Articles tagged with Gastrointestinal Disorders
Researchers developed an AI system that classifies IBDN lesions accurately, displaying image-based diagnostic ability with 64.5% sensitivity and 89.5% specificity. The correct diagnosis rate of the AI system was 79.0, surpassing that of endoscopists, who achieved a 77.8% accuracy rate.
A team of researchers created an in vitro human model of environmental enteric dysfunction (EED) using the Human Organ Chip technology. The EED Chips recapitulate features of EED found in biopsies from human patients, including inflammation and intestinal barrier dysfunction. The study sheds light on the complex interplay between malnu...
Research on wild Assamese macaques reveals that their gut bacteria composition changes uniquely with age, despite similar lifestyles. This finding suggests that the process is part of natural aging and not due to lifestyle changes, with potential implications for developing personalized therapies against intestinal diseases.
Researchers at Ural Federal University created a sensor to detect human saliva pH levels using a reusable, non-toxic fluorophore. The sensor can pick up small fluctuations in pH and provides accurate results in just 5-7 seconds.
Researchers have found a negative correlation between Helicobacter pylori infection and inflammatory bowel disease (IBD) prevalence, suggesting the bacterium may protect against IBD. This is supported by studies showing improved gut microbiota diversity and increased abundance of beneficial bacteria in H. pylori-infected individuals.
A new preclinical study by Weill Cornell Medicine researchers shows that naturally-produced IgG antibodies in breast milk can protect infants from infection-induced diarrheal illness. These antibodies enhance infant immunity against bacterial pathogens causing gastrointestinal diseases.
A new study found that microgravity analog culture profoundly affects the microbial infection process in 3-D human tissue models. This is critical for ensuring astronaut health on extended space missions and sheds light on mysterious processes of infection on Earth.
Researchers have shown ablation therapy can correct stomach dysrhythmias, eliminating abnormal electrical activity and restoring normal function. The technique may now be able to treat patients suffering from gastrointestinal disorders.
A new study found a bi-directional relationship between gastrointestinal issues and internalized symptoms in children with autism, highlighting the importance of the gut-brain axis. The research aims to develop personalized treatments for individuals with autism experiencing gastrointestinal problems.
Researchers have found that preterm infants with certain viral signatures in their gut are at risk of developing necrotizing enterocolitis (NEC), a serious and often fatal disease. The study highlights the potential for early warning signals to alert clinicians, allowing emergency action to be taken.
A study discovered that a common gut parasite, Blastocystis ST4, has beneficial properties by stabilizing the bacteria ecosystem and promoting quicker recovery from inflammation. The parasite may potentially be translated into probiotics to treat inflammation in patients.
Research reveals that an imbalance in gut microbiota, known as dysbiosis, may contribute to the development and progression of Parkinson's disease. Studies found a direct correlation between gut dysbiosis and Parkinson's, with certain bacteria contributing to protein aggregation and neuronal damage.
A recent report by the International Society of Microbiota confirms a bidirectional interplay between gut microbiota and various organs, highlighting the crucial role of microbiota in disease pathogenesis. The report also explores therapeutic strategies for manipulating gut microbiota to prevent and treat disorders.
Researchers at Penn Medicine have discovered a new approach to treat solid cancers using CDH17CAR T cells, which selectively target and eliminate gastrointestinal (GI) solid tumors like gastric, pancreatic, and colorectal cancers in preclinical models. Unlike other immunotherapies, CDH17CAR T cells do not show toxicity to healthy tissues.
Researchers at Clemson University have identified a genetic variation associated with congenital idiopathic megaesophagus (CIM) in German shepherd dogs, which is often fatal if left untreated. A genetic test using melanin-concentrating hormone receptor 2 and dog's sex can predict the risk of CIM with 75% accuracy.
The SynGAP Research Fund has developed a pre-screening tool to identify potential SYNGAP1 patients through a free online survey. The partnership with Probably Genetic aims to screen undiagnosed patients and provide them with genetic testing resources, ultimately advancing treatment development for SYNGAP1.
Researchers at Karolinska Institutet used spatial transcriptomics to create a map of gene expression in the mouse colon, gaining new insights into inflammatory bowel disease. The study's findings suggest that the colon is divided into more segments than previously thought and could lead to the development of new treatments.
A nationwide study in Germany found that liver cirrhosis has the highest mortality rate among chronic diseases, with 0.94% of hospital admissions affected. The study also showed a decline in mortality rates due to improvements in Hepatitis C treatment, but an increase in non-alcoholic fatty liver disease cases.
Scientists have identified a key receptor in the digestive tract that triggers pain and inflammation in the colon. By blocking this receptor from entering cells, researchers found significant reduction in pain and inflammation. This discovery holds promise for treating inflammatory bowel disease.
