Personalized Medicine
Articles tagged with Personalized Medicine
New targeted radiopharmaceutical therapy induces remission in pancreatic cancer model
Recognizing and managing IEC-HS: A life-threatening complication of CAR-T therapy
Experimental drug shows promise for some patients with advanced prostate cancer
Chinese Neurosurgical Journal study shows heat-based therapy alters epilepsy brain networks
Results of major heart study set to save lives, reduce unneeded heart implants
Bronchiectasis and NTM Care Center Network expands to 62 centers
ERASur colorectal cancer trial reaches one-third patient accrual milestone
The ERASur clinical trial is investigating whether total ablative therapy can improve overall survival in patients with newly diagnosed, limited metastatic colorectal cancer. The study has reached one-third patient accrual milestone, signaling strong momentum.
How can the same genetic mutation lead to different clinical outcomes?
Researchers developed a framework to study the impact of genetic variants on neurodevelopmental disorders. By analyzing induced pluripotent stem cells, they found that genetic background can lead to different clinical outcomes in individuals with the same deletion on chromosome 16.
New study finds low-dose eye drops successful in managing adult myopia for 24 hours
A new study published in Eye and Vision finds that one drop of low-dose atropine can produce daylong effects in managing myopia. The researchers found that the drop showed clear changes in pupil size and focusing ability, but no short-term structural effects on the eye.
The Journal of Nuclear Medicine Ahead-of-Print Tip Sheet: May 4, 2026
Recent research published in The Journal of Nuclear Medicine has made significant advancements in brain imaging and cancer treatment. A new wearable brain imaging system, SmartBrain, enables real-time imaging beyond the lab, capturing high-resolution images of brain activity without requiring patients to remain still.
Trial now enrolling seeks to answer key question: Does adding chemotherapy to hormone therapy improve survival for metastatic prostate cancer?
The ASPIRE trial aims to enroll 1,200 participants with advanced prostate cancer and assess the impact of chemotherapy on overall survival and disease progression. Genetic profiling is included to identify patients who benefit most from intensified treatment.
Novel theranostic approach for radioimmunotherapy achieves curative responses in colorectal cancer tumors
A new pretargeted radioimmunotherapy technique has been shown to be effective and safe in eradicating tumors from a preclinical colorectal cancer model. The multi-step theranostic approach delivers alpha-emitting radiation directly to tumors while limiting exposure to healthy tissues.
Revealing the unusual ability of a protein involved in lung and thyroid cancer
Researchers have discovered that the CCDC6-RET protein can activate itself, accelerating its function and making it a promising target for cancer therapy. The study also reveals a new mechanism of action, where the protein can utilize both ATP and ADP as energy sources.
Phone-based education improves inhaler use in people with COPD
A phone-based teach-to-goal program improved correct inhaler use in Medicare Advantage beneficiaries with COPD. The study found that nearly 40% of participants used their inhaler incorrectly initially, but after the program, only about 7% were incorrect, resulting in a significant reduction.
The Journal of Nuclear Medicine Ahead-of-Print Tip Sheet: April 23, 2026
Researchers have made significant breakthroughs in prostate cancer treatment with new imaging techniques and targeted therapies, including a PSMA-targeting antibody and a CD44v6-targeting radiotherapy. These advancements aim to improve patient outcomes by tailoring diagnosis and treatment to individual needs.
USC and Tempus form strategic collaboration aimed at accelerating innovation across research and patient care
The Keck School of Medicine of USC and Tempus are creating a system-wide framework to integrate clinical care, clinical trials, and research through AI-powered precision medicine tools. The goal is to enhance patient care and accelerate research and innovation.
City of Hope and UC Berkeley researchers teach AI to spot cancer risk by squeezing individual breast cells
Researchers developed a microfluidic platform that squeezes individual breast epithelial cells to measure their mechanical age, revealing an unexpected insight: older cells are stiffer and at higher risk of cancer. The AI-powered platform provides a non-genetic test for women with unknown genetic risks.
SNMMI annual meeting to take place May 30-June 2, 2026
The SNMMI 2026 Annual Meeting will showcase the latest scientific developments driving advances in nuclear medicine, including earlier diagnosis, personalized treatment, and improved disease management for various conditions. The meeting will feature over 150 scientific sessions, satellite symposia, and a cutting-edge exhibit hall.
