Articles tagged with Lung Cancer
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Researchers have developed a large-scale drug screening technique that tracks drug targets inside cells, allowing for the identification of potential new drugs. The technology screens candidate drugs 100 times faster than standard manual techniques, enabling the discovery of previously unknown drugs.
Researchers have discovered a therapeutic approach that shows promise in preclinical models for treating cancers driven by RAS mutations. The study found that tri-complex inhibitors can restore the normal functioning of mutated RAS proteins, aiming to correct the defect that drives cancer growth.
A recent study found that endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) provided sufficient tissue for identifying actionable genetic aberrations in patients with advanced non-small cell lung cancer. Liquid biopsy samples were also analyzed and compared to EBUS-TBNA results, demonstrating similar findings.
A new lung cancer screening initiative in Central Texas has successfully increased screenings among low-income and minority populations. The program's patient-centered approach, including bilingual support and no-cost screenings, resulted in an 83% completion rate of low-dose CT scans among eligible patients.
TYRA-300 shows promise in treating metastatic bladder cancer patients with FGFR3 gene mutations, achieving a 50% overall response rate and 100% disease control rate. The treatment also displays improved tolerability with lower side effects compared to existing pan-FGFR inhibitors.
Researchers have developed a 'mini-protein' that targets cancer cells expressing Nectin-4, allowing for direct delivery of radiation to tumours. The treatment shows promise in targeting multiple types of cancers and has the potential to be safe for repeated administrations.
A national report reveals nearly 18% of Canadian homes have radon levels above 200 Bq/m³, increasing lung cancer risk. Canadians are among the most highly exposed to radon, highlighting the need for urgent action to address this public health concern.
Researchers found that physically fitter patients with metastatic lung cancer live longer and respond better to chemotherapy. The study identified biomarkers in blood plasma that can indicate which patients are most likely to respond to treatment.
Researchers reported a complete and long-lasting response to immunotherapy in a stage IV non-small cell lung cancer patient with brain metastases. The patient achieved overall survival of 87 months and progression-free survival of 73 months after treatment sequencing.
A study at the University of Texas M.D. Anderson Cancer Center found that adding CTLA-4 immune checkpoint inhibitors to durvalumab and chemotherapy improved overall response rates, progression-free survival, and overall survival for patients with metastatic non-squamous non-small cell lung cancer harboring STK11 and/or KEAP1 mutations.
Researchers identified AM-101 as a potential new way to enhance radiation therapy for patients with lung cancer that has spread to the brain. The drug's ability to activate GABA(A) receptors increases autophagy in lung cancer cells, making them more sensitive to radiation treatment.
Researchers developed a microchip that captures exosomes from blood plasma to identify signs of lung cancer, achieving 10x faster detection and 14x greater sensitivity. The chip uses twisted gold nanoparticles to distinguish between healthy patients and those with lung cancer.
A new study suggests that banning the purchase of cigarettes and other tobacco products among people born between 2006 and 2010 could prevent an estimated 1.2 million lung cancer deaths in 185 countries by 2095. This could reduce the impact of smoking on lung cancer deaths in future generations.
The American College of Chest Physicians has released a new clinical guideline on endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) specimen processing and handling to standardize the process. The guidelines aim to improve diagnostic yield and specimen preservation for downstream ancillary testing.
UCLA investigators presented data on chemoradiotherapy in rectal cancer, MRI-guided radiotherapy for prostate cancer, and symptom self-reporting during treatment. Researchers developed a predictive model to identify patients most likely to respond to chemoradiotherapy in rectal cancer.
Researchers developed a mathematical model predicting enhanced survival outcomes for NSCLC patients with novel treatment combinations. The model neutralizes the negative effects of miR-155, boosting standard-of-care treatments like cisplatin and immune checkpoint inhibitors.
According to the Global Cancer Observatory (GLOBOCAN), lung cancer is the most common type of cancer, with 2.2 million new cases and 1.8 million deaths worldwide in 2020. China had the highest number of new cases, and incidence and mortality rates have been steadily rising from 1990 to 2019.
Researchers have tested a combination of treatments in mice with lung cancer and shown that these allow immunotherapies to target non-responsive tumours. The combination therapy allows 'immune cold' tumours to respond to the body's own defences.
A nonrandomized clinical trial found that wearable devices can increase moderate-to-vigorous physical activity and reduce dyspnea at 6 months post-lung cancer surgery. This suggests a promising role for wearable devices in personalizing perioperative rehabilitation strategies.
A new study by Boston University researchers found that the majority of social media posts from e-cigarette brands left out health warnings, despite a federal requirement to include them. The study used AI to analyze over 2,000 Instagram posts and discovered that only 13% complied with FDA health warning requirements.
