Articles tagged with Genome Sequencing
The study developed a new strategy to sequence thousands of bacterial isolates with collaborators from economically-challenged countries, aiming to make genomic data more accessible. The 10,000 Salmonella genomes research consortium sequenced and analysed 10,000 Salmonella genomes from Africa and Latin America, strengthening global res...
Researchers have created a new approach to edit genes within specific bacteria in a community using CRISPR-Cas9, enabling targeted genetic modifications. This technology could be used to track edited microbes and potentially treat diseases like digestive issues or create more resilient crops.
The research provides a foundation to better understand redwood responses to climate impacts and pathogens. Hundreds of gene families unique to the coast redwood were found, many helping trees respond to stress and resist disease.
Despite making progress, genome sequencing of 1.66 million animal species remains incomplete, with vertebrates accounting for 54% of current sequences. Invertebrates, including insects and spiders, comprise only 34% despite representing 78.5% of all species.
A new study led by York University reveals that Western Honey Bees originated in Western Asia, with genetic data suggesting a strong connection to this region. The research highlights the importance of understanding the origin and evolution of these vital pollinators to inform their management and conservation.
A study published in Proceedings of the Royal Society B reveals that a rare alga, Chlorokybus, contains at least five distinct species previously thought to be a single entity. Genetic analysis confirmed these findings, shedding new light on the biodiversity and evolutionary pathways of this key algal group.
A rapid same-day test has been developed to identify secondary infections in COVID-19 patients on intensive care, allowing for targeted antibiotic treatment and reduced risk of antimicrobial resistance. The test uses nanopore sequencing technology to analyze bacterial and fungal pathogens present in patient samples.
Researchers have sequenced the Arabidopsis genome at unprecedented detail, shedding light on centromere evolution and revealing genetic and epigenetic topography. The findings provide insights into the genomic equivalent of black holes, a region that has long been challenging to analyze.
A new study has catalogued all possible genetic variations in over 3,000 chickpea plants to improve the crop's yield and resilience to climate change. The research proposes a breeding model using genomics-assisted breeding to enhance agriculturally valuable traits.
An international team sequenced 3,366 chickpea lines from 60 countries, identifying 29,870 genes, including 1,582 novel ones. The study provides a complete picture of genetic variation within chickpea and validated roadmap for improvement.
New study traces common ancestry of Japanese, Korean, and Tungusic languages to millet cultivation and early Amur gene pool in West Liao River region. The Farming Hypothesis is supported by linguistic, archaeological, and genetic evidence showing early farmers' spread across Northeast Asia.
A new computer program called Codetta can analyze the genome sequences of over 250,000 bacteria and archaea to identify alternative genetic codes. This could help scientists understand how genetic codes evolve and change.
Researchers will identify and track SARS-CoV-2 variants using genomic sequence analyses. The project aims to understand the emergence and spread of the virus in West Virginia, helping public health officials prepare for future outbreaks.
A new study found that whole genome sequencing increases the diagnosis of rare genetic disorders by 31%, shortening the diagnostic odyssey for affected families. This approach provides opportunities for future research and can identify non-mitochondrial disorders with specific treatments.
Researchers have sequenced the quillwort genome, uncovering unique genetic mechanisms regulating CAM photosynthesis in these aquatic plants. The study found differences in phosphoenolpyruvate carboxylase function between quillworts and terrestrial plants.
An international team of researchers identified genes associated with plant survival in the Atacama Desert, a harsh environment in Chile. These findings may help scientists breed crops that can thrive in increasingly dry climates and mitigate the effects of climate change.
Mangroves have evolved a remarkable resistance to stress in harsh ocean environments. Researchers decoded the genome of Bruguiera gymnorhiza and found that it regulates genes to cope with stress, using adaptive epigenetic changes to survive.
Researchers developed a computational method to estimate new infection rates from genomic sequences, revealing decreased case detection in Europe during summer 2020 due to relaxed testing criteria. The study also highlights the effects of non-pharmaceutical interventions on COVID-19 spread.
Researchers developed an integrated framework combining single-cell and metagenomics to characterize microbes. The approach showed higher accuracy and precise binning, revealing more bacterial genera and intra-species diversity.
Scientists have developed a technique to sequence individual malaria parasites' genomes, allowing for the detection of new mutations. These mutations are often targeting a gene family controlling transcription in malaria, suggesting potential avenues for developing more effective treatments and vaccines.
A new research center will use genomic data and socioeconomic factors to better predict health outcomes in individuals of diverse ancestry. The center aims to develop computational tools to combine large datasets and analyze them for consistent relationships among admixed populations.
