A new international research collaboration has developed lay descriptions to visualize the global burden of disease caused by facial pain. Facial pain affects everyday activities like eating and speaking, and is often long-lasting.
Researchers suggest that dark matter may consist of multiple particles, whose behavior varies depending on the cosmic environment. This could explain why a signal observed at the center of our galaxy is not seen in dwarf galaxies.
The Paranal solar ESPRESSO Telescope (PoET) has made its first observations, aiming to understand how stellar activity affects the detection of exoplanets. PoET uses the Sun's light to analyze distant star spectra and remove 'noise' that can mask planetary signals.
A new study by the University of Eastern Finland highlights the challenges faced by older immigrants in Finland when seeking social and healthcare services. The study found that lack of language skills, incorrect diagnoses, and discriminatory practices hinder their access to employment and citizenship. Improving interpreter services, p...
Researchers at Osaka Metropolitan University discovered that dragonfly visual protein detects red light similarly to mammals. This finding has potential applications in medical fields relying on red light-sensing, such as optogenetics.
Soft robots could work as medical implants, deliver drugs inside the body, and explore dangerous environments. The researchers designed a reconfigurable robot that can move repeatedly without degradation, using targeted heating to control motion and embedded temperature sensors for closed-loop control.
A new paper warns that halting and reversing biodiversity loss by 2030 is urgent to avoid destabilizing the Earth's vital systems. The authors call for a unified 'Nature Positive' approach to global environmental goals and governance.
Nancy L. Lewis, MD, MBS, FACP, a renowned biomedical researcher and clinical trials expert, has been appointed as the new Chief Scientific Officer of the National Comprehensive Cancer Network (NCCN). She will oversee NCCN's programs to advance clinical trials and improve cancer care outcomes globally.
A new study reveals that two key BET proteins, BRD2 and BRD4, perform distinct roles in gene activation. Blocking both simultaneously disrupts the process, producing unpredictable effects. Targeted therapies may be more effective if they distinguish between these roles.
Researchers have discovered that native soil bacteria can degrade persistent pollutants like dioxins without genetic engineering. Using decoy molecules, the bacteria's natural enzymes are tricked into breaking down these toxic compounds.
Researchers generated a comprehensive view of DNA methylation abnormalities in human MDS HSCs, uncovering a novel TET2-GFI1 axis that suppresses malignant transformation. The study identifies key hematopoietic regulators and provides a panoramic view of DNA methylation disruption in MDS.
Experiment with 195 students in Germany found that local forest soundscapes had stronger positive effects on mental wellbeing, especially when participants felt familiar with the sounds. The study revealed that perceived animal diversity and familiarity played a significant role in triggering feelings of awe and restoration.
Researchers used theoretical modelling to explore graphene's interaction with TiO2, finding that defects lead to strong covalent bonds and hybridised electronic states. This enables efficient charge transfer and reduces electron-hole recombination, boosting photocatalytic performance.
A global study reveals treelines shift upslope in 42% of cases, retreating in 25%, due to complex interactions between temperature and human interventions like land use changes. Treeline dynamics also influenced by natural disturbances like fires.
Scientists at the University of Virginia Health System have developed a suite of AI-powered tools, called YuelDesign, YuelPocket and YuelBond, to transform how new drugs are created. These tools can design drug molecules tailored to fit their protein targets exactly, even accounting for protein flexibility.
Scientists have identified two non-coding genes as the cause of autoimmune neonatal diabetes in 19 children. The discovery sheds light on the importance of non-protein coding genes and their role in human disease.
Scientists at the University of Kent have found that madecassic acid inhibits the ability of antibiotic-resistant E. coli to grow, suggesting it could serve as an alternative antimicrobial. The study shows three modified variants of the compound effectively inhibited cytochrome bd and shut down bacterial growth.
Researchers propose a new framework for understanding microbiome health, focusing on the system's ability to reorganize in response to changing conditions. This shift helps explain inconsistent results of microbiome-based treatments, highlighting the importance of functional dynamics over static composition.
A new study reveals that the Madden–Julian Oscillation significantly influences climate conditions in Hawaiʻi, increasing rainfall on windward slopes during active phases and producing drier conditions during suppressed phases. Understanding this impact can help scientists and forecasters anticipate periods of heavy rainfall and drought.
Researchers found non-survivable conditions in six global heat events, exceeding previously defined wet-bulb temperature thresholds. Vulnerable groups face extreme risk of physiological heat stress unless access to shade or cooling is ensured.
Researchers have developed a novel doping approach inspired by the Maillard reaction, enhancing interphase chemistry and addressing multiple performance bottlenecks. The resulting hard carbon anode exhibits impressive reversible capacity and cycling stability, demonstrating strong potential for commercial applications.
