Research on blood and what it reveals about health. Covers blood biomarkers, occupational exposure, cell-preservation for CAR-T therapy, and blood supply.
A research team developed a workflow to quickly identify fungal pathogens from blood culture samples, generating genetic material for sequencing in real-time. The method achieved species-level identification within seven hours with high accuracy, detecting a range of fungal pathogens and mixed infections.
Scientists at the University of Osaka have developed a method to recreate human B cells with germinal center features using three immune signals, which closely match those found in human tonsils. This breakthrough could help improve vaccine-induced antibody responses and identify targets for autoimmune disease.
The grant will support research experiences for 12 WPI undergraduates in Solomon Mensah's lab, aiming to determine the molecular mechanisms behind sepsis-induced blood clotting. The goal is to rescue a damaged glycocalyx barrier, paving the way for sepsis treatments.
A new study in mice reveals that abdominal muscles used during normal movement can increase blood flow in the brain by creating ultrafast constrictions of major veins. The research suggests a previously underappreciated aspect of normal brain physiology, highlighting the connection between movement and blood flow.
Researchers found that rituximab treatment increases mitochondrial energy production and reduces cell stress in T cells, leading to improved response rates in patients with nephrotic syndrome. This discovery could help predict patient response to treatment and identify suitable candidates for early remission.
A new study reveals striking biological similarities between five major illnesses, including long Covid and PTSD, suggesting common underlying mechanisms. Chronic fatigue syndrome, rheumatoid arthritis, and multiple sclerosis may be driven by shared regulatory networks in immune and metabolic systems.
A new study by UTHealth Houston found measurable biological changes in firefighters' blood and urine 24 hours after fighting a fire, which may help identify early cancer risk. The study identified 75 significantly altered proteins in urine and 10 in blood serum, with several linked to cancer-related pathways.
Researchers at MIT developed a new cell-preservation technique using naturally occurring sugars, reducing the need for a chemical preservative. This approach significantly improves the viability and function of CAR-T cells, making them easier to deploy in hospitals.
Ukraine maintained a self-sufficient blood supply during the Russia-Ukraine War by centralizing operations and expanding donor recruitment. The country's 24-hour blood collection centers and public campaigns with patriotic slogans like “Your blood can fight!” increased donations.
A clinical trial found that refrigerated platelets stored for up to 21 days are just as effective as room-temperature platelets in treating bleeding patients. This discovery could extend the lifespan of platelets by nearly 4-fold, reducing waste and improving access to lifesaving therapy.
A retrospective cohort study found that patients treated with aripiprazole had a lower risk of hyponatremia than those on olanzapine. This association could inform clinical decision-making for high-risk patients, despite residual confounding considerations.
A new wearable system called ChromaSense can accurately measure blood oxygen saturation, heart rate, and respiration across a range of skin tones. It uses reflected light from skin and tissue to adjust the measurement, achieving accuracy within 1.4% of standard reference oximeters.
Researchers have identified a panel of key proteins in blood that can predict the emergence of ALS symptoms months to years before they arise. This discovery could enable early intervention with preventative therapies.
Researchers found that blood stem cells from young patients with sickle cell disease have features of aging, which can increase the risk for other complications. Using senolytics improved disease symptoms in model systems, highlighting a needed improvement to gene therapies.
A new study published in Nature Communications finds that a protein called saxiphilin can neutralize the potent neurotoxin saxitoxin, preventing and even reversing paralytic shellfish poisoning. The discovery could have important public health implications as saxitoxin accumulates in shellfish and causes poisoning when consumed.
A blood test measuring phosphorylated tau 217 (P-tau217) can estimate an individual's risk of developing cognitive impairment over 2, 5, and 10 years. Higher P-tau217 levels are associated with increased risk of progression to cognitive impairment in cognitively unimpaired older adults.
Mouse study uncovers how oxygen-sensing transcription factors regulate muscle physiology, improving glucose tolerance and producing erythropoietin. The findings suggest that selectively targeting each isoform can lead to different physiological outcomes.
A novel therapy targeting the bone marrow microenvironment is shown to accelerate recovery and promote hematopoietic regeneration after injury. Pharmacological activation of YAP/TAZ improves BM niche recovery, enhancing engraftment and white blood cell recovery following HSCT.
Research reveals birds can harness lactate to rapidly resurrect blood function, outperforming mammals. Lactate enables bird RBCs to convert methaemoglobin back to haemoglobin three times faster than mammalian RBCs.
