Articles tagged with Resistant Strains
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Researchers at the University of Chicago have discovered a light-sensitive signaling cascade in Pseudomonas aeruginosa that suppresses biofilm formation and virulence. The study, published in Nature Communications, identifies a small protein called DimA as the key trigger for this process.
The new guideline recommends full-time infection prevention staff, comprehensive training, and support for all staff, as well as partnerships with hospitals and public health agencies. This guidance aims to reduce the risk of infections in nursing homes, saving lives and money.
The Global Pathogen Analysis Platform (GPAP) will enable low- and middle-income countries to conduct research and surveillance of infectious diseases independently. The platform aims to prevent disease outbreaks from developing into pandemics by detecting genetic sequences of potential pathogens.
The winners of the Applied Microbiology International Horizon Awards 2025 have been recognized for their groundbreaking contributions to global challenges through applied microbiology. The awards celebrate excellence across various domains, including drug discovery and sustainable agriculture.
Researchers argue that AI can strengthen pandemic preparedness by detecting emerging diseases earlier. By combining data from humans, animals, and the environment, AI can reveal patterns and provide insights into potential pathogens.
Researchers have successfully increased the susceptibility of Candida albicans to drug treatment through light-activated therapy. Combining photodynamic inactivation with antifungal amphotericin B reduced fungal growth by up to 87.5% and demonstrated potential as an alternative to combat antimicrobial resistance.
A 30-year study by Radboud University Medical Center found increased resistance in fungi, with over 2,000 resistant fungal strains collected. The fungus thrives in waste heaps and can cause aspergillosis in vulnerable patients, increasing the risk of death.
Scientists at the Stowers Institute and University of Georgia discover how Cryptococcus neoformans thrives, identifying over 300 potential targets for novel antifungal drugs. The study provides an atlas for developing new therapies to combat this lethal fungus.
Changes to a pest's diet could delay the evolution of resistance to biopesticides, according to University of Stirling scientists. The study found that altering the crop a pest eats has a greater impact on resistance than switching pesticide types.
A new method using artificial intelligence and DNA decoding can predict how well disease-causing bacteria like Listeria tolerate disinfectants. The research may lead to smarter hygiene strategies and faster responses when pathogenic bacteria are present in food production.
Recent cases of multi-drug resistant cholera in the UK and Germany are linked to exposure to contaminated holy water from Ethiopia. The study found a connection between pilgrims consuming or bathing in the holy well and the spread of the disease.
A new artificial intelligence-based method detects genetic markers of antibiotic resistance in bacteria, potentially leading to faster and more effective treatments. The method, called Group Association Model, uses machine learning to identify key mutations linked to drug resistance, reducing false positives and misdiagnoses.
Researchers created a bacterial evolutionary map that tracks plasmid gene exchange and identifies barriers to treatment. The study reveals new insights into the co-evolution of plasmids and E. coli strains, paving the way for targeted therapies against antibiotic-resistant infections.
A study reveals that most Acinetobacter baumannii infections in a Malaysian hospital belonged to the Global Clone 2 lineage, which is also dominant worldwide. The majority of bacterial samples were resistant to multiple antibiotics, including carbapenems.
A groundbreaking study has identified a dual-target approach that significantly prevents the development of resistance in bacteria. This approach combines membrane disruption with an additional critical cellular pathway, offering a potential solution to mitigate the escalating threat of antimicrobial resistance.
Research finds over 25% of Egyptian milk and dairy products contain E. coli, with one strain causing a Japanese school outbreak; experts hope for effective treatment and prevention methods.
A new study published in the Journal of Antimicrobial Chemotherapy has found that lenacapavir is effective in controlling HIV in a population of patients in Uganda. The study sequenced the capsid proteins from 546 Ugandan patients and found little natural resistance to the drug.
A study found that even with impeccable cleaning, hospital sink drains can host bacterial populations that change over time. Dominant species include Stenotrophomonas and Pseudomonas aeruginosa, known to cause ventilator-associated pneumonia and sepsis.
Researchers found that people with diabetes are more likely to develop antibiotic-resistant strains of Staphylococcus aureus, which can spread rapidly and evade treatment. Controlling blood sugar levels through insulin use may be key in preventing antibiotic resistance.
Researchers at Texas A&M University have developed a low-cost technology using curcumin to curb bacterial resistance. The study shows that photodynamic inactivation can trigger deleterious reactions within bacteria, killing them and reducing the number of antibiotic-resistant strains.
Carbapenem-resistant Enterobacterales, including K. pneumoniae and E. coli, pose a significant risk to EU/EEA patients and healthcare systems. The epidemiological situation has deteriorated since 2019, with high-risk lineages spreading in hospitals.
