The study provides new insight into how the tick-borne virus replicates and matures, with detailed three-dimensional images revealing the virus's interior. The researchers also observed how a small genetic difference between variants affects maturation speeds, paving the way for future treatments against TBE.
A quantum processor with nine interacting spins outperformed classical networks with thousands of nodes in realistic weather forecasting tasks. The researchers leveraged the natural dynamics of quantum systems to bypass complex circuits, achieving higher accuracy than classical reservoir models.
A novel mechanical activation assisted strategy achieves selective extraction of Li+ from spent cathode materials with highly utilization efficiency of H+ (>97%), reducing secondary pollutant generation. The developed process obviates the need for auxiliary reagents and substantially reduces chemical consumption.
Researchers reveal lactylation as a key player in lung cancer progression and drug resistance, highlighting potential targets for overcoming treatment resistance. The study identifies self-reinforcing loops that sustain acquired resistance to EGFR-TKIs and provides a framework for developing precision therapies.
Researchers have identified a fundamental mechanism underlying Sanfilippo syndrome, a common form of childhood dementia. Chronic overactivity in the brain appears to be a key contributor to cognitive deterioration in children with the condition. The study's findings represent significant progress and may lead to personalized treatment ...
Research from Flinders University finds that people with sleep apnea who experience dramatic night-to-night breathing problems are 30% more likely to have a heart attack or stroke. The studies suggest that repeated changes in oxygen levels and sleep disruption can quietly stress the heart and blood vessels over time.
The TREM-1 receptor is a central amplifier of inflammatory responses, involved in sepsis, arthritis, and neurodegenerative diseases. Several antagonists have shown promise in preclinical models, but more research is needed to define therapeutic windows and identify responsive patient subgroups.
Gramine, a natural indole alkaloid, suppresses triple-negative breast cancer by inducing ferroptosis. It targets the CUL3–MTDH axis, reducing E3 ubiquitin ligase activity and downregulating ferroptosis inhibitors.
Researchers at KAIST have developed a new electrode design that blocks water while maintaining efficient electrical conduction and catalytic reactions. The technology achieves 86% efficiency in converting CO₂ into plastic precursors, outperforming previous systems.
Researchers developed a novel flowering spectral index model, FI-R, for precise fine-scale extraction of angiosperms over large areas. The model achieved high accuracy and applicability across multiple multi-spectral sensor images, with overall accuracies exceeding 94%.
Chronic breathlessness affects people's sex life, leading to reduced satisfaction and intimacy. People with breathlessness are 1.5 times more likely to report dissatisfaction with their overall sexual life.
The inaugural Ken Seng Tan Award 2026 celebrates interdisciplinary research that advances the field of risk sciences. The award honors innovative scholarship with a focus on societal impact and real-world risk management.
A new study highlights an extremely high short-term mortality rate for mechanically ventilated patients with cirrhosis, which remains unchanged despite recent ICU improvements. The research identifies key prognostic factors and sheds light on the need for early multidisciplinary discussions about care goals.
A new PN junction design enables a single device to exhibit three independent working modes: photosensing, photosynapse, and photomemory. The device demonstrates stable self-driven photosensing characteristics and achieves multi-state optical memory capacity.
A team of researchers used AI to analyze 289,513 global publications and isolated 4,177 highly relevant studies on China's major basins. The study highlights crucial milestones in Chinese hydrology and aims to guide future research priorities and sustainable water resource strategies worldwide.
Researchers found that rural households in Northern China face significant challenges in affording clean heating as subsidies shrink. Distributed rooftop solar photovoltaics could help offset heating costs, with an estimated compensation of 32.2-64.5% in regions with strong solar potential.
Scientists at NUS create a DNA-based approach to directly measure the activation of Piezo1, a key protein that allows cells to detect physical forces. They find that Piezo1 can be activated by a force of about 15 piconewtons, providing new insights into cellular mechanics.
Advanced or metastatic cancers often go without tumor genomic testing, with those from low-income backgrounds facing longer wait times. JAMA Network Open highlights the need for targeted healthcare policies to bridge these gaps.
A new active agent enables photodynamic therapy to target cancer cells without relying on oxygen levels. The agent's interaction with intracellular iron triggers a rapid electron transfer process, generating highly reactive hydroxyl radicals that kill cancer cells.
Researchers at UT Health San Antonio have made a significant breakthrough in treating combat post-traumatic stress disorder (PTSD) by adding navigated TMS to psychotherapy, showing an 85% reduction in symptoms. The study used a patented MRI-guided, robotic-controlled form of transcranial magnetic stimulation (TMS), known as navigated T...
