Articles tagged with Infectious Diseases
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
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Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers developed a new surveillance technique to track COVID-19 diversity using genomic data, predicting variant emergence with high accuracy. The software can forewarn public health officials of impending outbreaks, enabling timely responses and more effective disease monitoring.
A new study found that older macaques with smaller social networks suffer less from infectious disease. The research suggests a powerful reason for reduced social connections in aging animals, including humans.
A study from Osaka University found a reliable wastewater surveillance method, tracking regional infection trends with high sensitivity and reproducibility. The research team concluded that at least three samples per week are required for accurate monitoring.
A study found that 4.6% of Nigerian participants with COVID-19 experienced neurologic symptoms, with some still experiencing symptoms two years after their initial episode. Researchers plan to treat these patients using similar techniques used in the US, aiming to alleviate their suffering.
Providencia rustigianii carries a type III secretion system and cytolethal distending toxin virulence gene, increasing its pathogenicity, similar to Salmonella.
Researchers at Penn Medicine have developed the first mRNA vaccine against C. difficile, a bacterium that causes severe diarrhea and colon damage. The vaccine induces a robust immune response, promotes clearance of existing bacteria from the gut, and overcomes deficits in host immunity to protect against infections.
Researchers created a single cell atlas of prenatal human skin, providing a molecular recipe for building skin. The study also led to the creation of a mini organ model that grows hair, offering insights into scarless skin repair and potential clinical applications in regenerative medicine.
The Lancet Commission on Investing in Health recommends focusing on 15 priority health conditions to achieve a 50% reduction in premature deaths. Raising taxes on tobacco is key, with estimates suggesting it could reduce mortality rates by more than any other single policy.
A new study found that babesiosis rates rose 9% annually between 2015 and 2022, with 42% of cases linked to other tick-borne illnesses. Co-infection with Lyme disease did not increase mortality risk, but patients received doxycycline treatment more frequently.
The invasive tiger mosquito expands its host range as it spreads across regions, with a greater diversity of hosts in the invasive range. The mosquito's ability to adapt to new environments and act as a bridge vector for pathogens increases the risk of disease transmission.
A Canadian study finds that treatment for vulnerable people with endocarditis includes in-hospital addiction support and community care, with special attention to the needs of marginalized young women. Women who inject drugs are disproportionately affected by endocarditis and have higher long-term mortality rates than men.
A Spanish study found that the influenza vaccination campaign for children aged 6-59 months was effective in preventing acute respiratory infections and hospitalization. The study estimated the vaccine to be 70% effective against any influenza type and 77% effective against severe cases.
The Academy of Breastfeeding Medicine has released comprehensive guidelines for protecting, promoting, and supporting breastfeeding in emergency situations. The recommendations aim to safeguard the health and well-being of infants in disasters and conflicts by ensuring safe nutrition and immune protection.
A cross-sectional study found significant increases in sudden unexpected infant death (SUID) and sudden infant death syndrome (SIDS) during the COVID-19 pandemic. The rise in SUID rates was linked to off-season resurgences of infectious pathogens, with RSV rates closely approximating this shift.
Researchers have developed an antibody that can identify Campylobacter jejuni and inhibit its growth, reducing pathogenicity. The antibody targets a multiprotein complex essential for the bacteria's energy production, making it a potential target for therapy and vaccination.
A recent cohort study found that prenatal exposure to COVID-19 during pregnancy did not increase the risk of autism screening in toddlers. The research suggests that maternal SARS-CoV-2 infection and pandemic-related exposure had no significant impact on autism positivity rates.
A cohort study found a significant association between maternal influenza infection during pregnancy and an increased risk of childhood seizures. The study suggests that maternal influenza may affect childhood neurological development, particularly for febrile seizures, but not epilepsy.
Researchers analyzed over 150,000 COVID-19 cases in Japan and found CAPA occurred in 0.4% to 2.7% of severe or critical patients, with higher risk seen in men, older adults, and those with respiratory diseases. Early detection and treatment with antifungal drugs are crucial for improved outcomes.
Researchers have conducted the largest genomic survey of the syphilis bacterium to date, correlating genetic data with clinical information to identify potential targets for a vaccine. The study found differences in bacterial strains between continents, but also similarities that suggest a global vaccine could be effective.
A new study from European universities has developed a method to analyze wastewater data from seven major cities, identifying thousands of disease-causing bacteria, viruses, and antimicrobial resistance. This approach can detect potential health threats simultaneously, potentially preventing epidemics from escalating into outbreaks.
