Researchers have identified a promising drug to treat neurodegenerative conditions, including Alzheimer's disease and traumatic brain injury. The study found that inhibition of an enzyme called 15-PGDH was potently neuroprotective by restraining the production of reactive oxygen species that damage the brain.
The iMETRO Dynamic Simulation is an open-source platform that enables researchers to develop and test robotic systems for future space missions. By leveraging a digital twin of the NASA iMETRO facility, scientists can remotely create and test new robotic software and validate its performance with various hardware configurations.
A team of researchers has developed a new method for finding effective tuberculosis drugs by leveraging the PAC-MAN technique and artificial intelligence. The approach uses machine learning models to predict which chemical compounds can penetrate the outer membrane of the bacteria, paving the way for more efficient drug discovery.
A new PNAS special feature showcases the critical role of behavioral and decision sciences in U.S. governance, highlighting how psychological and economic research protect public health, consumer rights, and finances across federal agencies. The research demonstrates how 'invisible' scientific frameworks streamline medical drug reviews...
Climate-related damages could further weaken Italy's already fragile economic growth and worsen debt sustainability, with potential losses of up to 15% by the end of the century. The study highlights the need for mitigation and adaptation measures to protect economic growth and financial stability.
Researchers identified 17 additional regions of the brain that appear to play a role in language, including parts of the cerebellum and hippocampus. These regions make up about 5 percent of the total volume of the adult brain and contribute to language processing despite being distant from traditional language centers.
A study published in Proceedings of the National Academy of Sciences found that bumblebees display observable 'liking and disliking' behaviours after consuming different liquids. This suggests that insects can evaluate tastes as pleasant or unpleasant, pushing the understanding of their inner life.
Ochsner MD Anderson Cancer Center has earned two accreditations from the American College of Surgeons (ACS) Commission on Cancer and National Accreditation Program for Breast Centers. The center's multidisciplinary approach brings together specialists in cancer disciplines to support patients with complex needs. Additionally, Ochsner M...
Researchers will study blood samples and environmental exposures over 10 years to identify genetic, environmental, and cellular factors contributing to autoimmune diseases. The goal is to develop prevention strategies and treatments by understanding the earliest biological triggers of SARDs.
Scientists at La Jolla Institute for Immunology and Scripps Research have developed an HIV vaccine that trains immune cells to see past HIV's defenses. The vaccine resulted in the best HIV-fighting antibody response ever seen in primates, with human trials now underway.
Researchers discovered evidence of cultural exchange between Neanderthals and modern humans at Üçağızlı II Cave, including shared use of non-utilitarian materials like marine seashells. The findings suggest a deep level of interaction between the two species.
The US FDA has approved a new therapy regimen for patients with 'double-positive' metastatic breast cancer based on the PATINA study. The addition of palbociclib to standard therapy resulted in a more than 15-month improvement in progression-free survival.
A new AI-based tool identifies hundreds of molecular signals associated with thrombosis and improves the characterization of people with different risk profiles. By integrating clinical, genetic, and transcriptomic information, researchers can more accurately describe individuals with varying levels of risk.
A genetic analysis of Peruvian cacao trees reveals four previously unidentified groups, showcasing unique regional 'signatures' and potential high-quality bean producers. The discovery provides valuable resources for conservation and the fine flavor chocolate market.
A new study by Lawson Research Institute found that sacred moments, defined as short experiences of deep connection, contribute to well-being in healthcare settings. These moments are associated with improved emotional health, reduced burnout among clinicians, and enhanced patient care.
Dr. Bradley A. Maron, a renowned clinical cardiologist and researcher, takes the helm as editor-in-chief of Circulation, shaping the journal's editorial direction and commitment to practice-changing science. He aims to reinvigorate cardiovascular science and medicine published in Circulation with additional transparency.
A new study finds that public specialized gambling addiction treatment services are underutilized in Quebec, with patients averaging fewer than two treatments over 13 years. Researchers emphasize the need for sustained, long-term care to address this chronic condition, comparable to substance-related disorders.
Researchers found minor cardiac dysfunction can predict microscopic tissue degradation in brain regions associated with Alzheimer's disease, leading to poor long-term memory performance.
Scientists have discovered a way to control the disassembly of supramolecular cages using ultrasound, opening up new possibilities for drug delivery systems. The researchers used machine learning simulations to optimize their findings, revealing the forces needed to break individual bonds within the cages.
Sofia Doello will investigate how microorganisms reactivate their metabolism after prolonged dormancy using the prestigious Emmy Noether grant. Her project aims to uncover fundamental principles of survival and cell regeneration in bacteria.
