Research on diseases of the nervous system. Covers mitochondrial protection, macrophage replacement, Parkinson's costs, and brain-injury recovery.
Researchers developed a blood test to predict when Alzheimer's symptoms will start, using protein p-tau217 in plasma. The models predicted the onset of symptoms with accuracy, suggesting potential for preventive treatments.
Scientists have developed a technology that reveals which proteins are generated by individual brain cells. They mapped protein production across nearly 20,000 individual cells in the mouse hippocampus, finding surprising patterns and potential links to neurological conditions. The study sheds light on how translation affects memory ci...
Researchers created a simplified, scalable human cell model to study coordinated brain rhythms. They found that inhibitory signaling mediated by GABA helped promote sleep and prevent seizures, while potassium channel perturbations influenced rhythmic organization in distinct ways.
A study by University of Virginia Health System researchers found that Medicare Advantage patients had better access to preventive care and rehabilitation after a stroke, leading to faster recovery times. In contrast, traditional Medicare patients were less likely to receive these services due to prior authorization requirements.
Researchers developed a free-to-use software tool, PSBench, to verify the accuracy of artificial intelligence-based protein structure predictions. The database includes 1.4 million annotated protein models, verified by experts, and provides reliable information for building more accurate AI systems.
A large cohort study found that air pollution exposure increases the risk of Alzheimer's disease, particularly in individuals who have experienced a stroke. The study suggests that improving air quality could be an important way to prevent dementia and protect older adults.
A new national registry study found that people with traumatic brain injury (TBI) have an increased risk of work disability, which can recur years after the injury. The study included nearly 100,000 participants and found that even minor TBI injuries can affect long-term employment.
Myelin swellings are precursor lesions in MS, but research reveals they have a dynamic character, growing, shrinking and recovering. The underlying nerve fibre activity plays a key role in their formation.
Advanced 3D imaging reveals that vascular amyloid deposition follows a specific pattern, starting from surface vessels and spreading inward along connected pathways. The study provides new insights into the spatial organization of amyloid pathology in cerebral amyloid angiopathy.
Researchers at Case Western Reserve University identified a link between gut bacteria and neurodegenerative diseases like ALS and FTD. They discovered that certain bacterial sugars cause immune responses that kill cells, paving the way for new treatments.
The study found lecanemab to be safe and effective in slowing down cognitive decline and clearing brain Aβ deposition in Chinese patients with early AD. The results demonstrate a lower incidence of infusion-related reactions and amyloid-related imaging abnormalities compared to international clinical trials.
A new AI-powered model can read a brain MRI and diagnose neurological conditions with up to 97.5% accuracy, predicting treatment urgency and automating alerts for immediate medical attention. The technology has the potential to transform neuroimaging at health systems across the US, reducing workload and improving patient outcomes.
The UTA Pediatric Brain Health and Neurosciences Center will focus on developing novel treatments for drug-resistant epilepsy in children. Dr. Papadelis' team has already made significant discoveries in identifying the epileptogenic zone and predicting surgical outcomes.
Researchers found that certain types of CD8+ killer T cells are more abundant in people with MS and target the EBV virus, indicating the virus may trigger an immune response leading to progressive neurological damage. The study suggests that interfering with EBV could have a significant impact on other autoimmune diseases.
Researchers have developed a long, needle-thin brain electrode with channels that enables neural signal recording and precisely targeted medication delivery across different brain regions. The technology has primarily been developed for basic research but may be important for future treatments in epilepsy and other neurological diseases.
A new study highlights the clinical relevance of brain functional connectome uniqueness in identifying biomarkers for major depressive disorder. Researchers found that patients with MDD displayed reduced FC uniqueness, especially in frontoparietal and sensorimotor networks.
Researchers discovered Chlamydia pneumoniae can cause inflammation, nerve cell death and cognitive decline in Alzheimer's disease. The study suggests targeting chronic bacterial infection may represent a new treatment strategy.
A new study identifies the somato-cognitive action network (SCAN) as responsible for Parkinson's disease symptoms, which can be treated with non-invasive transcranial magnetic stimulation. Targeting this network improves symptoms more than twice as much as treatments targeting nearby brain areas.
A new study by UCLA anthropology professor Molly Fox found that pregnancy and breastfeeding are associated with stronger long-term cognitive ability in postmenopausal women. The study used data from the Women’s Health Initiative Memory Study and the Women’s Health Initiative Study of Cognitive Aging, which assessed over 7,000 women age...
A study published in the Journal of Neurologic Physical Therapy found that backward walking training improved postural stability and gait speed in most participants with multiple sclerosis. The researchers suggest that this therapy may promote neuroplasticity and be a potential new treatment for improving mobility and decreasing falls.
