Researchers propose targeting the PGAM1-Chk1 interaction to stabilize HIF-2alpha and support senescent cell survival. Preclinical studies suggest the compound Nutlin 3b selectively removes senescent cells with improved safety profiles in aged mice models.
Researchers at Helmholtz Munich have identified a tumor protein called ADAMTSL4 as a key driver of cancer cachexia, a wasting process that affects muscle and fat tissue. The protein locally activates the TGF-β signaling pathway, triggering a catabolic program that promotes muscle and fat breakdown.
A new high-throughput tool developed by Stanford University scientists can detect small changes in protein levels within cells, enabling faster and more efficient drug discovery. By amplifying these changes, researchers can identify potential therapeutic targets for diseases like cancer, potentially leading to breakthroughs in treatment.
A new atlas of the brain’s striatum has identified 31 subgroups of neurons, including those involved in addiction, depression, and schizophrenia. The atlas may help scientists develop new drugs to combat these conditions, particularly by targeting specific cell populations affected by Huntington’s disease.
A cohort study found that only 30.7% of brain donors with clinician-adjudicated dementia had neurodegenerative death certification. The study suggests factors like worsening cognitive symptoms and functional impairment may be associated with increased likelihood of neurodegenerative death certification.
A study suggests that protein build-up in tumours may affect how well cancer drugs like PROTAC work. PROTACs are more effective at removing proteins that accumulate due to poor breakdown, not just those produced in excess.
A research team has developed a reliable and economical method for studying proteins with sugar molecules attached to them in blood and tissue samples. The method uses commercially available magnetic particles and has the potential to aid in disease diagnosis and treatment.
Scientists introduce a second methyl group into the A-site cation of a perovskite framework, creating a one-dimensional chain structure with enhanced thermal stability. The material's structural flexibility promotes interchain energy dissipation, but reduces impact resistance.
Mara Mather's research focuses on the interplay between brain, body, and emotions, exploring how changes in the autonomic nervous system affect brain health across the lifespan. Her work aims to understand the consequences of physiological changes on brain health and develop interventions to promote emotional well-being.
Researchers developed a post-combustion reaction model for aluminum in thermobaric effects field, revealing the importance of balancing oxidizer-driven early combustion and oxygen-assisted afterburning. The model predicts that controlling this balance is key to understanding thermobaric formulation performance.
Researchers developed protein-coated CuS nanoparticles with excellent colloidal stability, pH-responsive behavior, and effective near-infrared-induced killing of breast cancer cells. The protein coating improved biocompatibility and reduced dark toxicity.
Researchers developed a new method for tracking moving targets using single-photon LiDAR, overcoming the motion-induced temporal-averaging bias. The method, P3DTT, exploits spatiotemporal correlations to identify and use photon events, recovering the target's instantaneous 3D position.
This collection features cutting-edge supramolecular hydrogel research, including applications for antibacterial therapy and diabetic wound treatment. Versatile materials are designed for biomedical use, offering potential solutions for various medical conditions.
A new drug patch is being developed to promote the repair of damaged myelin sheaths in multiple sclerosis patients. The patch, which delivers a low dose of theophylline, is being tested in a Phase I clinical trial for its safety and tolerability.
Researchers at Hokkaido University found that dopamine signaling in the brain's striatum region enables animals to adapt to threats by shifting their focus towards rewards. After repeated exposure, dopamine activity decreases, allowing attention to shift towards opportunities for learning and reward-seeking behavior.
A new MS therapy uses peptide-coupled red blood cells to redirect the immune response, potentially stopping the disease without suppressing the immune system. The clinical trial shows promising results, with the therapy showing good tolerability and safety.
Researchers have discovered that smaller bee species, such as bumblebees and solitary bees, possess sharper eyesight than previously believed. They can detect objects with higher visual resolution and fine detail than worker honey bees. This finding challenges the long-held assumption that large eyes are the key to sharp vision in bees.
A new programmable silicon photonic neuron enables directional control, addressing a longstanding challenge in photonic neurons. The device can control directionality, feedback and back-action between interconnected components, opening a path toward more adaptable neuromorphic computing systems.
Researchers develop field-calibrated design correlations for large-diameter bored piles in layered ground, improving reliability in shaft resistance prediction. The study evaluates shaft resistance layer by layer, delivering crucial insights for detailed foundation design in soil-rock transition environments.
A large, long-term study of 140 patients with Kikuchi-Fujimoto disease found that ANA positivity is common but transient, with minimal risk of progression to lupus or other connective tissue diseases. The study's findings provide reassuring evidence that patients with KFD can be reassured of their excellent prognosis.
