The ASPECT program will provide up to $58 million for bench-scale and pre-pilot scale projects to advance alternative or waste feedstock projects. SwRI will focus on scaling technologies beyond proof of concept and systems integration.
Researchers have found a reliable alternative to bone marrow sampling for children with rhabdomyosarcoma, using PET scans to detect bone marrow involvement with high accuracy. This approach could spare patients from painful procedures and improve diagnostic practices.
A new book by University of Virginia Health System expert Daniel J. Cox outlines a practical alternative to medication for managing pre-diabetes and type 2 diabetes. The GEM program emphasizes smart eating, physical activity, and listening to the body to regulate blood sugar levels.
A new study introduces a computational framework that leverages alternative splicing events to predict protein isoform functions. The framework outperforms existing approaches and provides biological insights into how splicing shapes protein function, highlighting the importance of studying proteins at the isoform level.
Researchers at Kaunas University of Technology have developed a greener alternative for fire-resistant concrete using waste-based geopolymer mortars. These materials retain high compressive strength even after exposure to extreme heat, making them ideal for construction applications where high temperatures are present.
Researchers have successfully synthesized a carbon-free boron alternative to ferrocene, opening up new possibilities for future materials. The new compound has stronger bonding and shows that boron can mimic carbon's ability to form stable rings and complex structures.
A new study finds that calorie restriction (CR) induces a cross-tissue alternative splicing program that scales with the level of restriction and involves distinct loci in each tissue. The AS response is largely independent of gene expression changes, yet converges on shared processes related to mitochondria and oxidative phosphorylation.
A new JACR focus issue explores alternative approaches to resident education, radiology residency applications, and investing in pre-clinical medical education. The study aims to spark meaningful dialogue around how radiology education is valued, supported, and delivered amidst economic challenges.
Researchers have created a yeast platform capable of producing calycosin-7-glucoside, a valuable isoflavonoid from Astragalus membranaceus. The optimized strain achieved a titer of 0.22 mg/L within 48 hours, providing a scalable alternative to plant-derived production and reducing dependence on medicinal plant cultivation.
Researchers have uncovered the critical function of occludin in regulating cell barriers, particularly in diabetic retinopathy. The study revealed that occludin's alternative splicing produces a form of occludin that controls leaky blood vessels and excessive vessel growth.
A team of scientists found alternative explanations for data in topological quantum computing, challenging the field's progress. They proposed changes to increase experimental result reliability by sharing more data and discussing alternative explanations.
Researchers have discovered a complex regulatory circuit involving SRSF1, AURKA, and MYC that promotes aggressive pancreatic cancer progression. The circuit, which involves alternative splicing, can be targeted with an antisense oligonucleotide to reduce tumor cells' viability and trigger apoptosis.
A study published in The BMJ reveals tai chi's long-term benefits in treating chronic insomnia, comparable to cognitive behavioural therapy. Tai chi offers a sustainable alternative with low costs and therapist availability.
A study by University of California, Riverside scientists found that alternative RNA processing, or
A systematic review suggests that garlic extract mouthwash may be a viable alternative to chlorhexidine, offering longer-lasting residual effects but potentially causing greater discomfort. The review found higher concentrations of garlic extract demonstrated antimicrobial efficacy comparable to chlorhexidine.
Researchers identified a 'sweet spot' in clinical decision-making, where presenting two or more appropriate treatment options increases the odds of physicians selecting a high-quality alternative. The study challenges the widely cited status-quo bias theory and suggests that more options can lead to better care decisions.
Scientists discovered that the APOE4 gene blocks brain cells from using alternative energy sources as we age, significantly increasing Alzheimer's risk. This knowledge could pave the way for new treatments by targeting lipid metabolism.
Researchers explored post-transcriptional regulation in peanut pods, identifying 14,627 newly discovered transcripts and 6,769 new genes across four developmental stages. The study found dynamic changes in polyA length and its correlation with transcript stability, as well as alternative splicing events and RNA m6A modification.
A comprehensive review of 248 meta-analyses and 200 clinical trials found that most complementary and alternative medicine (CAM) treatments for autism showed weak or poor-quality evidence, making their effects unreliable. The study also highlighted the lack of safety assessments for these treatments, which can be misleading.
A new survey reveals that 83% of U.S. college students believe animals should not be used in classroom teaching laboratories if they are killed afterward and alternative methods exist. The survey also found that most students feel coerced into participating, with 20% willing to do so despite concerns about animal welfare.
A new method for enhanced oil recovery proposed by researchers at The University of Texas at Austin is showing promising results in modeling studies. Alternative carbon carriers are chemical compounds engineered to store larger quantities of carbon molecules in subsurface formations, optimizing greenhouse gas transportation, utilizatio...
