Research on blood and what it reveals about health. Covers blood biomarkers, occupational exposure, cell-preservation for CAR-T therapy, and blood supply.
Scientists develop a revolutionary 'blood on demand' technology that can preserve red blood cells for extended periods, reducing thawing and washing times. This innovation has the potential to transform emergency medicine and provide a reliable blood supply in crisis situations.
A new blood-based biomarker study identifies a link between self-reported cognitive decline and blood-based biomarkers, paving the way for a simple blood test to diagnose Alzheimer’s disease and related dementias. The approach could be faster, less-invasive, and more affordable than existing screening tools.
Researchers at UCSF screened hundreds of industrial dyes to identify those that stick to protein clumps in the brain, a hallmark of dementia. They found 10 sure hits that illuminated tau clumps in animal models and human samples, offering new hope for diagnosis and treatment.
Researchers discovered that inflammatory bowel disease (IBD) leads to blood clotting due to a lack of layilin protein, which prevents platelets from forming unwanted clots. A drug targeting Rac1 activity could reduce excessive clotting and alleviate day-to-day IBD symptoms.
Researchers at University of Pennsylvania discover red blood cells contribute to clot contraction, shrinking and stabilizing blood clots. The finding opens door to new strategies for studying and treating clotting disorders, such as excessive bleeding or dangerous clots like those seen in strokes.
Researchers investigated the impact of skin pigmentation on pulse oximeter accuracy, finding that darker skin reduces red light absorption and affects oxygen level detection. This study provides experimental evidence for improving pulse oximeter accuracy across all skin tones.
A new study has provided insights into how blood stains cotton fabrics, allowing investigators to gather additional information from forensic evidence. The researchers found that the number and spread of 'fingers' in the bloodstain correlate to the velocity of the blood spatter, with faster-moving blood leaving more prominent tendrils.
A new study shows that a simple blood test taken in the first trimester of pregnancy can accurately identify women at risk of developing preeclampsia five months before clinical diagnosis. The test uses cell-free RNA, or cfRNA, to capture subtle molecular signals from multiple maternal tissues.
A circulating tumor DNA-based blood test demonstrated acceptable accuracy for colorectal cancer detection in an average-risk population. However, it struggled to detect advanced precancerous lesions, highlighting the need for further improvements.
A cohort study found that lower-than-recommended lead levels were associated with worse academic grades, suggesting the need to reconsider current blood lead reference values for further interventions. The findings support lowering these values to improve outcomes for children and adolescents.
Researchers developed a technique to analyze DNA methylation marks, identifying changes in blood production that occur with age. By age 50, many blood stem cells begin to drop out and larger clones take over, leading to a decline in diversity and resilience.
Researchers developed a new imaging technique that uses artificial intelligence and high-speed microscopy to track platelet behavior in real-time. The study shows promise for personalizing heart disease treatment by monitoring clotting risk in patients with coronary artery disease.
Researchers from USC Keck School of Medicine have developed a low-cost blood test that detects five biomarkers of Alzheimer's disease, including amyloid and tau proteins. The test uses xMAP technology and has the potential to catch the disease in its earliest stages, when treatment might be able to prevent or delay cognitive decline.
A systematic review and meta-analysis found that individuals with blood type A have a significantly higher risk of developing breast cancer compared to those with blood type O. The research, which pooled data from over 13,000 breast cancer patients and 717,000 controls, suggests an 18% increased risk associated with blood type A.
Researchers found that measuring lipoprotein markers in a simple blood test can identify individuals at high risk of cardiovascular disease more effectively. The study analyzed data from over 200,000 people and showed that the total number of 'bad cholesterol' particles is the most important factor to consider when testing for future h...
Research from the University of Oklahoma suggests that women with adequate iron levels in their blood perform better on cognitive tasks during menopause. Having enough iron does not necessarily mean accumulating more iron in the brain, which is a risk factor for neurodegenerative diseases like Alzheimer's.
Researchers used umbilical cord blood to analyze genetic changes linked to metabolic dysfunction in children. The study found multiple regions of altered DNA associated with metabolic issues later in childhood.
A study has identified an early blood marker for hereditary Alzheimer's disease, beta-synuclein, which can detect neurodegeneration up to 11 years before dementia symptoms. This biomarker could help with early diagnosis and treatment, improving the potential of new medicines for Alzheimer's.
A new study suggests a changing climate threatens the continuous availability of safe blood across the world. Researchers warn that warmer temperatures, natural disasters, and infectious diseases will impact the ability of people to donate and trigger a rise in blood demand.
Researchers at UCL developed a new scoring system, CAR, to identify patients with narrowed carotid arteries who can be effectively treated with optimised medical therapy. The study found low rates of recurrent strokes and heart attacks among patients treated with medication alone.
