death or disability. Early intervention could potentially limit brain damage and improve recovery after stroke.
Four Ontario-based research teams are receiving funding to develop next-generation cancer therapies with improved efficacy and reduced side effects. The projects focus on breast and ovarian cancers, a hard-to-treat form of leukemia, and a 'master regulator' protein involved in many different cancers.
The study found that the MDGA1 protein modulates brain neural circuits and its mutation leads to over-excitation. Administering bazedoxifene restored normal behavior in male mice with autism-like behaviors.
A research team at DGIST has discovered a mechanism to treat dementia by regulating brain immune cells. Somatostatin, a neurotransmitter, prevents the overactivation of immune cells and restores their protective role in removing waste from the brain.
Researchers engineered pak choi with a chimeric protein targeting glycolytic enzymes to flavonoids biosynthesis, resulting in intensified sweet flavors. This breakthrough offers a blueprint for sustainable flavor improvement through metabolic engineering.
A study by IRB Barcelona researchers sheds light on the regulation of protein production in fatty liver cells, revealing a key role for CPEB4 in controlling gene expression. The findings provide new perspectives on the disease and its progression towards more severe forms.
Researchers at Insilico Medicine have developed novel small molecular inhibitors and extremely selective PROTACs targeting the serine/threonine kinase PKMYT1. The discovery utilizes noncovalent interactions to achieve selectivity, masking hydrogen-bond donors that negatively affect permeability and solubility.
Researchers at Bar-Ilan University have discovered that changing just one letter in DNA can completely alter sex development in mice. A single-letter insertion in a non-coding regulatory region caused XX mice to develop as males with testis and male genitalia.
The ACP's 2026 Internal Medicine Meeting will gather over 5,000 clinicians and experts to explore cutting-edge research and innovations in patient care. Keynote speaker Ashish K. Jha, MD, MPH, will discuss clinical leadership and trust in the age of information chaos.
Researchers have developed a novel all-optical method called laser optothermal nanobomb (LOTB) for efficient flattening of nanobubbles in 2D materials. The method leverages an optothermally induced phase transition and stress-pulling effect to remove gas from the bubbles, flattening the film without damaging its intrinsic properties.
Researchers have discovered high levels of forever chemicals like PFAS in Svalbard reindeer, while toxic metals such as cadmium and lead have shown a decrease. The study suggests that PFAS levels have skyrocketed over the past decade, with implications for human consumption of the animals.