Researchers at Pohang University of Science & Technology discovered a way to prime skin cells for regeneration before injury, enabling rapid and effective healing. This approach, called mosaic partial reprogramming, reshapes surrounding cells and tissue microenvironment to accelerate wound healing.
Researchers at KAIST InnoCORE successfully designed artificial proteins using AI to recognize specific compounds. The team developed an AI model that reflects protein-ligand interactions and designed binding proteins for six types of compounds, including metabolites and small-molecule drugs.
Researchers developed an innovative multi-host epidemiological model to study African swine fever (ASF) transmission between domestic pigs and wild boars. The model found that inter-farm transmission was the primary driver sustaining outbreaks, while nearby infected wild boar populations played a significant role in ASF spread.
A peanut mutant's embryo development failure is linked to AhZAR1, a receptor-like kinase essential for early embryogenesis. The AhZAR1 protein interacts with key signaling pathways, including auxin and brassinosteroid pathways.
A study of 1,200 musicians in five countries reveals the 'streaming paradox': while artists are more visible than ever, meaningful income remains elusive. Musicians face growing pressure to create engaging content and manage their online presence.
A recent UNH study reveals that New Hampshire ski industry professionals are increasingly concerned about climate change, with 85% expressing alarm or concern. The industry generates $278.8 million annually and supports over 10,000 jobs, highlighting the need for sustainable practices and advocacy.
Research published in Ethnicity & Disease found that self-employed Hispanic women report less high blood pressure, obesity, and poor health compared to their salaried counterparts. They were also more likely to exercise, with a nearly 11% higher rate of physical activity.
Researchers at ExCELLS/NIPS successfully determined the capsid structure of Melbournevirus at 4.4 Å resolution using cryo-EM. The study's 'block-based reconstruction method' improved resolution, revealing detailed arrangement of proteins constituting the massive capsid.
The Salk Institute will lead an ARPA-H-funded project to develop ultrasound-sensitive protein tools, wearable ultrasound delivery technology, and a translational path to the clinic for major unmet medical needs. The team aims to create a noninvasive therapy for conditions such as peripheral neuropathy.
Astronomers have identified a metal-poor star in the Large Magellanic Cloud, which is almost entirely hydrogen and helium with trace amounts of carbon and iron. Studying this low-mass star can help clarify our understanding of the first generation of stars, called Population III stars.
A new framework for brain-computer interfaces is proposed using single-neuron recordings, integrating clinical advances with existing technologies. The framework enables two closed-loop strategies: adaptive neural feedback systems and adaptive neuromodulation systems, facilitating the study of memory processing and concept cells.
Researchers have identified GSK3α as a common checkpoint controlling stem cell differentiation, maintaining self-renewal and preserving identities in various stem cell types. Inhibiting GSK3α demonstrates its fundamental role in regulating stem cell biology across developmental stages and species.
A new Northwestern University study confirms that US drug overdose deaths have continued to decline following a peak in August 2023, contrary to speculation of manipulated CDC data. The study highlights the importance of accurate data for public health response and calls for greater transparency in federal data systems.
Matei Zaharia's work on open-source systems like Apache Spark, Delta Lake, and MLflow has enabled large-scale machine learning, analytics, and AI at global scale. His innovations have made scalable computing accessible to researchers, nonprofits, and enterprises across every industry.
A recent study reveals that linker histone H1 binds to nucleosomes and creates a dynamic, flexible network that condenses chromatin. This new understanding suggests that chromatin behaves like a liquid-like 'glue' rather than a rigid structure.
A study published by the American Academy of Neurology found that a higher quality plant-based diet is associated with a lower risk of Alzheimer's disease and other dementias. Researchers compared participants based on their diet scores, finding that those who followed healthier plant-based diets had a lower risk of dementia.
The Department of Energy's Oak Ridge National Laboratory was recently awarded six Federal Lab Consortium awards for Technology Transfer Excellence. The awards recognize the successful transfer of technology from laboratory to industry, including a breakthrough suite of lithium extraction technologies that enable secure domestic supply.
A study of nearly 200,000 Amazon reviews reveals that the structure of online product reviews plays a crucial role in their helpfulness. The researchers identified nine possible structures of online reviews and found that different review structures are more or less helpful depending on how highly the reviewer has rated the product.
A new study from the University of Chicago suggests that smoking may be linked to dementia through a previously unmapped route between the lungs and brain, involving pulmonary neuroendocrine cells and exosomes that disrupt iron balance in neurons.
