Researchers developed an innovative hydrogel called Amniogel to support insulin-producing cells after transplantation, achieving normal blood sugar levels in diabetic mice for at least 100 days. This breakthrough opens the door to developing a bioartificial pancreas that could eliminate the need for insulin injections.
Researchers have developed a potent and selective small-molecule inverse agonist targeting the itch receptor MRGPRX4, providing a new strategy for treating cholestatic itch. The compound HEP-50768 showed efficacy in animal studies and demonstrated good drug-like properties and safety profiles.
Researchers from the University of Tokyo developed SplashTune, a gamified rainfall–runoff model that simulates water movement and environmental effects on river flow. The interactive tool improves students' self-reported understanding of complex flood processes, including soil moisture and land use impact.
Researchers identified 27 established patterns of corporate capture, including narrative capture and elusion of law, in news stories around global AI events. Big AI companies use tactics like deregulation and revolving doors to undermine regulation and enforcement.
A new study from UC San Diego found that poorer sleep quality is associated with greater memory difficulties and more Alzheimer's-related brain changes in older women with a higher genetic risk. The study suggests that improving sleep could become a target for future Alzheimer's prevention strategies.
A systematic review and meta-analysis found that creatine supplementation does not significantly reduce inflammatory markers in the body. Despite its ergogenic effects on physical performance, creatine's anti-inflammatory properties are limited to specific contexts, such as intense exercise.
Researchers discovered that mezigdomide can reinvigorate exhausted T cells and enhance immunotherapies. The drug works by degrading key gene regulators Ikaros and Aiolos, which sustain genetic and epigenetic programs keeping T cells in an exhausted state.
The resonant trident process is theoretically studied for ultrarelativistic electrons and positrons in a strong circularly polarized wave. The study reveals two characteristic quantum energies, Compton effect energy and Breit-Wheeler energy, which determine the probability of a resonant process.
A post hoc analysis of a randomized clinical trial found high-dose vitamin D3 supplementation in pregnancy to be positively associated with visual memory, verbal memory, and flexibility among offspring at age 10. This strengthens evidence on the association between prenatal vitamin D exposure and childhood cognition.
KAIST researchers have identified a neural circuit that switches between past and recent memories, allowing the brain to select necessary information. The study suggests that specific brain rhythms and states are crucial for effective memory retrieval, with longer online states leading to better recall of recent memories.
A new study highlights how green product innovation and digital marketing strategies are essential for strengthening sustainable marketing performance among Generation Z consumers. Green brand image plays a critical mediating role between eco-innovation, digital strategy, and sustainable marketing outcomes.
Researchers analyzed brain tissue from MSA patients and found that the immune cells known as microglia appear to be exhausted or dysfunctional in later stages of the disease. The study suggests that an overactive immune system may contribute to the development of MSA, providing a potential target for future treatment.
A reanalysis of 14 years of Hubble data suggests that Europa's water vapor plumes may not exist as previously thought. The study, led by SwRI scientists, found reduced confidence in the original findings, and improved information on neutral hydrogen atom emissions from Europa's surface.
Researchers developed an oral spray using polyphenols from molasses to neutralize dog breath and harmful bacteria. The spray reduced odor-producing compounds and pathogenic bacteria in dogs' mouths after a single application.
A common genetic alteration in prostate cancers enables tumors to bypass dependence on male hormones and instead rely on cortisol, leading to treatment resistance. Combination therapy targeting both androgen signaling and cortisol activity can suppress tumor growth and extend survival.
Researchers at Mizzou's Molecular Imaging and Theranostics Center developed an automated approach to producing the prostate cancer treatment. The new method produces CTT1403 in just 38 minutes, compared to six hours with traditional methods, using a commercially available automated synthesis system.
The journal MedScience aims to integrate cutting-edge insights across medical sciences, focusing on emerging fields like cell therapy, AI-driven drug discovery, and precision medicine. This new platform serves as a dynamic hub for international academic exchange and translation of scientific breakthroughs into clinical practice.
A University of East London academic has published a book exploring how businesses can use AI, blockchain, and data analytics to become more adaptable and innovative. The publication argues that digital transformation is about people, strategy, and responsible leadership, not just technology.
A new study found that increased immigration enforcement by ICE led to significant declines in employment among immigrant women in regulated childcare settings, with a shift towards private household childcare. This may negatively impact childcare quality and stability, as well as labor markets for lower- and middle-income parents.
Aqueous zinc-ion batteries face complex interfacial challenges due to dendrite growth, parasitic hydrogen evolution, corrosion, and SEI instability. Advanced characterization techniques reveal chemical composition, solvation structures, and SEI evolution at buried interfaces.
