The STEM-PD trial demonstrated the safety and feasibility of stem cell-derived dopaminergic cell transplantation in patients with moderate to advanced Parkinson's disease. The findings mark an important step in evaluating this approach as a potential treatment strategy for neurodegenerative diseases.
A new study by researchers at the University of California, Santa Cruz, reveals that multipotent progenitors, 'parent' blood cells, protect blood cell production and function from aging effects. The findings confirm the safety of bone marrow transplants from older donors.
A new strategy makes stem cell transplants safer by replacing chemotherapy-based treatment with targeted antibodies that recognize specific markers on blood-forming stem cells. This approach allows for less toxic treatment and could enable chemotherapy-free or chemotherapy-sparing transplantation approaches.
A new study from Ben-Gurion University of the Negev found that long-term Salmonella infections severely damage blood stem cells. However, researchers discovered that giving an effective course of antibiotics fully restores the stem cells' health and rebuilds their power.
A pilot study suggests that physical exercise can support stem cell donation by releasing specific types of blood stem cells into the bloodstream. The exercise stimulus increases stem cell numbers only moderately, but may offer a more targeted approach than medication.
The Stem Cell Report podcast has marked five years of exploration in stem cell research, capturing significant progress in human development, disease, and regenerative medicine. The anniversary episode reunites past guests to discuss the field's evolution, highlighting advances in therapies, organoid systems, and global standards.
Researchers have identified GSK3α as a common checkpoint controlling stem cell differentiation, maintaining self-renewal and preserving identities in various stem cell types. Inhibiting GSK3α demonstrates its fundamental role in regulating stem cell biology across developmental stages and species.
The International Society for Stem Cell Research's official journal has implemented enhanced measures to strengthen scientific rigor and reproducibility in published research. New requirements include a completed ISSCR Standards Checklist shared with peer reviewers, ensuring critical experimental details are fully disclosed. All manusc...
The International Society for Stem Cell Research has named Stem Cell Reports as the official conference journal for the Latest Advances in Stem Cell-Based Disease Modelling and Drug Screening meeting. The journal will focus on high-impact research spanning basic discovery to clinical translation in stem cell science.
Researchers from Institute of Science Tokyo discovered a unique mechanism in which conventional stem cells can temporarily switch into a specialized regenerative state called revival stem cells, driving tissue repair. This process, known as fetal reversion, enables efficient regeneration without exhausting the stem cell pool.
The ISSCR has launched a new continuing education course on stem cell therapies for Parkinson’s disease, addressing the need for clinicians to provide accurate information on emerging treatments. The course features expert faculty and patient perspectives, and is available through a free and paid pathway.
Stem Cell COREdinates and CorEUstem have transformed the global infrastructure of pluripotent stem cell research by uniting 79 core facilities across continents to advance collaboration, rigor, inclusivity, and innovation. Their shared standards and protocols have strengthened reproducibility and ensured excellence in accessible for in...
The International Society for Stem Cell Research has awarded the 2026 ISSCR Lifetime Achievement Award to Dr. Allen Eaves and late Dr. Connie Eaves, recognizing their groundbreaking work on blood stem cell biology, leukemia, and cancer stem cells. Their research and mentorship have profoundly influenced the field of stem cell science.
The journal welcomes Bo Shen, Ph.D., and Luca Peruzzotti-Jametti, M.D., Ph.D. as Early Career Editors, bringing complementary strengths in stem cell niche biology and metabolism to the editorial board. Their perspectives will help ensure rigorous peer review, relevance, and global engagement.
Chromatin accessibility maps reveal that MDS stem cells gradually lose their normal identity and acquire characteristics typical of myeloid progenitors. A 'progenitor score' developed by the team tracks cell movement toward a progenitor-like state, correlating with disease severity and prognosis.
Researchers at UIC discovered that platelet factor 4 helps regulate hematopoietic stem cell division and proliferation. Adding the protein to old blood cells reversed signs of aging in mice and human stem cells, suggesting a promising therapeutic target for preventing or improving age-related disorders.
New research from the Stowers Institute for Medical Research reveals planarian stem cells ignore their nearest neighbors and respond to signals further away in the body. This discovery may help explain the flatworm's extraordinary ability to regenerate and offer clues for developing new ways to replace or repair tissues in humans.
Scientists discovered a precise communication system in the gut, where telocytes deliver signals directly to intestinal stem cells using fine extensions. This finding challenges long-standing assumptions about gut healing and repair, potentially leading to better treatments for conditions like IBD and colon cancer.
Researchers have discovered adult stem cells from a non-human primate that closely resemble human biology, offering new potential treatment targets for diseases. The discovery uses a novel computational method to identify the optimal animal model, reducing animal usage and paving the way for more effective stem cell therapies.
