Stem cell research reveals that aging brain stem cells enter a state of dormancy promoted by inflammatory signals, reducing their ability to regenerate neurons. However, blocking these inflammatory signals using antibodies increases dividing activity and improves neuron production.
Scientists have identified a key role for protein Akna in regulating neural stem cells via microtubule organization, promoting differentiation and detachment from the niche. This mechanism also plays a crucial role in epithelial-to-mesenchymal transition.
Researchers have successfully generated functional, transplantable B cells from mice using mouse embryonic stem cells. The study demonstrates that these cells can secrete natural antibodies and maintain themselves for over six months after transplantation.
Researchers at German Cancer Research Center discovered that stem cell genes remain active, allowing for reversible decision-making in becoming a neuron or reverting back to stem cell. Uncontrolled TOR activity can cause brain cancer, highlighting the importance of controlling this signal for future stem cell therapy developments
A clinical trial has shown promise in using stem cells from donors to repair the surface of the eye in patients with limbal stem cell deficiency, a significant cause of sight loss. The trial also sheds light on the causes of sight disorders and offers clues about how eye tissue loss could be repaired.
A recent USC-Stanford study reveals that successfully transplanted stem cells exhibit 'extreme behavior' due to radiation and chemotherapy, whereas healthy cells produce blood and immune cells more evenly. The research also shows that certain stem cells become dormant or biased towards producing specific immune cells.
Scientists have successfully reprogrammed human blood cells into a new type of neural stem cell, similar to those in early embryonic development. This breakthrough could lead to the development of regenerative therapies for treating diseases of the nervous system.
Researchers discovered a novel mechanism for sperm stem cell number control, where cells migrate and compete for fibroblast growth factors (FGFs). This self-organized process regulates stem cell density in the testis, maintaining uniformity despite the absence of a canonical niche.
Researchers have developed a new method to analyze cardiac muscle cells derived from human pluripotent stem cells, using a non-invasive fluorescence technique that enables faster and more accurate analysis. This breakthrough method uses CRISPR-Cas9 to generate a calcium-indicating reporter stem cell line, which allows for the examinati...
Researchers discovered a two-step control mechanism in neural stem cells that differentiates into neurons and astrocytes. PRC1 represses genes related to neuronal function temporarily and permanently at two distinct stages of brain development.
The National Science Foundation is partnering with federal agencies to expand its STEM diversity program and create new graduate internship opportunities. The partnerships aim to increase diversity in the STEM workforce and remove barriers to STEM careers.
Scientists at the University of Texas Health Science Center have engineered a novel human stem cell line for skeletal muscle, enabling faster and more efficient generation of muscle stem cells. The breakthrough could lead to disease modeling, gene correction, and potential cell therapy for patients with muscle disorders.
A new Louis Stokes Regional Center of Excellence will help broaden participation of minority students in nanotechnology and STEM fields. The center will provide remote access to nanotechnology instruments, research experience, and professional development for educators.
A team of scientists has identified a key protein that triggers the activation of mammary stem cells during puberty, leading to the rapid expansion of the mammary gland. FoxP1 plays a crucial role in switching off proteins that keep mammary stem cells dormant, allowing them to divide and drive growth.
Researchers at the University of Minnesota Medical School have discovered a subset of muscle stem cells that are located close to blood vessels and are likely to be the more potent stem cell population in maintaining muscle health. This groundbreaking study uses 3D technology to study the interaction between stem cells and blood vessel...
A new study examines Canadian clinics marketing unproven stem cell treatments, highlighting regulatory gaps and potential risks to patients. The majority of marketed treatments target orthopedic and musculoskeletal conditions, with some companies advertising for a wide range of disorders.
A unique source of stem cells in blood helps build blood vessels in embryos, contradicting previous theories. This finding brings scientists closer to using stem cells to repair damaged blood vessels and treat heart and circulatory diseases.
Researchers have discovered a new combination treatment targeting pre-leukemia stem cells by inhibiting protein synthesis and oxidative phosphorylation pathways. The treatment, involving FDA-approved drugs omacetaxine and venetoclax, has shown promising results in killing cancerous cells while leaving healthy stem cells unharmed.
Researchers from UCI have identified patterns of sugars on the surface of neural stem cells that determine their fate, affecting brain cell formation. This discovery may improve the use of stem cells in transplantation therapies to treat injury and disease.
A new study approach reveals that healthy adults have between 50,000 and 200,000 blood-creating stem cells in their bone marrow. This finding opens up new opportunities for studying how stem cells change during ageing and disease, and may lead to insights into cancer development and effective stem cell therapies.
