New research reveals widespread resistance to benzimidazole-based dewormers among canine hookworms in Australia. This increases the risk of gastrointestinal parasites, anaemia, diarrhea, and malnutrition in dogs, as well as cutaneous larva migrans disease in humans.
Researchers at NIH have identified a novel class of anti-malaria antibodies that target previously untargeted regions of the parasite. These antibodies have shown promise in providing protection against malaria parasites in animal models and could lead to new prevention methods.
Researchers have identified a new pathway for ergosterol biosynthesis in Leishmania parasites, paving the way for more effective antiparasitic drugs. The discovery reveals that azole antifungals targeting a specific enzyme can be highly effective against leishmaniasis.
Researchers have discovered that climate change and tsetse fly control measures can drive molecular changes in African trypanosomes, enabling them to infect animals without flies. New strains with reduced life cycles have been detected in Asia, South America, and southern Europe.
Researchers discovered a species of damselfish actively eating gnathiid isopods, which are common reef parasites, to protect their young. This unique 'great fish parenting' behavior increased the survival rate of juvenile fish by three times.
Researchers found that Toxoplasma gondii parasites lacking the protein MYR1 can survive and proliferate when co-infected with normal parasites, thanks to supportive secreted proteins. This study highlights a limitation of pooled CRISPR screens in studying parasite biology in live hosts.
Researchers have identified a molecular strategy employed by worm parasites to evade host immune defenses, offering promising solutions for addressing major infectious diseases, allergies, and asthma. By analyzing the unique immune-regulatory properties of helminths, scientists pinpointed key features essential to their activity.
A 500-year-old latrine from Bruges, Belgium has yielded evidence of intestinal parasites, shedding light on the spread of diseases through medieval travel and trade. The discovery provides key insights into human migration and disease transmission in the past.
A new gene-editing tool enables precise study of variable proteins that allow malaria parasites to stick to red blood cells and evade the immune system. The study introduces a platform to explore how malaria causes disease and identifies new proteins involved in the cytoadhesion process.
Swallow populations infected with parasites exhibit altered movement patterns, including reduced home ranges and foraging activity. This can lead to decreased foraging success and increased mortality rates.
Scientists have discovered a crucial protein called DMT1 that enables single-celled malaria parasites to use iron, essential for survival and reproduction. Blocking this protein may lead to effective antimalarial drugs.
A new study published in Journal of Biogeography finds that malaria-like blood parasites increase in prevalence with the number of bird species present, highlighting the importance of host diversity. The research also shows that parasites can spread more rapidly when they specialize in closely related or functionally similar bird species.
Researchers at the University of Nottingham uncover key regulators of malaria parasites' cell division, revealing NEK1 as a potential drug target. The study aims to find new therapeutic targets for controlling malaria transmission.
Scientists have mapped the global repertoire of genes that determine the male or female sexual fates in Plasmodium falciparum malaria parasites. This study reveals key regulators of gene expression during development and identifies novel candidate 'driver' genes, shedding light on the complex biology of malaria transmission.
A study by McGill University researchers found that the timing of malaria parasite infection affects disease severity and host response. Circadian rhythms influence vulnerability to malaria parasites, with night-time infections resulting in less severe symptoms and slower parasite spread.
Researchers at Australian National University create a new method to treat deadly diseases caused by parasites, including malaria, by attaching drugs to cholesterol. The method could lead to more effective and longer-lasting treatments, as well as implications for the agricultural industry.
Researchers developed a new antimalarial agent, DIF-1(+3), effective against drug-resistant Plasmodium falciparum. The compound showed stronger growth inhibitory effects than previous derivatives and significantly increased survival time in infected mice, suggesting it may offer more treatment options for malaria-endemic areas.
New research reveals oyster sanctuaries contain more abundant populations of oysters and other animal life, despite the presence of parasites. The study found that these areas support higher oyster densities and habitat quality than nearby harvest sites.
Researchers reconstructed ancient genomes of Plasmodium vivax and Plasmodium falciparum malaria parasites to study their worldwide spread. The analysis revealed that European colonizers introduced P. vivax to the Americas, while military activities in Europe facilitated the spread of P. falciparum.
A recent study reveals that a cellular process called transfer Ribonucleic acid (tRNA) modification influences the malaria parasite’s ability to develop resistance. This breakthrough discovery could help researchers develop new drugs to combat resistance and better tools for studying RNA modifications.
