The Penn Center for Multi-Scale Molecular Mapping of the Female Reproductive System will create a comprehensive resource for women's health by documenting the molecular characteristics of individual cells in the female reproductive system.
Physicists discovered that individual light-harvesting nanotubes with disordered molecular structures transport light energy in the same way. The result is attributed to the linkage of molecules, which averages out small differences, resulting in similar optical properties.
A team of NUS researchers has developed a solution to address the long-standing challenge of uniform switching mechanism in memristors, a key component of organic and molecular electronics. The breakthrough demonstrates homogeneous molecular switching with less than 7 nanometre spatial resolution.
Researchers built an interactome that includes a human lung cell host network integrated with a SARS-CoV-2 network, revealing potential molecular mechanisms and therapeutic targets for COVID-19. The study identified 33 high-value SARS-CoV-2 targets involved in viral entry, proliferation, and survival.
Recent studies in human genetics reveal insights into transcriptional regulation, gene expression, and mutation's role in shaping the human genome. These findings have important implications for understanding human health and disease, with applications in fields such as medicine and evolutionary biology.
Drs. Dennis Lo, Karen Mann and Ronald Przygodzki are recognized for their pioneering work in non-invasive prenatal testing and cancer detection using circulating nucleic acids. Their innovations have created a paradigm in prenatal medicine and advanced the field of molecular diagnostics.
The SNMMI Wagner-Torizuka Fellowship provides extensive training and experience for Japanese physicians in nuclear medicine and molecular imaging. The program has graduated 30 fellows since its inception and supports the worldwide advancement of nuclear medicine and molecular imaging.
A collaborative team of 28 professors from various biology fields will integrate recent discoveries about microbial symbiosis and its impact on evolution and ecology.
The study sheds light on the SARS-CoV-2 spike protein's flexibility and its impact on viral infection. The research reveals that the stalk is extremely flexible, allowing it to move and search for receptors on host cells.
Researchers at CeMM developed a scalable strategy to discover novel molecular glue degraders, which can eliminate disease-causing proteins by targeting the cellular protein quality control system. The study identifies a set of novel compounds that induce the degradation of cyclin K, essential in many cancer types.
A team of researchers has developed a computational model to describe the motion of molecular motors, shedding light on how they generate unidirectional motion. The study found that molecular motors follow a
Peter S. Conti, MD, PhD, received the 2020 Benedict Cassen Prize for his pioneering work in radiopharmaceuticals and clinical PET applications for cancer imaging. The award recognizes his contributions to advancing nuclear medicine and molecular imaging.
A team at Broad Institute of MIT and Harvard developed a new molecular editor that can precisely edit mitochondrial DNA, enabling modeling of disease-associated mutations. The editor, engineered from a bacterial toxin, enables researchers to study genetic changes associated with cancer, aging, and more.
Researchers developed a new set of computational tools to identify cell-type specific methylation patterns, known as molecular barcodes, in complex cell mixtures. These new methods can distinguish between different cell types in tissues made up of multiple cell types.
A European research team developed a photographic film at the atomic level to track the motion of a molecular building block. The result shows a light-controlled 'pedalo-type motion', moving forward and backward, which could help control material properties with molecular switches.
Researchers have developed Pillar[n]MaxQ molecules that bind neuromuscular blocking chemicals with high specificity and strength. These new molecular containers show promise for eliminating toxins and malodorous substances in water, outperforming existing macrocyclic agents.
Scientists investigated how dynamic magnetic properties of individual molecular magnets change with orientation in a magnetic field. They found strong anisotropy, which is crucial for building functional quantum computer components.
A new Stanford Medicine study provides a comprehensive analysis of the molecular effects of exercise, shedding light on how physical fitness is determined at a molecular level. The research reveals a strong correlation between specific molecules and an individual's aerobic fitness, paving the way for the development of a blood test tha...
The International Association for the Study of Lung Cancer found that molecular testing rates for lung cancer are less than 50% in most countries. The most frequent barrier to testing was cost, followed by quality/standards and access.
Researchers at Insilico Medicine developed a new AI model that combines generative biology and chemistry to generate novel molecular structures for a desired transcriptional response. The Bidirectional Adversarial Autoencoder can be used for virtual screening, discovering new molecular structures and predicting transcriptional responses.
Researchers found that molecule-plasmon coupling strength affects SEIRA spectral lineshapes, which are crucial for molecular detection. The study revealed how coupling distance, molecular density, and plasmon loss impact spectral profiles.