Researchers introduce a molecular bridge strategy to resolve the conflict between thermodynamic driving forces and charge kinetics in photocathodic protection. The 'hydrogen-bond-mediated molecular bridge' approach amplifies the driving force for electron injection while preserving efficient charge transfer.
A new study from the University of Southern Denmark finds that people with depression experience significant income loss, with losses averaging 17% lower than those without depression. Income loss persists and grows over time, even after diagnosis.
A research team has discovered how mechanosensitive ion channels trigger the selective breakdown of damaged ER fragments via calcium signaling. This process involves the coordinated action of ER-phagy receptor FAM134B and lipidated LC3, and has implications for understanding diseases associated with ER dysfunction.
OYE-101, a novel intravenous caffeine formulation, has been developed to accelerate recovery from general anesthesia and deep sedation. The company's lead program is being evaluated in a scientific bridging study to support a 505(b)(2) NDA for OYE-101.
Researchers developed TNF-α-primed mesenchymal stem cell-derived extracellular vesicles, which showed anti-inflammatory effects in treating retinal degeneration. The vesicles were found to inhibit M1 macrophage polarization and reduce pro-inflammatory gene expression, preserving retinal function.
Researchers discovered that PCGF1 is essential for maintaining H3K27me3 homeostasis during early embryonic development. Its absence leads to dysregulation of pluripotency gene silencing, causing cells to remain in a stem cell-like state and fail to commit to specific lineages.
A novel Ga–Na–PCN photocatalyst with enhanced charge separation and transfer has been developed using AI-assisted design. The built-in electric field at the heterointerface significantly improves hydrogen evolution in this work published on Acta Physico-Chimica Sinica.
Researchers Paula Cannon, Alan Epstein, Heinz-Josef Lenz, and Bodour Salhia recognized for their work harnessing the immune system, DNA, and gene expression to fight cancer and other diseases. Their innovations have led to patents, licensing, and commercialization, with potential real-world impact.
In vivo CAR-T therapy bypasses ex vivo manufacturing, preserving native T-cell function and improving accessibility. Recent clinical progress demonstrates encouraging results in hematologic malignancies and autoimmune diseases.
A new blueprint for creating research agreements enables respectful research with Tribes and on Tribal lands. The guidance defines rights of Tribes and researchers, aiming to avoid extractive practices and protect data sovereignty.
Researchers integrated natural diatom biochar with ZIF-67 to develop lightweight microwave stealth materials. The engineered hierarchical porosity enables stepwise impedance matching and multi-mechanism microwave dissipation, overcoming traditional absorber limitations.
Research suggests that mental time travel activates the brain's reward system, reinforcing behavior and making it easier to plan for the future. However, excessive mental time travel can also lead to negative emotions and maladaptive behavior, such as catastrophizing projections.
Researchers found that maternal oxycodone exposure alters the production and loading of tiny membrane-bound packets called sEVs in the placenta. These changes indicate a stressed placenta and may lead to cardiac vulnerability in offspring.
Researchers at TIFR, Hyderabad identified a mammalian protein Cnpy1 essential for vomeronasal sensory neurons in mice. The study shows that Cnpy1 acts as a specialized endoplasmic-reticulum-associated factor required to maintain functional receptor complexes in these neurons.
Violence intervention programs are reaching at-risk trauma patients with firearm injuries, but only a small percentage of eligible patients participate. The study aims to improve access and integration of these programs to enhance recovery outcomes after injury.
Researchers found that waterfowl in human-heavy landscapes move shorter distances, potentially leading to more intense disease outbreaks. By understanding these patterns, scientists can better predict where bird flu may spread next.
A new graphdiyne nano-iontronic device enables selective pH detection in single cells, showing fast and reversible responses to pH shifts. The device retains accurate proton sensing even in the presence of interferents, demonstrating its potential for real-time intracellular pH detection.
A research team has identified signalling molecules called Netrins and the corresponding receptor Frazzled/Deleted in Colorectal Cancer that control when individual cells separate from the tumour and migrate. These mechanisms can enable cancer cells to colonize new tissue, a major factor in metastasis.
A new study presents an interpretable artificial intelligence framework that improves the accuracy and transparency of genomic prediction, capturing complex genetic interactions and providing biological insight. Boosting algorithms outperform traditional statistical methods, particularly for traits with well-defined genetic signals.
A new study finds that aggressive policy action and cost reductions can accelerate the global shift to electric vehicles, reducing energy use and carbon emissions. The study suggests a uniform 20% reduction in non-energy costs could dramatically increase EV adoption rates, with market share rising from 25-50% to 70-85% globally by 2035.
