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Automated, accurate reporting for NGS-based clonality testing

Researchers have developed an automated calling algorithm for determining B and T cell clonality from NGS data with greater sensitivity than previous models. The new model increases the assay's sensitivity in detecting clonality, allowing for more accurate diagnosis and monitoring of lymphoproliferative disorders.

SourceImpact Journals LLC·JournalOncotarget·TypeData/statistical analysis·DateMay 16, 2023

Millions of U.S. households may struggle to afford basic water services

A study analyzing the affordability of water services for 28.3 million people in the US found that 15% of households, or one in seven, face financial hardship in paying for access to water and wastewater services. The researchers suggest that solutions require comprehensive strategies at local, state, and federal levels.

SourcePLOS·JournalPLOS Water·TypeObservational study·DateMay 10, 2023

A sharp increase in the price of the gout drug colchicine led to lower use and poorer disease control, UCLA research suggests

A sharp increase in colchicine's price led to a 17% drop in its use and worsened disease control in gout patients. Patients turned to alternative medications with potentially different side effects, resulting in increased emergency department visits and specialist consultations.

SourceUniversity of California - Los Angeles Health Sciences·JournalJAMA Internal Medicine·TypeData/statistical analysis·DateMay 8, 2023

Fame-seeking mass shooters more likely to plan ‘surprise’ attacks, and the novelty of their locations and targets brings added fame

A new study found that fame-seekers plan their mass shootings as 'surprises,' carefully crafting them in ways that set them apart from previous incidents. Researchers analyzed data from 189 mass shootings between 1966 and 2021, finding that attacks by fame-seekers were about three times more surprising than those from non-fame-seekers.

SourceNYU Tandon School of Engineering·JournalProceedings of the National Academy of Sciences·DateMay 8, 2023

Research Brief: People with anxiety and mood disorders more likely to experience alcohol use disorder symptoms than others who drink at the same level

Researchers found people with anxiety and depression disorder experience greater alcohol use disorder symptoms, even at similar levels of drinking. The study analyzed data on 26,000 adults and found that those with internalizing disorders predicted more alcohol-related symptoms.

SourceUniversity of Minnesota Medical School·JournalAlcoholism Clinical and Experimental Research·TypeData/statistical analysis·DateMay 3, 2023

Chronic thromboembolic pulmonary vascular disease and left heart disease are not mutually exclusive

A long-term analysis reveals that approximately one-third of CTEPH patients also have left heart disease, which can worsen breathing symptoms and requires more comprehensive diagnostic approaches. The study suggests that treatment options for both conditions may overlap, necessitating further research to find effective therapies.

SourceMedical University of Vienna·JournalJournal of the American College of Cardiology·DateApr 27, 2023

Big Data research points out Omicron outbreak had lower mortality rates compared to previous strains of Covid-19

A Brazilian study analyzed data from over 40,000 patients admitted to ICUs and found lower mortality rates during the Omicron outbreak compared to previous strains of Covid-19. Vaccination coverage contributed to the lower mortality observed in the Omicron period, but vulnerable patients remain at risk.

SourceD'Or Institute for Research and Education·JournalIntensive Care Medicine·DateApr 24, 2023

Eco-computing

A study at Kyoto University has demonstrated the computational power of ecological networks, providing a new direction for rapidly developing AI technologies. The researchers developed two types of ecological reservoir computing that efficiently process information and can be utilized as a computational resource.

SourceKyoto University·JournalRoyal Society Open Science·DateApr 19, 2023

A new primary care model proves effective for patients with severe mental illness

A new 'enhanced primary care' model has been found to be effective in reducing blood pressure and hemoglobin A1c levels among patients with severe mental illness. The study, conducted at UNC WakeBrook, showed significant improvements in screening for people with severe mental illness compared to usual primary care.

SourceUniversity of North Carolina Health Care·JournalJournal of Clinical Psychiatry·DateApr 10, 2023

UBC Okanagan researchers create real estate market assessment tool

A team of UBC Okanagan researchers has developed a regional house price mining and forecasting framework (RHPMF) that provides comprehensive reports on neighborhood data. The tool helps users analyze population, social dynamics, housing costs, and historical background to assess the market and make informed decisions.

SourceUniversity of British Columbia Okanagan campus·JournalInformation Fusion·TypeMeta-analysis·DateApr 6, 2023

Optimizing sepsis treatment timing with a machine learning model

A new machine learning model estimates optimal treatment timing for sepsis, taking into account vital signs and lab test results to predict patient survival. The model was trained on a dataset of over 14,000 individuals with sepsis and showed improved outcomes when actual treatment matched the recommended timeline.