University of Toronto researchers have developed a new material that repels both water and grease as well as standard non-stick coatings, but contains much lower amounts of per- and polyfluoroalkyl substances (PFAS). The material uses nanoscale fletching technology to achieve its performance, making it a safer alternative for consumer ...
This study reveals that SRSF7 promotes pulmonary fibrosis by modulating the alternative splicing of pyruvate kinase (PKM), leading to metabolic dysregulation and fibroblast activation. Lomitapide was identified as a novel modulator of SRSF7, effectively mitigating experimental pulmonary fibrosis.
The study identifies the need for more widely adopted non-animal methods to identify endocrine-disrupting substances in the EU. The researchers advocate a balanced approach that includes both developing and validating alternative methods and refining animal testing.
A combination of bazedoxifene and conjugated estrogens reduces obesity-related changes in rats, including fat cell accumulation and insulin resistance. The treatment also increases beneficial gut microbes and improves metabolic health, making it a promising alternative to tamoxifen for women at high breast cancer risk.
USC researchers developed a biocompatible material by adding calcium carbonate to poly (1,8-octanediol-co-citrate), an FDA-approved biodegradable material. The resulting material, POC-CC, is a safer alternative to traditional plastics and degrades in marine environments while maintaining strength.
A study published in Science Advances has revealed promising alternative pathways to overcome photorespiration, which can reduce crop productivity by up to 36%. The researchers identified mechanisms that could improve plant productivity while adapting to climate change and growing global food demands.
Researchers from the University of Ottawa develop films containing gum tragacanth and gelatin, finding an optimal 3-to-1 ratio for maintaining gel-like behavior. The plant-based alternative reduces animal-derived products and has potential applications in candy, food packaging, and more.
A recent study by Concordia researchers found that solutions journalism in Canadian alternative media outlets is often constrained by institutional lack of support and daily pressures. Despite its benefits, the practice requires strong nurturing environments to flourish.
A study of over 105,000 individuals found that following a healthy diet rich in plant-based foods and moderate animal-based foods can promote overall healthy aging. The Alternative Healthy Eating Index (AHEI) was the leading dietary pattern, emphasizing fruits, vegetables, whole grains, and healthy fats.
The Society for Cardiovascular Angiography and Interventions has published an expert consensus statement recommending two preferred alternative access techniques for transaortic valve replacement (TAVR), including transcarotid and transcaval access. The guidelines aim to improve outcomes for patients with inadequate femoral vascular ac...
Researchers at KTH Royal Institute of Technology found that cobalt-free studded tires can grip ice and packed snow without causing significant damage to road surfaces. The alternative stud material reduces airborne particles by 20 percent, a potential improvement for driver health.
Researchers developed a recyclable alternative to thermosets, making materials like car tires and hip joints more environmentally friendly. The new material, made from dihydrofuran, can be easily recycled and degrades naturally over time.
A national study suggests that the Adderall shortage may have led to an increase in the use of alternative ADHD medications in children. The research found that while prescription fills for ADHD treatments among children aged 5-17 fell during the pandemic, they increased again after the shortage was announced. The study's findings high...
Researchers have developed a new way to grow organoids using Invasin, a protein produced by bacteria, mimicking the original organ with its variety of cell types. This study provides an affordable, standardized and animal-free alternative to currently used methods.
A randomized clinical study found that an opioid-free treatment pathway is both safe and effective for bariatric surgery patients. The alternative method, which combines three different medicines, significantly reduces the need for opioids during treatment.
The Koc University-Esas Center for Alternative Investments (KUES) will focus on private equity, venture capital, and real estate investments. The center aims to nurture qualified human resources through PhD, master’s, and undergraduate programs.
The Increasing Organ Transplant Access (IOTA) Model aims to improve access to life-saving kidney transplants for patients with end-stage kidney disease while maintaining or improving the quality of care. The new rule will test performance-based upside or downside risk payments among selected kidney transplant hospitals.
A study published in the Journal of the American College of Surgeons found that using antibiotics alone to treat children with uncomplicated appendicitis is a cost-effective and safe alternative to surgery. This approach resulted in lower costs and similar quality-of-life scores compared to upfront surgery.
The FDA is advancing alternative methods, such as in vitro ocular irritation tests and computational models, to reduce animal use in product safety assessments. These new approaches have been validated and adopted by the agency, leading to more effective regulatory decisions.
A recent study demonstrates that stool DNA testing is highly sensitive and specific for detecting colorectal cancer among Thai individuals, with a sensitivity of 91.5% and specificity of 90.3%. The test targets methylation statuses of three genes and may provide a viable non-invasive alternative to colonoscopy.