A new era for nutritional epidemiology: researchers outline blueprint for precision and sustainable diets
Researchers outline blueprint for precision nutrition and sustainable diets, integrating AI, multi-omics and digital twin technology to provide personalized dietary recommendations and address environmental impact.
UNITE Project announces its first digital health winners as remote care and data-sharing push gains ground
The UNITE project has selected three joint interregional projects to tackle health data sharing and personalized remote care. The selected projects will focus on heart failure, neonatal intensive care, and radiation exposure in medical imaging.
Rett syndrome study highlights potential for personalized treatments
A new study by MIT researchers uses advanced human cell cultures to model Rett syndrome, revealing distinct abnormalities caused by two different mutations of the MECP2 gene. The findings suggest that correcting key differences made by each mutation requires different treatments, paving the way for personalized therapies.
Clinical trial aims to address vaginal complaints after breast cancer diagnosis
A clinical trial aims to evaluate whether laser therapy reduces vaginal dryness caused by breast cancer treatment. The study, REVITALIZE, plans to enroll approximately 250 women with a history of breast cancer who experience moderate to severe vaginal dryness.
New study reveals why some Chinese immigrants in the US may turn to China-based telehealth apps
A recent study found that 15% of Chinese immigrants use China-based telehealth apps for medical advice while living in the US. These apps are preferred due to lower costs, ease of access, and language support. However, reliance on foreign-based services raises concerns about patient safety, continuity of care, and regulatory oversight.
AI gives doctors early warning of disease “tipping points” — often from a single patient sample
Researchers develop dynamics-driven models to identify disease transitions before symptoms appear, transforming real-time care and personalized treatment. AI systems analyze health data to detect
The Journal of Nuclear Medicine Ahead-of-Print Tip Sheet: April 10, 2026
Researchers developed a new chelator to improve cancer imaging and therapy. Additionally, analyzing brain glucose uptake in patients with non–small cell lung cancer may help predict prognosis. A targeted PET imaging agent is also being developed to detect liver cancer more effectively.
Without the right tests, the best medicines make no difference
A new analysis from UC San Francisco argues that diagnostics are being overlooked, slowing progress against major diseases despite advances in targeted therapies. The study suggests that nearly half of the world's population lacks adequate access to diagnostics due to inadequate investment and insurance reimbursement.
Scientists reverse severe epilepsy in lab mice in promising step toward a cure
Researchers used base editing to correct the SCN8A gene mutation responsible for severe inherited epilepsy. The approach successfully eliminated or reduced seizures and improved brain function in lab mice, offering new hope for treating genetic epilepsies.
The Journal of Nuclear Medicine Ahead-of-Print Tip Sheet: April 3, 2026
Researchers have developed new PET tracers that can track synaptic density in epilepsy and monitor tau buildup in Alzheimer's disease. A novel PET tracer also maps cellular energy use across the body, enabling faster imaging approaches for studying mitochondrial function.
Prioritizing potentially cancer-causing mutations in real-world cancer genomics
A framework has been developed to identify candidate pathogenic variants hidden among uncertain significance variants detected in comprehensive genomic profiling. The framework was tested using BRCA1 and BRCA2 genes, leading to the classification of a previously unknown variant as pathogenic.
Molecular test doubles detection of bile duct cancer
The BiliSeq test detected approximately 82% of bile duct cancers, compared to 44% with pathology alone, and increased cancer detection to nearly 90% when combined with pathology. This improved accuracy enables physicians to provide more personalized medicine and treatment options for patients.
The Journal of Nuclear Medicine Ahead-of-Print Tip Sheet: March 27, 2026
Recent studies published in The Journal of Nuclear Medicine have made significant advancements in the field. Researchers have developed a new tracer to detect active collagen turnover following myocardial infarction and evaluated folate-based radioconjugates for ovarian cancer imaging. Additionally, targeted radiotherapy shows promise ...
Tumor DNA circulating in patients’ blood after pre-surgery treatments predicts whether breast cancer will return
A study found that tumor DNA in patients' blood can predict whether breast cancer will return, especially after neoadjuvant treatment. Patients with detectable DNA at the end of treatment were 3.5 times more likely to relapse during follow-up.