SourceOhio State University·JournalNature Machine Intelligence·TypeComputational simulation/modeling·DateApr 6, 2023

Study shows link between wealth, health differs across race in young adulthood

A new study from the University of Kansas reveals significant racial wealth gaps and disparities in health outcomes among young adults. The study found that white and Hispanic individuals with higher wealth had better health outcomes, but Black respondents showed a more nuanced relationship between wealth and health. Policymakers argue...

SourceUniversity of Kansas·JournalSSM - Population Health·TypeData/statistical analysis·DateApr 4, 2023

Insomnia, sleep apnea contribute to reports of cognitive decline in women with multiple sclerosis

Researchers found that women with multiple sclerosis were more likely to report sleep disorders, including obstructive sleep apnea, insomnia, and sleepiness. Insomnia mediated more than 10% of the cognitive problems reported by women with MS, while sleep apnea accounted for 34%.

SourceMichigan Medicine - University of Michigan·JournalMultiple Sclerosis Journal·TypeObservational study·DateMar 21, 2023

Richard McIndoe, PhD, will direct Coordinating Unit for new, national research initiative in diabetes, obesity

Richard McIndoe is leading a national research initiative to advance understanding of diabetes and obesity through the National Centers for Metabolic Phenotyping in Live Models of Obesity and Diabetes (MPMOD). The MPMOD initiative provides access to advanced testing services, including bariatric surgery on mice, to enable new insights ...

Young children develop better learning skills when taught by teachers of the same ethnicity, national US study suggests

A new national US study suggests that young children who are taught by a teacher of the same ethnicity as themselves develop better learning and problem-solving skills by the age of seven. The effect was most pronounced in Black and Latinx children, with improved working memory and reading achievement scores.

SourceTaylor & Francis Group·JournalEarly Education and Development·DateMar 17, 2023

How countries can benefit from linking data

A recent study analyzed data from 41,516 refugees and 207,729 Swedish-born individuals to investigate the impact of mental and somatic illnesses on labor market integration. The study found that multimorbidity poses a significant risk for unemployment among young refugees, highlighting the need for targeted public health actions.

SourceComplexity Science Hub·JournalFrontiers in Public Health·TypeData/statistical analysis·DateMar 16, 2023

New trials show promising, minimally invasive procedure to treat resistant hypertension

A recent study published in JAMA demonstrates the effectiveness of a minimally invasive procedure called renal denervation (RDN) to treat uncontrolled hypertension. RDN uses ultrasound energy delivered through a small balloon to denervate the renal artery, reducing sympathetic nerve activity and decreasing blood pressure.

SourceOchsner Health System·JournalJournal of the American Medical Association·DateMar 16, 2023

Sexual minority families fare as well as, and in some ways better than, ‘traditional’ ones

A pooled data analysis of 16 studies found that most family outcomes were similar between sexual minority and different sex parent families, with some advantages in child psychological adjustment and child-parent relationships. However, risk factors such as stigma and discrimination can negatively impact family outcomes.

SourceBMJ Group·JournalBMJ Global Health·TypeSystematic review·DateMar 6, 2023

Predicting outbreak of ALS disease with AI methods

Bielefeld University researchers developed an AI method using Capsule Networks to analyze genotype profiles of 3,000 ALS patients, achieving 87% accuracy in predicting whether or not people will develop ALS. The study reveals over 900 genes that play a role in identifying the disease.

SourceBielefeld University·JournalNature Machine Intelligence·TypeData/statistical analysis·DateFeb 28, 2023

The far-reaching consequences of child abuse

A new study published by researchers at Charité - Universitätsmedizin Berlin found a significant link between early childhood trauma experienced by mothers and various health problems in their children. The research analyzed data from over 4,300 American mothers and their children, revealing that children of mothers with adverse experi...

SourceCharité - Universitätsmedizin Berlin·JournalThe Lancet Public Health·DateFeb 24, 2023

Mystical and insightful psychedelic experience may improve mental health

Researchers found that individuals who scored high on questionnaires assessing mystical and insightful nature of their psychedelic experiences reported improvements in anxiety and depression symptoms. A challenging experience while on these substances was also beneficial, especially in the context of mystical and insightful experiences.

SourceOhio State University·JournalJournal of Affective Disorders·TypeData/statistical analysis·DateFeb 23, 2023

Electric vehicles can go the distance

A study by University of Delaware researchers found that electric vehicles (EVs) with smaller batteries, combined with community charging, can meet the driving needs of a diverse range of drivers. The study analyzed data from 333 gasoline-fueled cars and modeled the ability of EVs to handle similar trips.

SourceUniversity of Delaware·JournalEnergies·DateFeb 22, 2023