Research on depression and its treatment. Covers stress-response biology, ketamine and dopamine-targeting therapies, treatment-resistant cases, and brain mechanisms.
A study found that mothers with depression are not physiologically synchronized with their kids, even during positive interactions. The researchers measured heart rate variability and found that depressed moms missed matching their children's physiology, leading to a mismatch in social engagement.
A team of researchers has identified a ketamine metabolite that quickly reverses depression in mice without ketamine's major side effects. The study suggests that this compound may work by activating AMPA receptors, potentially opening up new vistas for the development of safer antidepressant treatments.
A new study provides first-person perspectives from African-American and Latina mothers on their experiences with postpartum depression, revealing that conventional treatments often provide little relief. The research highlights the need for concrete services like transportation and flexible work environments to manage depression effec...
Researchers found that yoga and aquatic exercise significantly improved symptoms of multiple sclerosis, including reduced fatigue, depression, and paresthesia. The study, involving 54 women with MS, showed a significant reduction in moderate to severe depression in those who exercised three times a week.
A national survey of over 34,000 adults found that individuals with bipolar disorder are equally likely to develop anxiety as depression after experiencing an episode of mania. This study may lead to a broader clinical definition of bipolar disorder that includes episodes of mania along with anxiety or depression.
A web-based guided self-help intervention has been shown to reduce the incidence of major depressive disorder in adults with subthreshold depression. The study found that 55 participants in the intervention group experienced MDD compared to 84 in the control group, resulting in a significant reduction in risk.
A long-term study of 3325 adults aged 55 and over found that depression symptoms that steadily increase in older age are more strongly linked to dementia than any other types of depression. The study suggests that increasing depressive symptoms may indicate the early stages of dementia.
Research found that children exposed to selective serotonin reuptake inhibitors (SSRIs) during gestation had a cumulative incidence of 8.2% of depression by age 15, compared to 1.9% for those without antidepressant use. The study also showed no significant difference in anxiety or ASD diagnoses.
A meta-analysis of nine published randomized trials found that mindfulness-based cognitive therapy (MBCT) was associated with a reduced risk of depressive relapse/recurrence over 60 weeks. The treatment effect appeared to be larger in patients with higher levels of depression symptoms at baseline.
A meta-analysis of nine randomized trials found that Mindfulness-Based Cognitive Therapy (MBCT) is an effective treatment option for preventing major depression relapse. Participants who received MBCT had a 31% lower risk of relapse compared to those who did not receive the therapy.
A meta-analysis of 40 clinical trials found that combining omega-3 fish oils with antidepressants had a statistically significant effect on improving mood. Other supplements like methylfolate, Vitamin D, and SAMe also showed promise as mood-enhancing therapies when taken with antidepressants.
A five-year study found that patients with negative beliefs about their diabetic foot ulcers had a higher risk of death. The study, published in PLOS ONE, suggests that addressing these attitudes could improve survival rates for people with diabetic foot ulcers.
A new study found that electronic health records (EHRs) frequently fail to capture comprehensive mental health data, resulting in potential medication errors and patient harm. The research highlights the importance of supplementing EHR-derived data with external sources to improve patient care.
A study of nearly 700 ICU survivors found that two-thirds experienced depression, anxiety, or PTSD, with most experiencing multiple symptoms. The risk factors were not related to illness severity or length of stay, but rather age, gender, unemployment, and substance misuse.
A 2-year study found that bupropion (Wellbutrin) is the only antidepressant to induce modest weight loss, while others lead to varying degrees of weight gain. Nonsmokers on bupropion lost an average of 2.4 pounds, compared to a 4.6-pound gain on fluoxetine.
Researchers found three genetic variants associated with subjective wellbeing, two with depressive symptoms, and 11 with neuroticism. The study suggests that these traits are influenced by the same set of genes and may be studied jointly in future work.
A recent study by Dr. Barbro Kjellström found that heart attack patients are more likely to be depressed, with 14% experiencing symptoms compared to 7% of control group members. However, antidepressants were prescribed less frequently among heart attack patients with depression, at just 16%, compared to 42% of control group members.
A recent study found that gang membership is associated with increased levels of depression and suicidal thoughts among middle- and high-school students. The research, conducted by Michigan State University and Bowling Green State University, highlights the negative impact of gang involvement on mental health outcomes.
Researchers found that depression combined with metabolic risk factors significantly increases the risk of developing type 2 diabetes. The study suggests a vicious cycle where depression and metabolic symptoms exacerbate each other, making integrated treatment crucial for prevention.
