A polyphenol-rich extract from Cistus salviifolius has shown fungicidal activity against several dermatophytes, including Trichophyton rubrum and Microsporum canis. The extract reduced fungal load and tissue invasion in a reconstructed human epidermis model, preserving the epidermal barrier and decreasing inflammation.
Researchers at Kyushu University have developed a novel molecule that can produce fluorescence and serve as an MRI contrast agent, addressing limitations of current imaging techniques. The molecule, a water-soluble and metal-free compound, demonstrates improved imaging depth and reduced toxicity compared to existing agents.
Researchers found that incorporating Antarctic radar observations into weather forecasting systems improves forecasts of atmospheric circulation and atmospheric rivers over the Southern Hemisphere. The study used continuous wind observations from the PANSY radar to demonstrate the value of high-frequency measurements for weather foreca...
Researchers at Graz University of Technology discovered vulnerabilities in file notification systems of various operating systems, allowing tracking of user activities, keystrokes, and password prompts. Patches have been rolled out to address some of the vulnerabilities, but users are still advised to be cautious.
A study from the University of California San Diego School of Medicine found that 11.4% of older adults who used cannabis in the past year met the criteria for cannabis use disorder (CUD). This condition is characterized by a pattern of cannabis use that causes problems or interferes with daily life. The study highlights the importance...
A new AI tool, ChromAgeNet, analyzes 3D chromatin organization in blood stem cells to identify age-related changes, which can inform rejuvenation strategies. The model outperforms previous methods, revealing subtle changes in nuclear architecture that can be used to detect age-associated states.
Researchers developed a current comparator using diamond quantum sensors to accurately evaluate both AC and DC current ratios with the same device setup. This technology eliminates the need for separate calibration systems and paves the way for standardization of current measurement in next-generation power grids.
Recent technical and computational improvements in coronary intravascular imaging can better characterize coronary lesions and identify high-risk plaques, improving outcomes for patients with coronary artery disease. The review highlights advances in imaging platforms, hybrid imaging systems, and artificial-intelligence approaches for ...
Researchers found that realistic seafloor topography can sustain and reshape the key features of climate system even when continents are removed. The study revealed that ocean bathymetry plays a crucial role in driving the modern Earth's climate in the absence of land surfaces.
Aoguangviridae, a marine virus family associated with Poseidoniales, has been found to be far more diverse and widespread than previously suspected. The expanded genomic framework reveals 22 subfamilies, 157 genera, and 167 species, with transcriptional activity in deep waters and potential influence on host metabolism.
A recent paper suggests AI can reconstruct ocean interior, predict waves, and forecast ENSO by incorporating physical knowledge and ocean dynamics. This approach improves reliability and interpretability of AI-based predictions, especially when observations are sparse or conditions differ from training data.
Recent studies have made significant progress in understanding the regeneration of bone, cartilage, tendon, and oral tissues using bioactive materials. These studies have led to the development of innovative biomaterials and tissue engineering strategies that can potentially treat various diseases and injuries, including periodontitis ...
Researchers from the University of Otago have unlocked the molecular mechanisms behind the parasitic mind-control code, revealing how parasites manipulate host behavior at the genetic level. The study used transcriptomic sequencing to decode the genetic crosstalk between the European earwig and the parasitic worm, mermithid nematode.
A study found that Acceptance and Commitment Therapy Plus (ACT+) helped cancer survivors reconnect with valued living, managing difficult thoughts and emotions through mindfulness practices and activities focused on
A KAIST research team has developed a genetic switch that works in both bacteria and yeast, allowing for controlled production of a green pigment in both microbes. The hybrid promoter system can be used to select the microbe best suited for producing a target compound, reducing the need for redesigning control elements.
Researchers have identified a key gene in a wild tea species that drives high levels of JA accumulation, offering a promising path toward breeding pest-resistant crops. The gene CtOPR2 functions as a positive regulator of JA-mediated insect defense, making it a valuable genetic resource for crop improvement.
A secure sense of attachment within a group enables members to express dissenting opinions more effectively, leading to better decision-making. This approach can help organizations tap into the knowledge and insights of their most critical employees, who often remain silent due to fear of backlash.
Researchers propose that humans' joint disease is linked to evolutionary changes, with a lack of GAG molecules in cartilage making joints less effective at absorbing shocks. This difference may have led to osteoarthritis and other skeletal diseases that are uncommon in other great apes.
Physicians in Türkiye are willing to order BRCA testing for eligible patients, but family participation and preventive care are lacking. A nationwide survey found that physician knowledge is the most influential factor in testing and screening recommendations.
Researchers developed a method called Concentration-Dependent Yield Analysis (CYAN) to connect reaction optimization and kinetic analysis. CYAN extracts kinetic information from yield data, estimating reaction speeds without requiring separate experiments. This approach helps chemists design complex high-yield reactions.