Researchers at University College London discovered that Alzheimer's disease disrupts the brain's 'memory replay' process, leading to impaired navigation and memory loss. The study found that even when mice were resting, their brains replayed recent experiences in an altered pattern, which had consequences on memory tasks.
A team at Chalmers University of Technology has discovered biomarkers for Parkinson's disease in the blood, which could lead to early diagnosis via blood tests within five years. The study found distinct gene activities linked to DNA damage repair and stress response in patients in the early phase of the disease.
A study published in Cell identified a protein complex called CRL5SOCS4 that marks tau for degradation, suggesting strengthening this natural defense mechanism could represent a new therapeutic strategy. Higher expression of CRL5SOCS4 components made neurons more likely to survive despite the accumulation of tau protein.
A novel AI framework uses speech patterns to detect cognitive decline years before traditional tools can, offering non-invasive screening for neurodegenerative conditions. The approach analyzes complex dynamics and transitions hidden in speech to reveal subtle patterns and extract objective biomarkers from natural patient behavior.
A new study reveals how Parkinson's spreads from the gut to the brain via immune cells, identifying a key role for gut macrophages in transporting toxic proteins. Reducing these cells can slow disease progression and improve motor symptoms in mice.
A brain-specific enzyme reshapes protein-linked sugar chains to facilitate the formation of complex glycans essential for normal brain function. This process is critical for efficient keratan sulfate formation and has implications for research into glycan-related brain disorders.
A quarter of pregnant patients suffering stroke symptoms were misdiagnosed due to overlooked warning signs, according to a new study. The researchers highlight the need for better clinician education and decision-support tools to improve maternal health outcomes.
Researchers analyzed 58 human studies to investigate the link between gut microbiome imbalances and cognitive decline. The findings suggest that individuals with mild cognitive impairment and Alzheimer's disease have distinct gut bacteria profiles compared to healthy individuals.
A study reviews decades of research on Hsp70's role in neurodegenerative diseases, highlighting its protective effects and potential therapeutic value. The review reveals that different Hsp70 isoforms interact with co-chaperones and cellular pathways to determine protein clearance.
The Global Brain Economy Initiative aims to establish brain capital as an essential asset for the 21st century, connecting neuroscience with economic policy. The initiative's mission is to address disparities in support for brain capital across various sectors and promote long-term growth, workforce resilience, and social well-being.
Researchers discovered exercise-induced mitochondrial migration through the bloodstream, protecting brain cells and reducing damage after a stroke. This innovative approach has potential for mitigating neurological sequelae and treating vascular dementia.
A new study suggests that gaps in the nation's stroke transfer system reduce survivors' chances of receiving critical treatment and increase disability. Patients with longer delays in hospital transfer experienced worse disability after their stroke, highlighting missed opportunities for many stroke patients.
Research highlights glial cells as dynamic regulators of brain health, playing both protective and harmful roles in neural function. Promising therapeutic targets include oligodendrocyte dysfunction, mitochondrial transfer, and extracellular vesicle engineering.
A Swedish study published in JAMA Neurology found that prolonged air pollution exposure is associated with a higher risk of developing motor neuron disease, including ALS. Long-term exposure to even low levels of air pollutants was linked to faster disease progression and increased mortality rates.
Studies exploring the role of histamine H3R receptor in the brain found that specific amino acid mutations can increase constitutive activity while compromising stability. The research provides a foundation for a better understanding of brain diseases and the design of safer drugs.
The study reveals cerebrovascular disease as the third leading cause of death among adults in China, with a higher risk among men and those residing in northern regions. Dementia and Parkinson's disease also show high prevalence rates, while unique demographic patterns are observed for other neurological disorders.
A research team at Goethe University Frankfurt has compiled a catalog of human E3 ligases and mapped their relationships, revealing family-specific functions. The study identifies 40 additional E3 ligases suitable for PROTAC development, expanding the range of tissues and diseases targeted by degradation therapies.
Researchers at Science Tokyo have elucidated the molecular mechanism of Golgi membrane-associated degradation (GOMED), a selective protein cleanup system. They found that GOMED recognizes substrates using K33-linked ubiquitin chains and employs optineurin (OPTN) as an adaptor molecule to guide them for degradation.
Researchers developed the BIND screener to identify brain-related comorbidities in individuals with Duchenne muscular dystrophy. The tool showed strong accuracy in identifying neurodevelopmental and psychiatric conditions in a large international sample of participants.
A new study from Karolinska Institutet reveals the Epstein-Barr virus can damage the brain and contribute to multiple sclerosis through molecular mimicry. The researchers found that cross-reactive T cells are significantly more common in people with MS, and targeting these cells may lead to new treatments.
