Articles tagged with Tissue Repair
Scientists have uncovered a new mechanism used by heart cells to resist reprogramming and found that carbohydrate sulfotransferase 7 (CHST7) is the most potent preventer of reprogramming in mouse and human cells. By targeting CHST7, researchers may develop treatments to help the heart fix itself after injury.
Researchers developed microparticles that infiltrate stubborn bacterial matrices and release tiny oxygen bubbles to clean surfaces and wounds efficiently. The particles were shown to effectively clean surgical instruments and infected wounds, accelerating healing and reducing inflammation.
Researchers found that discarded sea cucumber tissue can grow, diversify cells, and reorganize itself in natural seawater, challenging assumptions of tissue immortality. This discovery has profound implications for biomedical sciences and engineering, with potential applications in tissue regrowth and anti-microbial healing.
Researchers have created lab-grown human skin organoids that can form complex microvascular networks similar to those in native human skin. These self-organizing structures function similarly to native skin, responding to inflammatory stimuli and re-growing after injury.
Researchers developed a new mathematical model to understand wound healing, which found that surrounding tissue forces play a crucial role in closing wounds. The model predicts that these forces cause wounds to stretch or squish as they close, aligning with the natural direction of the tissue.
Researchers at Pohang University of Science & Technology discovered a way to prime skin cells for regeneration before injury, enabling rapid and effective healing. This approach, called mosaic partial reprogramming, reshapes surrounding cells and tissue microenvironment to accelerate wound healing.
Researchers from Institute of Science Tokyo discovered a unique mechanism in which conventional stem cells can temporarily switch into a specialized regenerative state called revival stem cells, driving tissue repair. This process, known as fetal reversion, enables efficient regeneration without exhausting the stem cell pool.
Using AI-driven analytical methods, researchers have created a custom OCT system that enables the objective measurement of wound progress over time. The platform shows that stiffer mechanical properties improve wound healing outcomes, with faster transition to intact regenerated tissue.
A team of researchers from the University of Mississippi has created a customizable wound scaffold that delivers natural antibacterials to encourage healing. The 3D-printed bandage is made from biodegradable materials that reduce the chance of infection and can be tailored to fit any wound.
Researchers at Penn State have developed a new class of tunable biomaterials, known as granular aerogel scaffolds, to support tissue regeneration and vascularization in wound healing. The material offers improved cell infiltration and may help rapidly form new blood vessels and regenerate damaged tissue.
Manuela Martins-Green, a renowned researcher at UC Riverside, has been selected as the 2026 recipient of The Lifetime Achievement Award from the Wound Healing Society. Her pioneering work on chemokines and wound healing has led to critical mechanistic insights and therapies advancing toward clinical application.
Researchers developed an oxygen-delivering gel to heal chronic wounds that fail to heal for more than a month. The gel conforms to the wound's shape and provides continuous oxygen levels, helping transform nonhealing wounds into normal injuries.
A study reveals that two key proteins, TSP1 and TSP2, play a central role in shaping the healing environment after injury, leading to abnormal bone growth. The findings suggest targeting these proteins may reduce harmful bone formation without interfering with healthy development.
Researchers at Arizona State University discovered that SerpinB3 plays a natural role in the body's wound-healing process, helping skin recover after damage. The protein helps activate keratinocytes to rebuild tissue and improve skin strength.
Lehigh University researchers used machine learning to compare bone marrow extracted from the hip and shoulder, finding six proteins that distinguish between the two extraction sites. This study may lead to standardized BMAC extraction protocols and personalized treatments based on protein concentrations.
Researchers at UZH have identified a new function of checkpoint inhibitors in promoting tissue healing, which could help treat fibrosis and chronic wounds. The study found that TIGIT upregulates a growth factor critical for repairing tissue after viral infections.
Researchers developed a composite bioabsorbable hemostatic sponge inspired by mussels and extracellular matrix. The sponge quickly absorbs blood and firmly adheres to tissues, enhancing hemostatic performance. It promotes wound stabilization, accelerates blood clotting, and reduces inflammation and tissue damage.
A wearable device called a-Heal optimizes each stage of the wound healing process using AI and bioelectronics, delivering medication or an electric field for personalized treatment. Initial preclinical results show the device speeds up the healing process by 25% compared to standard care.
Prostacyclin has been found to promote fetal membrane repair through the proliferation and migration of amnion mesenchymal cells. This discovery provides new insight into the mechanisms of fetal membrane healing, which could lead to new therapeutic strategies for managing preterm birth and infant mortality.
Researchers at Duke University developed a wireless patch that non-invasively measures skin and tissue stiffness, providing real-time feedback for medical applications like wound healing and chronic conditions. The technology also has potential for athletic performance optimization and rehabilitation.
