Articles tagged with Miscarriage
A Rutgers study predicts a woman's risk of miscarriage based on her genome, providing valuable insights for reproductive choices and fertility treatment plans. The researchers developed an algorithm using machine learning methods to identify genetic variants associated with aneuploidy in human eggs.
Researchers at the University of Copenhagen have developed a new method to characterize chromosomes with unprecedented detail. This allows for the detection of hidden chromosome defects that can cause miscarriages.
Researchers have identified the Xist gene as a critical regulator of fetal development in mice, leading to miscarriage and abnormal placentas when epigenetic instructions are missing. The study's findings suggest that failed Xist imprinting can be 'cured' by targeting specific genes involved in histone modifications.
Researchers analyzed nearly 100,000 pregnancies and found no association between COVID-19 vaccination and poor birth outcomes. The study provides further evidence on the safety of mRNA vaccines for pregnant individuals.
A research team discovered that human eggs are missing the protein KIFC1, which acts as a molecular motor to stabilize spindle poles during cell division. This finding opens up new avenues for therapeutic approaches to reduce chromosome segregation errors in human eggs.
A Zika virus vaccine candidate has been shown to prevent fetal malformations and detect maternal antibodies in pregnant animals. The vaccine has demonstrated high levels of protection against Zika infection in both mice and marmosets, with over 90% effectiveness observed.
Researchers have detected the Delta variant of SARS-CoV-2 in the blood and placentas of women who experienced stillbirths and serious pregnancy complications. The study found that the virus was widely disseminated, causing severe inflammation of the placenta and leading to stillbirths.
A new study by researchers at the University of Copenhagen found that an imbalance in vaginal bacteria is associated with a higher risk of emergency caesarean section. The study analyzed 1,396 samples from 736 pregnant women and discovered that those with greater levels of imbalance were more likely to deliver via C-section.
Researchers at the University of Kent identified strong evidence-based benefits of preimplantation genetic testing for aneuploidy (PGT-A) in IVF. Live birth rates per embryo transferred and per treatment cycle were significantly higher with PGT-A compared to regular IVF, especially in women over 40.
The UK government is being called on to recognize every miscarriage as a bereavement, rather than an illness, and award statutory bereavement leave. This would provide parents with up to 1 week of paid leave after a miscarriage, regardless of gestation, and address the current arbitrary cliff edge at 24 weeks.
A new study published in The New England Journal of Medicine has found no correlation between COVID-19 vaccinations and risk of first-trimester miscarriages. Vaccination during pregnancy is safe and provides protection to the newborn infant against COVID-19 infection.
The removal of the 14-day rule from international guidelines on embryo research has sparked concerns among bioethicists about the lack of consideration for potential consequences. The authors argue that countries should not automatically amend their laws without thoughtful discussions involving stakeholders and citizens.
A study published in Reproductive Toxicology found that rhesus macaques exposed to wildfire smoke early in pregnancy had an increased rate of miscarriage. The researchers discovered that high levels of small particles (PM2.5) and phthalates, known endocrine disruptors, were present in the smoke.
A study of 692 female surgeons found that nearly half experienced major pregnancy complications, including miscarriages and preterm birth. The researchers call for policy changes to support pregnant surgeons and change the culture surrounding childbearing.
Women with rheumatoid arthritis (RA) have an increased likelihood of pre-term birth and small babies. High maternal disease activity during pregnancy strengthens these associations. In contrast, paternal inflammatory disease is associated with a higher risk of miscarriage, particularly in pregnancies conceived after the father's diagno...
Emergency department visits for common conditions like appendicitis and miscarriage dropped significantly during the first wave of COVID-19, but there was no increase in adverse patient outcomes. Researchers found that management strategies remained unchanged, suggesting that patients who required emergency care continued to seek help ...
A new study published in the British Journal of Obstetrics and Gynaecology found that a combined drug treatment for missed miscarriage is more effective and cheaper than current standard medication. The treatment, combining mifepristone and misoprostol, was on average £182 cheaper per successfully managed miscarriage.
A new report highlights the need for a comprehensive system of care for miscarriage, including testing, treatment, pre-pregnancy counselling, and psychological support. The authors estimate that approximately 23 million miscarriages occur every year globally, affecting up to 15% of all pregnancies.
A new study published in Scientific Reports reveals that underweight and overweight women are significantly more likely to experience recurrent miscarriages due to their abnormal Body Mass Index. The research highlights the importance of weight management in reducing the risk of repeated pregnancy losses.
Women who experience a miscarriage are more likely to die prematurely due to cardiovascular disease. Research found that miscarriages, especially those occurring early in life or recurrently, can signal an increased risk of premature health risks.