Researchers at Rice University have developed a noninvasive method to track the expression of specific genes in living brain tissue, enabling real-time monitoring of gene activity. The tool, called In-vivo Tracking of Active Transcription (INTACT), uses engineered reporter molecules and sensors to detect target mRNA in the bloodstream.
A team of researchers at Kyoto University has reconstructed the family tree of blood cells over a 700-million-year span, revealing their evolutionary history. They found that early blood cells emerged around the same time as multicellular animals and were macrophage-like.
Researchers found that iron deficiency may be more common and diagnosable earlier in U.S. school-aged children using a new method, detecting early stages of iron deficiency by looking at changes in red blood cells.
A case-control study found that amateur-level soccer heading is associated with increased blood biomarkers of neural damage, including dose-response relationships. The findings suggest that even low-impact heading may acutely affect neural integrity.
A new study found that nearly every person in the US has multiple man-made chemicals, known as PFAS, in their system. The study examined over 10,500 samples and found that 98.8% contained at least one PFAS, with many carrying multiple types.
Researchers at the University of Texas MD Anderson Cancer Center have identified specific blood-based genomic biomarkers that distinguish inflammatory breast cancer from other subtypes. The study used an improved method of RNA sequencing, called TGIRT sequencing, which allowed for a more comprehensive overview of all RNA types and amou...
A new study from Karolinska Institutet found that small abnormalities in blood sugar, lipids, and inflammation years before pregnancy are associated with an increased risk of high blood pressure during pregnancy and pre-eclampsia. The findings may contribute to earlier risk assessment and preventive measures.
A new study finds that blood protein levels change markedly over the course of a lifetime, rendering adult reference values inadequate for children and adolescents. Gender differences also emerge, particularly after puberty.
A new mapping model uses geo-mapping and statistical analysis to identify areas with the greatest need for prehospital whole blood transfusions. The model can help hospital systems quickly deploy scarce blood resources and minimize waste, particularly in underserved communities.
Researchers have created a detailed molecular map of the thromboxane A2 receptor, which could lead to the development of safer and more effective therapies targeting this clinically important signalling system. The study reveals an unusual activation switch and provides insights into how signalling molecules interact with the receptor.
A team of researchers at North Carolina State University has created an injectable microgel called B-knob triggered microgels (BK-TriGs) that can help reduce bleeding in infants during surgery. The microgel works by mimicking the mechanical properties of natural platelets, which helps to create fibrin networks and stanch bleeding.
The oXiris membrane addresses complex sepsis by integrating diffusion, convection, and adsorptive properties to remove inflammatory mediators. Early physiological improvements and potential benefits for cardiac surgery-associated acute kidney injury and severe COVID-19 have been reported in observational studies.
Researchers found that older adults exhibit higher BOLD variability in cerebellar lobule VIIIb and greater modulation across task conditions. This modulation predicts performance in an age-dependent manner, with increased modulation linked to better performance in older adults.
Researchers discovered subtle changes in the blood can reveal early signs of cognitive decline caused by chemicals produced by gut bacteria. A blood test may one day transform how we detect dementia, potentially identifying people at risk years before symptoms appear.
Patients with atrial fibrillation have a higher risk of adverse cardiovascular events, including stroke, heart attack, and cardiac arrest. Serum neurofilament light chain levels can serve as a biomarker for cardiovascular risk in these patients.
Researchers developed a laboratory mouse model closely mirroring TCF3::HLF-positive B-ALL and found an inflammatory feedback loop linking leukemia progression and bone destruction. Blocking IL-1β action slowed leukemia growth and reduced bone damage, suggesting new cancer treatments.
Researchers developed two neural network models predicting human biological age based on blood biochemistry and gut microbiota. The models demonstrated high predictive accuracy and explainability, holding potential for monitoring intervention effects in clinical trials.
A decrease in colorectal cancer incidence was observed among individuals with negative screening colonoscopy results, particularly men, suggesting risk-based follow-up strategies. Nonadherence to scheduled colonoscopies increased the risk of CRC, highlighting the need for targeted interventions to improve early detection.
A gene therapy platform successfully mapped the living brain noninvasively, using engineered proteins to track gene expression in different brain regions. This technology has the potential to reveal critical information about cellular activity and neurological disease progression.
A University of California - Riverside study has identified bed bugs' fear of water and wet surfaces, which affects their behavior and movement patterns. Researchers found that all bed bug ages and genders avoid wet surfaces, with younger insects being more sensitive to moisture.
Research reveals that people living at high altitudes have better glucose control due to an increased ability of red blood cells to take up and metabolize glucose. Studies in mice show that this occurs when RBCs are reprogrammed by hypoxic conditions, allowing them to adapt to low oxygen levels and aid the body's oxygen delivery.