A TIFR Hyderabad study reveals that the Endoplasmic Reticulum (ER) senses wound gap curvature and changes its structure to guide cell movement. This distinct difference in ER morphology ends up playing a crucial role in deciding how cells move to seal wounds.
Researchers have created 'skin in a syringe' by mixing cells with gelatine beads, allowing for 3D printing of functional dermis. This technology could lead to new ways to heal burns and severe wounds with minimal scarring.
A new hydrogel patch with dual-sided design offers adjustable, revocable adhesion and anti-adhesive functions for enhanced tissue repair. It reduces inflammation, promotes healing, and allows repositioning during surgical procedures.
A recent study has identified a gene, Zelda, that plays a crucial role in regulating the end of regrowth in fruit fly larvae. The researchers found that Zelda helps control the activity of genes involved in tissue development, revealing a new understanding of the regenerative process.
The international conference will focus on translating phage research into clinical reality, exploring key sessions and major speakers. Companies from various sectors are attending the event, highlighting the growing interest in phage therapy.
The National Multiple Sclerosis Society has committed $18.1 million to support research projects aligned with its Pathways to Cures roadmap, which aims to stop MS, restore function, and end the disease. The funding includes 16 research grants and 28 training fellowships in the US and internationally.
A new 'glycan glue' based on glucomannan has been developed to repair damaged spinal discs, enhancing tissue hydration and maintaining disc height. The treatment also improved mechanical stability and alleviated pain in rat and rabbit models.
A team of researchers from Goethe University and Kiel University has discovered a way to prevent the formation of harmful protein aggregates in cultured cells. The study found that linking TDP-43 with SUMO prevents its aggregation, suggesting a potential new approach for treating ALS and other neurodegenerative diseases.
Researchers at Tulane University identified a potential new way to treat idiopathic pulmonary fibrosis (IPF) using an FDA-approved cancer drug. The treatment works by blocking the CTLA4 protein, which blocks overactive T cells, allowing the immune system to clear out damaged cells that cause lung scarring.
Researchers developed an injectable hydrogel containing fish swim bladder components to repair damaged heart tissue, showing enhanced cardiac cell adhesion and stretching. The treatment also promoted new blood vessel formation and reduced inflammation in a rat model of ischemic heart failure.
Researchers developed a 3D-printed hydrogel from cow meniscus tissue, customized to individual patient needs, offering a more precise solution for meniscus repairs. The treatment aims to outperform current methods, which often result in poor healing.
Researchers at the University of Houston College of Pharmacy have identified a potential therapeutic target to repair injured muscles. They discovered that fibroblast growth factor–inducible 14 (Fn14) plays a crucial role in regulating satellite cell stability and function, which are responsible for muscle growth, repair, and regenerat...
Researchers have characterised how dying cells contribute to the body's regeneration process, suggesting a new mechanism for tissue repair. The study found that cells released from necrosis play a role in signaling the production of other cells involved in controlling natural cell death and inflammation.
Researchers found that cannabidiol stimulates the biomineralization of teeth even under inflammatory conditions, promoting tissue repair. The substance also inhibited the synthesis of inflammatory mediators in macrophages, suggesting an anti-inflammatory effect.
The PREMSTEM Conference will present cutting-edge research on neonatal brain repair, focusing on human mesenchymal stem cells as a potential therapy for preterm birth-related brain injury. Associate Professor Atul Malhotra's keynote address will highlight successes and lessons learned from his ongoing stem cell-based therapy trials.
Researchers have made significant progress in applying tissue engineering to spinal cord injury (SCI) repair. Biomaterials such as hydrogels and decellularized extracellular matrix promote nerve regeneration, while stem cells and exosomes enhance functional recovery.
Researchers have developed a method to repair complex knee injuries using cartilage implants made from nasal septum cells. The study shows that longer maturation periods of the implant lead to better clinical efficacy and tissue composition.
Researchers at University of Gothenburg have identified a critical mechanism to slow down Crohn's disease progression by repairing the protective barrier of the gut. By reinforcing the gut's natural defenses, new drug targets may be developed to treat the disease.
A team from Tokyo Metropolitan University has successfully implanted myoblasts onto healthy muscle in mice using an extracellular matrix scaffold. This breakthrough treatment could treat ageing-related muscular atrophy without scarring, offering a promising avenue for regenerative medicine.
The Rice University lab, in collaboration with Baylor College of Medicine, has developed a new gene-editing strategy called Repair Drive that improves the effectiveness of gene therapies in the liver. The technique enables the repair of liver cells at higher rates and equips them with a selective advantage to outcompete incorrectly edi...