Researchers have discovered a new class of natural antimicrobials called microcins that can target specific strains of bacteria causing cholera, inflammatory bowel disease, and colon cancer. Microcins are highly selective and can potentially remove unwanted bacteria without disrupting the human gut microbiome.
A recent study by ISGlobal found a vast range of viable bacteria and fungi transported by air masses from northeast China to Japan, some potentially pathogenic to humans. The research team identified over 266 fungal and 305 bacterial genera in aerosol samples, including species resistant to commonly used antibiotics.
A study published by the European Respiratory Society found that hypertonic saline nasal drops reduced the length of the common cold in children by an average of two days. The treatment also reduced the need for medicines during illness and decreased family members catching a cold.
A team of researchers from Osaka University has pinpointed the B cells responsible for boosting COVID-19 immunity after vaccination. They found that activated atypical B cells are the main responders to mRNA vaccines, providing a new way to assess vaccine response and underlying biology.
Researchers identified seasonal patterns in Valley fever cases influenced by California droughts. The study found that while most cases occur from September to November, drought periods temporarily dampen these peaks, but lead to bigger surges once rain returns.
This study found modestly increased risks of inflammatory bowel disease and bullous skin disorders in hospitalized patients infected with the Omicron variant. Booster vaccination mitigated long-term autoimmune sequelae risk.
A subset of CD4 T cells create an anti-inflammatory environment within the lung tissue, protecting against TB reinfection by limiting bacterial growth and disease severity. The discovery complements previous research on protective immune T cells in controlling TB infection, suggesting a potential key to improving existing vaccines.
A new vaccine created by Mizzou researchers protects cattle from bovine anaplasmosis, a devastating tick-borne disease causing hundreds of millions of dollars in economic losses. The vaccine has been proven to give immunized cattle protection for at least a month and is being discussed with industry partners for future distribution.
Researchers discovered that the blood coagulation protein fibrin causes unusual clotting and inflammation in COVID-19, suppressing the body's ability to clear the virus. A promising therapeutic strategy has been identified, targeting fibrin to combat these deleterious effects.
Researchers found that Prunin laurate, derived from citrus and coconut biomass, inhibits bacterial growth in periodontal pathogen Porphyromonas gingivalis. The compound is tasteless and hypoallergenic, making it a potential inexpensive antimicrobial solution for preventing oral inflammation.
Patients with post-COVID-19 mRNA vaccination myocarditis show lower cardiovascular complications at 18 months compared to those with conventional myocarditis. However, affected patients may require medical management for several months after hospital discharge.
A European study found that prior smallpox vaccination in childhood could offer protection against infections caused by monkeypox virus (MPXV) clade II in men. The estimated degree of protection varied among countries, highlighting the need for further research.
A team of researchers at UC Davis Health discovered a novel bioelectrical mechanism that allows Salmonella bacteria to navigate the gut lining and find vulnerable entry points. The study found that Salmonella bacteria detect electric signals in FAE, which helps them move towards openings in the gut where they can enter.
Researchers found that COVID-19 proteins can lower cortisol levels in the brain, leading to a heightened stress response and inflammation. The study suggests that this phenomenon may contribute to the neurological symptoms of Long COVID, including fatigue, depression, and memory problems.
A study analyzing 12 years of data from over 500 hospitals in 25 US states found that weather and geographic location impact hospitalizations for waterborne diseases. Precipitation, soil moisture, and rural locations were linked to increased rates of certain infections.
A study found that individuals exposed to famine in early gestation had a two-fold likelihood of developing Type 2 diabetes, with extreme variations in intensity across provinces. The research highlights the importance of policies aimed at preventing events like the Holodomor from happening again.
Researchers at Karolinska Institutet have conducted a Phase 2 UNITY clinical trial involving pregnant women with a history of very severe HDFN. Nipocalimab was found to prevent and mitigate the disease without causing serious side effects in the mother or fetus.
A clinical study in Birmingham has found that nipocalimab can improve the survival rate of unborn babies with rare fetal anaemia. The majority of pregnant patients who received nipocalimab gave birth at or after 32 weeks without needing an intrauterine transfusion, resulting in a perinatal survival rate of 92%.
Researchers have trained dogs to sniff out Chronic Wasting Disease (CWD) in the droppings of farmed and wild deer. This method offers a promising non-invasive approach for detecting CWD.
A team of researchers from Stanford University and Brazil has developed models to predict the impact of environmental changes on schistosomiasis, a disease affecting over 200 million people worldwide. The collaboration has helped epidemiologists prioritize public health interventions and identify new transmission hotspots.