A new study published in Transfusion journal reveals sex-based disparities in the transfusion of whole blood to traumatically injured patients. Women, particularly younger females and those of childbearing potential, are less likely to receive whole blood transfusions compared to men. This disparity is despite whole blood being associa...
Researchers developed a simple, cost-effective blood test that detects Parkinson's disease long before symptoms emerge by analyzing transfer RNA fragments. The test has an accuracy surpassing existing clinical diagnostic tools and may alleviate uncertainty faced by patients and clinicians.
Tulane University scientists developed a handheld device to deliver rapid and accurate tuberculosis diagnoses in under an hour. The device, called the lab-in-tube assay (LIT), can detect Mycobacterium tuberculosis DNA in saliva, blood, and sputum samples, offering a cost-effective tool for improving TB diagnoses in resource-limited areas.
Researchers have identified a potential precision medicine approach to prevent chronic kidney disease progression by targeting type 5 collagen, a minor component of scar tissue. A repurposed anti-cancer drug, Cilengitide, has been shown to slow kidney scarring and disease progression in high-risk individuals.
A study found that pedometers capture a remarkable 88% of the health information provided by more advanced accelerometer measurements. Walking at a brisk pace is essential for cardiovascular health optimization, with a minimum cadence of 80 steps per minute strongly associated with good aerobic fitness.
Researchers created a thromboinflammation-on-a-chip model that can sustain blood clots for several months and track treatment options. This model reveals critical information on clot resolution and suggests new drug combinations to protect endothelial function in patients with sickle cell disease.
A new paper highlights emerging alternatives to traditional diabetes medicines, such as continuous glucose monitors and lifestyle interventions like GEM, which can improve patient adherence and long-term health outcomes.
The SUMMIT trial shows tirzepatide reduces the risk of cardiovascular death or worsening heart failure in patients with obesity, chronic kidney disease, and heart failure, while improving kidney function. Researchers found significant improvements in both patient groups with and without chronic kidney disease.
Researchers at Penn State are developing a next-generation synthetic blood substitute called Nano-RBC, which mimics the shape and movement of human red blood cells. The new blood substitute aims to address the shortage of safe blood sources quickly enough for trauma patients, with potential applications in rural or war-torn areas.
A new study found that three months of dual antiplatelet therapy (DAPT) was better than one month for reducing heart attacks, strokes, and other adverse events without increasing bleeding risk in high-risk patients. For low-risk patients, three months of DAPT was comparable to 12 months in reducing adverse events, while being better th...
A new study found that smartwatches paired with a health app can encourage people with newly diagnosed Type 2 Diabetes to maintain a home-delivered, personalised exercise programme. This programme showed improvements in blood sugar levels, systolic blood pressure, cholesterol, and quality of life.
A new study found that smartwatches paired with a health app can encourage people with newly diagnosed Type 2 Diabetes to start and maintain purposeful exercise, leading to improvements in blood sugar levels and systolic blood pressure. The programme also helped participants lower cholesterol and improve their quality of life.
A study found that consuming sucralose alters brain activity related to hunger and increases appetite, especially in people with obesity. The sugar substitute changes how the hypothalamus communicates with other brain regions, including those involved in motivation, potentially leading to cravings and eating behavior changes.
People with heart failure who can travel outside their home without assistance are less likely to be hospitalized or die within a year. Life-space mobility, a measure of how far patients move in their communities, is a reliable marker of risk for adverse outcomes in chronic diseases.
Researchers have developed a way to activate adult stem cells from human bone marrow, enabling their expansion outside the body for use in bone marrow regeneration. The new method significantly improves transplant success rates for patients with genetic disorders or those who require a bone marrow transplant.
The Dexcom G7 CGM device demonstrated an accuracy of 8.0% in a study involving 130 adults with type 1 or type 2 diabetes, setting a new standard for continuous glucose monitoring devices.
A team of scientists has successfully developed a novel platform for diabetes treatment utilizing bioink derived from pancreatic tissue and 3D bioprinting technology. The HICA-V platform replicates the structure and function of the human endocrine pancreas, supporting islet maturation and functional enhancement.
Researchers found that patients who received non-compliant care had more complex medical conditions and were more likely to present with unusual symptoms. The study's findings challenge the assumption that SEP-1 compliant care is associated with better survival, highlighting the need for risk-adjusted outcome measures.
Researchers at the University of Virginia Health System have developed a computational tool called LogiRx that can predict how drugs will affect biological processes in the body. The tool has demonstrated its potential by identifying a promising candidate to prevent heart failure, a leading cause of death worldwide.
A study from Aarhus University found a possible link between JAK inhibitor medication and unexpected blood clots. The researchers identified a potential mechanism behind the side effect, which could lead to the development of safer medications.