Researchers from the University of Groningen developed an algorithm that links large-scale changes to molecular-level simulations, enabling the simulation of a full-sized mitochondrial lipid membrane. This breakthrough allows for whole-cell simulations at a molecular level.
Researchers from the University of Tsukuba identified Myc as a central molecular actor in eliminating damaged germline cells to preserve germline integrity. Knockdown of Myc resulted in a similar germline-loss phenotype, suggesting its role in quality control during embryonic development.
The Association for Molecular Pathology (AMP) has released consensus recommendations to aid in the design, validation and interpretation of clinical genotyping tests for predicting warfarin response. The guidelines define a minimum set of pharmacogenetic alleles for inclusion in clinical warfarin sensitivity genotyping tests.
Researchers create novel molecular cage that confines and twists target molecules, activating specific chemical bonds. The twist angle can be precisely controlled using stuffing molecules, enabling accelerated reaction rates.
Researchers found that genetic variants at Tbx5 and Pitx1 contribute to foot feathering in both chickens and pigeons. A 17,000 base-pair long deletion near Pitx1 removes the same exact region in both species, indicating similar mutations and molecular pathways.
Researchers at Northwestern University found that a damaged fertilized egg sends a molecular signal to the mother that protects her from cellular stress and environmental damage. This allows the mother to live longer and produce healthier eggs.
Researchers at UNIGE have developed a new technique for creating chains of molecular rings that do not use standard chemical interactions but instead contact with large molecular surfaces. This discovery helps answer an old contradiction in classical chemistry and provides new prospects for molecular cyclization.
A comprehensive map of the proteome of the model plant Arabidopsis thaliana has been created, detailing the presence, location, and quantity of approximately 18,000 proteins in the plant. This study provides new insights into plant biology and offers potential avenues for improving crop yields and disease resistance.
Recent advances in bioengineering and computational modeling have enabled researchers to study complex biological processes with molecular-level detail. Multidisciplinary work on proteins and modeling highlights challenges as the field develops high-resolution, high-throughput organs on a chip.
A Japanese research team has uncovered more about how proteins move using high-speed imaging to track dynein's movement along a microtubule. They found dynein moves erratically with frequent backward steps and side steps, challenging the conventional understanding of molecular motor tasks.
Researchers at LMU München successfully couple a light-activated molecular motor to a receiver unit, demonstrating the motor's ability to accelerate rotation and perform useful work. The study provides unprecedented insights into the operation of an integrated molecular machine.
Scientists use molecular motors to manipulate protein structure, directing stem cells to differentiate into bone cells. The movement of motor molecules induces subtle structural changes, affecting cell attachment and behavior, ultimately leading to altered cell fate.
Researchers at Worcester Polytechnic Institute have developed a new tool to identify molecular receptors in Caenorhabditis elegans worms involved in sensing pheromones. This breakthrough could speed up neuroscience research into pheromones by streamlining the process and identifying specific receptors in just a month.
Researchers developed molecular factories by combining natural vesicles with synthetic organelles, demonstrating no toxicity in animal models. These factories can produce complex structures and assembled molecules, paving the way for artificial cells in laboratory or living organisms.
A recent focus issue explores the cell biology of virus-host and virus-vector interactions to improve crop management. Research reveals insights into plasmodesmatal connections, cell-cell signaling, and biotechnological approaches for host resistance.
The book Rethinking Biology highlights how biology is often oversimplified, leading to a false public understanding of biological processes. The authors study children and adults' perceptions, journalists' writing, legal contexts, and religious world views to shed light on this issue.
Researchers found that standard pathology tests provide better information on likely outcome and best treatment options for patients with bladder cancer than molecular subtyping techniques. The study suggests that more study is needed before molecular subtypes are used to guide patient care.
Researchers at Baylor College of Medicine classified over 500 cancers into 10 subtypes based on protein analysis, revealing novel molecular pathways and potential new players in cancer. Four subtypes were found to be linked to the tumor microenvironment, while three others were associated with previously unknown cellular components.
Researchers employ neural networks to predict molecular bond energies, reducing computational cost and improving accuracy. The combination of AI and quantum chemistry calculations provides an efficient tool for quickly predicting molecular bond energies in complex systems.
Molecular Systems Biology has appointed systems biologist M. Madan Babu as its new Chief Editor, strengthening the journal's position in the field of systems biology. The appointment aims to encourage interdisciplinary research and bridge silos between fields.