Researchers at UCSF and Wayne State University found that generative AI tools can perform orders of magnitude faster than human teams in analyzing health data. Junior researchers paired with AI generated viable prediction models in minutes, outperforming experienced programmers in hours or days.
The updated guidelines provide evidence-based recommendations to standardize catheter use, improve infection prevention, and enhance outcomes for critically ill patients. The guidelines emphasize the importance of daily clinical reassessment, routine blood sampling, and proper antimicrobial use.
Researchers discovered that highly 'stiff' red blood cells play a crucial role in sickle cell disease, causing blockages and pain. The study's findings could lead to more effective, personalized therapies and new testing for early warning of symptoms.
Researchers found that certain types of CD8+ killer T cells are more abundant in people with MS and target the EBV virus, indicating the virus may trigger an immune response leading to progressive neurological damage. The study suggests that interfering with EBV could have a significant impact on other autoimmune diseases.
Researchers developed an AI tool called ONCO-ACS to predict the risk of secondary heart attacks in cancer patients after a heart attack. The tool combines cancer-related factors with standard clinical data to provide reliable information for doctors to balance treatment benefits and harms.
Researchers have developed a fast and easy test that can track the aging process of red blood cells after storage, potentially improving the quality of blood transfusions. The device uses surface acoustic waves to detect changes in metabolites associated with aging cells.
A new blood test has identified a protein signature linked to cancer in patients with non-specific symptoms. The test distinguishes cancer from other conditions with high precision and can help prioritize patients for further diagnostics.
A large study found that home fingertip oxygen monitors give higher readings for patients with darker skin tones, which can lead to missed diagnoses and delayed medical attention. The researchers suggest interpreting SpO2 readings in context and developing guidance to address these limitations.
A new study from Karolinska Institutet identified seven blood biomarkers that predict the risk and progression of multimorbidity in older adults. These biomarkers reflect biological processes such as metabolism, inflammation, and neurodegeneration.
Researchers develop ex vivo treatment of blood stem cells with Rhosin, a RhoA inhibitor, to rejuvenate them and improve the production of healthy blood cells. This strategy targets the core of the ageing process, making blood stem cells more capable of regenerating and producing new healthy blood cells.
A new study by UC San Francisco combines genetic risk with cardiovascular disease risk factors to predict who is more likely to develop dementia. The expanded view may help those worried about dementia, as lifestyle changes and improved control of illnesses can reduce brain damage and potentially delay or prevent symptoms.
A team of scientists at the University of Tokyo has developed an automated, high-throughput system that uses machine learning to analyze droplets of biofluids for disease diagnosis. The technology relies on imaging drying processes to distinguish between normal and abnormal samples.
Researchers at Tokyo University of Science identified genes that predict CD8+ T cell expansion in cancer immunotherapy. A 'signature gene set' or 'expansion signature' was found to identify primed T cells for growth, predicting treatment response and offering a potential guide for new therapies.
Scientists analyzed thousands of proteins in blood samples to understand when multiple sclerosis attacks the myelin sheath and nerve fibers. Researchers identified a protein called IL-3, which plays a key role in this early phase of damage.
Researchers at the University of Cambridge have developed a new lab-grown human embryo model that replicates early human development, including the production of blood stem cells. The 'hematoids' model mimics the natural developmental process, offering potential medical advances in screening drugs and studying blood disorders.
Researchers discover that genetic glitches in the blood system, caused by aging, can spark obesity, diabetes, and fatty liver disease. Simple blood tests may help identify at-risk individuals to prevent chronic illnesses.
Researchers at UBC have successfully transplanted an enzyme-converted kidney into a brain-dead recipient, showing promise for universal donor organs in transplantation. The breakthrough uses special enzymes to remove blood-type antigens, making it possible to use mismatched organs from deceased donors.
Researchers found that higher SDMA levels, but not ADMA, correlated with weaker blood vessel function in patients with moderate chronic kidney disease. This suggests that measuring SDMA levels may provide a better approach to monitoring vascular function in these patients.
Researchers found tiny air pollution particles sticking to red blood cells after exposure to roadside pollution, which can travel to organs like brain and heart. Wearing an FFP2 face mask reduces the amount of particles stuck to red blood cells.
Heiko Yang, MD, PhD, has received a grant from the National Institutes of Health (NIH) to further research on his discovery of an earthworm-derived hemoglobin-like oxygen carrier. This substance has the potential to revolutionize organ perfusion by providing a shelf-stable alternative to donor blood.