Researchers at Duke-NUS Medical School discovered that gut stem cells have a unique population of cells with intrinsic toxin resistance, enabling them to withstand drugs and spicy foods. These 'drug efflux pumps' protect the gut from toxic compounds, promoting intestinal regeneration and overall health.
Scientists at the University of Cambridge have successfully generated key life event in artificial mouse embryo created from stem cells. The team used three types of stem cells to reconstruct the process of gastrulation, a crucial step in embryonic development.
Researchers at NUS have successfully reprogrammed mature cells into pluripotent stem cells by confining them in a defined geometric space for an extended period. By the 10th day, the cells expressed genes associated with embryonic stem cells and iPSCs, indicating complete transition into re-deployable stem cells.
Researchers have found that cancer stem cells exist in multiple states and can change form, making them resistant to treatment. By targeting cell metabolism, they may be able to kill these stem cells, potentially opening up a new approach to cancer therapy.
A new grant will explore the use of genome editing to modify human pluripotent stem cells for cardiac treatment. This approach could lead to unlimited production of cardiac cells in the lab for therapy, reducing the need for heart donors.
Researchers at Harvard University have discovered that the 'blood stem cell niche' evolved to protect blood stem cells from ultraviolet (UV) rays in sunlight. This finding has significant implications for improving the safety of blood stem cell transplants, a procedure used to treat patients with blood diseases and cancers.
Researchers from Newcastle University discovered that human embryonic stem cells travel back and forth in a line, revealing subtle patterns to their movement. This finding has important implications for the development of computer models to predict and control stem cell evolution.
The human intestine constantly regenerates itself, with 10 billion epithelial cells replaced each day. Researchers have identified the stem-cell niche responsible for providing the activating signal to these stem cells, called Gli1-positive cells surrounding crypts.
Researchers discovered that blood stem cells with a genetic mutation can be compensated by normal stem cells producing specific types of immune cells. Key findings suggest these highly productive stem cells proliferate dramatically and maintain a balanced immune system when transplanted into mice.
A new study reveals that macrophages nurture mammary stem cells through chemical signaling, enabling the precursors of milk-producing cells to mature. The research found that Dll1 signaling is essential for maintaining a healthy mammary gland and may hold clues to preventing breast cancer.
Researchers at the University of Calgary have shed new light on the identity of brain stem cells that exhibit neural stem cell function. The study found that ependymal cells do not become neural stem cells when activated by injury, but rather regulate their function.
A new review concludes that stem cells derived from adult body tissues can differentiate into mature body cells with similar efficiency to those from younger donors. This validates induced pluripotent stem cells (iPSCs) as a viable alternative to embryonic stem cells in regenerative medicine.
Researchers at Duke-NUS Medical School have identified key regulators of the intestinal stem cell niche, including hormones R-spondins and Wnts. The team's study shows that subepithelial myofibroblasts are essential sources of these hormones, highlighting the close interaction between epithelial stem cells and their niche.
Scientists at the University of Cambridge have discovered a new type of 'sleeping' stem cell in the brain that has a high potential for repair following brain injury or disease. The G2 quiescent stem cell can awaken and produce key brain cells, such as neurons and glia, faster than previously identified quiescent stem cells.
A new study suggests that sexual minority students are 8% less likely to persist in STEM degrees by their fourth year of college. Despite this, they were found to have participated in undergraduate research at higher rates than their heterosexual peers.
Researchers have identified over 250 genes involved in brain aging, including Dbx2, which can prematurely age stem cells. The study found that increasing the activity of Dbx2 in young brain stem cells slows their growth, causing them to behave more like older cells.
A team of researchers from Osaka University has identified adult endothelial stem cells capable of generating fully functional blood vessels. The discovery was made by isolating a population of endothelial cells expressing the glycoprotein CD157 and testing their ability to form new blood vessels in injured mice.
Researchers found that countries with greater gender equality have a paradoxical effect on women's participation in STEM fields, with higher gender equality leading to lower female graduation rates. This is due to personal academic strengths and interests driving girls towards non-STEM fields over STEM.
Researchers have developed a method for marking dividing stem cells with three different labels, increasing accuracy and speed of analysis. This allows study of new populations of stem cells, including those in the brain and other tissues.
Researchers found that manipulating culture environment and 'priming' stem cells can enhance their function, optimizing therapeutic potential for diseases in humans and animals. The study's results demonstrate a significant enhancement of reparative capacity in stem cells treated with interferon gamma.