A retrospective study of nearly a million pregnancies in the US found that men with metabolic syndrome had an increased risk of pregnancy loss, with risks increasing by 10-27% for each component. The study suggests that pre-conception counselling should not overlook the father's health as it may impact the pregnancy.
Researchers found genetic variation related to placental biology is partly responsible for miscarriage etiopathogenesis. Miscarriage has been linked to health outcomes such as asthma, depression, and irritable bowel syndrome.
A National Institutes of Health study has found that women trying to conceive who use opioids are more likely to experience lower chances of achieving pregnancy and an increased risk of miscarriage during early pregnancy. Opioid use was associated with a 29% lower chance of becoming pregnant within a given monthly cycle.
Research published in the American Journal of Obstetrics and Gynecology found that women who consume alcohol during early pregnancy face a higher risk of miscarriage. The study analyzed data from over 5,500 women and found an incremental 8% increase in miscarriage risk each week of alcohol use.
A new study reveals that the immune system works differently between a woman's first and second pregnancy, with potential implications for preventing miscarriages and preterm births. The research found that the immune pathways promoting a healthy first pregnancy are distinct from those in later pregnancies.
A KKH-led study evaluates a novel clinical protocol to screen and triage women with threatened miscarriages, saving pregnancies and reducing progestogen use. The protocol uses a single serum progesterone test to guide clinicians in managing patients.
A new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that up to one in five women with a history of miscarriage or subfertility have mild thyroid dysfunction. Detecting thyroid abnormalities prior to conception may improve pregnancy outcomes for these women.
Women with a history of miscarriage who engage in high-strain exercise may be at a greater risk of subclinical pregnancy loss, according to new research. The study found a two-fold higher risk of very early pregnancy loss for highly active women compared to those who were less active.
A new high-resolution melting analysis-based test (HRM) has been developed to improve the diagnosis of recurrent pregnancy loss (RPL), a condition affecting approximately five percent of women. The test is accurate, rapid, and cost-effective, offering better value than current genetic testing methods.
Research found fever, cold-like symptoms, and miscarriage threats during pregnancy are associated with congenital CMV infection in newborns. Blood tests may not be effective in predicting the likelihood of congenital CMV infection, highlighting the need for clinical factors to identify at-risk pregnancies.
Researchers found that giving progesterone to women with early pregnancy bleeding and a history of miscarriage can increase their chances of having a baby. The treatment is estimated to cost £204 per pregnancy and could lead to an additional 8,450 live births per year.
A study of over 650 women who experienced early-stage pregnancy loss found that nearly a third suffer post-traumatic stress, while one in four experience moderate to severe anxiety and depression. The research calls for improved care following an early-stage pregnancy loss.
Researchers found an average increase in stem cell count of 68% with minimal side effects, reducing 'stressed' cells and improving conditions for pregnancy. The treatment aims to prevent miscarriage by normalizing the womb lining.
A new study analyzing thousands of tweets reveals widespread misunderstanding of miscarriage's physical, emotional, and psychological impacts. Celebrity disclosures also sparked personal sharing of experiences, with grief and annoyance being the most common emotions expressed.
A study of 443 women with RA found that those who followed an ideal clinical pathway had a 40% lower risk of complicated birth or miscarriage. This suggests that simple interventions can positively impact pregnancy outcomes in women with rheumatoid arthritis.
A recent study found that disruptions in progesterone signaling between maternal and embryonic tissue may be linked to recurrent miscarriage. The study discovered that migratory cells from the placenta produce enzymes necessary for progesterone production, which are lower in women with a history of recurrent miscarriages.
A study on Instagram users' experiences of miscarriage reveals rich descriptions of medical and physical aspects, as well as emotional spectrum, social aspect, and family identity. The findings inform patient care by highlighting the need for clinicians to address emotional needs and redefine recurrent pregnancy loss.
An observational study of over 442,000 pregnancies in Canada found that benzodiazepine use in early pregnancy was associated with a higher risk of miscarriage. The study suggests that physicians should carefully evaluate the risks and benefits of prescribing benzodiazepines in early pregnancy due to alternative treatment options.
A large trial has found that progesterone treatment can increase the chances of a baby being born for women who experience early pregnancy bleeding and have a history of miscarriage. The study involved over 4,000 pregnant women and showed a significant increase in live births among those receiving progesterone treatment.
A study published in The Lancet Diabetes & Endocrinology journal found that metformin can halve the risk of late miscarriage and preterm births for women with polycystic ovary syndrome (PCOS). Women who received metformin during pregnancy also gained less weight, but there was no effect on gestational diabetes or pre-eclampsia.