JMIR Publications' JMIR Neurotechnology journal now accepts submissions on novel technological advances for neurological disorders. Researchers can submit review articles exploring emerging technologies, such as neurofeedback, neurosurgery, and brain-machine interfaces.
A new study from Murdoch University found that 66% of participants with Complex Regional Pain Syndrome (CRPS) experienced migraines that started or worsened after CRPS onset. This research highlights the connection between CRPS and migraine, suggesting a possible common cause for both conditions.
A study found that increased bone morphogenetic protein signaling is linked to impaired neurogenesis in Alzheimer's disease, particularly in female mice. The research suggests that activation of BMP signaling may be a key factor contributing to the sex-based differences observed in AD.
Researchers found that close to half of all dementia cases would not arise without the APOE gene's influence, and potentially more than 90% of Alzheimer's disease cases are linked to variants in this single gene. The study highlights the APOE gene as a powerful target for drug development.
Researchers at Sanford Burnham Prebys found that transplanted stem cells develop neurons with unique codes to navigate and form connections in the brain. These codes guide the growth of axons and explain why most neurons of a particular subtype send axons to specific brain regions.
A new UCLA study combines human and animal research to identify chlorpyrifos as a potential environmental cause of Parkinson's disease. Long-term residential exposure to the pesticide increases the risk of developing the condition by more than 2.5 times.
New research reveals that the immune system has a potent weapon against the brain parasite Toxoplasma gondii: an enzyme called caspase-8. This discovery offers new insights into how our bodies control the parasite and may lead to better treatments for patients with compromised immune systems.
A comprehensive review reveals the therapeutic effects of Borago officinalis, a plant with diverse compounds targeting inflammation and metabolic pathways. The study highlights its potential in treating cardiovascular disease, diabetes, and neurodegenerative disorders.
Researchers at the University of Illinois discovered that propofol, a common anesthetic agent, can improve cognitive function after surgery in older individuals. Additionally, intranasal insulin was found to mitigate age-related memory impairment by modulating neuroinflammatory mechanisms.
A comprehensive review synthesizes emerging evidence on AMPKα isoforms' dual roles in Alzheimer's disease. The analysis proposes that this complexity may explain why pharmacological approaches have yielded mixed results in treating the disease. Isoform-specific targeting is proposed as a novel therapeutic strategy.
The MONEAD study provides practical guidance for clinicians to manage epilepsy during pregnancy, reducing the risk of seizures and improving outcomes. The study's week-by-week playbook offers dose adjustments for antiseizure medications, empowering healthcare providers to provide the best possible care.
Researchers discovered that female brain immune cells called microglia express more interferon-related genes when responding to amyloid-β plaques, causing more harm to neuronal connections. This finding suggests a potential sex-specific treatment approach for Alzheimer's disease.
Researchers discovered that calcium alpha-ketoglutarate restores key memory-related brain functions disrupted in Alzheimer's disease. The molecule enhances synaptic plasticity, protects neurons from degenerative changes, and supports healthier cognitive ageing.
Researchers at Ben-Gurion University of the Negev identified SIRT6 as a critical upstream drug target for combating neurodegenerative pathology. By reprogramming gene expression, SIRT6 prevents the production of neurotoxic tryptophan metabolites and promotes protective neurotransmitters.
Researchers found that eradicating aging cells in mice with a combination of dasatinib and quercetin reduced senescent cells, improved memory, and decreased seizures. The study's results suggest a potential new approach to treating temporal lobe epilepsy.
A study published in the Journal of Proteome Research found that acute systemic inflammation causes region-specific metabolic disruption in the cerebrum, impairing neuronal metabolism. Key findings include reduced NAA levels and elevated urea accumulation, suggesting a link between inflammation and neurodegenerative disorders.
A newly discovered neural pathway connects the amygdala with arousal centers in mice, revealing a key mechanism for emotional regulation of sleep-wake cycles. This finding highlights potential therapeutic targets for stress-related insomnia and mood disorders.
In a new study, Northwestern scientists identified a previously unknown toxic sub-species of amyloid beta oligomers that drive brain changes in Alzheimer's disease. NU-9 decreased this toxin and reduced damage in a mouse model, suggesting it could prevent or delay the cascade of toxic events that destroy neurons.
A review in Developmental Medicine & Child Neurology summarizes the benefits of parasport participation for individuals with cerebral palsy. The authors highlight its value in combining therapeutic physical activity with social inclusion and community integration.
Scientists at Salk Institute find protein CCN1, secreted by astrocytes, maintains stable neural circuits in adult brains. The discovery could lead to new therapeutics for brain injury and stroke.