Researchers developed a unified graph theory framework to describe atom-light interactions across regimes, revealing a vast and intricate network of quantum states. The framework uses a magnetic Laplacian metric to compress complexity into a single number, replacing fragmented approaches for different coupling strengths.
Researchers at Kyoto University have developed a new SiC transistor structure that can operate at 600°C, scaling up production to wafer-level for high-temp applications. The team's achievement enables the fabrication of integrated circuits, opening doors to new areas like jet engine sensors and geothermal resource development.
A large U.S. insurance claims analysis found that fewer than 30% of patients with hormone receptor-positive early-stage breast cancer remained adherent to endocrine therapy for five years after lumpectomy. Younger age and radiation therapy omission were associated with lower adherence rates.
A new review found that insomnia is associated with a 26% higher risk of stroke and 28% higher odds of hospital admission. The study also linked insomnia to depression, suicidal behaviors, and dementia, particularly Alzheimer's disease.
A Danish study suggests that GLP-1 drugs could protect heart health in millions of people with overweight. The research found that individuals with a BMI of 25-26.9 and high remnant cholesterol and/or low-grade inflammation have a similar risk of coronary heart disease as those eligible for GLP-1 RAs for weight loss.
Researchers found a 44% lower risk of death from any cause after one year and 35% lower risk after two years among type 2 diabetes patients starting continuous glucose monitoring. CGM use also showed a reduced risk of cardiovascular events, including heart attack and stroke.
Researchers have identified a unique 'bacterial signature' that flags individuals at risk of type 2 diabetes, even if their blood sugar levels are normal. The study analyzed data from over 200,000 adults and found that changes in the gut microbiome can be detected before the onset of diabetes.
A new California law aims to eliminate ultra-processed foods from school menus, but researchers warn of fiscal and logistical challenges, including budget constraints and difficulty with food procurement. The study's findings highlight the need for increased funding to support healthier school menus and improve student nutrition.
A new study found that consuming red meat linked to a 63% higher risk of developing type 2 diabetes due to Neu5Gc, a non-human sugar found in red meat. Higher levels of Neu5Gc were associated with greater risk, even after adjusting for other factors.
A small study of 22 healthy medical students found significant increases in blood sugar levels during exams and the days leading up to them. The study suggests that prolonged exposure to examination stress may have a negative impact on metabolic health.
The shift to digital life is reshaping brains, communities, and empathy, warns Professor Vidar Halldorsson. He cites decreased empathy and increased loneliness as consequences of screen-based communication, which strips away social cues.
The analysis found that adding short-term androgen deprivation therapy (STADT) to radiation provided a greater benefit for patients with Luminal B tumors compared to those with non-LumB tumors. This suggests that tumor biology can help determine who may benefit from hormone therapy.
Low-dose radiation therapy may slow the progression of knee osteoarthritis, with sustained improvements in pain, physical function, and quality of life. The therapy was associated with a 67% lower adjusted hazard of government-certified disability due to knee osteoarthritis, particularly in patients with grade 2 disease.
A new study found that a shortened radiation schedule provides similar cancer control and patient-reported outcomes to standard radiation following surgery for high-risk prostate cancer. However, it was associated with a higher rate of grade 3 urinary adverse events, particularly cystitis and hematuria.
A multi-institutional trial found that ultra-low-dose radiation therapy relieved painful bone lesions from multiple myeloma for most patients, with 81% achieving pain control without additional radiation. Treatment side effects were limited to low-grade fatigue.
A nasal spray treatment has shown to provide rapid and effective pain relief for children in emergency departments, with 86.2% of children experiencing reduced pain 30 minutes after treatment. The treatment was well-tolerated with mild side effects, offering a simple and effective option for treating children in the emergency department.
A new post-hoc analysis of the ATTAIN-1 and -2 studies found significant and similar weight reductions for women of different menopausal status, with up to 14% body weight loss and 12.5cm waist circumference reduction
A study of over 6 million people found that individuals diagnosed with type 2 diabetes before the age of 20 were more likely to have ADHD (14%) and autism (5.7%) compared to those without T2D. This suggests that healthcare systems may need to consider the needs of neurodivergent people when providing care for early-onset T2D.
A new study suggests that eating a diet low in ultra-processed foods and exercising regularly can reduce the risk of type 2 diabetes, even in those with a strong genetic predisposition. The analysis of data on tens of thousands of people found that those who followed these habits were up to 70% less likely to develop the condition.
A blood test that compares two molecules in the blood can accurately distinguish between bacterial and viral infections in newborn babies with fever. The test showed a high sensitivity and specificity, and could potentially improve treatment and reduce unnecessary antibiotic use.
