A genetically edited form of a herpes simplex virus has outperformed a leading vaccine candidate in a new study, significantly increasing antibody production and reducing viral replication. The modified live virus demonstrated cross-protection against both HSV-1 and HSV-2, suggesting an HSV-2-specific edition could be even more effective.
Research suggests that genetic predisposition to increased weight is causally protective for breast and prostate cancer. Heavier women are less likely to develop breast cancer due to additional differences between groups, while heavier men are less likely to develop prostate cancer, particularly when exposed to carcinogenic substances.
Researchers at Penn State discovered that grafted plants with epigenetically modified rootstock exhibit increased vigor, productivity, and resilience compared to parental plants. The technique uses gene expression manipulation rather than genetic modification, sidestepping controversy surrounding GMOs.
Researchers found that a modified bentonite complex can remove 17α-ethinylestradiol and other pharmaceutical organic micropollutants from wastewater environments. The study demonstrates an effective and cost-efficient method for removing synthetic estrogen from bodies of water.
Researchers developed CAR NKT cells to target neuroblastoma, a childhood cancer. The modified cells showed safety, localization to tumors, and induced an objective response with regression of bone metastatic lesions in one patient.
Researchers at FEFU are working on genetically modified models of brain tumors to understand the role of IDH1 and TP53 gene mutations. They plan to create laboratory models of these mutations to develop new diagnostic markers and test antitumor compounds, potentially leading to personalized therapy for glioma patients.
A new study has quantified the extent of human development in oceans for the first time, mapping an area of approximately 30,000 square kilometers modified by human construction. This footprint is comparable to urbanized land and greater than some natural habitats like mangrove forests and seagrass beds.
Scientists at Joslin Diabetes Center have developed a novel cell-based therapy using 'HUMBLE' cells, genetically modified human white fat cells that mimic heat-generating brown fat cells. Transplanted into mice with type 2 diabetes, these cells improved insulin sensitivity and glucose clearance, reducing weight gain and related chronic...
A newly developed genotyping chip can help establish and maintain genetic diversity in reef restoration efforts. The chip allows researchers to genetically identify corals and their symbiotic algae, enabling conservation biologists to track coral diversity and compare samples.
Researchers at the Brazilian Center for Research in Energy and Materials (CNPEM) have developed a low-cost platform for producing enzymes that break down biomass into fermentable sugar for biofuel conversion. The enzyme cocktail, produced by genetically engineering a fungus, has significant potential industrial applications.
Scientists from Okayama University have developed genetically engineered proteins that can be controlled by light, offering a promising new tool for studying neurons. The engineered proteins, based on natural light-regulated channels, can be activated or silenced using different light frequencies, providing finer control over neural ac...
Scientists from the University of Edinburgh developed a sustainable method to produce adipic acid, a key component of nylon, using genetically modified bacteria grown in liquid solutions containing guaiacol. This approach produces adipic acid without emitting nitrous oxide greenhouse gases.
A new experimental COVID-19 vaccine has been shown to prevent pneumonia and elicit high levels of protective antibodies in mice infected with the virus. The vaccine uses a mild virus genetically modified to carry a key gene from the COVID-19 virus, generating a strong immune response.
Researchers from UCI School of Medicine evaluate anterograde and retrograde viral tracers for neural circuit analysis, providing guidance on experimental uses. The primer aims to advance the study of neural circuits using animal models to define mechanisms underlying neurodevelopmental and neuropsychiatric disorders.
Researchers have developed modified mRNAs with sulfur atoms that accelerate protein synthesis by at least 20 times, paving the way for efficient protein production and mRNA therapeutics. This breakthrough has significant implications for medical treatments, including vaccine therapy and protein replacement therapy.
Scientists at KIT have successfully introduced genetic information into a multicellular cyanobacterium, Phormidium lacuna, using natural transformation. This breakthrough opens up possibilities for basic research and biotechnical applications, including the synthesis of biofuels like ethanol and hydrogen.
A new sequencing technology will help scientists better understand the mechanisms of rare nucleotides thought to play an important role in the progression of some diseases. These modified nucleotides are crucial additions to the genetic code, but their detection is difficult and comes with high error rates.
Researchers at Goethe University have successfully produced tsetse fly attractants in genetically modified brewer's yeast, which could be used to contain sleeping sickness. The new production method is cost-effective and environmentally friendly, making it suitable for rural communities in Africa.
A genetically modified malaria vaccine has been found to be safe and elicit a defense response against malaria infection in humans. The vaccine, developed with the American company Sanaria Inc., targets the liver stage of the disease and was administered to 67 volunteers, showing promising results.
