Articles tagged with Drug Safety
A clinical trial found that a nasal spray called etripamil effectively and safely treated recurrent episodes of paroxysmal supraventricular tachycardia (PSVT) in patients. The study showed that two-thirds of participants experienced relief within an hour, with an average time needed for symptom relief being 17 minutes.
Researchers at University of Waterloo found that nasal-administered naloxone is more cost-effective than current intramuscular version, potentially reducing opioid-related deaths. The study suggests that publicly funding intranasal naloxone distribution across Canada could save additional lives.
Researchers found that withdrawing aspirin one month after PCI significantly reduced major and minor bleeding incidents by 55% compared to dual antiplatelet therapy. The study, ULTIMATE-DAPT, showed no increase in adverse ischemic events, suggesting continuing aspirin may cause harm without benefit.
Researchers at Gwangju Institute of Science and Technology (GIST) have discovered a novel compound, 11c, a 5HT2A antagonist, which exhibits robust biological activity and a favorable safety profile. The compound has shown promising efficacy in preclinical models and is poised to advance the treatment of metabolic liver diseases.
Researchers from China conducted a nationwide study to assess optimal treatment strategies for CSDH. The study found that multimodality management and personalized treatment plans significantly reduced recurrence rates.
Research highlights gaps in information, support, and resources for women with serious mental illness who are pregnant or planning a pregnancy. The study found that few women recalled discussions of pregnancy with their mental health providers and were dissatisfied with the information they received about potential safety concerns.
A study by Washington State University found that cats with the MDR1 genetic mutation are at high risk of experiencing serious adverse effects from products containing eprinomectin. Cats without this mutation appear safe when using these products, but many cases of severe reactions have been reported.
Purdue University researchers create biocompatible nanoparticles modified with ATP that slowly release anti-cancer drugs and recruit immune cells to fight tumors. In mouse studies, these nanoparticles improved the effectiveness of paclitaxel against various types of cancers, including those in distant locations.
The University of Cincinnati Cancer Center team has opened a Phase 2 clinical trial to test a new combination treatment for glioblastomas, a deadly form of brain tumors. The treatment uses letrozole, a drug that targets an enzyme present in breast cancer cells, and temozolomide, a chemotherapy drug already approved as a GBM treatment.
A new nanofluidic implant has been shown to deliver an HIV drug with increased potency compared to existing oral medications, providing a potential breakthrough in addressing treatment nonadherence. The device is intended for long-term controlled release and avoids repeated systemic treatment, which can lead to adverse side effects.
Researchers at WVU are developing an AI tool to reduce medication errors that lead to hospital readmissions, aiming to improve patient safety and reduce healthcare costs. The tool will analyze patient records and identify high-risk patients, alerting pharmacists to potential issues.
A new study from Harvard T.H. Chan School of Public Health finds that prenatal exposure to antiseizure medication topiramate does not increase the risk of autism spectrum disorder (ASD) among children. In contrast, valproate has been linked to a heightened risk of ASD.
A new trial demonstrates that non-allergy specialist healthcare professionals can safely assess and remove penicillin allergy labels in low-risk patients, with no serious hypersensitivity reactions reported. This approach has the potential to improve quality of clinical care and reduce antimicrobial resistance.
Researchers discovered toxic metal particles in unused cannabis vape liquids, with lead levels 100 times higher than acceptable limits. The contamination was linked to device production, not heating, and highlights the need for regulation and improved testing procedures.
A new international study led by UNSW Sydney found no increased risk of neurodevelopmental disorders and learning difficulties after exposure to antipsychotics during pregnancy. The study tracked the long-term risk of intellectual disability, poor academic performance in maths and language, or learning, speech and language disorders.
Researchers at the University of Texas at Arlington have developed a method to determine the clinical potency of psilocybin and psilocin in Psilocybe cubensis mushrooms. This technique uses liquid chromatography with tandem mass spectrometry, allowing for accurate extraction and measurement of the strength of the mushrooms.
A phase 3 trial co-led by a University of Cincinnati researcher found that subcutaneous levodopa delivery through an infusion pump is safe and effective in reducing symptoms for longer periods. The study resulted in almost two hours of additional 'on time' compared to traditional oral medication, paving the way for potential FDA approval.
A study published in Open Medicine found that Ginkgo Diterpene Lactone Meglumine (GDLM) improves cognitive function in patients who recently experienced an acute ischemic stroke. The treatment showed anti-inflammatory and anticoagulant effects, reducing inflammation and coagulation markers.
A new study by the Microbicide Trials Network found no safety concerns with using the dapivirine vaginal ring during all stages of pregnancy. The research provides sufficient evidence that the ring is safe to use throughout pregnancy to protect against HIV, which poses a higher risk than at any other time.