A prospective study found that pregnant women working two or more night shifts in one week had a 32% higher risk of miscarriage the following week. The association between night work and miscarriage was strongest after week eight of pregnancy.
A large study led by the University of Birmingham found that treating women with normal thyroid function and thyroid peroxidase antibodies with Levothyroxine did not increase live-birth rates. The researchers suggested that previous recommendations to use Levothyroxine in these women may have been based on limited evidence.
Researchers found five common metaphors used by men to describe their partner's miscarriage, including 'lost gift' and 'chaotic movement'. These metaphors revealed societal expectations around masculinity and pregnancy. The study aims to encourage couples to co-cope with miscarriage through metaphorical expression.
A Norwegian study found that women under 30 have the lowest risk of miscarriage, while those over 45 face a 53% risk. Previous pregnancy complications also increase the risk, with pre-eclampsia not being a factor.
A large-scale international trial led by the University of Birmingham examined if antibiotics can prevent surgical complications after miscarriage surgery. The trial showed that giving a preventative single dose of antibiotics prior to surgery did not result in a significant reduction in pelvic infection within 14 days post-surgery, bu...
Research published in CMAJ found that taking oral fluconazole during pregnancy may be associated with a higher chance of miscarriage and birth defects. The study analyzed data from 441,949 pregnancies and linked it to filled prescriptions, highlighting the need for safe prescribing practices.
A new study from the University of Warwick shows that medical and surgical treatment options for miscarriage are similarly effective, but with different side effects. Conservative treatment resolves about 70% of cases, while surgery and medication have comparable success rates.
A study of 50 men with partners who experienced recurrent miscarriages found higher levels of DNA damage in their sperm compared to healthy control groups. The researchers suggest that oxidative stress triggered by reactive oxygen species may contribute to the risk of miscarriage, and are investigating potential treatments.
Researchers at University of Utah Health found a 16 percent increased risk of miscarriage for women exposed to elevated air pollution levels, particularly nitrogen dioxide. The study suggests air quality is associated with adverse pregnancy outcomes and highlights the need for constructive solutions.
Children conceived via fertility treatment have up to 42% higher risk of asthma, while number of previous early miscarriages is also associated with increased risk. Research suggests that common factors underlying poorer fertility and recurrent miscarriages may influence asthma risk.
Research reveals a single missing gene in mothers leads to miscarriages due to placenta problems, including fewer blood vessels and altered shape. The study provides new insights into recurrent miscarriage in humans and lays the foundation for further research on placenta development.
The largest randomized trial on genetic screening before embryo transfer found no difference in live birth rates between groups with and without the procedure. However, there was a lower miscarriage rate and fewer embryo transfers in the group that received genetic screening.
A large randomized placebo-controlled study found no evidence that rhG-CSF improves outcomes in women with a history of unexplained recurrent pregnancy losses. The study involved 150 women and showed similar clinical pregnancy rates between the treatment and placebo groups.
A recent study published in Nature Medicine found that Zika virus infection increased the risk of miscarriage or stillbirth by 26% in pregnant monkeys. Researchers also discovered damage to the placenta and cell death, which can lead to poor pregnancy outcomes. The true rate of human miscarriage may be higher than previously reported.
A new study found that Zika virus-infected monkeys experienced a 26% fetal death rate, which could indicate more severe outcomes in human pregnancies. The research used data from six National Primate Research Centers and tracked fetal development in infected macaques.
A collaborative study published in Nature Medicine found that 26 percent of nonhuman primates infected with Zika during early stages of pregnancy experienced miscarriage or stillbirth. This is the first time such a finding has been demonstrated, highlighting the importance of understanding how the Zika virus damages the placenta.
A collaborative study between six National Primate Research Centers found that 26% of female nonhuman primates infected with Zika virus experienced miscarriage or stillbirth despite few clinical signs of infection. The study suggests that Zika-associated pregnancy loss in humans may be more frequent than currently thought.
Researchers at the University of Pennsylvania School of Medicine found that a two-drug combination of mifepristone and misoprostol can effectively complete miscarriages, reducing the need for surgical intervention. The study showed that 91.2% of women experienced gestational sac expulsion after receiving the treatment.
A recent study found that DES-exposed patients with clear-cell adenocarcinoma had significantly increased mortality rates, with risks up to 27 times higher than the general U.S. population. The risk of death decreased with age, emphasizing the importance of early detection and aggressive treatment.
A multicenter study found that metformin lowers the chance of late miscarriage and premature birth among women with polycystic ovary syndrome (PCOS), but has no effect on gestational diabetes risk. The medication also led to less weight gain during pregnancy, a positive finding for overweight women.