Radiotherapy rather than surgery may help reduce risk of lymphoedema in patients with breast cancer: results from pilot study
A pilot study found that axillary radiotherapy may be as effective as surgery in killing cancer cells while reducing the risk of painful swelling. The trial compared radiotherapy to axillary lymph node dissection and found similar cancer outcomes, but lower rates of lymphoedema after radiotherapy.
Mediterranean diet may boost mitochondrial signals linked to heart and brain health
Researchers found that people following a Mediterranean-style diet have higher levels of humanin and SHMOOSE, which are linked to protection against cardiovascular disease and neurodegeneration. The study suggests that specific components of the Mediterranean diet may directly influence mitochondrial biology.
European project brings AI-powered cancer genome interpretation closer to the clinic
The European project CGI-Clinics brings AI-powered Cancer Genome Interpreter (CGI) closer to clinical applications, enabling reliable and scalable tumour genome interpretation in precision oncology. The platform leverages machine learning to transform complex genomic data into actionable insights.
Medical centers highlight responsible ways to share genetic disease risk information
A study by Cincinnati Children's Hospital Medical Center and the eMERGE network found that sharing genetic disease risk information with patients can be done responsibly, with a 70% success rate. The team shared results with over 24,000 people using various methods, including one-to-one conversations for those with higher-risk findings.
David H. Ballard, MD, receives SNMMI Mars Shot Research Fund Award
Dr. David H. Ballard, MD, has been awarded a $100,000 grant from the SNMMI Mars Shot Research Fund to develop novel PET/MR imaging techniques for metabolic activity and inflammation in Crohn's disease. The study aims to improve biologically informed decision-making and guide treatment decisions.
Largest study of its kind tests hydration strategy for kidney stones
The largest behavioral study on kidney stone prevention tested a hydration program with Bluetooth-enabled smart water bottles and personalized hydration goals. While participants did hydrate more, the increase wasn't large enough to lower symptomatic kidney stone recurrence across the group.
The Journal of Nuclear Medicine Ahead-of-Print Tip Sheet: March 20, 2026
The study investigated the link between heart attack-induced inflammation and cognitive decline, as well as the potential of PET-based metabolic tumor volume to predict CAR T-cell therapy outcomes. Additionally, researchers combined advanced imaging with genetic profiling to explore hidden metabolic patterns in recurrent brain cancer.
How old are we really?
Researchers develop method using biomarkers to calculate individual biological age, finding significant differences in age-related changes between men and women. The study also identifies clinically relevant biomarkers linked to biological age, opening up new opportunities for preventive medicine.
Carolyn J. Anderson, PhD, receives SNMMI Mars Shot Research Fund Award
Dr. Carolyn J. Anderson has been awarded a $100,000 grant from the SNMMI Mars Shot Research Fund to develop a PET radiotracer for imaging vaso-occlusive crisis in sickle cell disease. The award will support the production and validation of an easy-to-produce and high-yielding PET radiotracer, 18F-LLP2A, for rapid translation to patients.
Chun Li, PhD, receives SNMMI Mars Shot Research Fund Award
Dr. Chun Li has been awarded the SNMMI Mars Shot Research Fund Award to investigate the PET radiotracer 64Cu-DbCD11b for detecting vulnerable atherosclerotic plaques. The study aims to assess the non-invasive assessment of vulnerable plaques and aid in patient risk identification and treatment.
Arvin Haj-Mirzaian, MD, and Pedram Heidari, MD, receive SNMMI Mars Shot Research Fund Award
Researchers Haj-Mirzaian and Heidari aim to develop non-invasive imaging biomarker <sup> 18 </sup> F-NaF PET/CT for early calciphylaxis diagnosis in dialysis-dependent patients. This could lead to timely interventions, reduced mortality, and improved patient outcomes.
European Psychiatric Association rolls out landmark action plan to modernize care and protect vulnerable mental health communities across Europe
The European Psychiatric Association has launched an action plan to address unmet needs in psychiatric care, focusing on brain health, treatment delivery, stigma reduction, and preventive measures. The plan aims to improve diagnostic accuracy and precision care through its 80,000-psychiatrist network.
Ansel Hillmer, PhD, and Eric Webb, PhD, receives SNMMI Mars Shot Research Fund Award
Researchers Ansel Hillmer and Eric Webb have received the $100,000 Drs. Jane & Abass Alavi Mars Shot Research Award to advance imaging research in infection and inflammation for Alzheimer's disease. They aim to develop a PET radiotracer targeting CSF1R to diagnose and monitor brain inflammation.