Researchers at MIT have developed a pill that can deliver RNA to the stomach, potentially making vaccines easier to tolerate and treat gastrointestinal diseases. The capsule is designed to release RNA in the stomach, where it can stimulate an immune response without being degraded by digestive enzymes.
A study analyzing US SEER data from 2000-2016 found that younger age groups experienced the steepest increase in distant-stage early-onset colorectal adenocarcinoma incidence. Younger non-Hispanic Black and Hispanic populations showed greater proportions of distant-stage disease.
Researchers at Boston Children's Hospital have developed an organoid platform that identifies drugs that enhance enteroendocrine cell action, potentially reversing diabetes, obesity and gastrointestinal conditions. The system identified three chemicals that drive the formation of EE cells and hormone production.
Proton pump inhibitors are underutilized in high-risk patients due to knowledge gaps and barriers among specialties. Multi-component interventions can improve guideline-based use to prevent upper gastrointestinal bleeding.
A recent study has investigated the effect of donor selection on transplanted microbiota establishment and long-term stability in aged hosts. Autologous FMT demonstrated better resilience than heterologous FMT in restoring gut microbiota diversity after antibiotic-induced perturbation.
Barrett's esophagus is caused by long-term GERD, which leads to changes in cells where the stomach and esophagus meet. Researchers found that stomach cells adopting intestinal cell qualities may be a key factor in its development.
Researchers found that adding tomato concentrate to a mouse's diet reduced intestinal and systemic inflammation in individuals with chronic HIV. The study suggests targeting the inflamed intestine may be a novel way to prevent persistent inflammation.
A study by Kennedy Krieger Institute explores how GI problems in children with autism affect their families. Researchers identified four main themes: anxiety, diet, microbiome imbalance, and medication impact. The findings highlight the need for interventions to address poor gut health and its consequences.
Researchers discovered that people with inflammatory bowel disease (IBD) have higher levels of microplastics in their feces compared to healthy individuals. The study suggests a possible link between microplastic exposure and IBD, but the exact relationship remains unclear.
A study of 685 Italian children found that certain factors, such as age and comorbidities, are associated with severe gastrointestinal symptoms. The research identified key risk factors for severe GI symptoms in this population, shedding light on the complex interactions between SARS-CoV-2 infection and the immune system.
The KEYNOTE-811 trial demonstrates a significant improvement in objective response rate (74.4%) and tumor size reduction compared to trastuzumab and chemotherapy. The combination of pembrolizumab, trastuzumab, and chemotherapy markedly reduces tumor size and induces complete responses in some patients.
Researchers developed an AI system to detect inflammation in ulcerative colitis patients using live colonoscopy videos. The system accurately predicted remission cases with high accuracy, reducing the need for invasive biopsies.
The coating protects bacteria during the freeze-drying and manufacturing process, allowing them to be used therapeutically. The researchers tested the coating on a strain of E. coli and another species that aids in digestion of plant starches.
A study found that specific DNA changes influence bowel habits and predisposition to IBS. Genetic profiles were correlated with questionnaire data, identifying regions of the genome involved in gut motility. This discovery may lead to new drug targets for treating constipation, diarrhoea, and dysmotility syndromes.
A new study links the composition of gut microbiome before infection to HIV susceptibility and progression. Men who contracted HIV in the early days of the pandemic had a greater relative abundance of pro-inflammatory vs. anti-inflammatory gut microbes, which contributed to their increased risk of developing AIDS.
A recent study found that antibiotic resistance rates for Helicobacter pylori are decreasing in European countries. The use of three antibiotics over 10-14 days resulted in success rates of over 90%. The researchers hope to reduce antibiotic consumption to prevent further resistance.
A study by Tokyo University of Science researchers identifies a novel regulatory axis targeting dendritic cell activity, suppressing autoimmune disease symptoms and bone loss. They discovered DCIR binds to glycoproteins on macrophages and osteoclasts, reducing inflammation and immune responses.
Researchers at Massachusetts General Hospital have uncovered important details about Shigella's translocon, a pore that injects bacterial proteins into infected cells. The findings may help develop an effective strategy to block this critical component of infection and prevent diseases like dysentery.
An international research team discovered that intestinal bacteria can distribute their metabolic products throughout the body via the bloodstream using membrane vesicles. The study found that these vesicles can overcome the blood-brain barrier and enter brain cells, suggesting a new method for delivering drugs or vaccines.
The American Gastroenterological Association (AGA) has released new clinical guidelines that recommend against extensive preprocedural testing to estimate clotting in patients with cirrhosis. This change aims to reduce the risk of morbidity and mortality associated with unnecessary blood clotting tests.
A woman-owned spinout company, Chosen Diagnostics Inc, has received a $2.1M NIH grant to develop and commercialize a noninvasive diagnostic biomarker test for necrotizing enterocolitis. The test, called NECDetect, identifies 93% true positives and 95% true negatives in diagnosing the disease.