A new study reveals that blowflies in southern Japan are carrying the bird flu virus, which could lead to transmission through contaminated surfaces, food sources, and water. This finding highlights the need for effective countermeasures to prevent and control the disease in poultry farms.
A comprehensive meta-analysis found that interventions increasing access to vaccines and providing transportation assistance tripled vaccination odds, particularly in low-income countries. Financial incentives also showed a moderate effect, but were less impactful.
Researchers find significant association between illicit fentanyl use and HCV transmission, highlighting need for point-of-care testing and treatment access. The study suggests that fentanyl's short half-life may lead to increased risk of HCV transmission through frequent dosing and sharing.
A preclinical study led by Weill Cornell Medicine researchers found that the iron-chelating drug deferiprone can selectively target and kill ovarian cancer cells. By starving cancer cells of iron, deferiprone triggers a cellular stress response, prompting the immune system to attack them.
A Madrid study found a significant decrease in active hepatitis C infection among people who use drugs (PWUD) from 23% to 6% between 2017 and 2023. The study attributed this decline to improved access to testing and treatment, as well as public health campaigns.
The study tested wearable sensors and associated alerts to guide people's behavior, finding that personalized timing and symptom-based notifications led to higher self-test rates. The researchers also emphasized the importance of designing and clinically implementing new wearable sensors that track various health parameters.
A study by Dr. Takanori Sekito and colleagues reveals a strong association between vaginal pathogenic Escherichia coli and recurrent cystitis in postmenopausal women, suggesting that targeting both the urinary bladder and vagina is crucial for effective treatment.
The new guidelines from the Surgical Infection Society offer updated recommendations for antimicrobial agent selection, source control, and treatment of specific pathogens. These evidence-based guidelines aim to improve clinical outcomes and reduce mortality rates from intra-abdominal infections globally.
A Cleveland Clinic-led study found that maternal Zika virus infections can reprogram fetal immune development, leading to long-term consequences in children's immunity. The changes occur even in children born without physical or neurological symptoms of congenital Zika syndrome, suggesting a broader impact.
Pamela J. Bjorkman, K. Christopher Garcia, and Ian A. Wilson receive inaugural prize for their groundbreaking research in structural immunology, which has paved the way for novel disease treatments and revealed new insights into the immune system.
Researchers found that certain flu viruses can use a second entry pathway, MHC class II protein complexes, to infect human and animal cells. This ability helps the viruses infect different species and potentially jump between animals and humans.
Researchers developed a strategy to identify new antimicrobial drugs with therapeutic promise from bacterial datasets. PHAb10 and PHAb11 showed robust antibacterial activity against various bacterial species, including those resistant to traditional antibiotics.
Researchers identified six priority pathogens for WWS during the Paris 2024 Games, including poliovirus, influenza A virus, and SARS-CoV-2. The study offers a model framework for context-specific WWS targets in mass gatherings.
A team of researchers has discovered a mechanism by which the liver's immune cells are suppressed in chronic hepatitis B, leading to organ damage. The 'sleep timer' function allows immune cells to weaken their activity over time, preventing them from proliferating excessively and causing further damage.
Researchers discovered Pradimicin A's molecular basis for binding to viral N-glycan, showing promise as an anti-SARS-CoV-2 drug. The compound inhibits SARS-CoV-2 infectivity by interacting with branched oligomannose-containing glycans.
Scientists have developed a new immunotherapy that can identify and fight cancer cells in patients with Merkel cell carcinoma. The treatment involves stimulating the immune system's T cells against specific elements of the virus involved in cancer formation.
Genital herpes infections have a significant global impact, with estimated health care expenditures and productivity losses totaling $13 billion annually. The study highlights the need for increased investment in preventing herpes transmission, including the development of effective vaccines.
Researchers found that H5N1 virus particles in unpasteurized milk can remain stable on metal and rubber components of commercial milking equipment for over an hour. This increases the potential for bird flu exposure among dairy farm workers and animal-to-animal transmission.
A new mathematical model suggests that waiting two days after symptoms arise for rapid COVID tests can increase accuracy by reducing false negatives. The model also recommends a 'test-to-exit' strategy to prevent infections and minimize inconvenience, which may be more effective than the five-day isolation policy.
Researchers at Georgia Tech have developed a method to improve adoptive T-cell therapy using nanowires to deliver therapeutic miRNA to naïve T-cells. This approach retains the cells' naïve state, making them more effective disease fighters when infused back into patients.