Scientists have discovered a protein called Setd7 that regulates stem cell growth and differentiation. Inhibiting this protein allows stem cells to remain undifferentiated, facilitating tissue regeneration and improved muscle function.
Researchers uncover new insights into how stem cells transform into brain cells controlling leg movements in fruit flies, with implications for understanding comparable systems in humans. The study finds that two critical cell types, born from the same stem cell, facilitate the construction of a mature motor system.
Researchers found that electrically stimulating implanted adult stem cells led to increased production of the animal's own stem cells and faster stroke recovery. The study suggests a promising approach for using stem cells to treat patients after stroke.
Researchers found that Hedgehog signaling proteins keep cancer stem cells alive and are required for their survival. The study suggests targeting the Hedgehog pathway could eliminate cancer stem cells and prevent recurrence.
The HLF gene plays a crucial role in maintaining blood stem cells in a resting state, protecting them from exhaustion and external damage. This study provides new insights into the regulation of blood stem cell activity and its potential applications in bone marrow transplants.
Researchers found that mature cells can revert to a stem cell-like state, carrying accumulated mutations that predispose them to developing into precancerous lesions. This new understanding could lead to the development of treatments targeting mature cells, potentially preventing cancer recurrence.
A new study by researchers at Sanford Burnham Prebys Medical Discovery Institute describes the biology behind why muscle stem cells respond differently to aging or injury. Adult muscle stem cells are essential for repairing and regenerating muscle throughout life, but their ability to cope with different stimuli varies depending on the...
Researchers discovered that TOR signaling becomes activated in stem cells during regenerative responses, leading to the loss of stem cell status. Inhibiting TOR with rapamycin prevented this loss and reversed age-related decline in mouse trachea and muscle tissues.
A new harvesting method has been developed by the Massachusetts General Hospital team, which rapidly produces superior stem cells for bone marrow transplantation. The procedure, which combines GRO-beta and AMD3100 injections, mobilizes stem cells in just 15 minutes, making it less painful and disruptive for donors.
Tufts researchers have developed a method to regenerate adult stem cells in the nasal tissue, improving sense of smell in mice. The discovery uses Yamanaka factors and offers a more efficient alternative to existing induced pluripotent stem cell technology, with implications for treating various tissue degeneration associated with aging.
Researchers have successfully treated paraplegic rats using human stem cells, which have shown significantly improved mobility and sensory perception after spinal cord injury. The engineered tissue containing stem cells also demonstrated some degree of spinal cord healing.
Scientists have found a key to unlock blocked differentiation in microRNA-deficient embryonic stem cells, enabling neural cell differentiation without p53 expression. This breakthrough supports the goal of using stem cells in therapy and could lead to innovative treatments for various diseases.
Researchers at Stanford Medicine found that isolated stem cells have a different gene-expression profile than their counterparts in the body. The study suggests that conclusions about stem cell function may need to be reconsidered due to changes in cell biology during isolation.
A study by Fred Hutchinson Cancer Center has identified a specific subset of adult blood stem cells responsible for regenerating the entire blood and immune system. The 5% subset, marked as CD34+CD45RA-CD90+, was found to rebuild all different cells of the blood and immune system within 10 days after being infused in nonhuman primates.
Dr. Paul Tesar receives the 2017 NYSCF Robertson Stem Cell Prize for his pioneering work on pluripotent epiblast stem cells, which holds promise for treating neurological disorders like multiple sclerosis and pediatric leukodystrophies.
Researchers created Expanded Potential Stem Cells (EPSCs) with greater development potential than current stem cell lines, shedding light on miscarriage and developmental disorders. The EPSCs can develop into any type of cell, offering a platform to study early embryo cells in detail.
Scientists have characterized the complex process of human sperm stem cell development, revealing four distinct cellular phases. The study's findings may lead to better tools for diagnosing and treating male infertility, as well as uncovering genetic changes underlying cancers associated with male infertility.
Researchers used flat worms to study the role of migrating stem cells in cancer. They found that regulatory genes controlling cell migration are also essential for planarian stem cells, providing a promising model for understanding human cancers.
Research reveals eight mental models used by teachers to construct STEM-based lesson plans, highlighting the need for better understanding of STEM education's value and online classroom design. Implementing teacher leadership techniques in digital classrooms also improves communication patterns.
A new study reveals that insulin is essential for preserving pluripotent stem cells' ability to become any cell type. Insufficient insulin leads to a specialized endoderm cell type, similar to early embryonic cells, suggesting potential importance in human development and pregnancy.