Articles tagged with Personalized Medicine
The UVA Weber Symposium will discuss the latest research and advancements in metastasis, a complex area of cancer research and care. The event will bring together top scientists and physicians to present findings on cancer metastasis, genetics, and treatment considerations.
Recent studies published in The Journal of Nuclear Medicine have investigated new treatments for liver fibrosis, thyroid cancer, and prostate cancer, including the use of PET tracers and radioactive iodine therapy. These studies have shown promising results, including improved imaging and biochemical responses, and increased radiation ...
A novel autologous gene therapy for Wiskott-Aldrich syndrome has demonstrated durable clinical benefits in a phase 3 study, with 96% survival at 1 and 5 years. The treatment, etu-cel, has also reduced severe infections and moderate-to-severe bleeding events.
A new drug, Kamuvudine K-9, has been shown to preserve nerve fibers and halt neurological damage in a mouse model of multiple sclerosis. The drug, derived from HIV drugs, has been found to be more effective than existing treatments in restoring function and reducing inflammation.
A new, incisionless liver cancer treatment called histotripsy was associated with low rates of laboratory toxicity and procedural complications in a real-world review of 972 patients. However, the study found that 11% of patients died within 30 days, suggesting that advanced cancer and overall disease burden may be contributing factors.
The guideline establishes a framework for personalized phage therapy, including standardized procedures for selecting and testing phages, infrastructure development, and quality control. Clinical research indicates a favorable safety profile, but efficacy has yet to be fully demonstrated.
New research in nuclear medicine advances detection and treatment of clear cell renal cell carcinoma with high accuracy, while SSTR antagonists show potential for imaging and treatment of neuroendocrine tumors. Alternative beta-emitting radionuclides are also being explored for targeted radiopharmaceutical therapy.
The new guidelines, developed by leading experts, focus on improving sepsis care by strengthening systems for diagnosis, treatment, prevention, and quality improvement. Emerging technologies, such as next-generation diagnostics and artificial intelligence, are also being explored to enhance sepsis care.
A new AI tool has been developed to predict treatment and survival outcomes in patients with advanced non-small cell lung cancer treated with immunotherapy. The tool consistently outperformed standard clinical biomarkers, achieving high accuracy scores in predicting survival outcomes.
Researchers at CU Anschutz have developed CAR T-cell therapy to target two pathways that help colorectal tumors grow and evade the immune system, B7-H3 and IL-8. The therapy aims to provide a more durable response than traditional chemotherapy.
Several new nuclear medicine approaches are being developed and evaluated for their potential to improve cancer imaging and treatment. Researchers have made significant progress in targeting specific markers and molecules in cancer cells, including CD163, CEACAM5, and DLL3. These advancements offer promising avenues for developing more...
Research evaluated ITGA3 expression across breast cancer subtypes and found its significance in prognosis and therapeutic relevance. High ITGA3 expression was associated with shorter recurrence-free survival and poorer clinical outcomes, making it a potential prognostic biomarker and therapeutic target.
The American College of Cardiology and American Heart Association have introduced a new framework, Tactical Clinical Management (TCM), to evaluate cardiovascular risk and fitness for duty in tactical athletes. This guidance addresses the unique needs of professionals working in high-risk environments, where sudden incapacitation can af...
Researchers at the University of Münster have found that using biomarkers to identify high-risk patients can significantly reduce the risk of kidney damage after major surgery. The approach has great potential to help sepsis patients too, and the team is working to incorporate these findings into international guidelines for the treatm...
Researchers found that meal timing programs the liver's daily rhythms and can have serious metabolic and health consequences when out of sync. The liver uses food signals to activate metabolic pathways, which can conflict with the body's natural circadian clock, leading to health issues.
The authors propose a spectrum of clinical autonomy, ranging from advisory tools to navigator systems that work with minimal human oversight, to enable early prediction and prevention of disease. However, challenges related to clinical validation, integration, data quality, and regulatory approval limit widespread deployment.
Prostate cancer affects 1 in 8 men, with 60% diagnosed in men 65 and older. Clinical trials like Alliance's help improve early detection and treatment, reducing mortality rates by half since 1993. These trials also explore new treatments and survivorship strategies.
A new theranostic pair, 68Ga/177Lu-NYM096, shows excellent tumor uptake in clear cell renal cell carcinoma lesions and demonstrates early evidence of tumor response in patients. The radiotracer can identify tumors and deliver targeted radiotherapy, mitigating toxicity issues common with treatment.
Researchers developed a dual-threshold approach for measuring tumor volume on PET/CT, showing higher total lesion volume associated with shorter overall survival and time to treatment failure. FAPI PET/CT improved detection of ovarian cancer spread, while CD8-targeted PET tracked immune response in lung cancer.
UCSF's new center aims to train 1,000 health care providers annually and develop screening tools to identify eating disorders. The center will also serve as a national hub for eating disorders research, connecting investigators across institutions and disciplines.
