Researchers found that African American women have a higher risk of breast cancer due to shared genes with white women, including BRCA1, BRCA2, and PALB2. Current breast cancer testing panels can be used for African American women, increasing the chances of early detection and prevention.
A recent study has identified 32 new sites on the human genome where variations in DNA appear to alter the risks of getting specific subtypes of breast cancer. The analysis, covering over 266,000 women, may eventually improve the ability to predict breast cancer risks at a subtype level.
The EULAR 2020 study investigates the connection between breast cancer, anti-hormonal therapy, and rheumatoid arthritis. The results show that the risk of breast cancer in women with RA is lower than in women with healthy joints, and no association was found between anti-hormonal breast cancer prophylaxis and later RA.
A Swedish study of over half a million women reveals that early mammography screening significantly lowers the rates of advanced and fatal breast cancers. The analysis found a 41% reduction in fatal breast cancers and a 25% reduction in advanced breast cancer cases among screened participants.
A new study by Mount Sinai researchers found that insulin resistance is a key factor mediating racial disparities in breast cancer prognosis. Black women with invasive breast cancer had higher rates of insulin resistance and more aggressive tumors than white women.
Researchers found that adding venetoclax to hormone therapy and CDK4/6 inhibitors can kill senescent cancer cells, potentially prolonging cancer response to therapy. The findings have underpinned a phase 1 clinical trial in Melbourne combining the treatments.
A new study published in Cancer Research found that Indigenous American ancestry is associated with a greater incidence of HER2-positive breast cancer in Latinas. The study analyzed data from over 1,300 patients and found that women with higher proportions of IA ancestry were more likely to develop HER2-positive tumors.
A Swedish cohort study found that breast density, microcalcifications, and masses have a significant genetic component, with heritability estimates of 58%, 23%, and 13% respectively. The study also identified positive associations between these traits and genetic predisposition to breast cancer.
A new trial led by Beth Israel Deaconess Medical Center found that platinum-based therapy was not superior to standard chemotherapy in treating patients with BRCA mutations. The study, known as INFORM, compared the efficacy of cisplatin to a standard treatment regimen in patients with breast cancer.
A study by Mayo Clinic researchers suggests that all women with a breast cancer diagnosis under the age of 66 be offered germline genetic testing. This approach would identify 98% of women with BRCA1 and BRCA2 mutations, while avoiding testing of 20% of all breast cancers.
A new study published in JAMA found that Fast Breast MRI detected significantly more breast cancers than digital breast tomosynthesis (3-D mammography) in average-risk women with dense breast tissue. The study showed that Fast Breast MRI was almost two and a half times more effective at detecting breast cancers in these women.
A study published in JAMA found abbreviated breast MRI to be more effective than digital breast tomosynthesis in detecting breast cancer in women with dense breasts. The test detected significantly more cancers and showed promise as a new screening tool for these patients.
A recent study found that radiation can trigger an inflammatory response in breast cancer cells, leading to the survival and growth of triple-negative breast cancer cells. This finding highlights the importance of understanding the microenvironment in cancer development.
Researchers are developing a new non-invasive test that analyzes breast milk to detect breast cancer in its earliest stages in high-risk breastfeeding women. The study aims to identify profiles of breast cells that may indicate increased risk of breast disease and shed light on breast cancer development.
A global study of 18,541 women in 40 countries found that 71% are unhappy with their breast size, with 48% wanting larger breasts and 29% satisfied. The study also linked breast size dissatisfaction to poorer psychological well-being, lower self-esteem, and reduced breast cancer awareness.
A new study suggests that targeting Hsp47 could block cancer cell-platelet interaction and inhibit metastasis in triple-negative breast cancer patients. The protein is often amplified in the genes of metastatic breast cancer tissue, potentially serving as a biomarker for metastasis.
A study examined racial and ethnic differences in genetic testing frequency and results among diverse young breast cancer patients. The study found that less than half of the participants completed hereditary breast and ovarian cancer genetic testing, but the percentage increased over time.
A University of Massachusetts Amherst researcher is studying the effects of endocrine-disrupting chemicals on breast density in college-age women, a strong risk factor for breast cancer. High breast density has been linked to increased breast cancer risk in older women, and this study aims to shed light on the link in younger women.
Researchers have identified several potentially useful breast cancer biomarkers that indicate the presence and risk of malignancy. PET/MRI imaging revealed differences in biomarkers between healthy contralateral breast tissue of patients with malignant and benign breast tumors.
Researchers developed a new compound that targets microRNA-21, a molecule linked to aggressive breast cancer, awakening its self-destruct system and killing cancer cells while leaving healthy cells unaffected. In mouse models, the compound showed promise in reducing breast cancer spread and decreasing invasiveness in other cancers.