Researchers at the University of Bristol have discovered a method to supercharge soft robots and wearable technology by harnessing the surface tension of a tiny liquid metal droplet. This breakthrough enables the creation of more powerful devices with reduced complexity, benefiting rehabilitation patients and biomedical technologies.
A new study found that prenatal oestrogen levels in mothers are positively related to their newborn's head circumference. The researchers also discovered that this influence is stronger for boys than girls, shedding light on the evolutionary drive for larger brains in humans.
Researchers at UCI and Mass General Brigham-affiliated McLean Hospital found that using biological and behavioral markers to guide antidepressant treatment selection boosted response rates by nearly 67 percent. The study suggests a new era of personalized depression treatment, where objective data helps guide treatment decisions.
A new winged composite pile system can enhance uplift resistance while reusing excavated soil, reducing off-site transport and minimizing waste. The study found that the optimal wing diameter varies with pile length, and shaft diameter has little effect on uplift resistance.
Researchers at McMaster University have identified a biological pathway that may explain why some people experience muscle pain and weakness when taking statin cholesterol medication. This mechanism drives statin-induced muscle damage, challenging longstanding assumptions about how side-effects develop.
Researchers found that wood frogs' adaptation to salty water increases their vulnerability to ranavirus, a common and fatal disease. The study highlights the hidden costs of survival in wildlife under environmental stress.
A new study links tire pollution to Alzheimer's disease through the exposure to 6PPD-quinone, a chemical formed from shaved-off tire particles. The researchers used computational methods to identify key genes that predict Alzheimer's disease and found strong binding of 6PPD-quinone to these genes.
Researchers have discovered that young sea stars' hollow tube develops into their later organs, similar to human embryonic development. By comparing the development of hydro-vascular organs across different species, scientists hope to better understand how organs form and maintain their shape.
Researchers at TUM developed a soft, pneumatic glove that uses electrical signals to predict when a person intends to grasp an object. The glove enables people with severe impairments to regain the ability to hold objects, showing promising results for ALS and stroke survivors.
Researchers have identified a molecular signaling pathway that contributes to the development of life-threatening aortic aneurysms and dissections in Marfan syndrome. The findings suggest extracellular matrix changes trigger vascular dysfunction and point to potential therapeutic targets.
Researchers propose a new classification method for end-to-end congestion control protocols in datacenters. The DCEF framework categorizes classic protocols from 2010 to 2022, evaluating their performance, convergence and deployability with the emergence of SmartNICs.
Healthcare-associated transmission of Andes virus is uncommon but can occur when infection is not recognized early or protective measures are delayed, research suggests. Implementing transmission-based precautions at earliest stages of infection can prevent transmission in healthcare settings.
A new study suggests that following a Mediterranean diet may provide additional benefits for mental health, particularly among older adults. The research found that individuals with greater adherence to the Mediterranean diet had less decline in emotional well-being during the COVID-19 pandemic.
A new study in Clinica Chimica Acta reviews the literature on novel liquid biomarkers for early detection, diagnosis, and treatment of colorectal cancer. The findings highlight their strong promise in addressing key limitations associated with traditional screening approaches, such as colonoscopy and fecal-based tests.
Scintillation detectors rely on efficient light collection, and researchers provide a system-level roadmap to improve this efficiency. Key strategies include optimizing crystal geometry, surface treatment, reflectors, optical coupling, photodetector matching, and AI-assisted optimization.
The University of Texas at Dallas is leading a new National Network for Microelectronics Education South Regional Node to build a workforce with the knowledge, skills and abilities that employers need. The initiative aims to address the growing demand for expertise in advanced manufacturing, particularly in technician positions.
The DFG strongly criticized the AfD's research policy, calling it incompatible with the constitution. The organization emphasized the importance of free and independent pursuit of knowledge for an open society and democracy. The DFG also discussed its funding activities and new developments since the 2025 General Assembly.
Researchers create tiny swimmers to deliver drugs through the human body, finding they reverse direction in non-Newtonian fluids like mucus and blood. This discovery enhances understanding of fluid behavior and could lead to targeted drug delivery.
A rare benign kidney tumor, renal oncocytoma, is diagnosed through biopsy and histopathology, guiding individualized treatment decisions. Minimally invasive approaches like percutaneous cryoablation provide effective disease control while preserving kidney function.
A new study reveals that microplastics in the air can trap heat, making them a previously unknown contributor to climate change. Researchers found that colored microplastics absorb roughly 16% as much heat as black carbon, with an effect equivalent to running 200 coal-fired power plants annually.
The collaboration aims to develop AI-powered ground systems that can assist operators with routine satellite operations, mission scheduling, and data analysis. The partnership seeks to automate routine tasks with human oversight, enabling more efficient management of larger satellite fleets.