Researchers have created a novel self-healing electronic skin that repairs itself in seconds, surpassing existing technologies by up to 80%. This technology integrates artificial intelligence and offers real-time fatigue detection and muscle strength assessment with remarkable precision.
A new Northwestern Medicine study reveals that macrophages in newborns use a process called efferocytosis to produce thromboxane, which triggers the production of a bioactive lipid that signals heart muscle cells to divide and regenerate. This process is less effective in adults, leading to scar-tissue buildup and often heart failure.
Researchers developed a novel biocompatible nanoadhesive for corneal transplantation, showcasing improved cell compatibility and antibacterial performance. The nanoadhesive demonstrates strong adhesive strength and prevents wound infection without causing necrosis.
Researchers successfully reversed existing inguinal hernias in male mice using an anti-estrogen drug, restoring their anatomy without surgery. Human tissue samples also showed identical molecular markers as in the mouse model, suggesting a promising treatment target for inguinal hernia repair.
Researchers discovered that a topical ABT-263 treatment effectively reduces aged skin senescence markers, priming the skin for improved subsequent wound healing. The treatment also triggered inflammation, which surprisingly helped the healing process by 'waking up' the skin's repair systems.
Seoul National University researchers create bioink from Kombucha SCOBY nanocellulose, suitable for in vivo tissue engineering. The bioink can be precisely applied directly onto damaged tissues using a digital biopen, paving the way for more personalized and effective wound healing.
New research reveals that lipid-associated macrophages (LAMs) are crucial for liver repair, while Kupffer cells also adapt to take on a LAM-like phenotype. The Trem2 gene is essential for clearance of dying liver cells and promoting tissue repair.
A new study from the University of Southern Denmark reveals that the brain's self-healing abilities are hindered by inflammation after a stroke. The researchers mapped specific cells that play a central role in rebuilding myelin, but found gender differences in how men and women respond to injuries.
Scientists from Mass General Brigham create bioprinted tissues that can be remotely stimulated by light to generate electrical activity, enabling non-invasive control of heart tissue. This breakthrough has the potential to promote long-term tissue regeneration and integration into the heart's biology.
Researchers found that heart muscle cells can grow and survive in microgravity, suggesting a new approach to regenerating damaged hearts. The study uses cardiac spheroids to mimic the human heart structure and function, leading to increased survival rates and potential for improved cell therapy.
Researchers have successfully developed a gene-editing approach using CRISPR-Cas9 to correct the genetic error causing dysferlin protein deficiency, a leading cause of muscular dystrophy. In new mouse models, they restored muscle function and regrowth after transplanting corrected cells.
Researchers from Korea University have developed a groundbreaking technique to transform fibroblasts into mature cardiomyocytes, holding promise for regenerative medicine in treating cardiovascular disease. The method combines fibroblast growth factor 4 (FGF4) with vitamin C to accelerate cell maturation and enhance function.
A preclinical study suggests the experimental compound K884 can restore lost muscle function in Duchenne muscular dystrophy (DMD) patients by strengthening muscle repair. The drug targets specific enzymes, allowing muscle stem cells to develop into functional tissue.
Researchers aim to advance eye transplantation through cutting-edge technologies and techniques, including cell-based therapies and device development. The six-year project, led by Kia Washington at the University of Colorado Anschutz Medical Campus, seeks to overcome current limitations in whole-eye transplant success rates.
A new study reveals that combining intermittent fasting with localized Wnt3a treatments can rejuvenate bone repair in older mice, suggesting a potential therapeutic approach to restore bone healing in aged animals. The treatment also showed promise in improving the repair and function of other aging tissues.
A team of researchers at Penn State developed a novel bioprinting technique that uses spheroids to create complex tissue, producing tissue 10-times faster and with high cell density. The technique enables the rapid fabrication of functional tissues and organs, opening new opportunities for regenerative medicine.
Researchers assess 20 years of clinical trials for cell therapy's safety and efficacy in treating heart failure, highlighting progress despite challenges. The field continues to evolve through lessons learned from past studies, with ongoing trials taking novel directions.
A new study published in Nature Aging details the changes in muscle regeneration over time, finding that immune cells exhibit differences in abundance and reaction time between age groups. The research also identifies altered stem cell states, leading to discoordination in the process of muscle repair in older mice.
Researchers at Karolinska Institutet discovered that patients with heart pumps can regenerate heart muscle cells at a rate more than six times higher than in healthy hearts, offering new hope for therapies to stimulate the heart's ability to repair itself after damage.
Researchers develop biocooperative materials by harnessing blood-clotting and peptide self-assembly to repair bones in animal models. The new approach enables the creation of regenerative materials that can be easily assembled, manipulated, and 3D printed while maintaining normal healing functions.