Researchers found that wild and hatchery coho salmon demonstrate different genetic markers for negative assortment, a common finding in mating. They are now trying to emulate the natural mating of coho salmon in a hatchery environment using genetic profile information.
The University of Maryland Center for Environmental Science has sequenced the genome of the blue crab, revealing approximately 24,000 genes and a genome length that is one third of the human genome. This breakthrough will aid in fisheries policies, aquaculture, and potentially track food source origins.
A study analyzed genetic material from 86 discordant couples infected by SARS-CoV-2 and found associations between certain genetic variants and efficient activation of natural killer cells. These cells play a crucial role in the innate immune response, destroying infected cells to prevent disease development.
Researchers found that ancient Siberian human populations interacted with outside dog populations at least 2,000 years ago, suggesting dogs were traded as goods. The study reveals that modern dog breeds like Samoyeds and Siberian Huskies maintain significant ancestry from a lineage established prior to 9,500 years ago.
A medieval Spanish individual, known as the 'Segorbe Giant,' has been analyzed using ancient DNA. The research found that he had a mix of North African and local Spanish ancestry, suggesting a complex history of migration and intermixing. This study sheds light on a dark event in medieval Spain's past.
A study by University of Utah biologists discovered a mutation in the ROR2 gene is linked to short beak length in domestic pigeons. This mutation also underlies the human disorder Robinow syndrome, which shares striking facial features with the pigeon phenotype.
Researchers analyzed genome sequences and mobile phone data to track Covid-19 spread in Bangladesh. A three-day window between lockdown announcements and enforcement led to increased infections as citizens traveled to other areas.
Researchers at OIST and Tokyo University of Marine Science and Technology have developed a genetic resource for the kuruma shrimp, a species prone to white spot disease. The genome sequence has identified genes related to disease resistance, which could be used to establish a disease-resistant line of shrimp.
A study published in PLOS Genetics found that smoking-related DNA methylation patterns explain around 1/5 of the variation in body mass index between individuals. The study analyzed genomic sequence data from over 390,000 participants and found that genetics accounted for 50% of the variation in BMI.
Despite 10,000 years of inbreeding, the kākāpō genome sequencing reveals that the species has lost potentially deleterious mutations and now carries fewer harmful mutations than extinct mainland populations. This finding suggests that natural selection may have facilitated genetic purging in small populations.
Researchers used functional genomics to identify key genes involved in inducing callus from immature maize embryos, overcoming a major roadblock in plant breeding. The study found that nearly 30% of predicted A188 genes were structurally different from other maize lines, accounting for high protein divergence and phenotypic variations.
The world's largest repository of raw genomic sequences is missing critical data necessary for monitoring and preserving biodiversity. Only 14% of archived datasets contain information about when and where organisms were sampled, highlighting the need for community standards to preserve metadata.
Researchers sequenced the genomes of an ancient date palm leaf and found evidence of hybridization with wild relatives. The study sheds light on the evolution of date palms in North Africa, showing that genetic material from another species was present 2,200 years ago.
Researchers discovered azole-resistant Aspergillus fumigatus strains isolated from a tulip bulb have genetic recombination and resistance to multiple fungicide classes. Plant bulbs serve as an ideal niche for the pathogens to evolve their resistance, posing a global health threat.
Scientists have sequenced the Indian wolf genome, revealing it to be one of the world's most endangered and evolutionarily distinct populations. The study suggests that Indian wolves may represent the most ancient surviving lineage of wolves.
The study provides a high-quality genome sequence of Aristolochia fimbriata, shedding light on angiosperm evolution, floral development, and chemical biosynthesis. The researchers identified two overlooked whole-genome duplications in Piperales and clarified the time of previously reported WGDs in Magnoliales and Laurales.
Research reveals cichlids exhibit highly dynamic sex chromosomes, transitioning between XY and ZW systems. Genome analysis identified over 70 species with distinct sex-determining genes.
A virulent Salmonella Enteritidis strain has been sequenced from two consecutive poultry flocks in North Carolina State University. The strain, SE_TAU19, exhibits seven antimicrobial resistance genes and 120 virulence genes, posing a threat to human health. Genome sequencing provides valuable data for tracing outbreaks and preventing f...
Researchers sequenced the bowfin genome to investigate its unique combination of ancestral and advanced features. The study found unexpected insights into diverse aspects of bowfin biology, including the absence of key genes in its pectoral fin.
