Researchers at UTHealth Houston developed a treatment that reverses nerve pain in diabetic mice by targeting the MMP-9 enzyme, which breaks down proteins and causes immune response. The new monoclonal antibodies selectively inhibit MMP-9 activity, regenerating nerve fibers and improving wound healing.
A Griffith University team discovered evidence of ancient betel nut use, dating back 25,000 years, which challenged the current timeline of drug use origins. The researchers found skeletal remains with unusual dental wear patterns, indicating early humans habitually sucked whole betel nuts, causing severe periodontal disease.
The adoption of millet in Bronze Age Europe led to a gradual shift in land use, with the new crop allowing communities to exploit previously marginal areas. This change was associated with increased food security and was not limited to specific social groups or ages.
Researchers at ISTA discover that chaotic environments around tumor cells can trigger specific behavior, leading to increased detachment and invasion. Computer simulations and experiments confirm the findings, shedding new light on the complex interactions between cancer cells and their microenvironment.
Researchers at CUNY Graduate Center found that Asian elephants can suppress impulsive behaviors and adapt to changing environments, a cognitive ability that may contribute to conservation strategies. The study provides new evidence of inhibitory control in elephants, offering insights into their decision-making and social behavior.
Legionnaire's disease incidence in the US has increased over the last two decades, primarily driven by rising temperatures, precipitation, and road traffic exposure. The study suggests that warming temperatures and increased exposure to the soil-dwelling Legionella bacteria are likely contributing factors to this increase.
Researchers found associations between splenic features and coronary artery disease in a large dataset, suggesting new targets for prevention and treatment. The study used artificial intelligence and imaging scans to identify CAD-relevant splenic features, shedding light on novel mechanisms linking the spleen to heart disease.
Researchers developed a method to combine blood protein analysis with genome sequencing to identify diagnoses and potential new disease-causing genes. The approach resolved previously uncertain genetic findings and provided evidence supporting diagnoses for patients with rare diseases.
Chiba University and Willo Technologies are working together to develop stable wireless power delivery systems in enclosed spaces, addressing the challenge of varying operating conditions. The research aims to maintain reliable power delivery as devices enter and leave the space, and as their power requirements change.
A multidisciplinary group of researchers examines potential interactions between urban green spaces, vector-borne diseases, and climate change to inform 21st century public health decisions. The study highlights the need for balancing benefits of urban green spaces with risks of vector-borne diseases under climate change.
Researchers developed MASTER, a distributed optimization method that addresses the challenge of matching measurements from different sensors in cooperative localization. The method produces smaller localization errors than existing methods, especially with more sensors participating, and works with various sensing data types.
Researchers at Tohoku University have discovered a systematic strategy for designing topological magnets by varying the number of layers in a crystal structure. The new approach, based on homologous series, could lead to new materials with unique magnetic and topological properties for applications in spintronics and quantum technologies.
The 2027 APE Award for Innovation in Scholarly Communication honors innovators improving scholarly communication. The award, presented at the 22nd Academic Publishing in Europe APE Conference, recognizes individuals who bring innovation to research and the academic publishing community.
A clinical trial found significant improvements in pain and sensation in people with treatment-resistant painful diabetic neuropathy after receiving spinal cord stimulation. The study also observed early evidence of increased density of small nerve fibers in the skin, which may indicate potential long-term benefits.
Researchers discovered nine novel regulatory small RNAs in Pseudomonas aeruginosa, revealing distinct modulatory effects on pathogen virulence. These sRNAs coordinated post-transcriptional networks in quorum sensing, biofilm formation, and interbacterial competition.
Researchers at BESSY II have made a breakthrough in spintronics by controlling spin patterns in magnetic material FNPP. By applying a tiny external magnetic field, the team was able to modify and create desired structures in a controlled manner, advancing the development of functional magnetic materials.
A new study estimates that 45%–55% of governments misreported COVID mortality, with underreporting common than overreporting. Countries with stronger institutional checks and balances show less underreporting, emphasizing the importance of verification in protecting the reliability of official information.
Researchers have created the first comprehensive atlas of DNA's physical properties, revealing how its sequence influences genome regulation and evolution. The study analyzed 2,080 unique DNA fragments and found that certain sequences can preserve physical properties necessary for DNA function, potentially influencing genome evolution.
Researchers from Shanxi University and Nanjing University demonstrate two-mode squeezed light in the audio-frequency band on a chip, achieving quantum entanglement between generated optical modes. The system enables stable quadrature measurements across multiple frequency channels, paving the way for future chip-scale quantum sensors a...
A new fabrication strategy called Mix-ice lithography enables direct construction of nanoporous carbon structures with tunable pores and complex geometries. The technique achieves simultaneous control over nanoscale patterning and pore formation without chemical developers or thermal pyrolysis.