A study published in JAMA Network Open found that body mass index (BMI) has a more complex relationship with mortality risk during cancer therapy than previously thought. For patients with advanced non-small cell lung cancer, higher BMI was associated with lower mortality when undergoing immunotherapy or conventional chemotherapy. Howe...
Researchers at NTU Singapore and Oxford have identified a new process called nucleophagy that helps cells remove harmful DNA-protein lesions, promoting genetic material stability and cell survival. This discovery may improve cancer treatment outcomes for patients with colorectal cancer.
A recent study published in JAMA found that telehealth delivery of early palliative care is equivalent to in-person care in terms of quality of life outcomes for patients with advanced non-small cell lung cancer. This finding highlights the potential benefits of expanding access to this evidence-based care model through telehealth.
A new study published in Cell found that TGF-beta and RAS signaling pathways are both required for lung cancer metastasis. Inhibiting RREB1, a transcription factor controlled by RAS, disabled the metastatic process in mouse models, suggesting it could be a potential new drug target.
Patients with chronic respiratory conditions like COPD and asthma may experience delays in being diagnosed with lung cancer due to obscured early symptoms. The study found significant delays in patients with comorbidities that provide alternative explanations for lung cancer symptoms.
Researchers have found that natural killer cells instinctively recognize and attack the XPO1 protein, which drives cancer growth. By targeting this protein, scientists may be able to activate more killer cells to destroy cancer cells. The study suggests that this approach could lead to personalized cancer treatment with less side effects.
Obesity-related cancer rates in China have risen sharply among young people, with an alarming 3.6% annual increase between 2007 and 2021. The trend is particularly pronounced among those aged 25-29, highlighting the urgent need for better public health policies to address China's growing overweight and obesity rates.
A new AI-based digital platform has been developed to analyze tissue sections from lung cancer patients, making diagnosis faster and more accurate. The platform uses algorithms that enable fully automated analysis of digitized tissue samples, allowing for personalized therapy based on molecularly specific genetic changes.
Researchers have identified HLA-E as a critical negative regulator of NK cell interactions with cancer cells. Disrupting NKG2A:HLA-E interactions may stimulate both NK cell and cytotoxic T cell effector functions against cancer, offering a promising anti-cancer strategy.
Researchers developed alternative criteria using a prediction model to identify people with the most to gain from lung cancer screening. The study found that high-benefit groups include those who smoked for a long duration but at a lower intensity, heavy smokers who quit over 15 years ago, and racial and ethnic minority groups.
A new approach combining machine and deep transfer learning improves the accuracy of diagnosing mediastinal lymph node metastases in lung cancer. The study developed a model that achieved strong classification performance even with limited datasets, enhancing healthcare management.
A recent study published in Radiology found that solid lung nodules were present in approximately 42% of non-smoking adults, with prevalence increasing with age. The study suggests that current nodule follow-up guidelines may lead to unnecessary follow-up examinations for low-risk individuals.
Researchers found that a simplified two-question test can predict smoking abstinence in cancer patients with equal accuracy as the full Fagerström Test. However, the test may not work well for Non-Hispanic Black people with a cancer diagnosis. The study aims to help doctors tailor tests for different groups.
A new treatment targeting two tumor-feeding genes is being tested to treat non-small cell lung cancer. The therapy, called PEPD-G278D, breaks down genetic mutations that contribute to drug resistance, showing strong suppression of NSCLC cell function and tumors.
A new editorial published in Aging suggests that starting targeted cancer therapies with high concentrations may slow down the selection for resistance. This approach could potentially be used as a preemptive measure to minimize the development of resistance.
A recent study published in CANCER found that patients with metastatic non–small cell lung cancer treated with immunotherapy had improved overall and cancer-specific survival rates compared to those without it. The median overall survival was eight months, while cancer-specific survival was 10 months.
Recent studies from Asia indicate that low-radiation dose computed tomography screening is more effective in detecting cancers in those with a family history of lung cancer, but the benefits are uncertain for never-smokers. The authors advocate for more rigorous research to understand the benefits and harms of screening this population.
A study by McGill University researchers has found a link between ultrafine particle exposure and increased mortality risk, particularly for respiratory deaths and coronary artery disease. Long-term exposure to these tiny particles is associated with a 7.3% increase in non-accidental death risk.
A new study published by Ohio State University has found that vaping combined with cigarette smoking increases the risk of lung cancer four times higher than people who only smoke. Researchers analyzed data from over 4,975 patients with lung cancer and a control group of 27,294 people without cancer.
A recent study published in Frontiers in Immunology highlights the crucial role of tissue-resident memory T cells in non-small cell lung cancer. The research found that these cells can significantly impact patient outcomes and guide personalized treatment strategies, particularly those involving immunotherapy.