USC researchers have developed custom, 3D-printed MRI sensors that provide clearer images of small organs in infants and children. The sensors, which can be customized to individual patients, are made in under 10 minutes and cost around $30.
A new research tool, PGS-TRI, analyzes family data to understand how genetics and environment contribute to autism risk. The tool provides a more precise look at how 'nature' and 'nurture' interact within families, allowing researchers to better understand the complex factors that shape a child's health.
A Swedish population-level study found that individuals with a comprehensive understanding of palliative care are more likely to prefer end-of-life care at home or in a hospice. The study also highlights the importance of earlier palliative care initiation to alleviate suffering and promote well-being.
PSMA PET/CT detected recurrent prostate cancer after minimally invasive treatments and identified malignant peripheral nerve sheath tumors with high accuracy. Researchers also found varying access to PSMA-targeted theranostics between Brazil and Europe.
A new app, WeCareAdvisor, has shown promise in improving the quality of life for dementia caregivers by providing a systematic approach to manage behavioral symptoms. Caregivers who used the app reported significant reductions in distress and behavioral symptoms, as well as improved well-being.
Researchers developed a genetic risk score to analyze risk of type 1 diabetes in patients with MODY, identifying 16% with atypical type 1 diabetes. The score, now adopted as part of NHS testing, provides a diagnosis for patients with negative MODY tests.
The Alliance for Clinical Trials in Oncology emphasizes the significance of clinical trials in advancing breast cancer treatments and early detection. The organization's work has led to a 44% decline in breast cancer mortality rates among women since 1989.
The RadiCaL study, the first randomized trial of a radiopharmaceutical in kidney cancer, found that adding radium-223 to the standard of care does not improve skeletal event-free survival. Patients who received the combination treatment lived a median of 28.3 months, compared with 19.7 months for those who received cabozantinib alone.
A new book by University of Virginia Health System expert Daniel J. Cox outlines a practical alternative to medication for managing pre-diabetes and type 2 diabetes. The GEM program emphasizes smart eating, physical activity, and listening to the body to regulate blood sugar levels.
Research published in The Journal of Nuclear Medicine highlights the importance of intermediate amyloid PET uptake in Alzheimer's disease diagnosis and its association with cognitive decline. Additionally, studies show promising results for early SPECT/CT response prediction in PSMA-positive prostate cancer treatment, as well as potent...
Researchers developed an AI model that analyzes routine whole histopathology images to predict cancer subtype, genetic mutations, and survival outcomes across 32 solid cancers. The model achieved a strong predictive accuracy score for TP53 mutation detection and demonstrated the ability to infer RNA expression levels and tumor taxonomy.
Researchers have developed a potential new approach against the highly drug-resistant hospital fungus Candida auris. A synthetic sugar molecule that corresponds to a component of the fungus's surface has been identified as a promising basis for a vaccine, protective antibodies, and a rapid diagnostic test.
The UH Health initiative expands training, accelerates research and innovation, and improves access to care in Texas. It brings together medicine, nursing, pharmacy, optometry, psychology, social work, population health, and others under one interprofessional vision.
New research articles published in The Journal of Nuclear Medicine explore intensified PSMA-targeted therapy for advanced prostate cancer, as well as novel approaches to targeted radiopharmaceutical therapy. Studies also investigate radiation doses from PSMA-targeted therapy and their relationship with treatment outcomes, while others ...
Researchers developed a method to predict how different types of breast cancer will respond to treatment using lab-grown mini tumors. The organoids mimicked a tumor's response to treatment and identified candidate combination therapies for cancers that don't respond to standard treatment.
The Human Cancer Model Initiative released a compendium of more than 150 organoid models of 25 types of cancer, which are now available to scientists worldwide. These patient-derived organoids provide state-of-the-art research tools for accelerating discovery and developing personalized treatment strategies.
A team of researchers at UMass Amherst has developed an AI model, DiffuDose, that generates a patient's radiation dose map with gold-standard accuracy in under 23 seconds. This technology has the potential to unlock the full potential of radiopharmaceutical therapy for prostate cancer treatment.
A CU Anschutz-led clinical trial found an automated oxygen delivery system helped hospitalized patients spend significantly more time in their target oxygen range compared to standard care. The system reduced exposure to both low and high oxygen levels, with no increase in serious adverse events.
Researchers explore how engineered lanthanide carriers can tune the optical and magnetic properties of ions for improved signal contrast and reduced background signals in biomedical imaging. The study highlights opportunities for multimodal imaging, theranostics, and AI-guided probe design.
Recent progress in lanthanide carriers is mapped to improve biomedical imaging and diagnosis, combining optical, X-ray, and magnetic resonance imaging techniques. These carriers enable high-resolution imaging with tunability for different applications, reducing tissue damage and enhancing image clarity.