A study of 1.6 million patients found that the risk of developing chronic kidney disease or heart failure increases substantially over time after a type 2 diabetes diagnosis. Early, proactive management is crucial to reduce the risk of serious complications.
Researchers warn of the dangers of smart vaping devices that reward users with cryptocurrency, increasing addiction risk and undermining smoking cessation efforts. These devices, such as Puffpaw and Gudtrip, use gamification, artificial intelligence, and financial rewards to encourage continued use, making it harder for users to quit.
Researchers analyzed over 800 radiation treatment plans, finding that planner choices, not machine accuracy, drove differences in dose delivery. A genomic test evaluated tumor genetic material, predicting long-term outcomes and identifying patients who may benefit from hormone therapy. This study advances radiation oncology, enabling m...
Researchers found that viewing natural landscapes with VR and listening to classical music reduced patients' blood pressure and anxiety. The study showed significant reductions in blood pressure and anxiety levels after 15 minutes, with no further significant difference after 60 minutes.
UCLA researchers present new radiotherapy research for prostate cancer, head and neck cancers, and personalized radiation therapy. A genetic test identifies men with prostate cancer at higher risk of urinary side effects after SBRT, suggesting personalized radiation treatment.
A new study found that drones can significantly reduce the time between cardiac arrest reporting and defibrillation, particularly in rural and congested areas. By combining fixed AEDs with drones, access times can be reduced by up to 3.76 minutes, with over 95% of cases covered within five minutes.
A new approach to aquatic pathogen surveillance combines automated sampling, pathogen concentration, and rapid signal detection for real-time monitoring of multiple pathogens. The proposed framework complements traditional methods, improving biosafety and early warning systems.
Researchers discovered a distinctive pattern in DNA polymerase genes from China's Napahai plateau wetland, suggesting the unique geography and environmental conditions of the wetland contribute to the genetic diversity of microbial communities. This finding raises the possibility that DNA polymerase genes could serve as biogeographical...
Mayo Clinic researchers will present emerging technologies, precision treatments, and new radiation therapy techniques at ASTRO 2026. The meeting highlights include presentations on AI-driven automation in pelvic radiation therapy and novel therapies for glioblastoma.
Studies on hypofractionated postmastectomy radiotherapy, proton therapy for hepatocellular carcinoma, and stereotactic body radiation therapy for Ewing sarcoma showcase improved patient outcomes. The findings also suggest potential benefits for short-course radiation therapy access and patient navigation in cancer centers.
USF Health researchers have uncovered a previously unknown brain region, the dorsal posterior periventricular hypothalamic nucleus, which plays a crucial role in regulating metabolic health in response to cold temperatures. The discovery offers a potential new pathway for developing treatments to improve metabolic function and prevent ...
A study in the Galápagos Islands found that livestock farming is associated with perceived negative changes in local biodiversity. The study involved livestock producers and found associations between the expansion and intensification of farming and changes in biodiversity.
Researchers developed an AI approach to predict glioblastoma recurrence, allowing for targeted treatments before the cancer becomes visible on MRI. The tool uses microscopic images of fresh, unprocessed tissue and scored based on tumor infiltration, with an accuracy of predicting recurrence within 5-10 millimeters of the sampled tissue.
A recent study from Georgetown University and the University of Washington suggests AI-generated summaries can manipulate people's memory, even when accuracy is assured. Participants who read misleading AI summaries were significantly less likely to accurately recall the original event, according to the study.
Researchers analyzed Nijinsky's diary to study language patterns during psychosis. The findings suggest a unique form of repetitive thinking, with a narrow vocabulary and mechanical coherence. The study aims to contribute to AI-powered tools for detecting mental illness symptoms in language.
A parasite, Toxoplasma gondii, reorganizes the host cell surface to create specialized patches for entry. The parasite's invasion machinery is triggered by a specific sugar-coated protein interaction, allowing it to exploit host-cell vulnerabilities.
UCF Assistant Professor Cali Calarco is investigating how nicotine affects brain cells, providing insights that could help improve treatments for addiction. Her research focuses on the nucleus accumbens, an area of the brain involved in reward, learning, and behavior, and explores the role of mitochondria in drug-seeking behavior.
NTU Singapore scientists have developed a method to strengthen plant immunity by grouping immune receptors together, allowing plants to detect disease-causing microbes more effectively. The approach shows promise for potential crop applications in the future, including disease-resistant vegetable seeds and crops.
Researchers analyzed brain activity in mice to find that neural scaling laws allow information to grow beyond a ceiling imposed by shared noise. The study, published in Science Advances, suggests that brains can process more information than previously thought.
Researchers have identified a way to strengthen bladder cells' ability to eliminate hidden bacteria, reducing recurrent UTIs. OM-89 increases lysosomal acidification and enzyme activity, allowing antibiotics to reach and kill bacteria more effectively.