Researchers developed a nanophotonic platform to generate quantum optical Stokes skyrmion states with controlled topological invariant, eliminating the need for post-selection. This enables robust morphing of quantum information into free-space.
Scientists at NTU Singapore found that glycerol-3-phosphate acyltransferase (GPAT) amplifies α-synuclein toxicity by altering fat metabolism in brain cells. Targeting GPAT activity may offer a new strategy for treating Parkinson's disease.
Researchers are evaluating the state's domestic violence resources to better support survivors and prevent further abuse. Through a $257,384 grant, UCF faculty are analyzing data from various sources and surveying organizations that provide domestic violence services.
The Global Flourishing Study dataset, spanning two waves and 200,000 participants across 22 countries, is now publicly available. Researchers can access the data without pre-registration, expanding the study's impact on understanding human flourishing.
Researchers found that auxin's partner proteins serve as internal plant 'thermostats' that directly sense temperature and change genetic programs to direct root growth accordingly. This discovery could lead to engineering plants that withstand extreme temperatures, protecting crop productivity under challenging conditions.
A comprehensive review of artificial intelligence in steel modular structures' generative design reveals a shift from rule-based automation to integrated, data-driven solutions. The study proposes future directions for hybrid knowledge-data integration models and practical engineering deployment.
A study published in Cell Reports reveals a two-phase model explaining the origin of childhood B-ALL, involving hyperdiploidy and subsequent malignant transformation. Hyperdiploidy causes chromosomal instability, delaying cell differentiation and allowing rare clones to persist without triggering leukaemia.
Using new genetic markers, fruit breeders can predict flower sex type and seedlessness in muscadines and other grapes with high accuracy. The approach will save time and resources in developing new grape varieties, including the major challenge of creating flavorful seedless muscadines on self-pollinating vines.
Researchers at the University of Minnesota Medical School have developed a new method called PARTAGE that provides a clearer picture of how the genome is regulated and disrupted in diseases like cancer. The method allows for the measurement of three key features from the same sample: DNA duplication, genomic alterations, and gene activ...
Researchers developed a halide-perovskite metasurface strategy using dual quasi-bound states in the continuum (q-BICs) to overcome pump absorption and radiative efficiency limitations. The system achieved an external quantum efficiency of up to 98.8% and cooled materials from room temperature to -201 °C.
A recent genetic study analyzing DNA from 2 million people found that similar chunks of DNA are associated with both psychiatric disorders like depression and PTSD, as well as various physical ailments. This discovery could lead to more effective treatments that address both mental and physical health.
Researchers developed a flexible optical fiber that can be steered into the larynx to destroy hard-to-reach tumors, expanding outpatient laser treatment options. The device successfully reached 81% of targets in tests with a 3D-printed replica of a human larynx.
The Chancellor’s Innovation Fund Awards support cutting-edge research and development projects across various fields. Faculty recipients will use the funding to refine their technologies, build prototypes, and assess market opportunities. The awards aim to bridge publicly funded academic research with private financing, fostering entre...
A new enzyme from a fungus cultivated in sugarcane bagasse or wheat bran can promote cellulose pulp bleaching. The xylanase facilitates the removal of xylan fractions associated with residual lignin, increasing brightness and efficiency in subsequent stages of pulp processing. This non-toxic alternative reduces chemical load and has gr...
A 289-million-year-old mummified reptile has provided scientists with a unique window into the evolution of breathing and movement in ancient reptiles. The study found that the reptile's respiratory system is similar to that of modern reptiles, birds, and mammals, suggesting an efficient mechanism for respiration.
A new study found that targeted, case-based learning improved provider confidence and identified critical unmet educational needs in menopause care. Clinicians reported high satisfaction with the program and noted anticipated changes in clinical practice, such as increased comfort initiating treatment.
Researchers found that blocking clusterin, a molecule linked to stress and tumor growth, slows tumor growth signals and makes the cancer more responsive to cisplatin. The study's findings offer a possible strategy for treating cervical gastric-type adenocarcinoma, one of the most aggressive non-HPV associated cervical adenocarcinomas.
A national Canadian study found that older adults who are socially connected, physically healthy, and spiritually engaged are significantly more likely to experience complete mental health. Social support emerged as one of the strongest predictors, doubling the odds of achieving complete mental health.
Researchers are diversifying CAR therapy to overcome limitations, exploring engineered cell platforms like NK cells, γδ T cells, and macrophages. This expansion could treat a broader range of diseases, including lupus, infection, cardiac fibrosis, and senescence-related disorders.
A study reveals improved quality of mammal species descriptions from temperate regions, with authors from wealthy countries using more advanced techniques. The study, supported by FAPESP, analyzed 1,116 new species descriptions between 1990 and 2025.