Articles tagged with Influenza Viruses
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The new platform developed by UVA Health scientists can produce vaccines much faster, cheaper, and more easily than traditional approaches. The platform's proof-of-concept demonstrates its ability to produce highly immunogenic vaccines that can be manufactured at extremely low cost.
A new study found that nudging both patients and providers with reminders increased flu vaccine numbers by almost 3,000 more people than expected. The researchers believe this could lead to strategies to boost annual flu vaccination rates.
Researchers at Georgia State University found that segmented filamentous bacteria (SFB) provide marked protection against post-influenza bacterial pneumonia in mice. SFB reprograms alveolar macrophages to resist influenza virus-induced dysfunction, maintaining their defense against respiratory bacterial pathogens.
The Influenza A(H3N2) subclade K virus is a growing concern due to its antigenic variants and reduced vaccine effectiveness. Researchers emphasize the need for swift responses to protect public health.
The emergence of A(H3N2) subclade K viruses in Australia and New Zealand extended their influenza seasons, with Australia experiencing a record-breaking season. The viruses were likely imported from the US and accounted for half of Australian viruses and over two-thirds of New Zealand viruses.
A study by Iowa State University researchers reveals that avian influenza can infect livestock and humans through their mammary glands, which have high levels of sialic acids. This increases the risk of transmission and potentially more dangerous adaptations emerging.
The new guideline recommends full-time infection prevention staff, comprehensive training, and support for all staff, as well as partnerships with hospitals and public health agencies. This guidance aims to reduce the risk of infections in nursing homes, saving lives and money.
The partnership aims to co-develop and evaluate next-generation self-amplifying RNA (saRNA) vaccines targeting seasonal and pandemic influenza. Apriori's Octavia platform will be combined with A*STAR IDL's saRNA delivery technology to develop improved H5 influenza vaccines that anticipate infection in humans.
Research found acute and chronic viral infections increase risk of heart attacks and strokes, while long-term risks persist for HIV, hepatitis C, and herpes zoster. Vaccination measures, including flu shots, can reduce cardiovascular disease risk by 34%.
A study of 200 classrooms found that HEPA purifiers did not significantly reduce respiratory viral exposures, suggesting additional interventions are needed. Maintaining classroom humidity between 40% and 60% may help lower viral exposures and improve comfort for students and teachers.
Scientists have developed a monoclonal antibody to combat life-threatening inflammatory diseases like sepsis and ARDS. The antibody shows promise in blocking the immune system's hyperactive response and restoring healthy function without unwanted side effects.
A new study found that most air cleaning technologies have not been tested on humans and their potential risks are not yet fully understood. Researchers recommend choosing technologies independently tested in real-world environments to reduce illness in homes, schools, or workplaces.
A UK study monitored antimicrobial resistance and influenza viruses in water bodies frequented by wild birds, finding widespread AMR genes in 92% of samples. Influenza virus was detected in just 3.4% of samples, highlighting the need for more sensitive detection methods.
Researchers at EPFL have created ultra-selective aptamers that target specific binding sites on viral spike proteins with unprecedented precision. These multivalent binders show stronger and more selective binding affinities than traditional monovalent binders, making them promising for biomedical diagnostics and therapeutics.
A study reveals claudin-11 facilitates depolymerization of F-actin, promoting maturation of influenza virus-containing clathrin-coated vehicles. Claudin-11 silencing leads to increased survival rate in infected mice.
The new Epigraph vaccine developed by University of Nebraska-Lincoln virologist Eric Weaver protects against H1N1 swine flu and can also protect against influenza in humans and birds. The vaccine significantly outperformed commercial vaccines, providing protection for up to a decade.
Scientists have engineered a monoclonal antibody that protects mice from a lethal dose of influenza A with sticky staying power. The new molecule combines specificity and broad binding capacity, adhering to the lung lining and blocking infection in mice.
A major global review of bird flu in cats found 607 cases, including 302 deaths, from 18 countries and 12 cat species. The virus is highly infectious and can spread through direct contact with infected birds or other mammals, leading to severe symptoms like brain swelling.
Scientists have developed a universal protocol to investigate how viruses interact with host cells, revealing a cascade of cellular reactions triggered by contact between the virus and cell surface. This breakthrough provides insights into the biology of influenza viruses and identifies potential targets for antiviral therapies.
Researchers at the University of Gothenburg discovered that the influenza A virus exploits a protein called AGO2 to regulate gene activity and weaken the immune system. An existing drug, arsenic trioxide, showed promise in increasing interferon production and reducing viral loads.