A new study finds a significant association between androgen deprivation therapy and depression in patients with localized prostate cancer. Patients treated with hormone therapy experienced higher incidences of depression, with risks increasing with treatment duration.
Researchers at Oregon Health & Science University have discovered the precise structure of the serotonin transporter, a key player in regulating mood and behavior. This breakthrough provides a platform for designing new, more effective small molecule therapeutics to treat depression and anxiety.
A recent study published in Frontiers in Neural Circuits identified specific brain areas that may contribute to stress-induced depression. The research found that mice displaying 'helpless' behavior had reduced neuronal activation and stereotypical brain-wide activity patterns, which are distinct from those showing 'resilient' behavior.
A Northwestern University study shows that engaging environment can alleviate depression in genetically depressed rats, suggesting that nurture can override nature. The study found that psychotherapy and behavioral activation therapy can change blood biomarkers for depression, potentially leading to more precise treatment.
The American College of Physicians (ACP) calls for policy changes to slow the rising cost of prescription drugs. Recommendations include price transparency, patient cost-sharing, and novel approaches such as price negotiation by Medicare. While some studies suggest potential prevention methods, more research is needed.
A study by Northwestern University found that higher oxytocin levels during pregnancy can predict the severity of postpartum depression symptoms. The research suggests that screening for depression biomarkers in pregnancy could lead to preventive treatment, reducing the likelihood of women seeking help and accepting treatment.
Patients with coronary artery disease diagnosed with depression are more likely to suffer a heart attack or die compared to those without depression. Depression was also associated with more severe chest pain and co-existing medical conditions.
A new study from the University of Pittsburgh School of Medicine found a significant association between social media use and depression among US young adults. Participants who spent more time on social media had a higher risk of depression, with some platforms showing stronger correlations than others.
A new meta-analysis supports the link between Omega-3 supplementation and reduced major depressive disorder (MDD) rates. The study found a comparable benefit to antidepressants in patients taking EPA and DHA supplements.
Researchers discovered a potent inhibitor of soluble epoxide hydrolase, which plays a key role in modulating inflammation and neuropathic pain in the brain. The compound, TPPU, displayed rapid effects in animal models of depression, with potential as a new therapeutic medication.
A new study found that younger grandmothers face different needs and require unique types of support to manage depression and improve their mental health quality of life. The study suggests that age affects the effectiveness of social support services, highlighting the need for tailored interventions.
A new study found that standard depression screening tools may not work as well for black Americans as they do for whites. However, listening to black participants' own descriptions of their mental health may help predict risk. Self-rated health was found to be a key predictor of later depression in black participants.
Research reveals depression alters oxidative stress levels, leading to increased risk of cardiovascular disease and cancer. Treatment can improve malondialdehyde levels, while zinc and uric acid levels normalize.
A new study from Trinity College Dublin reveals that modifying ECT can minimize cognitive side effects while maintaining its effectiveness in treating severe depression. The 'unilateral' approach, involving unilateral electrode placement, shows promising results.
A new study found that a computer-based attention bias modification treatment reduced negative attention biases and clinician-rated depressive symptoms in adolescents with major depression. After 12 months, participants in the active ABM group reported even greater reductions in self-reported depressive and anxious feelings.
Researchers discovered a molecular link between mood disorders and circadian rhythms in a study on familial advanced sleep phase (FASP) and faulty PER3 gene variants. Mice carrying the faulty gene exhibited depression-like symptoms when exposed to short light periods, mirroring human seasonal affective disorder.
A RAND Corporation study found that the US military health system provides good care in following up with patients after discharge, but needs improvement in other realms. Most patients receive at least one psychotherapy visit, but may not receive sufficient evidence-based therapy.
Researchers have identified a specific gene mutation that appears to link unusual sleep patterns and Seasonal Affective Disorder (SAD). The PER3 gene mutation was found in family members with both conditions, suggesting a connection between circadian genes and mood disorders.
A new study of firefighters suggests that insomnia and nightmares may increase the risk of depression by impairing emotion regulation strategies. The study found that limited access to these strategies, such as problem-solving skills and negative emotions decrease, was the strongest indirect effect for both relationships.
A new study from UCL and ICREA-University of Barcelona found that immersive virtual reality therapy can reduce depressive symptoms in patients. The therapy involved wearing a virtual reality headset and expressing compassion towards a distressed virtual child, resulting in a significant drop in depression severity for some participants.