A global virus atlas has been created by mapping RNA viruses in 102 cities worldwide, identifying nearly 55,000 different types, 80% of which were unknown to science. This data can be used for biological risk assessment, crime scene investigations, and environmental monitoring, providing a unique viral fingerprint for each location.
A study from the University of Cologne identified a critical dependency in small cell lung cancer that can be exploited therapeutically. Targeted inhibition of the NMD pathway offers a promising approach to treat SCLC by accumulating mutated proteins and presenting abnormal peptides on the cell surface, making it detectable to the immu...
Researchers developed a potassium channel-inspired composite membrane for efficient Mg²⁺/Li⁺ separation, overcoming the selectivity-permeability trade-off of traditional membranes. The membrane achieved high Mg²⁺ rejection rates and excellent Li⁺ permeability, with stable separation performance in complex water bodies.
A team of researchers has developed a sea cucumber-inspired ionotronic hydrogel that combines intrinsic adhesion, room-temperature self-healing, and interfacial capacitive sensing. The hydrogel exhibits exceptional stretchability, high ionic conductivity, and strong adhesion to various substrates.
Researchers developed a synthetic bacterium-based vaccine platform that leverages engineered bacterial surfaces to assemble glucan nanofilms for enhanced antifungal immunity. The vaccine platform induces immune cell activation, increases antigen presentation markers, and promotes protective antifungal responses.
Researchers have measured the amount of helium created in the universe's first five minutes with unprecedented accuracy, reducing uncertainty by a factor of three. The team's findings provide new clues about the beginning of the universe and help researchers better understand the fundamentals of physics.
Researchers found that methylglyoxal stress stimulates the expansion of immunosuppressive cells, which can help cancer evade immune surveillance. The study also identified a potential biomarker for predicting response to immunotherapy.
A new study by KTU researchers explores whether artificial intelligence can uncover patterns in glucose data to predict changes and assess hypoglycaemia risk. The model achieved high accuracy in forecasting glucose levels and performing well on patients with unseen data.
Researchers have successfully edited genes in human embryos using base editing, but the technique also causes unpredictable changes and is not safe for clinical use. The study's findings highlight the need for caution when applying gene editing technologies to human embryos.
A new study suggests that slow electrical rhythms traveling along individual nerve fibers may help coordinate communication between key memory centers in the hippocampus. Researchers detected theta-band signals in individual axons connecting hippocampal subregions, linked to stronger bursts of activity in downstream neurons.
Scientists developed laser-carved microvalves to protect fragile brain catheters from backflow, enabling smooth delivery of therapies. The valves regulate fluid flow through geometry without moving parts, suppressing reverse pressure surges by up to 82%.
A new study found that psychiatrists agree on a diagnosis in only 55% of cases, raising concerns about misdiagnosis and treatment errors. The study's results also suggest that diagnostic categories are not as clearly defined as assumed, leading to disagreement among clinicians.
Researchers have discovered that plants have a built-in season-meter that integrates past temperatures over distinct timescales, allowing them to forecast seasonal changes. This system, comprising three genes, enables plants to prepare for winter, spring, or autumn, and could be extended to other genes and environmental signals.
A kissing bug native to the southwestern US and northwestern Mexico was found in a Lisbon hotel room, highlighting the risks of Chagas disease transmission. The insect's 5,000-mile journey across the Atlantic has raised concerns about the potential for the parasite Trypanosoma cruzi to be introduced to Europe.
A study found that just 10 minutes of very slow running improves mood and executive function, activating the prefrontal cortex. This suggests that even low-intensity exercise can have cognitive benefits.
Researchers at Janelia Research Campus have developed a method to study cellular communication across the entire animal, capturing signals from nearly every cell in a living vertebrate. This technique, called WHOLISTIC, provides a complete, concurrent picture of how biological systems interact, offering new insights into the machinery ...
The study found that faster receive-to-pass transitions were linked to avoiding rapid foot approaches, maintaining upright body posture, and limiting ball rebound. This research provides a new biomechanical perspective on the soccer 'first touch' and may help translate coaching concepts into measurable movement characteristics.
The Endocrine Society's new Scientific Statement emphasizes the importance of addressing overall health in obesity treatment, rather than solely focusing on weight loss. Research highlights the benefits of improved health and reduced risk of conditions like heart disease, sleep apnea, and liver disease.
A clinical trial found that combining mental health coaching with medication optimization before surgery reduces post-surgery anxiety and depression in older adults. The study supports adding mental health care and medication optimization to routine pre-surgical care, leading to improved recovery and overall health.