A non-invasive brush biopsy test has been validated for accurate oral cancer detection within one hour, potentially sparing over 90% of low-risk patients from unnecessary invasive procedures. The test's performance is comparable to a microbiopsy-based assay, making it a game-changer in oral cancer diagnosis and treatment.
A new study reveals IL-6 plays a crucial role in regulating neuroinflammation and protecting the nigrostriatal pathway in Parkinson's disease. The research found that restoring IL-6 levels can reverse aggravated pathology and partially ameliorate motor dysfunction in mice.
Researchers developed a physics-informed neural network approach to predict material properties and optimize controlled-release systems. The new method requires significantly less data than traditional AI models, slashing development time for patches, bandages, and implants.
Researchers developed SST-MedChain, a patient-centric framework for secure electronic medical record sharing on permissioned blockchains. The system uses non-interactive delegation, one-time access tokens, and policy-bounded re-delegation to reduce costly on-chain authorization while preserving traceability and revocation.
Researchers have identified high rates of overweight/obesity (82%) and hypertension (higher than statewide average) in Franklin Parish, with income levels linked to lower hypertension rates. Older residents are also more likely to have undiagnosed high cholesterol and diabetes.
Researchers from Tohoku University and IIT Indore developed a sulfide-templated Cu nanocluster that selectively produces methanol from CO₂ under mild conditions. This breakthrough enables precise modulation of the copper valence state in nanoclusters, unlocking cleaner and more efficient pathways for converting CO₂ into valuable fuels.
Researchers are designing molecules that mimic natural sugar structures to block viral binding proteins, preventing cell infection. Broadly effective therapies against multiple viruses, including influenza and coronaviruses, aim to be developed using this innovative platform.
A new AI model predicts job salaries with high accuracy by identifying key skill combinations that significantly impact compensation. The model offers transparent salary predictions, revealing the monetary value of specific skills, and provides market insights on skill premiums across industries.
Researchers at TU Wien have developed a new practical method to estimate the actual expected lifetime of electronic components using novel materials. This approach allows for reliable and rapid lifetime prediction, helping industry identify the right materials and manufacturing techniques more quickly and with greater confidence.
Research from the University of Georgia found that adverse childhood experiences can negatively impact romantic relationships, leading to lower relationship satisfaction. Couples who struggle with everyday interactions and communication may be more likely to experience depression, anxiety, and loneliness in adulthood.
Researchers from Tohoku University developed a molecularly designed COF-graphene interlayer to mitigate polysulfide shuttling in Li-S batteries. The TUS-44@G layer delivered high reversible capacity, excellent rate capability, and long-term durability.
A comprehensive systematic review clarifies life expectancy across rare progeria disorders, revealing striking differences among subtypes. The analysis demonstrates that patients with Hutchinson-Gilford progeria syndrome have a median survival of 16 years, while those with mandibuloacral dysplasia type B have a median survival of 37 ye...
Research on Malaysia's Shah Alam Expressway found that accidents cluster at specific locations, particularly toll plaza areas and interchanges, and that vehicle type is a critical factor in determining crash severity. The study recommends targeted engineering improvements and vehicle-specific safety policies to address these issues.
The study reveals that early-age concrete's reduction in strength originates from the irreversible loss of cohesive strength, while frictional effects become dominant as damage develops. This new experimental method separates cohesive and frictional contributions, providing a clearer way to understand early-age concrete's behavior.
The American Journal of Occupational Therapy (AJOT) will move to the Sage Journals digital platform, strengthening reader experience and expanding visibility of occupational therapy scholarship. AJOT's mission remains unchanged, publishing peer-reviewed research supporting practitioners, educators, students, and researchers.
Researchers developed a new method to prepare pseudopregnant mouse recipients by utilizing nonestrous female mice. This approach minimizes the number of stock animals needed, optimizing facility space and supporting the 3Rs principles in laboratory animal care.
Ferroelectric memristors overcome computing hardware bottlenecks by processing data directly where it's stored. This enables significant reductions in data transfer overhead and improvements in computing efficiency.
Researchers at Ann & Robert H. Lurie Children's Hospital of Chicago identified a subtype of eosinophilic esophagitis associated with hypermobile joints and autonomic symptoms, including chronic light-headedness. Simple treatments for these symptoms can significantly improve quality of life in affected children.
Researchers have developed micro-flowers that focus applied magnetic fields into central regions, increasing local field strength and enabling imaging of previously inaccessible systems. This innovation expands the range of applications for nanoscale magnetic microscopy, including spintronics and nanometric materials.