A new study found that AI-induced job insecurity significantly increases employee burnout in emerging economies, but psychological safety and confidence in working with AI systems can buffer workers from negative emotional impacts.
A global study led by George Mason University found that balanced energy and protein supplements improve birth weights and reduce high-risk newborns in low- and middle-income countries. The research adds to the evidence that improving maternal nutrition during pregnancy may be a key intervention to improve birth outcomes.
A case-control study found that amateur-level soccer heading is associated with increased blood biomarkers of neural damage, including dose-response relationships. The findings suggest that even low-impact heading may acutely affect neural integrity.
A research study, COACH trial, is testing different ways to help children and families improve their health through lifestyle changes delivered by primary care clinics. The study aims to assess the effectiveness of personalized nutrition counseling, community resources, and online interactive lessons on weight management.
Researchers at Arizona State University measured air temperatures downwind and upwind of data centers in Phoenix, finding a significant impact on surrounding neighborhoods. Temperatures downwind averaged 1.3-1.6 degrees warmer than upwind, with detectable effects up to five city blocks away.
International experts in laboratory medicine, osteoporosis, and chronic kidney disease recommend ending routine reporting of albumin-adjusted ('corrected') calcium. The practice may misclassify patients and compromise care due to unreliable correction formulas and variability in local measurements.
A Peking University study found that population ageing, not just air pollution, contributes to rising dementia deaths in China. Lower PM2.5 levels have brought health benefits, but the rapid growth of China's older population offsets progress.
Surgical patients with mental health and/or substance use disorders who receive music therapy have a 41.8% longer length of stay compared to those without music therapy. They also exhibit increased resource-intensive admissions, anxiety, trauma/stress-related disorders, and heart failure.
Physicist Jun Ye proposes building a highly stable laser inside permanently shadowed lunar craters, leveraging their extremely low vibrations and temperature to achieve unparalleled precision. This could form the backbone of a lunar time scale, GPS-like navigation, and space-based optical atomic clocks.
Researchers developed a new tool to track ancient climate from wetland sediments, revealing turbulent environmental past in the Mediterranean. People adapted creatively, developing new technologies and strategies, such as floodwater farming and herd animal management.
A new study presents dual immunization against respiratory syncytial virus (RSV) using RSVpreF and nirsevimab, showing reduced hospitalizations among infants in France. The study found that this combined approach demonstrates potential for enhanced RSV prevention and protection
Researchers studied how hibernation affects the visual brain of squirrels, finding that certain neurons undergo quick structural changes during deep sleep and arousal stages. These changes reverse within hours after waking and have no lasting effects on neuron structure six months after hibernation.
High-altitude exposure disrupts the gut ecosystem, leading to dysbiosis, impaired barrier function, and increased intestinal permeability. The gut microbiome influences host energy metabolism, immune responses, and acclimatization capacity, and alterations are linked to diseases such as metabolic disorders and colorectal cancer.
Stefan Isaac will investigate mitochondrial DNA packaging and gene expression using novel sequencing-based assays. He aims to understand the fundamental mechanisms of mitochondrial energy production and how cells regulate this process.
A long-term study of patients treated with flow diversion devices (FDDs) for intracranial aneurysms revealed excellent safety profiles, with no significant differences in outcomes between various FDD platforms. The study found that multiple FDDs were associated with a higher risk of insufficient closure and delayed complications.
A new study shows that an AI-powered CPR coaching agent can significantly improve survival rates by providing more accurate and comprehensive instructions. ChatCPR scored 100% on guideline-based CPR checklists and outperformed human dispatchers in guiding bystander resuscitation, with a 36-point gap in advanced steps.
A study found that school anthems referencing local mountains, such as Mt. Takao, correlate with the use of nearby green spaces for educational activities. This suggests a potential link between symbolic cultural representations and concrete actions in nature-related education.
Researchers discovered that stem cells can mature into potent antimicrobial cells when infected with bacteria, sacrificing their own lifespan to prevent prolonged infection and promote tissue repair. This newfound mechanism may hold potential for understanding inflammatory diseases like Crohn's disease.
A Rutgers-led study offers a hopeful twist on the classic game theory problem, suggesting that cooperation can emerge naturally without special rules or genetic ties. By keeping track of opponents, individuals can react in the same way, leading to cooperation's emergence as an emergent property.
The study demonstrates a rational precursor design principle for heavy-pnictogen-based III–V nanocrystals, enabling safer and more scalable semiconductor quantum dot synthesis. Metal-amide species play a central role in controlling the reduction of heavy-pnictogen precursors.