A landmark study found that a single oral dose of baloxavir marboxil significantly reduces influenza transmission within households. Conducted across 15 countries, the CENTERSTONE trial provides robust evidence for an antiviral treatment's potential to curb the spread of influenza.
The CDC has awarded a $3 million grant to the Texas A&M School of Public Health to investigate avian flu among dairy farm workers in Texas. The team, led by Dr. David Douphrate, aims to identify the scope of exposure and workplace factors involved in transmission.
A recent study suggests that many Americans are unaware of simple food safety practices that can reduce the risk of bird flu infection. The survey found that over half of respondents did not know to pasteurize milk and more than a quarter expressed reluctance to take a potential vaccine.
A new vaccine platform developed at the University at Buffalo has demonstrated complete protection in mice against a deadly variant of bird flu. The vaccine, which combines key proteins hemagglutinin and neuraminidase, shows promise as a versatile and easy-to-produce vaccine that could be effective against evolving bird flu strains.
Researchers identified three hotspots of hantavirus circulation in wildlife, including Virginia, Colorado, and Texas. The study found 15 rodent species as carriers, including six new hosts, and explored the impact of climate change on transmission.
Researchers developed an antiviral chewing gum containing a natural protein that neutralizes viral loads of influenza A strains and two herpes simplex viruses. The gum, made from lablab beans, was found to be safe and effective in reducing viral loads by over 95%.
Researchers at Lancaster University discovered a new type of vaccine-specific scepticism, where some people perceive COVID-19 vaccines as 'not a vaccine' compared to MMR. This phenomenon may also apply to the flu vaccine, highlighting the need for clear public health messaging.
A new study finds that Canada is the slowest country to report genetic information about bird flu, with an average time of 618 days. However, the same researchers note that Canada was able to improve its response to COVID-19, highlighting the need for similar urgency in addressing this public health threat.
Scientists from the University of Zurich created decoy molecules that bind to autoantibodies, preventing them from inhibiting type I interferons. This restoration restores antiviral effect on viruses like influenza, offering hope for treatment and reducing viral disease susceptibility.
Scientists at St. Jude Children's Research Hospital found that frequently used flu antivirals do not work well against the H5N1 avian influenza virus in cows' milk. The study showed that reducing infection risk through methods like avoiding raw milk and minimizing dairy farm workers' exposures may be more effective interventions.
Consuming raw milk and its products increases the risk of foodborne illness, including from Salmonella, E. coli, and Campylobacter. The Centers for Disease Control and Prevention have detected H5N1 bird flu in raw milk, posing a risk to human health.
Researchers developed CeSPIACE, a 39-amino-acid peptide drug candidate that binds to the spike protein, blocking viral entry. It demonstrates strong binding to major SARS-CoV-2 variants and shows efficacy against multiple strains in vivo and in vitro experiments.
Researchers found that older adults exposed to seasonal flu viruses before 1968 have higher antibodies against the H5N1 avian flu virus. In contrast, young children who were not exposed had low levels of antibodies that could fight H5N1. The study suggests that younger adults and children would benefit more from H5N1 vaccinations.
Researchers have discovered how severe COVID-19 can destroy immune cells' ability to repair the lungs, leading to lingering effects of long COVID. By enhancing damaged organelles using a FDA-approved drug, they found improved lung healing and reduced inflammation.
Eradivir's EV25 is a small molecule immunotherapy biotech company developing treatments for influenza. The Phase 2 challenge study will gather safety and efficacy data from healthy participants infected with influenza.
Researchers developed a prototype sensor that detects H5N1 viruses in air samples, detecting the virus at levels below an infectious dose. The sensor produced results within 5 minutes and showed over 90% accuracy compared to traditional methods, offering promise for noninvasive air monitoring.
Researchers developed a new vaccine platform that provides robust, long-lasting protection against multiple flu strains and COVID-19. The vaccine boasts 100% survival rates in vaccinated mice following challenge with either virus.
The influenza vaccine provided moderate protection against influenza A strains, but strong protection against influenza B. The vaccine was most effective in preventing severe disease among children and adolescents, with a high effectiveness rate.
A study suggests that pre-existing immunity against seasonal H1N1 flu can reduce the severity of bird flu in ferrets. In the study, ferrets with prior H1N1 immunity were protected against severe disease and death caused by H5N1 bird flu, whereas those without prior immunity had more severe illness and fatal outcomes.
A recent study found that different birds react differently to being infected with bird flu, and microRNAs may play a key role in this variation. The researchers analyzed blood samples from ruddy turnstones and found 163 different forms of microRNA, including two unique to birds.