$3.4 million grant to improve weight-management programs
A $3.4 million NIH grant will fund a semi-automated feedback system to support people tracking diet, exercise, and weight in weight-management programs. The system aims to provide personalized feedback to increase tracking and weight loss success.
Smartphone healthcare app features motivate users to increase physical activity
The study highlights the importance of personalized features in healthcare apps to promote physical activity. Key findings include the need for educational components, timely feedback, and tailored exercise suggestions to support users' daily routines and work demands.
The ISSCR launches new continuing education course on stem cell therapies for Parkinson’s disease
The ISSCR has launched a new continuing education course on stem cell therapies for Parkinson’s disease, addressing the need for clinicians to provide accurate information on emerging treatments. The course features expert faculty and patient perspectives, and is available through a free and paid pathway.
Severe COVID-19, flu facilitate lung cancer months or years later, new research shows
Severe COVID-19 and influenza infections can prime the lungs for cancer development, according to new research. Vaccination, however, largely prevents these changes, suggesting a reduced risk of lung cancer.
Optical genome mapping detects additional genetic variants in nearly 20% of individuals with acute leukemia
A new clinical diagnostic test using optical genome mapping (OGM) has been shown to detect additional genetic variants in nearly 20% of individuals with acute leukemia. OGM offers a comprehensive view of the genome, refining diagnosis and risk stratification, and improving therapy selection. The test's high diagnostic yield and ability...
16-year study finds major health burden in single‑ventricle heart
A 16-year study found that 87% of children with single-ventricle heart disease either died or developed a major health problem over time. The study provides new direction for improving care and offers guidance for tailoring therapies to each child.
Alliance trial aims to improve outcomes for chronic lymphocytic leukemia
The Alliance trial explores the combination of zanubrutinib and sonrotoclax for CLL treatment, aiming to send cancer into remission and allow patients to stop treatment earlier. The study has the potential to be life-changing for patients and their families, reducing the burden of ongoing therapy and improving quality of life.
Chinese Neurosurgical Journal reports new therapy for hard-to-treat brain aneurysms
A prospective multicenter study found Woven EndoBridge therapy safe and effective for unruptured wide-necked bifurcation aneurysms in Chinese patients. The therapy promotes durable aneurysm occlusion with minimal risks.
Alliance for Clinical Trials in Oncology highlights new and open colorectal cancer trials in March
The Alliance for Clinical Trials in Oncology is spotlighting new trials for colorectal cancer in March, focusing on early detection methods and treatments for treatment delays and loss of appetite. The trials aim to improve patient outcomes, with several enrolling patients with newly diagnosed colon or rectal cancer.
The Journal of Nuclear Medicine Ahead-of-Print Tip Sheet: March 6, 2026
Researchers have developed new imaging techniques to detect hidden infections, inflammatory diseases, and cancers, while also evaluating the effectiveness of AI-powered tumor measurement and targeted radiotherapy for advanced solid tumors.
Buck Institute launches Healthspan Horizons to turn long-term health data into Actionable healthspan insights
Healthspan Horizons links real-world longitudinal data with deep discovery science to create uniquely powerful, long-term datasets revealing what drives human healthspan over time. The platform aims to translate discoveries into clearer guidance on what helps people stay resilient, supporting more years of energy, strength, and indepen...
Using the vagus nerve to treat disease: Review maps today’s science, points to tomorrow’s therapies
A comprehensive review synthesizes the science behind vagus nerve modulation therapies, which use controlled signals to influence brain circuits and inflammation. The authors identify key mechanisms and propose next-generation treatments tailored to individual patients and conditions.
A decision-support system to personalize antidepressant treatment in major depressive disorder
A decision-support system improved depressive and anxiety symptoms, increased medication adherence, and reduced symptoms over time for patients with major depressive disorder. The system used clinical and demographic predictors to tailor treatment, resulting in better outcomes for patients compared to usual care.
The Journal of Nuclear Medicine ahead-of-print tip sheet: February 27, 2026
Researchers have developed a new PSMA-targeted PET tracer that shows promise in early human studies, providing strong tumor uptake and favorable radiation dosimetry. Additionally, advanced dynamic PET imaging has been used to track heart amyloid buildup more precisely, detecting significant reductions after six months of tafamidis ther...