A new report by Frontier Economics reveals that EMBL-EBI's open data resources support growing numbers of scientists and innovators worldwide, driving £11.8 billion in annual productivity gains. The report highlights the critical role of these resources in enabling breakthroughs across science, medicine, and biotechnology.
Tomas Grejtak has been selected for the Early Career Award from the Society of Tribologists and Lubrication Engineers (STLE) for his research on wear, friction, and material deformation. The award recognizes his contributions to advancing the field of tribology and improving machine efficiency.
A study published in PNAS found that faster decision-making in complex strategic situations leads to better outcomes. Researchers analyzed professional chess games, correlating speed with quality and suggesting intuition plays a key role in human decision-making.
Researchers found that personalized, engagement-based ranking algorithms lead to polarized and less accurate beliefs, while bridging-based and intelligence-based ranking algorithms promote consensus and accuracy. Alternative algorithms could help social media platforms support more positive values.
Researchers at Northwestern University and NIH emphasize the need to define plagiarism in AI-assisted research writing, as intellectual theft can occur without proper credit. The commentary recommends revising definitions of research misconduct to include GenAI tool misuse, promoting more responsible use.
After Dobbs v Jackson, US abortion management shifted towards expectant approaches in ban states, with persistent reliance on suboptimal misoprostol-only regimens. State-level abortion bans were associated with a decrease in management options for individuals with spontaneous abortion in ban states.
New research from North Carolina State University predicts data center power demand will increase by up to 57% by 2030, leading to higher electricity costs and CO2 emissions. The study finds that regional price increases will vary depending on where new data centers are built.
Researchers discovered that disrupted PTH1R signaling drives abnormal cementum growth and tooth-bone fusion in adult mice, leading to severe dental complications. The study identified the loss of PTH1R signaling as a critical molecular safeguard against excessive cementum formation.
In this study, researchers investigate the photocurrent response of a bilayer atomically thin antiferromagnet, discovering a finite current generated by illumination even without applied voltage. The direction of the photocurrent reverses between two antiferromagnetic states, directly reflecting the material's magnetic configuration.
Scientists at Kaunas University of Technology discovered that low-frequency ultrasound can dissociate erythrocyte aggregates into single cells, decreasing blood viscosity. This effect may improve oxygen exchange and support treatment of cardiovascular diseases, Alzheimer's disease, and diabetes.
Scientists have identified novel peptides in carpenter ant venom that contribute to the ants' hygiene and provide an external immune defense against pathogens. The findings, published in Science Advances, offer new avenues for medical drug discovery and understanding of insect community health.
A new study by University of Nottingham researchers explores the impact of positive emotions on climate creativity and behavior. The study found that inspiring hope can lead to increased levels of creative problem-solving around sustainability and climate change.
TEGNet accelerates optimization in thermoelectric generator design by predicting performance with high accuracy and speed. The AI model enables designers to freely combine independent models for various materials, enabling complex structure exploration and high conversion efficiencies.
A systematic review by 16 leading researchers at Rutgers University and other institutions highlights recurring problems in studies of infection-associated chronic illnesses, including the failure to prove participants have the relevant pathogen. The authors propose a framework for rigorous study design to confirm diagnoses, choose com...
A new study reveals how ancient galactic collisions can destroy stellar discs, affecting star formation and galaxy structure. Simulations show that rotating discs often formed earlier than thought but can be partially or completely destroyed by major mergers.
Researchers at TU Wien have shown that water molecules' structures impact charged particles in electrochemistry. The team found that ions with stronger effects on surrounding water create more order, leading to lower entropy and reduced attachment to surfaces.
Researchers at the University of Toronto and the University of Ottawa have discovered large volumes of natural hydrogen in the Canadian Shield, which could provide a domestic source of cost-effective energy. The study suggests that harnessing this resource could reduce greenhouse gas emissions and support local industry hubs.
Osaka Metropolitan University researchers developed a light-driven method to rapidly collect microscopic targets, outperforming traditional techniques. The technique concentrates bacteria between 1000-10,000 times faster than existing approaches, paving the way for early disease detection and analysis of nanoparticles.
A recent study reveals that nearly one in three adolescents with cannabis use disorder (CUD) experience treatment delays, highlighting the need for system-level improvements. Younger adolescents, males, White non-Hispanic youth, and those in residential rehabilitation and outpatient settings are particularly at risk.
Researchers at Brown University found that payments to Medicare Advantage brokers more than doubled between 2014 and 2022, rising from $3.9 billion to roughly $10 billion a year. The study also revealed that broker involvement is common and growing, with 70% of Medicare Advantage beneficiaries generating renewal commissions.