A personalized approach to acupuncture has been shown to decrease pain levels and improve functional capacity in individuals with chronic pain, known as fibromyalgia. Fibromyalgia is characterized by widespread pain, fatigue, and depression, affecting up to one in twenty people.
Researchers at McGill University found a connection between noradrenergic neurons and depression vulnerability. Increased dopaminergic neuron activity corresponds to depression, while noradrenergic neurons control this activity, influencing resilience or vulnerability.
A clinical trial found that modulating the endogenous opioid system improves serotonin-targeting antidepressant therapy effectiveness in patients with persistent depression. The combination drug ALKS-5461 produced significant symptom improvement, with lower doses showing stronger effects.
A combination of mental and physical training reduced depressive symptoms in students with major depressive disorder. The study found that individuals experienced fewer negative thoughts and improved focus after just eight weeks of MAP training. This innovative approach offers a low-cost solution for depression treatment.
Researchers report successful reduction of depressive symptoms in patients using a novel non-invasive method of vagus nerve stimulation. The transcutaneous approach, which stimulates the vagus nerve through electrodes clipped onto the ear, shows promise as a low-cost and safe treatment option.
A Swedish study of over 1.1 million children found that parental depression was associated with poorer school performance at age 16, with maternal depression having a larger negative effect on girls. The study suggests that early intervention and support for affected parents could have far-reaching effects on child development.
Participating in women-only cardiac rehab resulted in lower symptoms of anxiety and depression and improvements in diet. Women who attended the supervised programs exhibited increased physical activity and improved quality of life.
A new study found that parental depression can significantly negatively affect children's school performance, with mothers' diagnoses having a greater impact on girls. Children whose parents have depression are more likely to achieve lower grades, similar to those in low-income families but with smaller effects.
A new study published in Biological Psychiatry suggests that inflammation can directly affect the brain's reward center, leading to changes in behavior similar to depression. The study found that patients with hepatitis C who received interferon-alpha treatment showed microstructural changes in their striatum, which was associated with...
Researchers at Vanderbilt University Medical Center have found a potential treatment for depressive-like symptoms in alcoholics using ketamine and an endocannabinoid system booster. The study, published in Neuropsychopharmacology, validates a mouse model of alcoholism and shows promise for developing novel treatments for mood disorders.
A new UCLA-led study reports the success of a Finnish anti-bullying program called KiVa, which improves the mental health of sixth-graders who experience bullying. The research-based program includes role-playing exercises and computer simulations to increase bystander empathy and intervention.
A study found that nearly 40% of adolescents prescribed antidepressant medication did not receive documented follow-up care for three months. This lack of care raises concerns about the quality of treatment for adolescent depression, a condition affecting 12% of adolescents.
A study found that around 10% of UK primary care patients prescribed antidepressants for depression or anxiety have undiagnosed bipolar disorder. The condition often presents with depression and can be difficult to diagnose, leading to inappropriate treatment.
A study published in the British Journal of Sports Medicine found that nearly a quarter of Division I college athletes reported depressive symptoms. Women were almost twice as likely to experience symptoms than their male peers. The researchers also discovered significant differences in depression rates across different sports, with fe...
A new Northwestern University and UCLA study found that young people with high neuroticism are highly likely to develop both anxiety and depression disorders. Researchers suggest a single intervention could help prevent the development of both conditions.
The USPSTF recommends screening for depression in adults, including pregnant and postpartum women, to improve accurate identification of patients with depression. Screening with adequate support systems can also improve clinical outcomes and reduce symptoms.
Researchers found that people living in self-oriented cultures are less emotionally complex than those in other-oriented cultures, which prioritize feelings of duty and familial bonds. People in various parts of Asia and Russia showed more emotional complexity.
A new brain imaging study from MIT and Harvard Medical School may lead to a screen that could identify children at high risk of developing depression later in life. The researchers found distinctive brain differences in children known to be at high risk due to family history of depression, suggesting an early intervention strategy.
A large-scale survey of U.S. adults found no association between depressive symptoms and seasonality, contradicting the notion of seasonal depression as a commonly occurring disorder. The study's findings cast doubt on major depression with seasonal variation as a legitimate psychiatric disorder.
Researchers found that regions of the brain normally working together to process emotion become decoupled in people who experience multiple episodes of depression. This disruption may lead to inaccurate emotional information processing and negative biases.
A study found a correlation between serotonin gene alleles and brain thinning in individuals at high familial risk of depression. Those with the 'S' allele had lower brain plasticity and were more likely to develop depression when exposed to stressors.