A preclinical trial has uncovered how beta-glucan can 'reprogram' immune cells to prevent lung inflammation and reduce the risk of illness and death from influenza. The study's findings highlight beta-glucan as a promising therapy for influenza and other emerging viral pathogens.
Researchers discovered immune cells that can recognise influenza (flu) viruses even as they mutate, providing a potential solution to the annual updates of flu vaccines. The study found that certain T cells, which play a critical role in fighting infections, can detect multiple flu strains, even those that have evolved over a century.
Influenza A virus particles can change shape from spheres to larger filaments to favor infection efficiency, according to a new NIH study. The researchers developed a method to observe real-time structure formation and found that filament shape requires more energy, helping the virus evade immune responses.
A broadly neutralizing antibody has been shown to protect monkeys against severe H5N1 avian flu disease. The antibody's stable structure ensures it can withstand virus variants, providing universal protection against a globally spreading airborne infection. Serum levels of the antibody remained stable for up to 12 weeks.
Researchers have discovered novel antiviral compounds from Antarctic fungus and developed effective methods to inactivate SARS-CoV-2 virus using UV-C light and ozone gas. Additionally, bleach and ethanol solutions have been found to remove over 99% of mpox virus, while a new class of quaternary phosphonium compounds has been identified...
A cohort study found COVID-19 to be associated with more severe disease outcomes compared to influenza and RSV during the 2022-2023 season. Vaccination attenuated these differences in severity and long-term mortality rates.
Researchers discover how cigarette smoke alters the function of mucosal-associated invariant T (MAIT) cells, a key type of immune cell in the lungs. This impairment increases susceptibility to respiratory infections and worsens chronic obstructive pulmonary disease (COPD).
A novel diagnostic system called TwinDemic Detection offers simultaneous and rapid detection of SARS-CoV-2 and influenza A virus. The system has a detection limit of 0.46 picomolar for CoV and 0.39 pM for IAV, correctly predicting positive and negative samples in high percentages.
Researchers at Texas Biomed identified nine mutations in a bird flu strain from a person in Texas that enable it to more easily replicate in human cells and cause severe disease. Approved antivirals still effectively combat the virus, according to mouse studies.
Researchers at the University of Gothenburg have discovered an antibody-like molecule, E10, that can protect mice from various influenza viruses. The molecule targets a conserved part of the virus's surface protein shared across multiple influenza types, providing effective protection against seasonal epidemics.
The NIH and its partners remain focused on monitoring the H5N1 virus, which has caused sporadic infections among wild birds and poultry farms. Researchers highlight four keys to controlling the current outbreak: timely collaborations, disease surveillance, medical countermeasures, and precautions to prevent exposure.
A new study by La Jolla Institute for Immunology researchers suggests that many people may already have immune cells on standby to combat the H5N1 virus. The study found similarities between H5N1 and seasonal influenza viruses, allowing scientists to predict cross-reactive T cell responses that could help decrease disease severity.
A new system can quickly identify emerging virus variants and provide information on their genetic changes, helping to understand why they spread differently in human populations. This enables the development of more effective vaccines and targeted treatments for diseases such as flu, COVID, and tuberculosis.
According to a new survey, over half of U.S. adults believe the RSV vaccine is effective in protecting infants from the virus, up from 42% last year. The rise in perceived effectiveness comes as several politicians have cast doubt on the vaccine's safety and efficacy.
A study by the University of Surrey found that high-quality face masks reduce transmission risk by ninefold and doubling indoor air ventilation cuts it by nearly a third. Improving ventilation and physical distancing further minimizes the risk.
The researchers have revealed the precise positioning of RNA molecules and their interactions with the protective coat. This breakthrough enables the design of new drug molecules capable of binding to the protein coat, weakening viral RNA and inhibiting influenza virus replication.
A new Stanford University study found that influenza viruses can persist in refrigerated raw milk for up to five days, raising concerns about potential transmission pathways. The researchers also discovered that the viral RNA remained detectable in raw milk for at least 57 days.
Researchers discovered a single mutation in the H5N1 virus that improves its ability to attach to human cells, potentially making it easier for humans to become infected. The study's findings stress the importance of continued genomic surveillance and public health preparedness to monitor potential genetic changes.
Researchers developed a microfluidic chip that can measure memory B cells' binding affinity to flu virus, helping track immunity. The device, Shear Activated Cell Sorting (SACS), can compare how well cells bind to original and new variants.
Researchers at McGill University have discovered that pregnancy enhances the body's natural immunity to block severe flu infection. By activating a powerful molecule in the nasal cavity, pregnant women may benefit from stronger antiviral defenses against the Influenza A virus.