Recent studies have found that new antibiotics are prone to rapid development of resistance, even before they are widely used. This raises concerns about the effectiveness of these treatments in the long run. To address this issue, researchers call for a shift in antibiotic development prioritizing novel modes of action and responsible...
A new compound, V-161, has been discovered to effectively inhibit the growth of vancomycin-resistant Enterococci (VRE) by targeting a crucial enzyme. The study reveals that V-161 not only disrupts the enzyme function but also reduces VRE colonization in the mouse small intestine.
A research team led by Hidemasa Bono mapped the genomes of susceptible and resistant bed bug strains, revealing new insights into the development of pyrethroid resistance. The study identified 729 resistance-specific mutations in protein-coding genes related to DNA damage response, cell cycle regulation, and lysosome functions.
A highly drug-resistant cholera strain has been identified in Yemen and later detected in Lebanon, Kenya, Tanzania, and the Comoros Islands, including Mayotte. The strain's spread highlights the need for strengthened global surveillance of the cholera agent to monitor its resistance to antibiotics.
Scientists have discovered a weakness in antibiotic-resistant bacteria that can be exploited to stop the spread of this public health crisis. By understanding the link between magnesium limitation and ribosome variants, researchers may develop novel drug-free approaches to combat antibiotic resistance.
Researchers identified a genetic weakness in drug-resistant Mycobacterium tuberculosis, allowing them to develop targeted drugs. This technology has the potential to combat other drug-resistant pathogens and prevent their spread.
A multidrug-resistant strain of Klebsiella pneumoniae has been detected in Northeast Brazil, with the bacterium being resistant to all available antibiotics. The strain had previously been detected in the US and can potentially spread globally.
A new strain of antibiotic-resistant bacteria, ST164, has been spreading widely across Asia, posing significant challenges to global public health. Researchers discovered that 80.9% of A. baumannii bacteria found in patients were CRAB, with ST164 accounting for 40.2% of samples.
Researchers at Houston Methodist have identified a new strain of bacteria, Streptococcus dysgalactiae subspecies equisimilis (SDSE), linked to increasingly severe human infections. The study used integrative analysis to investigate the genome, transcriptome, and virulence of SDSE strains, shedding light on their molecular pathogenesis.
A new study reveals widespread resistance of Pseudomonas aeruginosa to commonly used cleaning agents, including quaternary ammonium compounds. The researchers identify biocides that work well against the pathogen, highlighting the need for revised sanitation protocols in hospitals and homes.
A new study has identified novel strains of microbes that have adapted to use limited resources in cities, including those found in Hong Kong's subways and skin. These microbes can metabolize manufactured products, posing health risks if they are pathogenic.
A new study reveals how three species of bacteria coexist in biofilms by playing a game of 'nice' and then moving out when the surface becomes too crowded. The dominant species, Pseudomonas aeruginosa, disperses to allow other species to thrive.
Researchers from Duke University have discovered the mechanism behind the discrepancies in how resistant infections react to combination treatments. The study found that bacteria with a higher level of 'selfishness' are more likely to thrive after treatment, while less selfish strains benefit more.
A study found that doxycycline post-exposure prophylaxis (doxy-PEP) did not significantly alter the overall composition of gut bacteria in individuals who took it for six months. However, the researchers noted signs of resistance building against tetracycline, a class of antibiotics to which doxycycline belongs.
In this study, researchers from Tokyo Institute of Technology found that hydrogen sulfide-dependent transcription factor YgaV regulates iron uptake dynamics in Escherichia coli. The team observed elevated intracellular H2S levels resulting in increased antibiotic resistance and upregulated genes involved in sulfur metabolism.
Researchers isolated drug-resistant strains of SARS-CoV-2 from immunocompromised individuals who received antiviral treatments. The virus variants showed resistance to Paxlovid and remdesivir, highlighting the need for combination therapy to treat COVID-19 in highly vulnerable patients.
Researchers have discovered a new class of natural antimicrobials called microcins that can target specific strains of bacteria causing cholera, inflammatory bowel disease, and colon cancer. Microcins are highly selective and can potentially remove unwanted bacteria without disrupting the human gut microbiome.
Researchers have identified two compounds with strong antivirulence activity from actinobacteria in the Arctic Sea, targeting EPEC bacteria that cause severe diarrhea. The compounds inhibit virulence factor formation and binding to host cells, reducing disease severity and potential for resistance.
Researchers found a Leishmania amazonensis strain resistant to amphotericin B, a widely used treatment for cutaneous leishmaniasis. The study highlights the urgent need for alternative drugs to combat the disease, which affects over 15,000 people in Brazil annually.
Researchers at the University of Houston have developed two nasal sprays, NanoSTING and NanoSTING-SN, to prevent respiratory virus transmission. NanoSTING is an immune activator that can protect against multiple viruses, while NanoSTING-SN is a pan-coronavirus vaccine that can prevent transmission to unvaccinated individuals.