A recent study identified three distinct BMI trajectories among people with type 2 diabetes, with stable, increasing, and decreasing trajectories associated with different comorbidities and healthcare service use. Increasing BMI was linked to a clustering of chronic diseases, while weight loss was not always indicative of better health...
A new study highlights biological sex-driven disparities in pneumonia management, including underrepresentation in diagnostic tests and antibiotic underexposure for women. The study advocates for tailoring antimicrobial therapy more precisely and integrating sex- and gender-aware research protocols to reduce inequities.
Researchers found associations between gut microbiome and brain chemistry in specific brain regions, including GABA and glutamate levels. The study suggests a regionally specific picture of the gut-brain axis, with different microbial pathways linked to different brain regions and psychological wellbeing.
The authors propose a spectrum of clinical autonomy, ranging from advisory tools to navigator systems that work with minimal human oversight, to enable early prediction and prevention of disease. However, challenges related to clinical validation, integration, data quality, and regulatory approval limit widespread deployment.
Researchers at Tsinghua University have developed microwave catalytic systems for the conversion of waste plastics into high-value chemicals. The technology achieves efficient and rapid conversion of various types of plastics, including polyesters, polyolefins, and others, with high yields and selectivity. The study highlights the pote...
Researchers have successfully synthesized novel MAX ceramics with V solubility threshold, achieving 35% hardness and 5% toughness gains. The team's findings establish a clear route to property optimization via site-selective solid solution.
A graded recycling framework for real-world waste plastics aims to maximize carbon retention and improve recycling efficiency. The framework organizes mechanical recycling, chemical reconstruction, gasification, and biological upgrading as complementary strategies.
HHMI is launching five new competitions to support scientists across various career stages, including PhD students, postdoctoral researchers, and early-career faculty. The competitions will provide significant funding and support to help talented researchers advance their work and pursue ambitious ideas.
Researchers developed a rapid-heating furnace to test oxidation resistance of diboride ceramics at 2300 ℃. The Ti-containing composition exhibited superior oxidation resistance, with a dense outer layer and porous inner layer that buffered thermal stress accumulation.
Researchers at Guizhou University developed a lead-free ceramic material with near-zero strain hysteresis by introducing Sb³⁺ at the B-site and creating high-activity glassy polar nanoregions. The material exhibits a nearly linear strain loop under positive electric fields, demonstrating its potential for actuator applications.
Researchers developed a new screening strategy for low-conductivity rare-earth tantalates to improve thermal-barrier coating design. The new approach, which considers mean sound velocity and unit-cell volume, reveals a composition with lower lattice thermal conductivity at x = 0.8, contrary to the conventional point-defect parameter.
Researchers at the LUX-ZEPLIN (LZ) experiment have recorded a single particle interaction that is difficult to explain with known background signals from normal matter. This finding, although not yet conclusive, is the most compelling hint of dark matter reported by the experiment to date.
Scientists have developed a novel multiscale ceramic aerogel structure for thermal protection and EMW absorption, exhibiting ultralow density and exceptional thermal insulation. The aerogel demonstrated outstanding thermal shielding and
Children's Hospital Colorado has launched a Sublingual Immunotherapy Program to treat children with 10 common food allergies, including milk, egg, peanut, and sesame. The program involves daily liquid drops under the tongue and may gradually build tolerance and provide greater protection against accidental exposure.
A new viewpoint argues that field ecology's working conditions can heighten vulnerability to harassment, particularly for women of color and LGBTQ+ researchers. The author calls for prevention measures, including clear codes of conduct and team involvement, to ensure research team safety and prevent distortions in knowledge production.
Advances in blood cancer treatment have saved 25.8 million life-years, with significant gains for Hodgkin lymphoma and non-Hodgkin lymphoma patients. However, Black patients and those with acute myeloid leukemia (AML) continue to experience worse outcomes, highlighting the need for continued research investment.
Eric Perreault, a renowned research executive and academic leader, will lead the Morgridge Institute for Research, a biomedical research organization affiliated with the University of Wisconsin-Madison. The institute focuses on improving human health through cross-disciplinary research and collaborations.
The study aims to improve health and quality of life for people with sickle cell disease by understanding the impact of daily life on the disease. Researchers will measure everyday exposures, including air quality, temperature, food, and stress, to develop tools for clinicians to counsel patients.
Researchers used infrared cameras to create a 3D view of biodiversity in the Congo Basin, revealing which mammals share the forest and how they use that space. The study identified 47 mammal taxa and found that 25% of arboreal mammals preferred the understory, highlighting the value of surveying the lower-mid forest strata.
A four-country study explores the effectiveness of a digital health coaching program in reducing gestational diabetes incidence and improving maternal and child health. The Bump2Baby & Me+ program uses a smartphone coaching platform to support women at risk, with results expected in 2028.