Two malaria vaccines developed using genetically engineered malaria parasites have shown safety and preliminary protection in phase 1/2a clinical trials. The vaccines, created by Isaie Reuling and Meta Roestenberg teams, delayed infections when exposed to mosquitoes infected with Plasmodium falciparum, the primary cause of malaria in h...
Researchers have developed genetically-encoded X-ray-sensitive tags for site-specific labeling of protein-of-interest in mammalian cells. This enables endogenous labeling of diverse molecules and subcellular structures with an ultrahigh spatial resolution of ~30 nm. The high photostability of these tags allows long-term observation of ...
Researchers at Penn State discovered that manipulating a single gene can induce stress memory in plants, giving them increased vigor and productivity. This epigenetic technique allows for non-genetically modified crops with improved resilience.
Researchers found that feelings of preparedness in one area can lead to more confident thoughts about unrelated topics, even if those thoughts are not based on actual knowledge. Participants who were told they had to prepare for bad news later showed more positive attitudes towards research funding proposals than those who didn't prepare.
A modified form of tubulin traps signaling molecules, reducing brain messaging in people with depression. Tubulin levels may provide a diagnostic marker and target for antidepressant treatment.
Scientists have made a groundbreaking discovery about the function of actin, a crucial protein in cells, by uncovering its atomic-scale structure as it is modified. The research reveals that actin's modification plays a key role in regulating its ability to form filaments and interact with other proteins.
Scientists successfully incorporated noncanonical amino acids into human hematopoietic stem cells, enabling the production of ncAA-containing proteins in living organisms. The modified stem cells provided a tool for studying human proteins in cell culture and living systems.
Researchers at UCI found that depriving colon cancer cells of glutamine causes them to adapt and become more invasive, but a modified version of the metabolite alpha-ketoglutarate inhibits key signaling pathways and curbs tumor growth
Researchers at Karolinska Institutet and UBC found that a genetically modified variant of ACE2 reduced SARS-CoV-2 viral growth by a factor of 1,000 to 5,000 in cell cultures. The study suggests the potential for a novel drug treatment to help patients with early-stage COVID-19.
Researchers propose that modified nucleobases could have facilitated the emergence of rudimentary self-replicating systems by stabilizing short RNA molecule structures and providing catalytic activity. This could have increased the breadth of available functions for short RNAs.
A team of researchers has developed a groundbreaking 'cardiac patch with bioink' to repair heart damage. The patch uses genetically engineered stem cells and 3D bioprinting technology to enhance vascular regeneration and improve myocardiocyte survival. The innovative method has shown promising results in treating myocardial infarction.
A clinical trial using genetic testing to guide antiplatelet medication found a 34% reduction in serious cardiovascular events at one year, as well as a significant decrease in the number of events per patient. This finding suggests that genetically guided therapy may be beneficial for patients with specific genetic variants.
A modified Grunow-Finke assessment tool (mGFT) has been validated against previous outbreaks, outlining 11 criteria for determining if an outbreak is of unnatural origin. The tool helps identify unusual strain patterns, genetic manipulation, and peculiar geographic distribution, indicating potential artificial origin.
Researchers at Kazan Federal University have made significant progress in developing CAR T-cell therapy for solid tumors. The treatment uses genetically modified lymphocytes to target and destroy tumor cells, showing promising results in animal models.
Researchers developed a method to engineer specific populations of neurons to manufacture electronic-tissue composites within living cells. This approach enables targeted use of electrical fields for therapeutic applications, such as pain relief and tissue regeneration.
A pilot study found that the Spanish adaptation of the modified Story Memory Technique improved learning and life satisfaction in Mexicans with multiple sclerosis. The intervention, which teaches imagery and context to facilitate learning, may be an effective rehabilitative tool for Spanish-speaking populations with MS.
A new single-cell prenatal blood test can identify genetic abnormalities in fetuses with high accuracy, improving the likelihood of detection. The test uses a modified droplet digital PCR assay that assesses DNA from live cells without cell fixation or whole-genome amplification.
A new protein-based method, STOP-CAR, switches off modified T cells on command, reducing toxicity and organ damage in cancer patients. This breakthrough could speed the clinical development of new CAR therapies.
A new cryopreservation technique has been developed to preserve genetically modified rat spermatozoa, which are difficult to store due to their large size and sensitivity to temperature changes. The method, tested on genetically modified rats, successfully produced over 300 offspring from a single male rat.
Researchers at Duke University Medical Center have developed a poliovirus-based therapy that stimulates a natural immune attack on cancer cells in animal studies. The modified virus, called PVSRIPO, induces an immune response against mutated cancer cells found in diffuse midline glioma tumors, which are universally deadly in children.