Researchers have discovered a blood test that can identify patients with a sleep disorder who are most likely to develop Dementia with Lewy Bodies. The blood test analyzes two proteins in the blood associated with Alzheimer's disease and predicted dementia risk in almost 90% of patients, four years before symptoms appeared.
A new study suggests that hospital rehabilitation for older adults might only be the beginning of a longer journey. While therapy is crucial in mitigating functional decline, only a small minority of patients receiving intensive therapy (14+ hours/week) had a greater likelihood of home discharge.
Researchers at the University of Missouri have identified a small molecule drug that targets a specific serotonin receptor, showing promise as a treatment for sarcopenia. The study suggests that this neurotherapeutic can improve muscle strength by activating motor neurons to fire more effectively.
Researchers have discovered a novel approach to protecting insulin-producing beta cells from glucolipotoxicity, a condition linked to type 2 diabetes progression. The findings could lead to promising treatments targeting beta cell dysfunction, potentially slowing or preventing disease progression.
The Texas Tech University Health Sciences Center is conducting a randomized controlled trial to investigate the effectiveness of calcium and vasopressin in treating severely injured patients who experience significant blood loss. The study, known as CAVALIER, will enroll approximately 1,050 participants aged 18-90.
Scientists are studying how microplastics affect microbial communities in ponds, with potential implications for carbon cycling and the global biosphere. Microbes have adapted to plastic surfaces, which could impact aquatic environments.
Researchers at UCSF have discovered that human lung tissue contains hematopoietic stem cells (HSCs) capable of producing red blood cells, platelets, and immune cells. The finding suggests the lungs could be a potent source for life-saving stem cell transplants, particularly for patients with leukemia.
Researchers studied how bacteria like Klebsiella pneumoniae cause systemic infection by tracking its movement in mouse models using a barcoding system. They found that bacteria can spread through two routes: metastatic dissemination and direct dissemination, with the former correlating to a stronger infection.
Researchers at the University of Malaga have identified multiple genetic variants causing Familial Chilomicronemia Syndrome, a rare disease characterized by high triglyceride levels. This discovery enables accurate clinical diagnosis and treatment selection for patients with this condition.
Researchers have found that Continuous Glucose Monitors (CGMs) can overestimate blood sugar levels in healthy adults by up to 400%, potentially causing unnecessary worry and dietary restrictions. The study suggests that CGMs may not be a valid method for determining the glycaemic index of foods.
A new study warns that blood tests for Alzheimer's disease are not reliable, particularly for Black patients. The test has lower sensitivity and specificity in Black participants, leading to a higher risk of false positives.
Ebru Demir aims to study how groups of AI-driven microswimmers move in biological fluids for potential applications in drug delivery, fertility treatments, and other medical fields. Her research combines artificial microswimmers with machine learning to uncover the underlying physics governing their movement.
A new test called EpiAgePublic estimates biological age using only three DNA sites in the ELOVL2 gene, simplifying traditional methods while maintaining accuracy. The study found that EpiAgePublic accurately tracks aging patterns and can identify factors accelerating the aging process.
A new study at the University of Gothenburg found that a software robot can detect side effects faster than physicians during amiodarone treatment for cardiac arrhythmia. The robot also recommends appropriate intervals between lab tests, aligning with standard practices and reducing unnecessary testing.
The American Heart Association has chosen five US regions to implement a new preventive health initiative aimed at improving care for people with cardiovascular-kidney-metabolic (CKM) syndrome. The initiative will increase awareness and screening for CKM syndrome and facilitate collaboration among healthcare professionals.
Researchers at the University of Sydney are using Zwitterions to create materials that can prevent blood clots from forming in medical devices and implants. They have successfully created a zwitterionic coating that repels water beyond the material's boundaries.
Researchers explore the connection between Alzheimer's and metabolic syndrome, finding links between insulin regulation, high blood pressure, and obesity. The study suggests that maintaining healthy blood fat levels may be crucial for brain health, paving way for potential therapeutic developments.
Emboa Medical creates a microstructured catheter called TRAP, which mimics a boa constrictor's teeth arrangement to grab onto blood clots without tearing them. The TRAP design has shown significant benefits in removing clots on the first attempt and improving outcomes for stroke patients.
Researchers discovered a link between neuroactive steroids in pregnant women's blood and the risk of developing postpartum depression. Measuring these molecules via a blood test could enable doctors to provide treatment sooner. The study may lead to a preventive treatment using existing prescription drugs.
A study by University of Gothenburg researchers found that consuming sulforaphane from broccoli sprouts improved blood sugar levels in people with prediabetes. The compound had a significant effect on fasting blood sugar levels, particularly in those with certain pathophysiological and microbiome characteristics.