The review highlights the controversy surrounding asbestos-related research and the varying results on its carcinogenicity. It emphasizes the need for high-quality, independent studies to resolve existing debates and inform public health policies.
The American College of Chest Physicians has released a new clinical guideline for managing central airway obstruction, providing evidence-based recommendations to guide its management. The guideline emphasizes the importance of shared decision-making and a multidisciplinary approach in optimizing care and improving outcomes.
Scientists have successfully collected and profiled lung biomarkers from human breath, developing animal models to identify key markers for early detection of metastatic lung tumors. The research establishes a scientific roadmap for an exhaled-breath test, which may revolutionize the diagnosis and surveillance of human lung diseases.
Researchers from Leiden University discuss targeting ABC transporters in pancreatic ductal carcinoma (PDAC), a cancer with poor survival rates. The authors highlight the potential of inhibiting ABC transporters to overcome chemoresistance and suggest developing stratification protocols to identify patients most likely to benefit.
Researchers developed an AI model that can estimate lung function from chest radiographs with high accuracy, potentially expanding options for pulmonary function assessment in patients who have difficulty performing spirometry. The study found a remarkably high agreement rate between the AI model's estimates and actual spirometric data.
The study identified RNF144B as a tumour suppressor that prevents genomic instability, but low expression leads to poor prognosis and treatment resistance in lung adenocarcinoma. The research suggests that even non-mutated genes like RNF144B can have a significant impact on cancer development.
Scientists have mapped over 5,000 genetic variants in the 'tumour protection' gene BAP1 that significantly increase cancer risk. These variants can be used to develop new treatments, including IGF-1 inhibitors, to slow down or prevent cancer progression.
A cross-sectional study found that e-cigarette users were less likely to undergo lung cancer screening. The research suggests that e-cigarettes contain carcinogens and may cause similar gene deregulations as combustible tobacco. This association may be particularly concerning for individuals who have quit smoking combustible cigarettes.
Researchers at MD Anderson Cancer Center found fewer side effects with intensity-modulated radiotherapy (IMRT), with similar survival outcomes compared to 3D-CRT. The study validated heart exposure as an important radiation planning objective, revealing better five-year overall and progression-free survival rates for IMRT.
Researchers found that stress responses differ between patients living in high-violence areas and those in lower-crime zones. The study suggests glucocorticoid receptors play a key role in driving adverse tumor outcomes in patients with chronically high environmental stress.
Researchers found that adding an anti-inflammatory drug to immune checkpoint inhibitor therapy resulted in a high response rate of 67% among patients with stage 4 non-small cell lung cancer. The study suggests that reducing chronic inflammation may improve the effectiveness of immunotherapy.
Researchers analyzed three tumor markers for associations with radiographic response and clinical outcomes in NSCLC patients. The study found that CEA, CA-125, and CA-19-9 were associated with progression and radiographic responses in NSCLC.
Researchers at Weill Cornell Medicine developed an artificial intelligence-powered method for detecting tumor DNA in blood, showing high sensitivity and accuracy in predicting cancer recurrence. The technology, called MRD-EDGE, can detect subtle patterns in sequencing data to distinguish between cancer and non-cancerous signals.
Researchers at Brigham and Women's Hospital have developed a new nanomedicine therapy that delivers anticancer drugs to lung cancer cells and enhances the immune system's ability to fight cancer. The therapy shows promising results in cancer cells in the lab and in mouse lung tumor models, with potential applications for improving care...
Researchers discovered that lung cancer cells with specific genetic mutations, including EGFR and p53, are more likely to double their genome, leading to drug resistance. This discovery has implications for the development of targeted treatments for non-smoking lung cancer patients.
Researchers developed microscopic robots that swim through lungs to deliver cancer-fighting medication directly to metastatic tumors. The approach inhibited tumor growth and spread, improving survival rates compared to control treatments.
US Veterans Health Administration data shows lung cancer screening before diagnosis increases early stage detection and lower mortality rates. Researchers found that those who underwent screening had a higher cure rate and improved survival over five years compared to those without screening.
Generation X sees gains in leading cancers, but lower rates of lung and cervical cancers compared to previous generations. Cancer incidence could remain high for decades if current trends continue.
Researchers found that only 41.5% of cancer patients could successfully book a new appointment at a clinic due to various barriers, including language issues and workflow challenges.
Researchers developed an AI-driven liquid biopsy to identify lung cancer through DNA fragment patterns in the blood, demonstrating a high negative predictive value of 99.8%. The test could quadruple lung cancer detection rates and prevent thousands of deaths if implemented nationwide.