Articles tagged with Protein Abundance
This study used SILAC-based quantitative proteomics to investigate the impact of missense mutations on protein expression in prostate cancer versus healthy tissues. The results show that missense mutations correlate with changes in protein abundance, and specific mutations have deleterious effects on protein stability and function.
Researchers at UCSF describe how to curb MYC levels by disrupting the protein assembly line controlled by RBM42. Disrupting RBM42 in pancreatic cancer cells stopped them from growing, suggesting drugs could be developed to do the same for other fast-growing cancers.
Researchers have developed a new protocol to exclusively access and quantify proteins carried by extracellular vesicles in the blood. This breakthrough may lead to early diagnosis of Parkinson's disease and other brain disorders, providing treatment opportunities before symptoms appear.
Researchers at UCSF have discovered a way to turn ordinary white fat cells into beige fat cells that burn calories, opening the door to developing new weight-loss drugs. The approach uses a protein called KLF-15 and may avoid side effects associated with current treatments.
Researchers investigated molecular changes in aging mouse sweat glands, finding 171 mRNAs enriched in secretory cells. Altered mRNA and protein abundance were associated with age-related declines in sweat gland function.
Researchers at the University of Seville discovered Galectin-3's crucial role in brain tumour progression, finding its inhibition significantly reduces glioblastoma size and brain metastases. Inhibition promotes pro-inflammatory markers and reverses immunosuppressive biomarkers, leading to improved outcomes.
Researchers used a novel deep proteomics approach to investigate the effects of aging and resistance training on skeletal muscle. The study found that aging predominantly affects non-contractile proteins, while resistance training has minimal effects on protein abundance.
Researchers at Kobe University identified differences in synaptic protein production between mice and marmosets during development. The study found that these differences may relate to evolutionary differences between rodent and primate brains, as well as their relevance to autism spectrum disorders.
Scientists have mapped out the proteins involved in motor neurone disease (MND) across its trajectory, identifying potential therapeutic pathways for further investigation. The study found that a protein-folding factor called DNAJB5 is elevated early on in MND, sparking curiosity about its role in disease progression.
Researchers found that DNA damage accumulates in arteries with aging and contributes to impaired vascular function. In mice lacking or heterozygous for the double-strand DNA break repair protein ATM kinase, aging accelerated vascular dysfunction, including increased arterial stiffness and oxidative stress.
A study found that specific proteins in breast milk correlate with the abundance of certain gut microbes in infants, potentially playing a role in early immune and metabolic development. The research suggests a regulatory function of these proteins on the immune function of the gut microbiome in humans.
Researchers used proteomics and small RNA sequencing to analyze 103 human blood plasma samples, identifying 21 proteins and 315 small RNAs associated with aging. Combining protein and miRNA data improved age predictions (R2 = 0.70 ± 0.01), suggesting a broader range of age-related physiological changes.
Researchers at UNC School of Medicine identified molecular pathways critical for heart development, revealing that the mevalonate pathway regulates embryonic heart cell cycling and signaling molecules. This study provides a foundational data set to identify biological causes of congenital heart disease.
Researchers at Ohio State University have found a clear link between the survival motor neuron protein and age-related muscle decline in mice, which may lead to the development of new therapies for sarcopenia. The study suggests that increasing SMN protein production could be a viable approach to addressing this age-related condition.
Researchers have discovered that zinc ions tune the ability of human serum albumin to prevent α-synuclein aggregation, a process linked to Parkinson's disease. Zinc binding alters HSA's chaperone function, blunting fibril formation and slowing down protein deposition that can lead to neurodegeneration.
A blood test taken at the time of Covid-19 infection could predict who is most likely to develop long Covid. Researchers identified a 'signature' in protein levels that predicted persistent symptoms after one year.
Researchers at Sanford Burnham Prebys have discovered the flexible structure of a key blood protein involved in macular degeneration and other age-related diseases. The study reveals how this protein adapts to changing pressure, leading to calcified plaque deposits characteristic of these conditions.
Researchers used chemoproteomics to profile 53 HDAC drugs and found many had additional targets beyond their intended HDACs. The study identified MBLAC2 as a common off-target protein that affects extracellular vesicle accumulation.
A study found that a methionine-deficient diet alters gene expression and DNA methylation in liver cells, increasing the risk of non-alcoholic fatty liver disease. A methionine-supplemented diet had the opposite effect, reducing the risk of liver damage.