A study found 35% of illicit drugs sourced from the dark web contained unexpected substances, including mixtures or no advertised substance at all. This highlights the urgent need for more local drug testing facilities in Australia to prevent harm and overdose.
A University of Cincinnati study found liraglutide to be efficacious and safe for weight loss in individuals with stable bipolar disorder, without destabilizing the illness. The drug reduced binge eating behavior and significantly lowered hemoglobin A1C levels.
A combination of CS1002 and CS1003 showed promising anti-tumor activity and a manageable safety profile across various dosing ranges in patients with advanced solid tumors. The treatment was found to be effective in certain types of cancers, including melanoma and skin cancer.
A recent study by Binghamton University researchers found that 90% of commercial tattoo inks in the US market contain major discrepancies between their actual and labeled contents. The study analyzed 54 inks from nine manufacturers and discovered unlisted polyethylene glycol, propylene glycol, and other contaminants.
A study by UC Davis Health found that a single dose of BCG reduced liver tumor burden and extended the survival of mice with liver cancer. The vaccine boosted the body's immunity, leading to tumor shrinkage and improved liver function.
Researchers developed a multipronged strategy to identify transporters used by different drugs, revealing potential interactions between commonly prescribed antibiotics and blood thinners. The approach has the potential to improve patient treatment and predict potential toxicities.
A large national study of over 6,000 patients found that video visits, texting and mailing pills were effective and safe for medication abortion. The research supports the safety and efficacy of telemedicine abortion, which has become increasingly important due to clinic closures and wait times.
A new study reveals significant variations in emergency medical service (EMS) performance across urban and rural communities. EMS systems often focus on response times rather than patient-specific clinical care, leading to inconsistent quality of care.
Researchers found that adding blood thinners to clot-busting medications for ischemic strokes did not improve physical function at 90 days post-stroke. The study, MOST, enrolled 514 patients and analyzed the effectiveness of two blood-thinning medications.
Xylazine, a veterinary medication, has been found in the illicit opioid supply, rendering naloxone ineffective in treating overdose cases. Specialized addictions care remains crucial in addressing underlying substance use disorders.
A phase II clinical trial found Muse cell-based product CL2020 to be highly tolerated and improved ALS symptoms, but may not halt disease progression. The treatment's efficacy depends on combining it with other drugs for future treatments.
A study found that tenecteplase is safe and effective for treating ischemic stroke in mobile stroke units, offering a simpler alternative to alteplase. The new medication requires only a single injection, reducing administration time and complications.
A preliminary study found that most stroke survivors can safely take two common types of antidepressants without increasing the risk of hemorrhagic stroke. However, patients on dual anti-platelet therapy may be at increased risk of bleeding.
Researchers developed a novel deep learning method to study crystal structure and molecular interactions of perchlorate salts. The analysis revealed that the explosives' nature is linked to chemical bonding and intermolecular interactions.
A recent study by researchers at Columbia University's Mailman School of Public Health found a significant link between cannabis use and current asthma prevalence among US adolescents and adults. The study analyzed data from the 2020 National Survey on Drug Use and Health, finding that individuals who reported cannabis use in the past ...
A study led by Amsterdam UMC found that a tailored computerised decision support system reduced high-risk drug combinations and improved patient safety. The system only showed alerts for high-risk or needing extra monitoring, resulting in 12% fewer high-risk drug combinations and shorter ICU stays.
A multisite clinical trial will evaluate repurposed FDA-approved drugs as treatment options for patients with Rett syndrome, a rare genetic neurodevelopmental disorder affecting brain development. The study aims to find new therapies to improve the lives of individuals with Rett syndrome, potentially providing multiple treatment options.
A new study published in Heart Rhythm found that over 10% of patients taking quetiapine or haloperidol developed heart rhythm disorders. The study highlights the need for vigilant monitoring of patients using these medications to minimize the risk of cardiac complications.
Researchers found that small declines in blood lead levels were associated with long-term cardiovascular health improvements, including reductions in systolic blood pressure and markers of hypertrophic cardiomyopathy and heart failure. This study suggests that even small decreases in blood lead levels can have meaningful health outcomes.
A study of nearly 900 patients found that delayed or missed diagnoses contributed to temporary or permanent harm in three-quarters of cases. Improving diagnostic tools and techniques could reduce errors by up to 40%, according to researchers.
A new study found that fentanyl-laced prescription pills are driving a surge in overdose deaths among high school age adolescents in the US. The death rate for this group has increased to 5.2 per 100,000, with Arizona and Colorado experiencing rates double the national average.