Recent research reveals that adipose-derived stem cells from obese individuals do not fully recover their anti-inflammatory capacity even two to three years after significant weight loss. The study, published in Stem Cells International, used bariatric surgery as a model to investigate the impact of weight loss on these stem cells.
Scientists at the University of Copenhagen have created 'super stem cells' that outperform regular stem cells by developing into multiple cell types. These 'super stem cells' show promise in improving fertility treatment, particularly IVF success rates, by producing essential tissue for early embryonic development.
BaCell 3D conference to feature original research in organoids and regenerative medicine, published in Stem Cell Reports. The International Society for Stem Cell Research (ISSCR) partners with Stem Cell Reports to promote discoveries with potential to transform regenerative medicine.
Scientists discovered a novel method to activate extraembryonic trophoblast potentials in conventional human pluripotent stem cells through transient treatment of epigenetic regulators. This approach holds promise for advancing understanding and treatment of diseases related to placental development.
Stem Cell Reports, an open access journal of the International Society for Stem Cell Research, is seeking highly motivated early career scientists to join its Early Career Scientist Editorial Board. The selected members will have the opportunity to shape the journal's editorial direction and promote stem cell research.
Janet Rossant takes over as Editor-in-Chief of Stem Cell Reports, aiming to publish high-quality primary research articles and commentaries that shape the field of stem cell science. She brings extensive experience and scientific expertise to the position, previously serving as ISSCR President.
Researchers found that prenatal exposure to Akkermansia muciniphila increased offspring's stem cell activity, leading to less anxiety and faster recovery from colitis. Postnatal exposure did not replicate these effects. The study suggests microbiome-based intervention strategies may improve child health.
A new study has unveiled how stem cells respond to their environment, with implications for inflammatory bowel disease and colorectal cancer. Stem cells rely on PIEZO1 and PIEZO2 ion channels for survival, and loss of these channels leads to severe illness and rapid death.
A recent study published in American Journal of Education found that White English-speaking students are the only group with a positive relationship between early STEM aptitude and majoring in a STEM subject in college. For Black and Latine students, early STEM aptitude does not translate into STEM enrollment.
A study by Kumamoto University researchers reveals that ApoE plays a crucial role in promoting hematopoietic stem cells to produce more red blood cells in response to acute anemia. This mechanism differs from the previously known pathway and may pave the way for new treatments for patients with severe anemia.
Plant stem cells play a vital role in growth and development, controlling cell division and differentiation. Researchers have discovered a transcription factor gene called HVA that controls cell division in vascular stem cells, leading to an increase in the number of vascular bundles and overall stem cell activity.
The Harvard team successfully recreated the satellite cell niche using 3D organoid culture techniques, generating stem cells that closely resemble native adult stem cells. These cells can engraft, repopulate the stem cell niche, persist long-term, and regenerate muscle after repeated injury.
Scientists identified key changes in chromosome structure and gene expression that affect stem cell function during aging. Blocking a specific gene, ced-6, triggered stem cell exhaustion at any age, indicating a general process that maintains balance when proliferation is too high.
Scientists have discovered that epigenetic changes can reprogram astrocytes into brain stem cells, which can potentially be used to replace damaged nerve cells in regenerative medicine. This breakthrough is made possible by the methylation of genetic material, allowing these special astrocytes to acquire stem cell properties.
Researchers have identified multipotent stem cells in sea anemones that are regulated by highly conserved genes, which could provide insights into human aging. These stem cells express genes like nanos and piwi, essential for germ cell formation, and may hold the key to understanding the potential immortality of sea anemones.
A new technique developed by McGill researchers allows for precise targeting of stem cells to become specific cell types, such as bone or fat cells. This breakthrough has the potential to lead to new stem cell treatments for various diseases, including multiple sclerosis, Alzheimer’s and Type 1 diabetes.
Two independent studies by Columbia scientists challenge long-held assumptions about gut stem cells, revealing they are descendants of true stem cells producing different proteins and responding to distinct signals. The discovery could revitalize regenerative medicine by targeting the correct stem cell populations.
Researchers at UCLA have identified a key protein MYCT1 that enables blood stem cells to sense and interpret signals from their environment. The study's findings could lead to the development of methods to expand blood stem cells in a lab dish, making life-saving transplants more available.
Brain stem cells express genes for both maintaining their identity and differentiating into neurons without conflicts. Researchers found that messenger RNAs of stem cell genes are retained in the nucleus, preventing translation and allowing cells to maintain their status as stem cells.
Researchers developed a new tool to study adult neural stem cells, identifying their dormant state and behavior. By analyzing autofluorescence signatures, they can study the aging process and neurological diseases.
Researchers discovered a new type of stem cell that can regenerate cartilage in arthritic mice, offering potential for treating osteoarthritis. The stem cells, derived from human pluripotent stem cells, were found to efficiently generate new cartilage when transplanted into the knees of OA mice.