Researchers from Tokyo University of Science discovered that bony fish head cartilage contains abundant proteoglycans, including aggrecan, with similar CS structures to salmon nasal cartilage. This finding reveals the potential of sturgeon as an alternative source of CSPGs for health food formulations.
A receptor protein called insulin receptor is pivotal for brain stem cell longevity, according to a Rutgers study. The researchers also found that the same protein plays a crucial role in sustaining brain cancer cells.
Research reveals that an imbalance in gut microbiota, known as dysbiosis, may contribute to the development and progression of Parkinson's disease. Studies found a direct correlation between gut dysbiosis and Parkinson's, with certain bacteria contributing to protein aggregation and neuronal damage.
A new study identifies the age-dependent formation of TMEM106B amyloid filaments in human brains, which may not be linked to neurodegenerative diseases. Researchers found these protein structures in older but not younger individuals, suggesting a potential role in aging and other pathologies.
Researchers have solved atomic-level structures of the muscle-type nicotinic acetylcholine receptor, a crucial step in understanding its function. The new findings could lead to breakthroughs in treating neurological disorders such as congenital myasthenic syndrome and myasthenia gravis.
Researchers found that flavanols activate brown adipose tissue, causing it to burn calories and produce heat. Long-term consumption of flavanols increased the levels of heat-related proteins in mice, suggesting a potential therapeutic effect against obesity-related diseases.
Scientists at the University of Groningen have developed a nanopore-based method for protein identification and sequencing. They constructed a proteosome-nanopore system that can recognize proteins from peptide spectra and sequence entire proteins directly.
A new study identified thousands of protein connections to various human diseases, suggesting a common origin in the genome. This approach linked genetic variations to specific proteins, providing insights into disease mechanisms and potential treatment strategies.
Researchers at Johns Hopkins Medicine have identified promising new targets for pancreatic cancer treatment and early detection, including glycosylated proteins that could be captured in the blood for diagnosis. The study also suggests new ways to improve immune response to these tumors.
A team of scientists has developed a comprehensive understanding of the SARS-CoV-2 protein-based machine responsible for viral replication. By analyzing its structure and function, they have identified potential weak spots for drug development, paving the way for new treatments.
A University of California, Irvine-led study reveals albumin activates a proton channel giving sperm the ability to penetrate and fertilize an egg, and allowing white blood cells to secrete inflammatory mediators. The interaction also enables neutrophils to produce and secrete inflammatory mediators that kill bacteria and fight infection.
Researchers at Scripps Research Institute shed light on the mysterious Gao protein, crucial for brain signaling and motor control. They found that mutations disrupt this process, causing severe developmental delays, seizures, and uncontrolled muscle movements in affected children.
A new study has created the most complete annotated resource of proteins present in synapses, which could aid in early diagnosis and specific drug targets for brain diseases. Researchers identified 1466 synaptic vesicle proteins, many of which were previously unknown, and found that lower-abundance proteins often have crucial functions.
Researchers found a new microbial pathway producing ethylene, providing a potential avenue for biomanufacturing a common plastic component. The discovery also sheds light on a long-standing mystery about how ethylene is produced in anaerobic soils and points to potential paths to prevent crop damage from high levels of ethylene.
A new study reveals that exercise conveys its benefits to the brain through circulating blood factors, improving cognitive function and regenerative effects in aged mice. GPLD1, a protein abundant in exercised mice's plasma, is identified as a potential mediator of this effect.
Scientists have made a groundbreaking discovery about the function of actin, a crucial protein in cells, by uncovering its atomic-scale structure as it is modified. The research reveals that actin's modification plays a key role in regulating its ability to form filaments and interact with other proteins.
A U-shaped relationship was found between egg consumption and the risks of incident CVD and total death among general Chinese. Consumption of 3-6 eggs/week was associated with the lowest risk. Higher or lower egg intake was linked to increased cardiovascular disease and mortality risks, respectively.
Researchers found a molecular switch mechanism that regulates biological clocks, explaining how mutations can shorten clock timing. This discovery may enable the development of therapies to alleviate disruptions caused by clock dysregulation.
Research reveals that methionine in spider silk proteins increases flexibility, enabling close interactions between proteins. The discovery may enable the synthesis of novel biomaterials with improved stability.
Research by LMU Munich chronobiologists reveals that sleep-wake cycles drive cycles of protein abundance and phosphorylation in synaptic proteins. Synaptic phosphorylation plays a key role in regulating synaptic function, particularly during sleep-wake transitions.