Clinicians use specific cues to detect and address drug-drug interactions, which can be addressed by investigating alternative treatments, altering dosage, or stopping a medication. The study provides recommendations for EHR system alert design to improve clinician decision-making and patient safety.
Researchers from Brazil discuss the management of refractory or relapsed classic Hodgkin lymphoma in adults, highlighting novel agents such as brentuximab vedotin and immunotherapy. The Brazilian healthcare system's constraints are also considered when making treatment decisions.
A large randomized study investigated the effect of preoperative, low-dose oral administration of midazolam in older patients on patient satisfaction and safety. No significant difference was found between midazolam and placebo groups regarding patient safety.
A new study found that people with Alzheimer's dementia who were treated with lipid-lowering statins showed slower cognitive decline compared to those not treated. The researchers emphasize caution due to the observational nature of the study and initial concerns about statins' effects on patients with dementia.
A phase-one human clinical trial shows that Omadacycline causes a distinctly different effect on the gut microbiome than Vancomycin, making it a safe drug option for patients at high risk for C diff infection. The antibiotic achieves high concentrations in the gut quickly, reducing the risk of long-term colonization.
A phase II clinical trial found that psilocybin-assisted therapy significantly reduced depressive symptoms in adults with cancer and major depression. Participants who received the therapy experienced a decrease in depression severity scores, with 80% showing sustained responses to treatment.
A new U-M study found that 72% of adults in the US have heard of CBD, while fewer are aware of other hemp-derived cannabinoids like delta-8-THC and CBG. The products' lack of regulation and inadequate safety testing pose health risks to consumers, especially young people.
A U of M-led study introduces an innovative genetic engineering method that avoids cost and safety concerns associated with viral vectors. The method combines CRISPR-Cas9 precision genome editing and a novel DNA integration mechanism, integrating large DNA sequences into human T-cells with high efficiency.
A new study found no increased risk of major congenital malformations in infants exposed to second-line non-insulin antidiabetic medications during pregnancy compared to those treated with insulin. The study examined over 3.5 million pregnancies and provided reassurance on the safety of these medications for fetuses.
Researchers developed a modular flow platform to safely execute SuFEx click chemistry, generating toxic sulfuryl fluoride in a controlled manner. The system facilitates rapid functionalization of small molecules, peptides, and proteins.
A study of over 50 babies with HIV found that starting antiretroviral therapy within hours of birth can safely suppress HIV in the blood to undetectable levels. The treatment regimen was shown to halt the formation of hard-to-treat viral reservoirs, potentially leading to ART-free remission.
Two large studies found that people with ADHD who take medication for a long time and in higher doses are at a higher risk of developing some cardiovascular diseases. The highest rate of discontinuation occurred among 18 to 19-year-olds, highlighting the need for better transition to adult psychiatry services.
A novel contamination-detection method enables faster and safer T-cell therapy production, reducing the risk for patients and speeding up treatment. The method uses cutting-edge technology to identify harmful microorganisms within 24 hours.
A phase 2 trial found that durvalumab is safe and may benefit overall survival in non-small cell lung cancer patients with borderline performance status. The study also showed stable quality of life and a lower incidence of severe treatment-related adverse events compared to platinum doublet chemotherapy.
A new pill-sized device has been developed to monitor vital signs like breathing and heart rate from inside humans. The device, known as the VM Pill, was tested in a clinical trial and showed accurate results in detecting breathing stops and monitoring respiration rates with high accuracy.
Researchers have developed a handheld device called MicroNIR that can accurately identify and quantify suspected drug specimens. The device has been shown to be highly accurate, correctly predicting the identity of suspected drugs over 95% of the time.
A new study reveals that melatonin use is increasing among US children and adolescents, with nearly 1 in 5 school-aged children taking the hormone for sleep. The study found that parents are giving melatonin to preschoolers without proper regulation, raising concerns about safety and efficacy.
A three-year intensive treatment strategy to lower systolic blood pressure below 120mmHg significantly reduced cardiovascular events, including heart attack, stroke, and death, compared to standard treatment. The study found that participants in the intensive group experienced fewer major vascular events and deaths over a two-year period.
A new therapeutic, lepodisiran, has shown promising results in reducing lipoprotein(a) levels to undetectable levels for nearly one year. The study found that the medication is safe and effective in lowering Lp(a) levels by more than 94%.
A single dose of zilebesiran safely and effectively lowered systolic blood pressure in people with mild-to-moderate high blood pressure for up to six months. The study found significant reductions in daytime and nighttime systolic blood pressure, as well as low rates of adverse events.