Researchers at the University of Toronto have found a family of natural compounds that stall the unique metabolic process used by parasites to survive in the human gut. The discovery offers potential as new and more effective treatments for parasitic worm infections, which cause debilitating symptoms and developmental defects.
Researchers from Queen Mary University of London developed a novel analysis to explore the impact of parasite virulence and infection probability on species coexistence in a complex system. The study found that stochasticity plays a significant role in determining whether species coexist or go extinct.
A parasitic wasp has evolved to perfectly target a common fruit fly pest, demonstrating key principles of ecologically driven evolution. The Trichopria drosophilae wasp overcomes the pest's defenses by producing venom and specialized cells that speed up digestion and increase nutrition for its young.
A new study reveals that corallicolids, thought to be only associated with tropical coral reefs, have been found in a variety of creatures in cold marine ecosystems along the Northeast Pacific. The discovery greatly expands our understanding of microbial biodiversity and highlights significant blind spots in current sampling approaches.
A recent study by academics from British and Finnish business schools has warned that organisations can be destroyed from within and without by 'institutional parasites' such as suppliers or employees. These parasites can initially benefit both the organisation and the parasite, but can ultimately cause significant harm if left unchecked.
Researchers at São Paulo State University developed a novel technique using lipid nanoparticles to administer lupeol, killing Leishmania protozoan parasites. The therapy eliminated parasites from organs in animal tests, reducing spleen and liver parasite numbers by 99.9% with minimal side effects.
Researchers from ANU discovered a new ability of Atypical B cells (ABCs) to fight infectious diseases like malaria. ABCs play a crucial role in developing T follicular helper cells that generate powerful antibodies.
A new study published in Nature Communications has provided structural insights into a potent antimalarial drug candidate's interaction with the malaria parasite Plasmodium falciparum. The research suggests that the drug, TDI-8304, can selectively target and kill resistant parasites, offering hope for more effective treatments against ...
Researchers analyzed leishmaniasis lesions on mouse skin to detect metabolic signaling pathways that differed from uninfected mice. They found pathways with pain-relief properties tied to the brain's endocannabinoid system, which is involved in a host of physiological processes, including the pain response.
A team of scientists developed a technique to rapidly detect genetic changes in malaria parasites using portable MinION sequencers. They demonstrated the first end-to-end, real-time pathogen monitoring from clinical blood samples in rural, resource-limited malaria hotspots.
Researchers discovered a malaria protein, PfAP2-P, that plays a key regulatory role in immune evasion and parasite development. This protein acts as an activator of proteins required for the parasite to exit infected red blood cells and invade new ones.
A study published in Nature Communications suggests that a key mutation rendering malaria parasites resistant to atovaquone also makes them non-transmissible via mosquitoes. Researchers propose an injectable formulation of atovaquone for long-acting protection against malaria, overcoming concerns about resistance.
Researchers discovered that parasites like horsehair worms use stolen genes to control host behavior. They found over 3,000 genes expressed more in manipulated hosts, suggesting the parasite produces its own proteins for manipulating nervous systems.
A study found that the host's immune response to Trypanosoma brucei infection triggers lipolysis, leading to weight loss and a protective effect against disease progression. This discovery opens up new treatment strategies targeting the infection in adipose tissue.
A systematic review by ISGlobal found that malaria parasite prevalence is highest in migrants from the Sub-Saharan region, particularly those from Central Africa. The study included 23 studies with a total of 4,203 participants tested for malaria parasites.
Researchers discovered Leishmania parasites in blood-related stem cells of chronically infected mice, challenging the textbook understanding of the disease. The finding may lead to new treatment options and improve our understanding of why some people develop visceral leishmaniasis despite having immune disorders.
Malaria parasites have developed resistance to artemisinins, a critical treatment for non-severe cases, with devastating consequences. The study found that effectiveness declined by 2025% between 2016 and 2019, highlighting the urgent need for new treatments.
Scientists have detected new strains of malaria-causing parasites in Ethiopia that are resistant to current treatments and escape detection by common diagnostic tests. The prevalence of these double-resistant parasites is a concern for malaria control and elimination efforts in Africa, where the disease remains endemic.
Researchers argue that considering an animal's entire 'parasitome' is crucial for understanding its place in the food chain. By analyzing stable isotopes, scientists can determine who is eating whom and how parasites affect behavior and metabolism.
Scientists have established the effectiveness of vaccines against leishmaniasis in animal studies, revealing specific molecular-level changes in host cells. The vaccines, created using mutated parasites, prompt distinct immune responses in hosts, offering new insights into their mechanisms and potential applications.