The US government's withdrawal of funding for global HIV programs led to a sharp reduction in the number of people entering HIV care across East Africa. New patient enrollment dropped by 59% and viral load testing declined by 33% within weeks, according to findings from researchers at UC San Francisco.
Researchers found that genetic factors play a role in how individuals respond to a low-carb, high-fat diet, with those at higher risk experiencing greater increases in LDL cholesterol. The study suggests personalized dietary guidance based on genetic profiles could help identify who may experience adverse responses to certain diets.
A new study published in The Journal of Nuclear Medicine has found that dual-energy SPECT may enable faster monitoring of PSMA therapy, reducing imaging time from 18 minutes to 9 minutes. Another study showed a prognostic model using PSMA PET can predict outcomes after therapy, including overall survival and PSA progression-free survival.
Researchers discovered 171 distinct mutations causing MET exon 14 skipping in lung cancer patients. RNA-based testing confirmed these alterations, highlighting the importance of complementary diagnostic approaches.
A retrospective cohort study found that language-concordant physician care significantly reduces all-cause mortality in both Francophone and Allophone patients. The study suggests prioritizing patient-physician linguistic matching and evidence-based interpretation services to improve long-term survival in Canada's increasingly linguist...
Researchers developed a framework to integrate AI into hospitals, emphasizing patient care, staff experience, and economic sustainability. The Total Mission Value framework aims to ensure high-quality patient care remains the top priority amidst AI's transformative potential.
A Chinese neurosurgical journal's study found that severe stenosis of major intracranial arteries increases the risk of cerebral infarction after revascularization surgery in moyamoya disease. Severe blockage was associated with postoperative infarctions, highlighting the importance of monitoring and mitigating this risk factor.
A noninvasive DNA blood test can identify patients with metastatic castration-resistant prostate cancer most likely to benefit from <sup> 223 </sup> Ra radiopharmaceutical therapy and monitor their progress. The test showed associations between ctDNA profiles and clinical outcomes, including biomarker response and overall survival.
Researchers have made significant breakthroughs in targeted radiation therapy for pancreatic cancer, PARP inhibitor treatment, and Alzheimer's disease detection. New PET-based scores may predict prostate cancer outcomes, while blood cell mutations are associated with side effects in advanced prostate cancer patients.
Researchers analyzed genetic data from almost 100,000 people across eleven world regions, identifying regional differences in gene variants GBA1 and LRRK2. This study is crucial for globally equitable diagnostics and therapies as it highlights the need to consider ancestry when diagnosing Parkinson's disease.
A new machine learning version of the Martin-Hopkins equation accurately assesses LDL cholesterol risk with minimal difference to the original, making it accessible to all laboratories. The simplified code enables clinicians and patients to make better decisions about starting treatments that prevent heart attacks and strokes.
A buildup of bile acids caused by an unhealthy gut can drive breast cancer to other parts of the body, researchers reveal. The study found that replenishing beneficial bacteria or treating patients with FDA-approved bile acid sequestrants may reduce breast cancer metastasis.
A new statistical test developed by Stanford researchers assesses whether personalizing interventions is worth it. The K-fold personalization test (KPT) provides an estimate of expected benefits and a range for potential gains, helping users understand trade-offs involved in tailoring interventions to individuals. This tool can aid inf...
The Association for Molecular Pathology has elected new leaders for several committees, including Genetics, Hematopathology, Infectious Diseases, Informatics, and Solid Tumors. The newly elected leaders will work together to drive the organization's mission forward.
A new study found that simple weekly electronic symptom check-ins with care teams significantly improves the quality of life for individuals undergoing treatment for advanced cancer. The benefits were notable among patient groups that historically faced barriers to care, including Black patients and those with less formal education.
Recent studies published in The Journal of Nuclear Medicine have shown that combining multiparametric MRI with PET improves the detection of clinically significant prostate cancer. Additionally, PSMA PET/CT-guided biopsies have been found to detect more significant cancers than standard biopsies.
The center aims to address the structural gap in care delivery by offering advanced functional diagnostics, individualized treatment planning, surgical intervention, and long-term management. Led by Professor Sungsoo Park, it provides objective, precision-based diagnosis and tailored treatment strategies for patients with refractory GERD.
A large-scale study of an online patient portal shows that AI-generated responses can introduce errors and extraneous details, leading to increased editing time for physicians. Adapting AI to individual physician communication styles can improve accuracy by 33% and reduce editing by 26%.
A French multicenter study found that nearly half of ICU survivors had unfavourable functional outcomes 1 year after intensive care for bacterial meningitis. Hearing loss, depressive symptoms, and impaired physical quality of life were common among survivors.
A blood test may help identify which patients with colorectal cancer that has spread to the liver are most likely to benefit from chemotherapy after surgery. Patients with detectable circulating tumour DNA (ctDNA) who received adjuvant chemotherapy had markedly better outcomes, including a 93% reduction in recurrence.