A novel photocatalytic system captures and converts low-concentration CO2 from industrial flue gas into high-value chemicals using amino-functionalized bismuth catalysts. The catalyst achieves high CO2 capture rates under natural sunlight, demonstrating promising industrial application potential.
The Italian Society of Gerontology and Geriatrics has partnered with MDPI to publish its Journal of Gerontology and Geriatrics in open access. The journal, which was founded in 1953, will transition to a digital-only format starting with Volume 74, Issue 1 in March 2026.
The introduction of transition metal single atoms improves carrier separation and surface reaction kinetics, leading to enhanced photocatalytic performance. Strategically arranging metal single atoms on different components of an S-scheme heterojunction can synergistically enhance both reduction and oxidation half-reactions.
Researchers surveyed how transformers are integrated into graph-based recommender systems, improving handling of long-range patterns, sparse interactions, and complex heterogeneous data. The study proposes a taxonomy and design strategies for transformer-based recommender systems across various tasks.
The article highlights the urgent need to modernize scientific record with AI-powered discoveries trapped in a predigital system. Top-tier research universities face $10-15 million annual subscription expenditures, while author-facing processing charges range from $5,000 to over $11,000 per article.
A new study introduces a large multimodal colonoscopy dataset, ColonINST, and a lightweight colonoscopy-specific multimodal model, ColonGPT. ColonGPT outperforms existing models in three multimodal tasks and can be trained in about seven hours on two NVIDIA GPUs.
Researchers found that microorganisms in the plastisphere have more functional genes to survive under extreme ocean conditions. They can absorb nutrients effectively and utilize alternative energy sources like anoxygenic photosynthesis.
New class of moiré materials enables exploration of diverse quantum phases, including strongly correlated and topological phases. Researchers have observed various effects, such as integer and fractional quantum anomalous Hall effects, at zero external magnetic field.
Southwest Research Institute (SwRI) invested $13 million in internally funded projects in 2025, focusing on emerging industry challenges. The institute's IR&D program aims to transform novel ideas into new technical discoveries and applications.
A 12-week integrated cognitive-motor exercise program reduced core ADHD symptoms in children, producing stronger improvements in inhibitory control and immediate working memory compared to aerobic exercise alone. The combined training also eased inattention and hyperactivity-impulsivity, improving key executive functions.
The Adams Valve Institute aims to expand the treatment of valvular heart disease, focusing on complex surgeries and underserved populations. The Institute will promote innovation in advanced imaging, reconstructive surgical techniques, and breakthrough research.
Researchers have created a detailed molecular map of the thromboxane A2 receptor, which could lead to the development of safer and more effective therapies targeting this clinically important signalling system. The study reveals an unusual activation switch and provides insights into how signalling molecules interact with the receptor.
Researchers developed micro-pillar patterned electrodes with ordered ionomer structures to improve proton conduction and oxygen delivery, enhancing fuel cell performance. The design enabled robust operation under dry conditions and maintained electrochemical surface area, outperforming conventional electrodes.
People aged 50 and over who serve as unpaid family caregivers are more likely to support government-funded care, while non-caregivers prefer family or older adult payment. Concerns about long-term care costs and access persist among caregivers versus non-caregivers.
Researchers found that consuming sugar before a relaxing massage impairs the body's ability to relax by activating the sympathetic nervous system. The study, published in the International Journal of Psychophysiology, involved 94 healthy adults who received either a drink containing glucose or water before undergoing relaxation exercises.
Replacing meat and dairy with plant-based foods reduces greenhouse gas emissions by 35%, equivalent to eliminating 600 miles of driving. A low-fat vegan diet with soybeans also produces major health improvements, including a 92% reduction in severe hot flashes.
Researchers developed an intelligent monitoring pipe combining optical sensing and machine learning to monitor and predict 3D soil settlement. The system provides precision 3D measurements, capturing dynamic changes in soft or unstable soils like loess.
Treatment with i.v. furosemide plus HSS significantly decreased serum levels of inflammatory biomarkers IL-6, sST2, hsTnT, galectin-3, and NT-proBNP. The study found that this combination therapy modulated some miRNA expression and was associated with reduced miR181b expression compared to furosemide alone.
Scientists at the University of Amsterdam have developed metamaterials that learn and adapt without a central brain, allowing them to change shape and perform advanced tasks. These 'smart' materials can forget old shapes and learn new ones, enabling them to evolve and perform complex tasks.
Researchers found that viewers question the sincerity of fear or sadness expressed about climate change in simulated news reports, text messages, and TikTok posts. Emotional expression can serve an important role in helping people find a community, but it may not necessarily persuade others.