A new study explores women's knowledge and perceptions of breast density and breast cancer screening across three states with varying notification laws. Women from all states had varying knowledge about their own breast density and breast density in general, and expressed a strong desire for more information.
A phase 2 clinical trial has demonstrated an effective alternative to mastectomy for breast cancer patients experiencing recurrence after initial lumpectomy and whole-breast radiation. The treatment involved a second lumpectomy followed by partial breast reirradiation, resulting in long-term cancer control and low toxic side effects.
A large US population-based analysis found that breast cancer survivors face significant non-cancer-related deaths, including heart diseases and Alzheimer's. Most deaths occurred within 10 years of diagnosis, with patients at higher risk for chronic liver disease and other conditions compared to the general population.
Researchers found that women who used ibuprofen or naproxen had a 40% reduced breast cancer risk, while aspirin use offered no benefit. Young women with HER2-positive breast cancer may preserve fertility by choosing less intensive chemotherapy regimens.
A team of researchers from IU School of Medicine has discovered a way to predict the recurrence of triple negative breast cancer in women. They found that patients without circulating tumor DNA in their plasma had an 81% chance of being cancer-free after two years, compared to 56% for those with detectable levels.
The IBIS-II study confirms anastrozole offers long term protection for women at high risk of developing breast cancer, with a 49% reduction in breast cancer incidence 12 years after stopping treatment. This is significantly higher than the 28% decrease in breast cancer recorded for women who take tamoxifen.
Breast cancer incidence rates are significantly higher in black men than white men, particularly for hormone receptor-positive subtypes. These racial differences have significant implications for patient outcomes and may be linked to genetic and non-genetic factors.
Researchers at Dartmouth's Norris Cotton Cancer Center found that breast cancer cells can take up large quantities of fat from the bloodstream through a novel mechanism called endocytosis of lipoproteins. This uptake provides a reliable source of energy for cancer cell proliferation.
A multi-centre trial led by McMaster researchers found that accelerated partial breast irradiation (APBI) is as effective as whole breast radiation in reducing breast cancer recurrence, with similar recurrence rates after one week of treatment. However, APBI was associated with higher late toxic effects and worse cosmetic outcomes.
A study published by NIH found that frequent use of permanent hair dye and chemical straighteners increases breast cancer risk, especially among African American women. Women who regularly used permanent dyes were 9% more likely to develop breast cancer than those who didn't use hair dye.
Research reveals that inhibiting Mcl-1 protein can induce apoptosis in estrogen receptor-positive breast cancer cells, suggesting a potential therapeutic strategy for this type of cancer. The study also found that combining Mcl-1 inhibition with ABT-263 increased cell death in ER+ breast cancer cells.
A new trial shows that breast cancer patients who experience a local recurrence in the same breast after lumpectomy and radiation can benefit from partial-breast re-irradiation as an alternative to mastectomy. The treatment targets the affected area with high-dose radiation, reducing exposure to surrounding tissue.
Women from Appalachia are less likely to receive breast reconstruction surgery following a mastectomy due to lack of adequate care and patient education. Researchers highlight the need for better comprehensive breast cancer care, including access to reconstructive plastic surgeons.
Researchers identify potential environmental risk factors and new treatment strategies for triple negative breast cancer (TNBC), an aggressive form of breast cancer. The study suggests that exposure to common chemicals may increase the risk of developing TNBC, and highlights the potential for combination therapy as a treatment option.
Researchers have developed a simple blood test that detects breast cancer up to five years before clinical signs appear, identifying tumor-associated antigens and autoantibodies. The test shows promising accuracy in detecting breast cancer with reasonable accuracy, especially when using panels of multiple antigens.
A study by Yale University found that sentinel lymph node biopsies do not reduce the risk of death from breast cancer or decrease invasive cancer development in women with ductal carcinoma in situ (DCIS), a non-invasive breast cancer. The procedure also increases the risk of pain, wound infection, and lymphedema.
Researchers identified gamma delta T cells in breast tissue, which are associated with remission and higher survival rates. The study suggests that these cells may be used to develop new treatments for breast cancer.
Breast cancer researchers at the University of Notre Dame have identified a pair of proteins, CXCL5 and CXCR2, critical for spreading breast cancer to bone. These proteins cause cancer cells to rapidly reproduce and spread throughout the bone and marrow.
The breast cancer death rate has slowed in recent years, but the gap between black and white women remains significant. Breast cancer incidence rates have continued to rise, with a greater increase seen in hormone receptor-positive disease.
A new trial analysis found that women diagnosed with early stages of cancer who undergo lumpectomies and receive either partial or whole breast radiation have equivalent cosmetic outcomes, according to patient and physician ratings. The study's findings aim to guide women seeking breast-conserving therapy for early-stage disease.