A survey of over 50,000 people found that around 11% experience abdominal pain when eating, with symptoms also affecting mental health and daily life. The study highlights the need for meal-related symptoms to be considered in diagnosis and treatment of functional gastrointestinal disorders.
A new surgical procedure called Kareem's procedure has been introduced to treat congenital intestinal malrotation, a condition where the intestines twist, causing serious complications. The study shows favorable outcomes in patients with intact gut and disabling symptoms, with significant improvement in digestive symptoms after surgery.
A comprehensive review reveals how excessive fructose intake can disrupt metabolic pathways, leading to diseases such as diabetes, fatty liver disease, and heart disease. The study highlights the role of protein transporters, gluconeogenesis, and gene-level changes in regulating fructose metabolism.
A study by Kazan Federal University found that probiotics administered to antibiotic-treated mice improved behavior, reduced oxidative stress, and restored gut microbiota diversity. The researchers demonstrated a strong link between the gut microbiota and brain functioning, with potential therapeutic benefits for treating dysbiosis-rel...
Researchers found that hematopoietic cell transplantation (HCT) normalizes the gut microbiota of patients with IBD associated with XIAP deficiency. The study revealed that HCT decreases gut inflammation and restores diversity in gut microbiota, improving symptoms and quality of life for affected individuals.
A study from the University of South Carolina's Environmental Health & Disease Laboratory found that andrographolide successfully restored bacteriomes and viromes, increasing beneficial bacteria and decreasing harmful bacteria. The treatment also decreased gut inflammation and neuroinflammation in veterans with Gulf War Illness.
A new study from the University of Sheffield reveals that vitamin D supplements do not reduce the severity of IBS symptoms or improve quality of life. Despite correcting deficiencies in those with poor vitamin D status, high-dose vitamin D supplementation did not alleviate symptoms.
A review article summarizing IBS research in China aims to bridge the gap in global literature and improve management of the disorder. The study reveals high prevalence rates, recognized risk factors, and effective treatments, including probiotics and traditional Chinese medicine.
A new laboratory method called TaqMan Array Card (TAC) has been validated for detecting a diverse range of bacteria that cause diarrheal disease. The TAC is faster and cheaper than traditional methods while delivering comparable results, enabling comprehensive monitoring of enteropathogens in informal settlements.
A new stem cell therapy strategy has shown promising results in treating intestinal bowel disease in premature infants. The treatment uses human placental-derived stem cells to repair damage caused by the disease and promote healing of the intestinal barrier.
The International Journal of Gastroenterology and Hepatology Diseases is a new subscription-based journal publishing articles on global significance gastrointestinal and liver diseases. It aims to publish experimental and theoretical results in detail, covering advancements in management and diagnosis of diseases.
A link between depression and stomach ulcers has been confirmed in the world's largest study of genetic factors in peptic ulcer disease, involving nearly half a million people. Genetic variations associated with an increased risk of peptic ulcer disease have also been identified.
Researchers have discovered a molecular switch that regulates inflammation in the stomach, triggered by H. Pylori bacteria. The 'switch' uses a previously unknown mechanism to control the infection, allowing it to evade the immune system and cause stomach diseases such as ulcers and cancer.
Researchers at Flinders University have unraveled the neural circuits of the enteric nervous system, revealing how food is slowly mixed and propelled along the digestive tube. This understanding could lead to more effective treatments for conditions like constipation, diarrhea, and pain.
Research found symptomatic GERD a risk factor for TMD, with longer GERD history linked to higher TMD risk. Multidisciplinary management programs may help patients with co-occurring conditions.
A new breath test could diagnose gastrointestinal damage in children without invasive procedures, reducing trauma and costs associated with oesophageal testing. The trial uses a Dipeptidyl peptidase-4 (DPP4) enzyme found in the small intestine to measure gut health.
A new study from the University of Kent has found that a common gut parasite, Blastocystis, can survive under conditions with increased oxygen levels, contrary to previous thinking. This discovery could provide insights into its role in intestinal diseases such as irritable bowel syndrome.
A new study introduces a 17-item questionnaire to identify gastrointestinal disorders in children with autism, which can lead to behavioral problems. The screening tool correctly identified over 80% of children with GI disorders, offering hope for more effective treatment.
Researchers at the University at Buffalo discovered barley as an ideal and safe contrast agent for diagnosing swallowing disorders. The grain's roasted version can illuminate the throat and gastrointestinal tract when struck by a laser beam, providing nuanced and real-time views inside the body.
Researchers at the University of Colorado Anschutz Medical Campus have shed light on intestinal failure-associated liver disease, a condition that affects people relying on IV nutrition due to intestinal damage. The study suggests three possible new targets for drug intervention to prevent or treat the disease.