Articles tagged with Memory
A recent study in mice reveals a shared hub of memory cells that links incoming and outgoing signals, allowing the brain to reuse some cells to store many different memories. This 'switchboard' helps maintain stability while learning new information.
A new study by researchers at UC Davis Health and Kaiser Permanente found that long-term exposure to fine air pollution particles (PM2.5) is associated with lower semantic memory, a type of brain's encyclopedia. The study analyzed data from 740 adults aged 53-94 and found no impact on executive function or verbal episodic memory.
Researchers have identified an experimental molecule called OLE that helps restore microglia's protective function against Alzheimer's disease. The compound reduces beta-amyloid plaque size and toxicity, improving cognitive performance in memory tests.
Researchers at UCLA Health have identified a brain region called the ventromedial prefrontal cortex (vmPFC) that regulates memory integration. The vmPFC acts as a quality control checkpoint, preventing memories from getting mixed up when they are significantly different or far apart in time.
A new preclinical study finds that estrogen loss in the extracellular matrix of the hippocampus may contribute to memory decline and increased risk of Alzheimer's disease in postmenopausal women. The study suggests a possible new treatment approach focused on restoring the brain's supportive environment.
A cohort study found that participants with unfavorable long-term memory trajectories were less active and more sedentary, suggesting a link between cognitive change and later-life movement patterns. The study's results have implications for understanding the relationship between aging, cognition, and physical activity.
A post hoc analysis of a randomized clinical trial found high-dose vitamin D3 supplementation in pregnancy to be positively associated with visual memory, verbal memory, and flexibility among offspring at age 10. This strengthens evidence on the association between prenatal vitamin D exposure and childhood cognition.
Research suggests that switching to a nutritious diet can improve memory, but does not fully reverse cognitive deficits and impairment caused by high sugar intake. Diets high in added sugar show little evidence of recovery, highlighting the potential detrimental effects on brain health.
A new study by Tohoku University researchers has identified dopamine dysfunction as a previously unrecognized mechanism underlying memory impairment in Alzheimer's disease. The discovery may lead to the development of targeted therapies to restore cognitive function and potentially reverse cognitive decline.
Researchers discovered that interictal epileptiform discharges (IEDs) occur in a predictable pattern, unfolding sequentially in individual neurons. Nearly 80% of IED-involving neurons are also involved in language and perception, suggesting the brain blips can derail cognition.
Researchers found that women with prediabetes had persistent changes in gene expression in fat tissue after bariatric surgery, leading to impaired lipid metabolism and greater weight regain. Despite clinical improvement, these molecular alterations may reduce the ability of adipose tissue to adapt after weight loss.
A study found that young adults' memories of their drinking habits may not accurately reflect their daily experiences, highlighting the need for new assessment strategies. Real-time measurements of alcohol use disorder symptoms provide more detailed insights than traditional retrospective self-reports.
Researchers develop molecular tool called SynTrogo, which enables selective dismantling of synaptic connections in brain circuits. By harnessing astrocytes, the system reduces synapse number while strengthening remaining connections, leading to enhanced long-term potentiation and improved memory.
Researchers developed a nasal spray that reversibly reduces brain inflammation, restores cellular power plants, and improves memory. The treatment bypasses the brain's protective shield through intranasal delivery, suppressing chronic inflammation and promoting successful brain aging.
A major European study found that loneliness affects the memory of older adults, but does not speed up mental decline over time. Participants who reported high levels of loneliness performed worse on initial memory tests, but their ability to recall information declined at a similar rate as those with lower loneliness levels.
Researchers analyzed brain interactions to explain attention, decision-making, and memory. Models with competitive interactions outperform cooperative ones, enabling flexible activation of regions and intelligent behavior. This breakthrough brings us closer to creating realistic digital twins of the human brain for personalized medicine.
A recent study led by Cedars-Sinai Health Sciences University found that the same brain neurons are activated when people perceive and imagine objects. The research provides a detailed understanding of the neural mechanism underlying visual perception and creation of mental images in the human brain.
The research team will analyze mouse models and human brain tissue to identify cell types that show early signs of stress before neurons die. The multiscale model simulates how the progressive loss or disconnection of specific neurons disrupts memory-related brain networks.
A Northwestern University study found that imagination is not just a copy of sensation, but emerges at later stages of processing when the brain represents information holistically. The researchers mapped brain activity during imagination and perception, finding overlap in higher-level association areas.