Penn Medicine is conducting a Phase I clinical trial to test the precision form of FLASH proton therapy, a faster and potentially less-toxic radiation therapy for cancer treatment. The trial aims to provide a treatment with minimal toxicity for patients with recurrent head and neck cancer.
Research suggests that strong ESG investor pressure can lead to pollution outsourcing to suppliers, but also enable firms to adopt eco-friendly technologies and improve emissions. ESG investors can mitigate this by engaging with suppliers and supporting green technologies.
A review of existing evidence on testosterone and heart health found that both low and high testosterone levels increase the risk of atrial fibrillation. The risk appears to follow a U-shaped pattern, with the lowest risk in the middle of the normal testosterone range. This suggests that treatment should be individualized and monitored.
The Single Cell Genomics Center is expanding its services, becoming more accessible, and exploring new applications of single-cell sequencing. New tools, including robotics and a sequencer, are streamlining the center's analytical workflow and enabling the team to explore new opportunities.
The Journal of Integrative Medicine is expanding its global reach through EurekAlert!, providing a platform for researchers and science journalists to discover research in traditional Chinese medicine, complementary and integrative medicine. The journal publishes high-quality research in basic science, clinical medicine and evidence-ba...
Non-police safety practitioners in San Francisco reduced crime and disorder, particularly behavioral health-related incidents and drug crime, through consistent relationships and referrals to services. The program achieved significant reductions in crime rates by intervening early and preventing escalation.
Researchers have discovered a novel approach to treating influenza by targeting the host's machinery, rather than the virus itself. By binding to a key protein called nucleolin, two new drugs have been shown to trap and inhibit the replication of both pandemic and seasonal flu strains.
A new method called freeze-structuring turns whole legumes into a fibrous product with a desired texture. The process involves soaking, blending, heating, and freezing the legumes to create a directional fibrous structure.
A Rutgers-led international team identified 36 genes linked to obsessive-compulsive disorder (OCD) and chronic tic disorders, providing a detailed biological understanding of how these conditions develop. The findings suggest that many of the genes are shared between the conditions and can be targeted using whole-network approaches.
Researchers identified a key protein, isthmin-2, as a predictor for pre-eclampsia and fetal growth restriction. The protein's association with placental cell invasion could lead to better test development and treatment options for at-risk pregnancies.
Researchers found that cosmic star formation has declined dramatically, but neutral atomic hydrogen density has only decreased slightly. The study suggests that the decline in star formation activity is not due to the depletion of gas, but rather a decrease in the efficiency of converting gas into molecular hydrogen.
A new study suggests that estrogen hormone treatment combining estriol and progesterone may help alleviate 'brain fog' symptoms in menopausal women. The study found significant reductions in cognitive symptoms such as memory, concentration, and problem-solving after 12 months of treatment.
Scientists have discovered specialized compartments within the sperm nucleus packed with proteasomes, which are responsible for breaking down and recycling proteins. This finding could open new avenues for understanding male fertility and provides an unprecedented look inside sperm cells.
The Digital Science Catalyst Grant 2026 seeks novel applications of agentic AI workflows that can benefit any part of the research lifecycle, including areas such as data management and knowledge discovery. The grant aims to support early-stage solutions building research agents with provenance, governance, and accountability.
scLS detects pseudotime-associated genes without explicit regression models, suitable for irregularly distributed data and complex cell trajectories. It offers a computationally efficient approach for downstream trajectory analysis, identifying dynamic and shifted gene expression patterns.
Enterovirus infections in children can lead to severe diseases, and current vaccines only cover certain serotypes. The review highlights the need for further research to expand preventive and therapeutic options. Rapid viral evolution complicates disease diagnosis and treatment.
William Gordon Frankle, MD, MBA, will lead the Department of Psychiatry at NYU Grossman School of Medicine, focusing on innovation and community psychiatry. He succeeds Charles R. Marmar, who completed 17 years of distinguished leadership, and builds on NYU Langone's excellence in clinical care, research, and education.
Researchers found that melanoma cells suppress LL-37 production in neighboring keratinocytes, weakening a local epithelial defense pathway. This mechanism, mediated by melanoma-derived exosomal signals, can be targeted for therapeutic strategies.
Researchers successfully film the generation of electrical energy from light, providing a fundamental understanding of the physical processes involved in organic solar cells. The study, published in Physical Review X, reveals the spatial distribution and temporal evolution of excitons in the first moments of their existence.
A UNIGE study shows that climate communication campaigns designed to appeal to people's emotions, such as evoking a sense of wonder, are more effective at inspiring climate action than those relying solely on scientific facts. Messages that include images and draw on moral or ethical considerations also achieve better results.