A new study found that heteroresistance, a phenomenon where a tiny fraction of bacteria remain resistant to antibiotics, is also present in fungal bloodstream infections in bone marrow transplant patients. The research identified the specific species of fungi responsible and developed a machine learning model to detect this type of inf...
Researchers at Stowers Institute for Medical Research have identified the dengue virus genome's use of less efficient codons in its host's machinery to replicate and spread. This discovery has implications for developing novel antiviral treatments and vaccines, as well as understanding the relationship between viruses and their hosts.
Researchers analyzed genomic data and human travel patterns to understand the spread and evolution of Streptococcus pneumoniae. The study found that a pneumococcal vaccine reduced antibiotic resistance but allowed non-targeted strains to gain a competitive advantage, suggesting short-lived protection.
A new study finds that antimicrobial peptide mixtures can delay the evolution of antibiotic resistance in Pseudomonas aeruginosa. The mixtures, which are synthesized in a lab, were found to prevent cross-resistance and maintain drug sensitivity.
Researchers have discovered a new source of resistance to the devastating wheat blast disease, leveraging a gene that also protects against powdery mildew. The Pm4 gene, found in European wheat varieties, confers dual protection against the pathogen and its effector molecule AVR-Rmg8.
Researchers have gained insight into how a deadly strain of salmonella adapts to invasion, flourishing in hostile environments and evading immune defenses. The study sheds light on the role of fluid shear forces in bacterial behavior, which may accelerate the design of new therapies for life-threatening infections.
Experts at NYU Langone Health have warned of a growing public health threat from hard-to-treat fungal skin infections in the US. Two new reports document cases of highly contagious forms of ringworm and jock itch that can take months to clear up with treatment.
A study from the University of Notre Dame identifies fibrinolytic deficiencies as a key factor increasing risk for catheter-associated urinary tract infections (CAUTIs) and sepsis in catheterized patients. The research suggests that antifibrinolytic medications may be linked to this increased risk.
This study investigates the impact of Zeolitic tuffs on the dynamic creep and tensile performance of Superpave asphalt mixtures. The results show that incorporating Zeolitic tuffs improves the mixtures' resistance to rutting and fatigue, with enhanced performance at 25% and 50% filler concentrations.
Researchers have mapped the critical developmental stages of malaria parasite Plasmodium falciparum using single-cell RNA sequencing. This high-resolution approach reveals new insights into the life stages of the parasite, including its transformation from an asexual to sexual state.
Clinical trials show decreased effectiveness of vancomycin in treating C. diff infection, with reduced cure rates and lower sustained clinical responses associated with antimicrobial resistance. The finding poses a significant concern for the management of C. diff infection, with only two recommended antibiotics available.
A new study reveals that disease-resistant fish exhibit lower viral loads and higher survival rates compared to susceptible counterparts. The results demonstrate the benefits of breeding resistant animals for sustainable food production and animal welfare.
A new study finds that the high burden of typhoid fever in sub-Saharan African countries calls for stronger prevention strategies, including the use and implementation of typhoid conjugate vaccines. The study estimates that there are 12.5 to 16.3 million cases of typhoid every year with 140,000 deaths.
A new study published in npj Antimicrobials and Resistance found that pathogenic bacteria E. coli and A. baumannii employ shared and unique mechanisms to acquire resistance to antibiotics ciprofloxacin and GP6. The researchers developed a method to track the acquisition of drug resistance using whole genome sequencing, which revealed t...
Researchers found duplicated antibiotic resistance genes in bacteria from environments with higher antibiotic use, increasing the likelihood of evolution and resistance to new treatments. The study suggests using antibiotics more efficiently could address the growing antibiotic resistance crisis.
A new study from the University of Cincinnati finds that being in prison is a significant driver of multidrug-resistant tuberculosis (MDR-TB) transmission. The researchers identified molecular resistance patterns and defined recent transmissions, highlighting the need for targeted interventions to control the MDR-TB epidemic in prisons.
Researchers will analyze publicly available data using machine learning and computational methods to identify key species in a healthy microbial community. They plan to use this information to design a healthy microbiome model and assess its response to diseases, which could lead to targeted therapies and improved medication absorption.
Researchers analyzed UK and Norway data on antibiotic-resistant bacteria, finding that antibiotic use amplifies the spread, but genetic makeup and environmental pressures are also crucial factors. The study suggests a more nuanced understanding of antibiotic resistance is needed to inform public health interventions.
Community antibiotic consumption in the EU increased by 18.8% between 2021 and 2022, reversing a significant decline seen during the pandemic. The resurgence of infections may have contributed to the rebound, but highlights the need for continued prudent use of antibiotics.