Researchers unveil molecular mechanisms governing saliva's lubrication properties, resolving distinct roles played by mucin- and non-mucinous proteins. Hydrated mucin forms a mesh-like nano-reservoir trapping water molecules, while positively-charged small molecular proteins aid boundary lubrication.
Molecular electronic devices use molecules to build ordered systems with quantum effects, offering advantages like small volume, easy synthesis, and high efficiency. However, research is still theoretical, and device manufacturing reliability, repeatability, and cost need improvement.
Integral Molecular to receive up to $5.5 million from NIAID to study antibody responses to Zika, Marburg and EEV viruses. The company's Shotgun Mutagenesis technology will aid in the discovery of vaccines and therapeutics against these deadly viruses.
New studies reveal a broader range of genetic code deviations than previously thought, particularly among green algae. The research suggests that these changes may have driven the evolution of unique mitochondrial genome organizations.
Researchers from the University of Tennessee Institute of Agriculture join a global call for responsible synthetic biology development. The authors highlight four major areas where improvements are needed to advance the field, including genome design, DNA synthesis, genome editing, and chromosome construction.
Researchers at Hokkaido University developed a method to control swarming molecular machines using simple mechanical stimuli, exhibiting zigzag patterns or forming vortices. The system uses motor proteins and microtubules, which can self-repair after disruption.
Researchers develop new synthesis method to create molecules with partial structures of fullerenes, graphene, and carbon nanotubes. They successfully synthesize catenanes and knots, which are expected to be used in molecular machines and have specific properties derived from the topology.
Researchers at LMU develop first molecular motor that moves on an eight-shaped path using hemithioindigo dyes and green light. The new motor system offers improved switching properties and reduces environmental harm compared to existing motors.
A research team has found a way to overcome the limitations of graphene-based molecular devices, creating structures that are both electrically and mechanically stable at room temperature. The breakthrough, published in Nature Nanotechnology, uses a combination of covalent binding and large ۆ-conjugated head groups to achieve stability.
Molecular clouds in distant galaxies have higher mass, density, and internal turbulence than those in nearby galaxies, producing more stars. The international team used ALMA to detect clouds in a Milky Way progenitor 8 billion light-years away.
Twelve emerging scientists from Argentina, Brazil, Chile, Mexico, Spain, and Uruguay have won PROLAB travel grants to collaborate with top researchers in the US, Canada, and Spain. They will work on various projects, including reproductive biology, neuronal proteostasis regulation, exercise-induced mood changes, and cancer progression.
A team of scientists led by OHIO Professor Saw-Wai Hla developed a molecular propeller that enables unidirectional rotations on a material surface when energized. The tiny propeller, composed of three components, can be controlled using an electric field or mechanical force.
Scientists have developed a new technique to visualize gas-liquid collisions using lasers, enabling the study of fundamental molecular interactions. The method captures individual frames of molecular movement, revealing the rough surface of liquids and their impact on atmospheric chemistry.
Twelve scientists have been recognized by the American Society for Biochemistry and Molecular Biology for their significant contributions to biochemistry, molecular biology, and education. The award winners include Paul Black, Manajit Hayer-Hartl, Jean Schaffer, Edward Dennis, Yang Zhang, David Pagliarini, Kevin Campbell, among others.
A team of Kiel University chemists built the first artificial molecular assembler, which uses light as the energy source. The system combines selective binding, accurate positioning, and active release of the product, solving the 'sticky fingers' problem.
A team of researchers has successfully measured the rate of heat transfer through a single molecule, a key step towards building molecular computers. The study found that the heat transfer rate was relatively constant across different chain lengths, with rates of up to 20 picowatts per degree Celsius.
Scientists at the University of Warwick have discovered a new process that activates the fastest molecular motor in neurons, paving the way for new treatments. The research focuses on KIF1C, a tiny protein-based molecular motor that converts chemical energy into mechanical energy to transport cargoes along microtubule tracks.
Researchers developed molecular imaging probes that can track changes in biological processes at the molecular level, detecting acute kidney failure up to 1.5 days earlier than current methods. The probes have high renal clearance efficiency and could be used as non-invasive test strips for urine samples.
Researchers at Baylor College of Medicine reanalyzed preexisting molecular data with new disease-causing genes and genetic knowledge, increasing the diagnostic rate nearly doubling it in one cohort. The computational pipeline facilitated semi-automated reanalysis, reducing labor intensity and cost.