A team at Harvard's Wyss Institute developed Immuno-SABER, a DNA-based signal amplification method that allows for the multiplexed visualization of many proteins in single cells. The approach enables independent tuning of signal intensity and simultaneous detection of multiple proteins with high sensitivity and speed.
Researchers explore new tools and strategies to interpret multiomics data, revealing insights into bacterial strains and cancer phenotypes.
U of Guelph researchers found that alligators' hearts become bigger and stronger when exposed to low oxygen during early development, unlike many other animals. This discovery has significant potential to benefit humans, particularly those with weakened hearts.
Scientists have developed a novel nanoparticle formulation targeting PD-L1 with high specificity, allowing for improved infiltration of T cells into tumors and increased sensitivity to checkpoint blockade. This approach achieved an 80% mouse survival rate over 70 days, outperforming traditional antibody therapies.
Researchers have discovered the genetic puzzle behind a mollusk's ability to produce magnetite nanomaterials. The study found that specific proteins are involved in transforming raw materials into magnetite, which could lead to the development of next-generation electronics and energy sources.
Researchers analyzed 56 samples of blister fluid from burns of different depths and healing times to develop a new classification system. They found that specific protein patterns in blister fluid could predict burn depth and time to re-epithelialization, leading to more accurate diagnoses and potential reductions in scarring.
A team of Penn State researchers found that hot temperatures lead to changes in plant RNA structure, linked to a loss in messenger RNAs. This process may help plants cope with heat stress and drought conditions, offering insights into developing more resilient crops.
Researchers at Johns Hopkins Medicine discovered that low copper levels in cells make fat cells fatter by altering how they process fuels like fat and sugar. The study adds evidence that copper homeostasis could be a therapeutic target for metabolic disorders, including obesity.
A team of researchers investigated influenza A's impact on lung-derived cell lines, discovering that the virus alters protein levels and locations. The study found that many proteins are relocalized, with viral and ribosomal proteins increasing in autophagosomes.
The study reveals that cells adjust tRNA abundance to optimize protein production in stressful situations, suggesting a new regulatory mechanism. This mechanism may play a vital role in preventing the proliferation of tumors by selectively modifying translation rates.
Researchers found that Hsp90 stimulates exosome release, a process linked to neurodegenerative diseases and cancer. This novel function could inform drug development for these conditions.
A new protein analysis tool, IonStar, improves measurement consistency of proteins in low abundance and lowers missing data. It could increase medical diagnosis quality and speed up pharmaceutical development.
Scientists used mass spectrometry to analyze proteins in beer at three stages of production, revealing over 200 unique proteins from barley and yeast. The study aims to understand how these proteins control beer's properties and potentially improve brewing techniques.
Researchers at Stanford have discovered how a disease-associated protein gets inactivated, potentially paving the way for new treatments for celiac disease. The discovery of ERp57, an enzyme that re-forms a disulfide bond to turn off TG2, raises questions about its functions in healthy people and could lead to targeted therapies.
A team of researchers has estimated the number of protein molecules in a simple cell for the first time, revealing around 42 million molecules. The study's findings provide insights into how cells control protein abundance and may help reveal molecular roots of disease.
Fibroblasts' circadian clocks affect wound healing, with slower healing times observed at night. Researchers found that resetting cellular clocks before surgery could help maximize healing outcomes.
A team of SUTD researchers identified over 1800 proteins in young reticulocytes, revealing key changes in protein composition during maturation. These findings provide insights into the transition from a multi-lobular to biconcave shape and increased deformability.
A particular protein, DNAJB9, is found in abundance in the kidneys of patients with fibrillary glomerulonephritis, an aggressive kidney disease. The discovery may improve diagnosis and treatment options for this disease, which affects nearly half of patients who become dependent on dialysis.
Researchers have designed a new assay that uses gold nanoparticles to improve the accuracy of medical screening, reducing false positives and wait times. The technology has been shown to be up to clinical standards, allowing patients to receive results in about an hour.
Researchers from NYU Dentistry studied a sea urchin protein that forms hydrogels, capturing mineral nanoparticles and organizing them into crystalline bricks. The protein, rSpSM50, induces fracture resistance and enables the creation of tunable fracture-resistant materials.
Researchers discover that Calcium/Calmodlin-dependent kinase II (CaMKII) is the main effector behind the adaptation of the circadian clock to geographical environment in marine midges. This protein, also found in humans, may play a role in human chronotypes and neuropsychiatric disorders.