A study by The World Cancer Research Fund and the American Institute for Cancer Research suggests that lifestyle modifications can prevent up to 30% of breast cancer cases. The recommended modifications include maintaining a healthy weight, engaging in regular physical activity, and consuming a balanced diet rich in non-starch vegetables.
A recent study found that men at high risk for breast cancer can benefit from mammography screening. The study involved 1,869 men who had a mammogram between 2005 and 2017, with 41 men diagnosed with breast cancer.
A landmark study found that selective mammography screening can detect male breast cancer in high-risk men at an early stage, improving survival prognosis. The cancers detected were often benign, but the study's results support targeted screening for men with elevated risk.
A substudy of the NRG Oncology clinical trial found that women rated post-lumpectomy partial breast irradiation as equivalent to whole breast irradiation in terms of cosmetic outcomes and satisfaction. The results suggest that PBI may be a viable option for patients seeking to minimize radiation time commitment and healthcare costs.
Women with breast cancer who experience depression, anxiety, or mental health conditions are more likely to use opioids and have lower survival rates. Researchers recommend alternative pain management options like physical therapy, massage, and acupuncture to improve treatment outcomes.
Researchers found that DNA methylation patterns can affect the impact of aspirin on mortality in women with breast cancer. Women with certain DNA characteristics who take aspirin before a breast cancer diagnosis may live longer, according to the study published in Cancer journal.
A recent study found that increasing consumption of red meat was associated with a higher risk of invasive breast cancer, while consuming poultry was linked to decreased risk. Substituting poultry for red meat may be a simple way to reduce breast cancer incidence.
A new study found that Slug promotes breast stem cell health by repairing DNA damage, and its deficiency is linked to increased DNA damage and decreased stem cell activity in both young and aged breast tissue. This suggests that Slug functions as a safeguard against age-related decline of breast stem cell function.
Researchers found that patients undergoing combined breast and gynecologic surgeries had significantly longer hospital stays and higher complication rates compared to those with single-site surgery. The study highlights the importance of separating these procedures for better patient outcomes.
A recent study published in CANCER found significant disparities in triple-negative breast cancer diagnoses among women of color and younger women. Non-Hispanic black women had a significantly higher incidence of the disease, with over 21% diagnosed compared to under 11% for other ethnic groups.
A new study published in the Journal of Cancer reveals significant disparities in triple-negative breast cancer diagnoses among women of color and younger women. The research found that non-Hispanic black women had a 2.3-times higher odds of being diagnosed with triple-negative breast cancer compared to non-Hispanic white women.
A multidisciplinary team at LSU Health is using two new research techniques to study the link between obesity and breast cancer. They will observe breast tumor development in real-time using a biomimetic tissue-engineered 3D culture system, and analyze the extracellular matrix of breast cancer tumors using decellularization technique.
Researchers at the University of Alberta have identified a specific genetic marker linked to an increased risk of breast cancer in premenopausal women. The study found that up to 40% of women carrying the genetic variation are at higher risk of developing breast cancer compared to those without it.
Research published in BMJ Open reveals that only one in five women attending breast clinics and screening appointments know that alcohol is a risk factor for breast cancer. The study suggests that understanding modifiable risk factors for the disease needs to be increased, particularly through brief information on health risks associat...
A large study published in Radiology found that breast MRI screening for breast cancer survivors leads to higher cancer detection rates, but also results in more unnecessary biopsies. The study analyzed data from over 13,000 women and found no significant differences in sensitivity between breast MRI and mammography.
A new clinical trial has shown that partial breast irradiation produces similar long-term survival rates and risk for recurrence compared to whole breast irradiation for many women with low-risk, early stage breast cancer. The study found a 4.6% recurrence rate for partial breast irradiation and a 3.9% rate for whole breast irradiation.
A study found that clinicians over-order imaging for breast pain, despite a weak correlation with breast cancer. Most respondents (72%) believe there is no strong link between breast pain and breast cancer.
Women with early, low-risk hormone-driven breast cancer who receive radiotherapy after surgery have a significantly lower risk of recurrence and improved disease-free survival compared to those without radiotherapy. The study found that whole breast irradiation is effective in reducing in-breast recurrences and improving overall survival.
Professor Jonas Bergh is recognized for his work on breast cancer biology, including tailored treatments and the impact of chemotherapy. He has made significant contributions to primary breast cancer treatment through his involvement in clinical trials and research collaborations.
The D.C. Council has passed the Breast Density Screening and Notification Act, requiring women with dense breast tissue to be informed and receive additional screenings. This legislation aims to reduce deaths from breast cancer by promoting early detection among high-risk groups.