Researchers discovered that mild hypoxia shortly after birth hinders learning and memory into adulthood through altered neuron-to-neuron communication in the hippocampus. The study also found a second protein involved in hypoxia's effects on this channel's functioning, which was restored when targeted.
A NUS Medicine study reveals that caffeine can restore social memory impaired by sleep deprivation. Caffeine targets a specific brain pathway to reverse disruptions in neural communication and plasticity. The study provides insights into the effects of caffeine on cognitive function and memory.
New research from the University of Mississippi suggests that storytelling is just as effective, and sometimes better, than survival processing in improving memory. By creating a narrative with unrelated nouns, participants were able to remember more than those who used survival processing or pleasantness processing.
A new study found that cannabis intoxication disrupts many types of memory, including verbal, visuospatial, and episodic content memory. Participants who consumed cannabis performed significantly worse than the placebo group on most measures, with significant differences appearing in 15 of the 21 tests.
A new study led by Dr. Shira Baror and Dr. Aya Ben-Yakov found that the brain's sense of continuity and segmentation are shaped by context in distinct ways. The researchers used three large-scale experiments involving 816 participants to investigate this fundamental question.
Researchers at EPFL's Brain Mind Institute have discovered that rejuvenating specific engram neurons can restore memory performance in multiple mouse settings. This approach uses a short pulse of genes to 'reprogram' these cells, bringing their functionality back to levels seen in young mice.
The FENS Forum 2026 will be Europe's largest neuroscience congress, covering areas of basic to translational research. Journalists can register for free and attend symposia and poster sessions.
Researchers discovered that while older rats were as social as younger ones, a subpopulation preferred familiar peers. Altering neural communication reversed this preference, enhancing approach towards new peers. This suggests a distinct neural system underlying aging-related social behavior.
A new treatment combining cognitive and occupational therapy is being tested to improve stroke recovery, especially for rural patients. The 'cognition-first' approach tackles cognitive difficulties before physical rehabilitation, addressing a significant gap in existing treatments.
Researchers at University College London discovered that Alzheimer's disease disrupts the brain's 'memory replay' process, leading to impaired navigation and memory loss. The study found that even when mice were resting, their brains replayed recent experiences in an altered pattern, which had consequences on memory tasks.
Researchers found no difference in neural activity between successful semantic and episodic retrieval, challenging long-standing research tradition. This overlap suggests that the whole brain is involved in different types of memory, potentially leading to new interventions for diseases like dementia and Alzheimer's.
Researchers observed episodic memory in rats, suggesting they can model complex cognitive processes. The study shows rats can recall memories with accuracy and context, even after a long delay, implying evolutionarily ancient forms of memory.
Scientists found that blocking microglia prevents infant forgetting and improves memory in mice, suggesting a role for microglia in memory formation. Microglia inhibition also enhances engram cell activation, providing a functional explanation for enhanced memory recall.
A new study finds that cognitive bias modification for memory (CBM-M) training reduces both psychological and physical stress by altering biased memory processing patterns. Participants showed reductions in anxiety and depressive traits, as well as improved mood and reduced cortisol levels.
Researchers at NUS Medicine have found a critical driver of neural stem cell function during ageing, called DMTF1. Restoring DMTF1 expression can restore neural stem cell regeneration capabilities in aged brain cells.
A new study published in Communications Psychology found that verbal justifications supporting memories remain rich, detailed, and consistent even after a delay of 24 hours. The study suggests that memory justifications provide a temporally stable window into episodic memory, making them a reliable basis for evaluating memory credibility.
A new study published in Neurology found that using hearing aids was associated with a lower risk of dementia but little impact on cognitive test scores among older adults with moderate hearing loss. The study suggests that hearing aid use may support brain health and reduce the risk of cognitive impairment.
Researchers discovered that calcium alpha-ketoglutarate restores key memory-related brain functions disrupted in Alzheimer's disease. The molecule enhances synaptic plasticity, protects neurons from degenerative changes, and supports healthier cognitive ageing.
Scientists have observed changes in brain cells' signal transmission during learning processes, shedding light on the brain's adaptability. The study found that axon initial segments, responsible for generating electrical signals, can lengthen or shorten in response to experiences, influencing neuronal activity.
A new study published in Sleep Health found that the quality of a night's sleep, rather than its length, predicts how quickly older adults process information the next day. Researchers analyzed data from 261 participants aged 70 and above, who wore devices to track their sleep and completed cognitive assessments six times a day.
Scientists at Max Planck Florida Institute for Neuroscience have identified a neural code that allows the brain to track distance traveled without visual cues. This ability is essential for navigation and memory formation, and may offer insight into early navigation problems in Alzheimer's disease.