Researchers at the University of Helsinki discovered a new mechanism by which nutrient adaptation influences intestinal stem cell function and ageing. Intermittent fasting has been shown to benefit intestinal stem cells by preserving their flexible regulation, which is essential for differentiation.
Researchers mapped dental pulp and periodontal ligament stem cells' genomes, revealing significant differences in their differentiation potential. The study identifies the genetic composition and mechanisms of differentiation, paving the way for targeted regenerative therapies.
Researchers have successfully genetically modified pluripotent stem cells to evade immune recognition, offering a viable path forward for pluripotent stem cell-based therapies. The study's findings suggest that these engineered stem cells could pave the way for new treatments for diseases such as Type 1 diabetes and macular degeneration.
A microbial sensor, Nod1, plays a crucial role in the development of blood stem cells. The discovery could lead to the creation of patient-derived blood stem cells, eliminating the need for bone marrow transplants and improving lives of leukemia, lymphoma, and anemia patients. Researchers are continuing to study the complex interaction...
Researchers at IMBA Institute of Molecular Biotechnology have identified a new gene, Daam1, that plays an essential role in switching on the development of secretory cells in the intestine. The finding opens new perspectives in cancer research.
Researchers have developed a method to camouflage stem cell-derived transplants, avoiding immune rejection and tumor formation. Genetically engineered liver cells can persist in the body despite lack of immune matching, offering a potential solution to organ donor shortage.
Researchers at Hokkaido University found that cancer stem cells cause macrophages to age, suppressing their antitumor activity. Supplementing mice with nicotinamide mononucleotide restored macrophage function and prevented tumor growth.
A new MU study shows that high school students who attended college-run STEM Career Days were far more likely to have STEM-related career aspirations than those who did not attend. The study highlights the benefits of introducing high school students to STEM opportunities and can help increase diversity in the STEM workforce.
Researchers from the Center for Regenerative Medicine at Boston University School of Medicine have discovered a novel approach for engrafting engineered cells into injured lung tissue. They successfully reconstituted the stem cell compartment of injured airways and alveoli using cells engineered from pluripotent stem cells, resulting i...
Researchers at HKUST have found that the stem cell niche uses gap junctions to transport cAMP into stem cell progeny, controlling their differentiation. This discovery is significant for developing stem cell therapies to treat diseases such as Parkinson's and Alzheimer's.
A study published in Nature Cell Biology found that blood stem cell diversity arises during embryonic development and can be manipulated in childhood to improve overall health. The researchers used zebrafish and human pluripotent stem cells to demonstrate the potential of enhancing blood stem cell production.
A new study from the University of Georgia suggests that more women in supervisory positions can improve representation of women in federal STEM jobs. However, research also found that women continue to quit their STEM jobs at a disproportionately high rate, highlighting the need for support and role models.
A UC Irvine research team discovered that the MGAT5 glycosylation enzyme plays a critical role in brain development. The study found that neural stem cells use glycosylation to regulate their reactions to external signals and develop mature brain cells. This discovery may contribute to new therapeutic purposes for neural stem cells.
Scientists have developed a new method to deliver genetic information to stem cells using nanoparticles coated with a specific polymer, enabling more efficient control over cellular differentiation. This innovation has the potential to improve the efficiency and effectiveness of regenerative medicine treatments.
A phase 3 clinical trial shows that motixafortide combined with standard therapy increases the number of stem cells that can be harvested in over 92% of patients. The combination also enhances the collection of primitive stem cells, which have greater potential for reconstituting blood cell types.
Researchers at the University of Washington School Medicine have engineered stem cells that do not generate dangerous arrhythmias. These 'MEDUSA' cardiomyocytes can engraft in the heart, mature into adult cells and beat in sync with natural pacemaking without generating dangerous heart rates.
Researchers found that hematopoietic stem cells use aggrephagy to collect and destroy misfolded proteins, a process that is critical for maintaining stem cell fitness and longevity. Boosting this pathway could help preserve stem cell health and mitigate blood and immune disorders.
Researchers have successfully converted pluripotent stem cells into hematopoietic stem and progenitor cells using optimized transcription factors. The resulting PSC-derived cells generated all types of white blood cells in mice without giving rise to tumors or leukemias, suggesting a promising future for PSC-based transplant therapies.
In an emergency situation like infections or blood loss, the body needs to quickly compensate for the loss of blood cells. Scientists have found that progenitor cells in mice are responsible for regenerating mature blood cells, not hematopoietic stem cells.
Researchers have identified a master gene that controls stem cell behavior, found in an ancient fish species, which can be used to improve human stem cell growth. The study sheds light on the evolutionary origins of pluripotent stem cells, a crucial step towards creating artificial organs.