Physicians with life-threatening illness often experience clashes between their professional and personal identities, hindering their return to work. Institutions are advised to adopt relationship-centered policies to better support and retain physicians during this critical transition period.
Research finds substantial partner similarity for psychiatric disorders, contributing to family-based heritability and prevalence. This clustering has important societal and public health implications, highlighting the need for targeted interventions and family-based strategies.
Researchers discover two Denisovan parietal bones and one partial radius, providing clues to Denisovan physical traits. The study uses a novel proteomic strategy to identify hominin remains, filling a long-standing distribution gap for Denisovans in Southwest China.
An international collaboration co-led by the CNIO has identified eight faulty DNA processes driving most prostate cancers, which differ between patients and influence tumor spread. The study offers potential for reliable prognostic markers and personalized treatment, but further validation is needed.
Scientists at Kyoto University's iCeMS created a foam-based technology that mimics nature to produce brilliant white materials with water repellency. The technology, called Deep Foam Photolithography (DFP), uses precisely engineered porous structures to scatter light and control water repellency.
Researchers at UC Berkeley have developed a new genomic language AI model, GPN-Star, that excels at spotting genetic variants impacting human health. The model is computationally efficient and can identify important genetic variants in a fraction of the time required by larger models.
A new study has mapped eight genetic 'fingerprints' that may explain why some men develop aggressive prostate cancer, while others do not. The researchers found that errors during DNA replication play a crucial role in the development of prostate cancer.
A new study found that caloric restriction reduces DNA mutations in mice, slowing the rate of mutations with age. The study showed that caloric restriction had the strongest impact on the least active genomic regions, suggesting that diet may play a role in genome health.
Researchers analyzed DNA samples to determine the origin of goosegrass on Nishinoshima, finding it closely related to populations from the Ogasawara Islands and Indonesia. Seabirds are believed to have transported seeds, establishing the population on the island.
Canada's last epishelf lake, a millennia-old ecosystem, has been confirmed to be gone for good. The loss of the lake shows that even the Arctic's projected last ice refuge is vulnerable to rapid change, and that once this ecosystem is lost, it cannot be restored.
According to the Annenberg Public Policy Center survey, Americans' confidence in Dr. Anthony Fauci has declined to 50% since spring 2026, with a 5 percentage point decrease from 55% in April 2026. However, Fauci still maintains higher confidence than Kennedy, the secretary of health and human services, with a 12 percentage point gap.
Digital behavioral infrastructure leverages digital health apps to drive medication persistence, side-effect mitigation, and durable weight loss. The 'habit window' hypothesis proposes building healthy behaviors during medication's peak efficacy window.
A national study of over 230,000 pediatric trauma patients found that signs of hemodynamic instability may appear earlier than current standards indicate, highlighting the need for more accurate blood pressure thresholds. The study suggests that clinicians may need to recognize and respond to signs of circulatory instability at higher ...
A new study found that regional microbial imprints in wine can remain detectable under commercial winemaking conditions, shaping fermentation dynamics and wine aroma. The study, published in Applied and Environmental Microbiology, suggests that vineyard management and environmental conditions play a crucial role in the quality of wine.
Researchers found changes in infants' skin microbiome before symptoms of eczema and food allergies appeared. The study suggests skin microbiome composition could help identify children at risk earlier, potentially serving as early biomarkers.
Researchers developed a new analysis method, LM-QASAS, combining antibody language models with B-cell receptor repertoires to identify candidate sequences responding to an immune stimulus. The method successfully tracked the rise, peak, and decline of immune responses in new individuals, even for emerging infectious diseases.
The Open Access Journal of Italian Medical Laboratory (JDReAM) has been revived by MDPI, aiming to promote high-quality, interdisciplinary research in medicine. The journal, led by Prof. Michele Maffia and Prof. Prisco Piscitelli, publishes research addressing human health and disease from various scientific perspectives.
A randomized clinical trial found that nurses experiencing mental distress benefited from combining mental health screening with a digital cognitive-behavior skills-building program, resulting in significant reductions in anxiety, depression, and suicidal thoughts. The program also improved healthy lifestyle beliefs and behaviors.
A study of 826 young men found a dose-response relationship between workplace stress and erectile dysfunction, with a 54.37% prevalence in the high-stress group. Working hours and supervisor support were found to impact erectile function through cortisol and testosterone levels.
New research reveals a significant increase in stroke risk within 3 months of cancer diagnosis, with pancreatic and lung cancers showing the highest rates. The study, published in CANCER, found that younger patients and those with advanced cancer are particularly at risk.
Researchers developed biodegradable particles with microscopic needles to improve skin absorption of drugs delivered through patches or creams. The technology increased intradermal drug delivery up to 37-fold for three different drugs.