A genetically engineered diamondback moth has been successfully released into an open field, showing promise for effective and sustainable pest control. The self-limiting strain, developed by Oxitec Ltd, is modified to target pest populations without harming the environment.
A Japanese survey reveals differing perceptions of gene-edited crops among experts and the general public. Experts see benefits, while the public perceives risks despite acknowledging value. The findings shed light on the deficit model's boundaries in science communication.
A new study reveals genetically engineered mosquitoes that are refractory to all four types of dengue virus, providing a promising approach for controlling the spread of this mosquito-borne disease. The mosquitoes express an anti-DENV gene that prevents them from being infected or transmitting the virus.
Research collaboration discovers genetically modified poplar trees can grow and produce biomass without emitting harmful isoprene. The modification allows trees to adjust to climate stress through natural seasonal cycles, retaining their growth potential. This breakthrough could lead to more sustainable forest plantations.
Researchers genetically modified poplar trees to reduce negative impacts on air quality, finding they can grow as well as non-modified trees. The study suggests that these modifications may help improve biomass productivity and plant health without impairing growth.
Researchers at Moffitt Cancer Center have developed a new platform for creating genetically engineered mice to study melanoma, which is significantly faster than the traditional approach. This new method uses chimera mouse models and chimera-derived melanoma cell lines to provide a faster way to study skin cancer.
Several studies investigate how social media shapes consumers' perceptions of food technologies, including GMOs, and the resulting disinformation. Researchers analyze online articles, social media engagement, and brain responses to infographics about food technologies, highlighting the need for effective communication campaigns.
Researchers at Stanford University School of Medicine have developed a new approach to programming CAR-T cells that can prolong their activity and increase their effectiveness against human cancer cells. The technique uses ATAC-Seq to understand what happens when T cells become exhausted, and modifying CAR-T cells to restore balance in...
Researchers have characterized three genes associated with insecticide resistance in malaria mosquitoes, found to cause resistance to all four classes of public health insecticides. This breakthrough work provides much-needed tools for monitoring the growing problem through molecular testing.
Researchers developed a modified Mg metal anode via surface ion-exchange reaction, enabling stable electrochemical performance and reversible plating/stripping at high current densities. The artificial layer improves ion transport kinetics, reducing overpotential and increasing battery lifespan.
Researchers have developed a non-invasive method to visualize kidney disease in live animals using genetically modified mice. They found that a promising chemical found in citrus fruit, G-Hes, reduces inflammation in the kidneys when fed to mice with kidney disease.
Researchers genetically engineered CAR T cells with molecular tags, allowing them to be monitored in animal models using PET imaging. This technology enables clinicians to track the number and location of CAR T cells over time, providing a more accurate measure of therapy durability and potential efficacy.
A Cornell University study found that non-GMO labeled produce experiences a significant boost in demand when accompanied by a GMO label on other products. The 'halo effect' suggests consumers perceive non-GMO labels as more trustworthy and desirable.
A Clemson University researcher is developing genetically improved perennial grasses that can thrive with less water and serve as a sustainable fuel source. The goal is to create more stress-resistant plants through molecular strategies, including site-specific DNA recombination systems.
A novel transfection method called nano-electro-injection delivers DNA into immune cells two to three times more efficiently than conventional methods. This technique improves the process of generating high-quality genetically modified immune cells for cancer immunotherapy, reducing cell stress and improving cell health.
A team of US and Chinese scientists, led by UCI Professors Xiangmin Xu and Rozanne Sandri-Goldin, will develop a new brain mapping tool using genetically engineered herpesviruses. The tool aims to enhance signal outputs and generate variants carrying different functional payloads.
Researchers have designed a new class of modified pantothenamides that stop malaria parasites from replicating in humans and preventing transmission to mosquitoes. These compounds are effective against malaria parasites resistant to currently available drugs.
Scientists genetically modified mycoparasites to express Green Fluorescent Protein, revealing they can live up to 21-days on host plant surfaces without harming the environment. The study showed that these mycoparasites cannot spread in sterile soil or decomposing leaves, addressing concerns about their impact.
Research using stable isotopes shows that some mammals thrive on agricultural products in modified landscapes, while others rely on forest resources. Habitat loss from agriculture may pose conservation challenges, highlighting the need for sustainable land-use practices.
Consuming more gluten during early childhood is associated with higher risk of celiac disease and autoimmunity among genetically predisposed children. The study found a significant increase in risk for every 1-gram per day increase in gluten consumption.
Researchers at the University of Pittsburgh School of Medicine have successfully grown genetically modified miniature human livers in a laboratory setting. These mini livers mimic non-alcoholic fatty liver disease progression and can be used to test therapeutics, providing a valuable tool for understanding and treating diseases.