Researchers found that abundant mRNA molecules tend to cluster together in brain neurons, driven by chance overlap rather than coordinated movement. This discovery provides insights into how neurons manage genetic instructions and supports learning and memory, with potential implications for conditions like Fragile X syndrome.
The study demonstrates the auditory cortex's ability to integrate fine-scale and coarse-scale temporal cues during synchronization, with better performance in macaques compared to the middle glandular body. The nonlinguistic oddball paradigm shows promise for clinical applications in psychiatric disorders and future research should exp...
Researchers at Cornell University used optogenetics to boost large sharp-wave ripples in the brains of mice, improving their ability to remember new experiences. The technique showed promise in extending memory consolidation even in mice engineered to have cognitive deficits.
Researchers found that words with phonetically pleasing sound patterns are more memorable due to their aesthetic appeal. The study was supported by a grant from the Austrian Academy of Sciences and the Austrian Science Fund.
Researchers identified a molecular mechanism linking early-life environments with memory by activating AP-1, which regulates genes involved in neuronal plasticity and learning. Early-life experiences produce long-lasting modulation of AP-1 activity, boosting gene networks that strengthen neuronal connections.
A collaboration between physics, neuroscience groups develops a unified model of memory and perception. The study suggests that distinct perceptual biases can be explained by a single biologically grounded mechanism, Hebbian learning.
Researchers have discovered a key role for the Frazzled protein in fruit fly neural circuits, revealing how it helps neurons form reliable connections. The study showed that when Frazzled is missing or mutated, neurons fail to form proper electrical connections, leading to communication breakdowns.
Researchers found that a rotating brain wave helps the cortex recover its computational path after a distraction, improving performance in visual working memory tasks. Longer time intervals between distractions also aid recovery.
Researchers develop CRISPR-based tools to epigenetically silence or boost memory gene Arc, demonstrating its direct impact on memory expression and storage. This breakthrough offers new avenues for exploring memory processing disorders in humans.
A new $2.9 million grant refines the LifeBio Memory app to enhance reminiscence therapy for dementia care, expanding to multiple languages and cultural contexts. The research aims to improve quality of life and relationships for both older adults and caregivers, using storytelling technology to reduce loneliness and depression.
Researchers at Virginia Tech found that adjusting molecular processes can improve memory in older subjects. They used CRISPR-dCas13 and CRISPR-dCas9 to target age-related changes in K63 polyubiquitination and IGF2, two genes linked to memory formation.
The team aims to build an anonymized database representative of the whole population by collecting two vivid memories from participants. The findings will inform new ways to help people remember in more detail and understand human memories across the lifespan.
A new MIT study found that a theta-frequency brain wave scans the mental image and a region of the cortex maps visual information. The researchers observed that performance depends on the phase of this wave when the changed square appears, and the vertical location on the screen of that target square.
A new study found that storytelling strategies with conceptual or perceptual details activate distinct brain networks, predicting how well participants recall core elements of the story. This suggests that people's preferred memory systems may vary across age groups, and tailored information could improve memory for older adults.
A new study published in JNeurosci used fMRI to investigate how the brain acquires semantic information. The results suggest that the quality of activity in distinct brain regions can predict whether people successfully acquire knowledge about places and characters in fictional civilizations.
Researchers have discovered that deep sleep plays a crucial role in controlling cerebrospinal fluid dynamics, which is essential for clearing waste from the brain. During slow-wave sleep, changes in cerebrospinal fluid signals are time-locked to slow brain waves and other neural events.
A new study reveals that astrocytes, a type of glial cell, are responsible for stabilizing memories through repeated engagement. The researchers found that Fos activity in astrocytes only occurs during recall, and that these cells can be activated to produce stable memories.
Researchers found that Rab4 boosts neural connection strengthening while Rab10 decreases it, directing supplies to the surface of growing connections. This discovery may lead to new strategies for protecting memory in neurodegenerative conditions like Alzheimer's disease.
A study published in The Lancet Healthy Longevity found that quitting smoking, even in the 50s or older, significantly reduces cognitive decline. Cognitive scores of quitters declined 20% less for memory and 50% less for verbal fluency over six years after cessation.
Terrence Sejnowski, a renowned neuroscientist at Salk Institute, has been awarded the 2025 NIH Director's Pioneer Award to develop advanced computational techniques for analyzing working memory. His research aims to better understand and treat memory disorders in mental health conditions.