Research found that increased biodiversity can either help or hinder disease outbreaks in wildlife, depending on environmental conditions. Environmental pollutants like road salt changed the susceptibility of amphibian species to parasites, with higher biodiversity communities experiencing a dilution effect when exposed to pollutants.
Researchers tested an automated microscope combined with AI software to diagnose malaria in blood samples. The system achieved 88% accuracy, comparable to expert microscopists, and has potential benefits including reducing workload and increasing patient load.
A study published in PLOS ONE has discovered parasite eggs in a 200-million-year-old coprolite from Thailand, providing insight into the life of an ancient aquatic predator. The discovery is significant, as it is one of only a few known examples of nematode eggs preserved within the coprolites of Mesozoic animals.
Research by the Peter Doherty Institute found that inflammation alters plasma composition, hindering parasite maturation. This work reveals a new mechanism slowing down malaria parasite development in the bloodstream.
Researchers from Leicester and Nottingham universities have received £600,000 funding to study sexual development and gene shuffling in the malaria parasite. The study aims to uncover new targets for therapies to control disease transmission.
Researchers discovered a class of cyanotriazoles that selectively poison trypanosomatids' topoisomerase II enzyme, causing lethal DNA damage and rapid parasite clearance. The compounds showed potent trypanocidal activity both in vitro and in mouse models of Chagas disease.
Scientists have discovered a new class of compounds called cyanotriazoles that effectively inhibit the growth of trypanosomes, the parasites responsible for Chagas disease and African sleeping sickness. The results offer hope for the development of new and improved treatments for these neglected tropical diseases.
Researchers at UCalgary have found that Leishmania parasites exploit immune cells by targeting receptors to gain access and resist elimination, leading to stalled apoptosis and hindered vaccination efforts.
The study found that drug-resistant Leishmania parasites have distinct protein production profiles compared to sensitive parasites, suggesting a global reprogramming of protein synthesis. This pre-emptive adaptation enables the parasite to quickly respond to the presence of the drug and survive when it is absent.
Researchers found that malaria parasites synchronize their gene expression with the host's internal clock, repeating every 24 hours. The study reveals a potential new target for anti-malarial drugs by 'jet-lagging' the parasites' clocks.
Scientists studying Leishmania parasites found that they can adapt quickly to drug resistance by altering gene expression and protein synthesis. This understanding could lead to more effective targeted treatments by removing specific genes or interrupting information flow.
A new study has identified a second key gene, AAT1, involved in malaria's resistance to the drug chloroquine. The finding, published in Nature Microbiology, has implications for the ongoing battle against malaria.
A recent study by Kennesaw State University biologist Whitney Preisser found that a decrease in parasites in U.S. waters may signal potential danger for fish and other wildlife due to changes in water temperature, hinting at an ecological threat impacting all species.
A recent study published in The Science of Nature found that parasites and body condition are crucial factors in determining the vulnerability of fish to angling. The research revealed that fish with high body condition and parasites, as well as those with low body condition but no parasites, were less likely to be caught by anglers.
Researchers used cryo-electron microscopy to visualize the protein synthesis mechanism in Giardia intestinalis, resolving high-resolution structures of six different states of elongation. These findings provide valuable information for screening specific drugs against Giardia and other protozoan parasites.
A new diagnostic test can detect people with dormant Plasmodium vivax parasites, which are difficult to treat due to their ability to remain dormant in the liver for years. The test has the potential to improve malaria control programs and accelerate eradication efforts.
A study of preserved fish specimens reveals a 140-year decline in parasite populations due to warming oceans. Parasites with multiple host species declined severely, threatening ecosystems and top apex predators. The study highlights the vulnerability of parasites to climate change and inspires further research.
Researchers created an atlas of the malaria infection by Plasmodium parasites in the liver, revealing differences in infected cell localization and immune response. The study's findings hold promise for developing treatments targeting the asymptomatic liver stage of the disease.
A cercarial dermatitis outbreak occurred in Chana district, South Thailand, affecting rice farmers, due to ruminant parasites like Schistosoma indicum. The study identified two snail species as intermediate hosts for flatworms causing the disease.
Researchers genetically mapped one of the oldest human parasites, the whipworm, using stool samples from Viking latrines. The study reveals a delicate relationship between humans and the parasite, which can make us healthier or ill, and provides new knowledge on its development and prehistoric dispersal.