A recent study highlights alternative splicing as a key regulatory mechanism in plant secondary metabolism, influencing the synthesis of essential metabolites like terpenoids and flavonoids. The research provides new insights for bioengineering approaches to enhance plant performance and metabolite production.
A UCL-led research team has crystallized the first alternative DNA structure from the insulin gene, revealing its shape and structure. The discovery suggests that different variants in the insulin gene can form different DNA structures, which could affect insulin function and potentially play a role in diabetes development.
Cells produce three times as many 'unproductive' transcripts with mistakes or unexpected configurations as they do steady-state, finished RNA. These unproductive transcripts are quickly destroyed by a cellular process called nonsense-mediated decay (NMD), which suggests the cell intentionally makes mistakes to regulate gene expression....
Researchers mapped 1.65 million cells from 437 aging brains, identifying two distinct paths of cellular change that lead to either Alzheimer's disease or alternative brain aging. These findings offer new insights into the development of Alzheimer's and how it differs from healthy brain aging.
Researchers developed alternative criteria using a prediction model to identify people with the most to gain from lung cancer screening. The study found that high-benefit groups include those who smoked for a long duration but at a lower intensity, heavy smokers who quit over 15 years ago, and racial and ethnic minority groups.
Researchers from Tokyo Medical and Dental University used long-read RNA sequencing to decode genetic intricacies and disease links. The study identified novel isoforms, cell-type-specific splicing patterns, and disease-linked transcripts associated with immune-related diseases.
A recent study found that the SMCHD1 protein plays a crucial role in regulating alternative splicing, which affects the progression of FSHD. Mutations in SMCHD1 lead to splicing errors, disrupting genes like DNMT3B and causing harmful overexpression of DUX4.
While some European countries like Denmark, Finland, and Spain show positive attitudes towards alternative protein food, others such as Italy have lower acceptance rates. Additionally, young Polish consumers are less likely to adopt novel foods compared to Danish and German consumers.
A recent study analyzed 53 peer-reviewed Life Cycle Assessment studies and found that conventional plastics are not always the least environmentally friendly choice. Bioplastics emerge as a viable alternative for climate change and fossil resource depletion, but other environmental impact categories show some disadvantages. The analysi...
A new study found extensive alternative splicing of messenger RNA in untreated multiple sclerosis patients compared to healthy controls. Interferon-ß therapy corrected dysregulated alternative splicing, linking it to future clinical exacerbations.
A new national poll finds that 60% of people aged 50-80 have visited urgent care clinics or retail clinics for medical care in the past two years. Many sought immediate attention, vaccinations, or tests, and 75% plan to use these sites again in the next two years.
The college will investigate the harmful effects of alternative tobacco products, exploring their toxicity and addictiveness. The funding supports a trio of studies led by the Center for Research on Tobacco and Health, which aims to inform better regulation and improve public health.
Researchers suggest replacing 50% of animal products with alternative proteins by 2050 to unlock vast energy and negative emission potentials via BECCS. This transition could free up large agricultural areas, generating enough renewable energy equivalent to today's coal-generated power while removing substantial CO2 from the atmosphere.
Researchers found that pancreatic cancer cells employ a 'favorable genetic reshuffling' to evade treatments, leading to a potential breakthrough in developing targeted drugs. Alternative splicing plays a crucial role in this process, and the study identifies a specific splicing regulator called 'Quaking' that promotes chemoresistance.
The UC Davis Integrative Center for Alternative Meat and Protein (iCAMP) aims to advance sustainable food innovation through research and partnerships. The center will focus on scaling up alternative protein production, improving consumer acceptance, and reducing environmental impact.
Researchers found that the loss of RBFOX2 protein leads to increased cell migration, invasion, tumor development, and metastasis in pancreatic cancer. The study suggests alternative RNA splicing plays a critical role in pancreatic cancer progression.
Aya Kubota emphasizes the importance of engaging local residents in historical environment preservation and regeneration. This approach supports the preservation and utilization of 'Legacy of Catastrophe' and presents a valuable alternative to current urbanization methods.
A world-first report found that alternative reporting options could help increase the number of women who report sexual assaults to police. Trauma-informed interviews designed in line with best-practice techniques can improve outcomes for victim-survivors of sexual assault who use them.
A study published in the Journal of Dental Research found that cannabidiol (CBD) reduces dental pain intensity by 70% and improves bite force. While side effects occurred more frequently than placebo, promising results suggest CBD may be an effective alternative to opioid painkillers for managing acute toothache.