A study published by the European Society of Human Genetics found that genetic testing can identify the cause of childhood epilepsy in half of those studied, allowing for tailored treatments. This breakthrough discovery has the potential to improve treatment possibilities and avoid unnecessary procedures.
A recent study from University of Cambridge and Addenbrooke's Hospital found that most patients infected with COVID-19 in hospitals contracted it from other patients rather than healthcare workers. The research highlights the importance of regular screening for asymptomatic patients and proper use of face masks.
A reservoir of genes allowing sorghum to adapt to environmental stresses has been identified from 13 contrasting genomes. This genetic diversity is valuable for breeders, enabling them to improve crop yield and resilience. The analysis, led by the University of Queensland, provides unprecedented insights into the genome's dynamic nature.
Research at Washington University in St. Louis reveals that white clover's chemical defense against insect pests comes from both of its parental species, not just one as previously thought. The plant's ecological success can be attributed to this cyanogenesis process.
Researchers completed the first genetic sequencing of a Brazilian snake's genome, revealing that most toxin genes likely arose from existing functions in ancestral species. The study identified markers for comparing toxin genes with non-toxic 'ancestral' genes, shedding light on the evolution of venom production.
Researchers found Philippine Negrito ethnic group, Ayta Magbukon, possess the highest level of Denisovan ancestry in the world. Their Denisovan DNA is up to 46% greater than that of Australians and Papuans.
A new collection of corn genomes provides a detailed understanding of the genetic diversity and adaptability of corn plants. Researchers have mapped the first corn genome in 2009 and filled in gaps since, revealing how the corn genome was shuffled over time.
A new study published in Cell Reports Medicine reveals the origins of a 2012 Bundibugyo virus disease outbreak in the Democratic Republic of Congo. The analysis, conducted by an international team, used high-throughput sequencing to identify multiple virus 'spillover' events that contributed to the outbreak. This research highlights th...
Researchers developed a machine learning tool, BoostDM, that evaluates the potential contribution of mutations in genes to cancer development. The tool helps understand how tumors are caused at the molecular level and can facilitate medical decisions regarding therapy.
The NIH is awarding $80 million to the Mendelian Genomics Research Consortium to develop new methods and approaches for identifying genetic causes of single-gene diseases. The consortium aims to significantly increase the number of Mendelian disorders with known genetic causes.
An international team has developed a method to analyze ancient DNA in museum specimens, allowing for their placement on the evolutionary timeline. The technique enabled researchers to trace the evolutionary history of several species over tens of millions of years.
Researchers identified genetic markers to control fatty acid content in sunflower oil, a key source of vegetable fats. The study used genomic selection to create new crop varieties with tailored properties suitable for different uses.
A Belgian case report documents a 90-year-old woman's simultaneous infection with two different SARS-CoV-2 variants of concern: B.1.1.7 (UK) and B.1.351 (South Africa). The patient developed rapidly worsening respiratory symptoms, leading to death. This is one of the first documented cases of co-infection with VOCs.
A new study evaluated eight miRNA applications to simplify the process of discovery and characterization. Two programs, sRNAbench and miRExpress, stood out for their high sensitivity and low run times, making them suitable for use in plants with varying genome sizes.
Researchers at UIC are expanding testing for vulnerable communities, performing genomic sequencing on samples to identify emerging SARS-CoV-2 strains. This helps gather info on variant dynamics and human immune responses, aiding public health surveillance.
Researchers study rare warbler hybrid with mismatched color patterns to disentangle genetic drivers of traits usually inherited together. The team identifies new location in genome linked to black face mask and confirms previously identified region for black throat patch.
RAMBO, a new method, cuts indexing times for large DNA databases from weeks to hours and search times from hours to seconds. The researchers used a data structure that has a significantly faster query time than state-of-the-art genome indexing methods.
A new UC Davis study confirms that SARS-CoV-2 contamination on hospital surfaces is unlikely to be infectious. The research used genome sequencing to detect the virus on surfaces and found that only a small percentage of samples were positive, suggesting that improved cleaning protocols may have reduced transmission.
Researchers have sequenced the nuclear genome of the koala lemur, a giant primate that went extinct in Madagascar around 500-2,000 years ago. The findings reveal new insights into its position on the primate family tree and how it interacted with its environment, which could help understand past lemur extinctions.
Researchers at Karolinska Institutet have developed a cost-effective method for detecting new coronavirus variants. The COVseq technology uses multiplex PCR and pooling to sequence thousands of viral genomes per week, making it an affordable solution for global surveillance.